Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | insulin activates the enzyme migration from the intracellular vesicles to the cellular membrane | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
angiotensin IV | AngIV, induces an increase in the intracellular calcium concentration in pinealocytes by 72% at 10 nM, but AngIV does not alter cAMP levels | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell membrane | enzyme IRAP is localized in intracellular vesicles which can translocate to the cell membrane under insulin stimulation | Rattus norvegicus | - |
- |
vesicle | enzyme IRAP is localized in intracellular vesicles which can translocate to the cell membrane under insulin stimulation | Rattus norvegicus | 31982 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | IRAP is a zinc-dependent aminopeptidase | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
oxytocin + H2O | Rattus norvegicus | - |
? | - |
? | |
Vasopressin + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P97629 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Rattus norvegicus | - |
basal ganglion | - |
Rattus norvegicus | - |
brain | AT4 receptor/IRAP is found in neurons in the cortex, hippocampus and basal ganglia | Rattus norvegicus | - |
brain cortex | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
pineal gland | - |
Rattus norvegicus | - |
pinealocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
oxytocin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Vasopressin + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AT4 receptor | - |
Rattus norvegicus |
insulin-regulated aminopeptidase | - |
Rattus norvegicus |
IRAP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
evolution | IRAP is a type-2 membrane glycoprotein from the M1 family of zinc-dependent aminopeptidases | Rattus norvegicus |
physiological function | the AT4 receptor identified as the IRAP is found in neurons in the cortex, hippocampus and basal ganglia. The presence of aminopeptidases A and N in the pineal gland suggests local production of Ang IV that could act through its specific receptor (IRAP)/AT4 to modulate melatonin synthesis, analysis of the role of enzyme inhibitor Ang IV on melatonin synthesis using isolated pinealocyte cultures, overview. IRAP is an enzyme that is mostly associated with cellular membranes, and its translocation appears to be regulated by insulin, which activates its migration from the intracellular vesicles to the cellular membrane together with the glucose transporter, Glut4. IRAP plays either the role of a true receptor, the (IRAP)/AT4 receptor, inducing intracellular signaling pathways, or the role of an enzyme that metabolizes several peptides, such as oxytocin and arginine vasopressin | Rattus norvegicus |