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Literature summary for 3.4.11.3 extracted from

  • Ruixadz-Sanjuan, M.; Martinez-Martos, J.; Carrera-Gonzalez, M.; Mayas, M.; Garcia, M.; Arrazola, M.; Ramirez-Exposito, M.
    Normolipidic dietary fat modifies circulating renin-angiotensin system-regulating aminopeptidase activities in rat with breast cancer (2015), Integr. Cancer Ther., 14, 149-155 .
No PubMed abstract available
Search for more literature for 3.4.11.3

Application

Application Comment Organism
diagnostics the increase in serum IRAP activity can be an indicator of a misregulation of vasopressin (AVP) function Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Vasopressin + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P97629
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Rattus norvegicus
-
breast cancer cell N-methyl nitrosourea (NMU)-induced breast cancer Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leucyl-beta-naphthylamide + H2O
-
 Rattus norvegicus leucine + beta-naphthylamine
-
 ?
Vasopressin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
insulin-regulated aminopeptidase
-
 Rattus norvegicus
IRAP
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

General Information

General Information Comment Organism
metabolism the type of dietary fat does not influence latency period, incidence of animals with tumors, incidence of mortality, or tumor yield per rat. However, changes are observed in tumor volume and the histopathology. The type of dietary fat also differently modifies the enzymes involved in RAS regulation. Both insulin-regulated aminopeptidase (IRAP) and angiotensin IV forming activities are involved in this animal model of breast pathogenesis. The increase in serum IRAP activity can be an indicator of a misregulation of vasopressin (AVP) function Rattus norvegicus