Literature summary for 3.4.11.3 extracted from

Prieto, I.; Villarejo, A.B.; Segarra, A.B.; Wangensteen, R.; Banegas, I.; de Gasparo, M.; Vanderheyden, P.; Zorad, S.; Vives, F.; Ramirez-Sanchez, M.
Tissue distribution of CysAP activity and its relationship to blood pressure and water balance (2015), Life Sci., 134, 73-78 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	membrane-bound	Rattus norvegicus	16020	-
soluble	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P97629	-	-
Rattus norvegicus Wistar-Kyoto	P97629	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
hypothalamus	-	Rattus norvegicus	-
kidney	-	Rattus norvegicus	-
additional information	organ distribution in adult male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with or without treatment with captopril, overview. Soluble or membrane-bound activities are generally higher in SHR compared to WKY notably in hypothalamus and kidney than in the other tissues. Captopril mainly decreases CysAP in SHR whereas it increases in WKY. The distribution of soluble CysAP is more homogeneous among tissues of WKY than SHR. In contrast, the distribution of membrane-bound CysAP is more heterogeneous than soluble CysAP in both WKY and SHR	Rattus norvegicus	-
renal medulla	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-cystine-di-beta-naphthylamide + 2 H2O	-	Rattus norvegicus	L-cystine + 2 beta-naphthylamine	-	?
L-cystine-di-beta-naphthylamide + 2 H2O	-	Rattus norvegicus Wistar-Kyoto	L-cystine + 2 beta-naphthylamine	-	?

Synonyms

Synonyms	Comment	Organism
CysAP	-	Rattus norvegicus
cystinylaminopeptidase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	functional roles of soluble (Sol) and membrane-bound (MB) cystinylaminopeptidase (CysAP) activities, overview. Soluble and membrane-bound CysAP activities, acting separately or in concert and mainly in renal medulla, regulate the function of their susceptible endogenous substrates, and may participate meaningfully in the control of blood pressure and fluid balance	Rattus norvegicus

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Release 2023.1 (January 2023)