EC Number |
Protein Variants |
Reference |
---|
3.4.11.3 | A429G |
no activity with L-Arg-vasopressin, no activity with L-Leu-enkephalin |
683204 |
3.4.11.3 | A429G |
the ratio of maximal velocity to Km-value is 75% of the value for the wild-type enzyme |
651116 |
3.4.11.3 | A6909T |
naturally occuing mutation, polymorphism A609T interacts with the hinge domain III of IRAP, similarly to SNP K528R in ERAP1, which has been repeatedly validated for disease association and effects on activity. The A609T mutation leads to an almost 2fold reduction in activity compared to wild-type |
754324 |
3.4.11.3 | C103A/C114A |
no effects of mutating the modified cysteines on the plasma membrane localisation of IRAP in transfected HEK-293T cells are detected. Combined mutation of both C103A and C114A leads to a complete loss of IRAP S-acylation |
755404 |
3.4.11.3 | C35A/C103A/C114A |
no effects of mutating the modified cysteines on the plasma membrane localisation of IRAP in transfected HEK-293T cells are detected. Combined mutation of both C103A and C114A leads to a complete loss of IRAP S-acylation |
755404 |
3.4.11.3 | E431A |
strong decrease in aminopeptidase activity towards Leu-4-nitroanilide |
651116 |
3.4.11.3 | E431D |
strong decrease in aminopeptidase activity towards Leu-4-nitroanilide |
651116 |
3.4.11.3 | E465D |
strong decrease in aminopeptidase activity towards Leu-4-nitroanilide |
651116 |
3.4.11.3 | E465Q |
strong decrease in aminopeptidase activity towards Leu-4-nitroanilide |
651116 |
3.4.11.3 | E487D |
strong decrease in aminopeptidase activity towards Leu-4-nitroanilide |
651116 |