Literature summary for 3.4.11.3 extracted from

Borhade, S.R.; Rosenstroem, U.; Saevmarker, J.; Lundbaeck, T.; Jenmalm-Jensen, A.; Sigmundsson, K.; Axelsson, H.; Svensson, F.; Konda, V.; Skoeld, C.; Larhed, M.; Hallberg, M.
Inhibition of insulin-regulated aminopeptidase (IRAP) by arylsulfonamides (2014), ChemistryOpen, 3, 256-263.

Search for more literature for 3.4.11.3

Inhibitors

Inhibitors	Comment	Organism	Structure
1-methyl-N-[3-(1H-tetrazol-5-yl)phenyl]-1H-indole-6-sulfonamide	-	Cricetulus griseus
2,4,5-trichloro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide	-	Cricetulus griseus
3,4-dichloro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide	-	Cricetulus griseus
3,4-dimethyl-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide	-	Cricetulus griseus
3-([(4-bromo-5-chlorothiophen-2-yl)sulfonyl]amino)-N-methylbenzamide	-	Cricetulus griseus
4,5-dichloro-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide	-	Cricetulus griseus
4-bromo-2,6-difluoro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide	-	Cricetulus griseus
4-bromo-2-fluoro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide	-	Cricetulus griseus
4-bromo-5-chloro-N-methyl-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide	-	Cricetulus griseus
4-bromo-5-chloro-N-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide	-	Cricetulus griseus
4-bromo-5-chloro-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-carboxamide	-	Cricetulus griseus
4-bromo-5-chloro-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide	-	Cricetulus griseus
7-chloro-N-[3-(1H-tetrazol-5-yl)phenyl]-1,3-dihydro-2,1,3-benzoxadiazole-4-sulfonamide	-	Cricetulus griseus
N-[3-(1H-tetrazol-5-yl)phenyl]-1-benzothiophene-2-sulfonamide	-	Cricetulus griseus
N-[3-(1H-tetrazol-5-yl)phenyl]-2-benzothiophene-4-sulfonamide	-	Cricetulus griseus
N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide	-	Cricetulus griseus
N-[3-(1H-tetrazol-5-yl)phenyl]biphenyl-4-sulfonamide	-	Cricetulus griseus
N-[3-(1H-tetrazol-5-yl)phenyl]pyridine-3-sulfonamide	-	Cricetulus griseus
N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide	-	Cricetulus griseus

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CHO cell	-	Cricetulus griseus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Leu-4-nitroanilide + H2O	-	Cricetulus griseus	L-Leu + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
insulin-regulated aminopeptidase	-	Cricetulus griseus
IRAP	-	Cricetulus griseus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Cricetulus griseus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0011	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	3,4-dichloro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide
0.0013	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	7-chloro-N-[3-(1H-tetrazol-5-yl)phenyl]-1,3-dihydro-2,1,3-benzoxadiazole-4-sulfonamide
0.0016	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	4-bromo-2-fluoro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide
0.0018	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	4,5-dichloro-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide
0.0021	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	4-bromo-5-chloro-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide
0.0029	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	2,4,5-trichloro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide
0.0031	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	3,4-dimethyl-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide
0.0079	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	4-bromo-2,6-difluoro-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide
0.016	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	N-[3-(1H-tetrazol-5-yl)phenyl]-1-benzothiophene-2-sulfonamide
0.022	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	1-methyl-N-[3-(1H-tetrazol-5-yl)phenyl]-1H-indole-6-sulfonamide
0.039	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	N-[3-(1H-tetrazol-5-yl)phenyl]-2-benzothiophene-4-sulfonamide
0.044	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	N-[3-(1H-tetrazol-5-yl)phenyl]biphenyl-4-sulfonamide
0.058	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	4-bromo-5-chloro-N-methyl-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide
0.067	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	4-bromo-5-chloro-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-carboxamide
0.125	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	4-bromo-5-chloro-N-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide
0.125	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	3-([(4-bromo-5-chlorothiophen-2-yl)sulfonyl]amino)-N-methylbenzamide
0.125	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide
0.125	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide
0.125	-	pH 7.4, temperature not specified in the publication	Cricetulus griseus	N-[3-(1H-tetrazol-5-yl)phenyl]pyridine-3-sulfonamide

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Release 2023.1 (January 2023)