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EC Number Localization Commentary GeneOntology No. Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3cell membrane enzyme IRAP is localized in intracellular vesicles which can translocate to the cell membrane under insulin stimulation - 753121
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3cell surface the enzyme translocates to the cell surface within GLUT4 vesicles in response to insulin GO:0009986 AmiGO QuickGO 668760
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3cell surface TUG regulates IRAP cell surface targeting in 3T3-L1 adipocytes GO:0009986 AmiGO QuickGO -, 754109
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3cytoplasmic vesicle GLUT4-containing. Insulin-regulated aminopeptidase is a marker protein for specialized vesicles containing the insulin-responsive glucose transporter, GLUT4. The enzyme is thought to be involved in the tethering of GLUT4 vesicles to intracellular compartments GO:0031410 AmiGO QuickGO 670742
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3cytoplasmic vesicle GLUT4-containing; defects in the intracellular trafficking of P-LAP/IRAP-containing GLUT4 vesicle are associated with type 2 diabetes GO:0031410 AmiGO QuickGO 667811
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3cytoplasmic vesicle GLUT4-containing; the enzyme colocalizes with GLUT4 in specific intracellular vesicles GO:0031410 AmiGO QuickGO 667888
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3cytosol P-LAP is translocated from the cytosol to the plasma membrane by oxytocin stimulation in vascular endothelial cells and by vasopressin in renal cells GO:0005829 AmiGO QuickGO 670742
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3endosome insulin-stimulated translocation of IRAP remains intact despite substantial knock-down of glucose transporter GLUT4. By contrast, insulin-stimulated GLUT4 translocation is impaired upon IRAP knock-down. Tankyrase knock-down alters the basal partitioning of GLUT4 and IRAP within endosomal compartments GO:0005768 AmiGO QuickGO 683133
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3Golgi apparatus co-localization with marker TGN 38 GO:0005794 AmiGO QuickGO 683795
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.3lysosome - GO:0005764 AmiGO QuickGO 35902, 35918
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