EC Number   |
General Information |
Reference |
|---|
   3.4.11.3 | evolution |
IRAP is a member of the M1 family of zinc-dependent metalloproteinases |
-, 754445 |
| 3.4.11.3 | evolution |
IRAP is a member of the oxytocinase subfamily of M1 aminopeptidases characterised by the presence of two key sequence motifs, the HEXXH zinc-binding and GXMEN substrate recognition sequences |
753769 |
| 3.4.11.3 | evolution |
IRAP is a type-2 membrane glycoprotein from the M1 family of zinc-dependent aminopeptidases |
753121 |
| 3.4.11.3 | evolution |
ovarian tissue LNPEP of Amargosa pupfish, Cyprinodon nevadensis, exhibits high amino acid identity to human LNPEP both in the protein's active domain that includes the peptide binding site and zinc cofactor binding motif (53.1% identity), and in an intracellular region that distinguishes LNPEP from other aminopeptidases (70.3% identity). The pupfish LNPEP-like enzyme also shares a conserved di-leucine amino acid sequence in the N-terminus intracellular region with placental LNPEP |
753723 |
| 3.4.11.3 | malfunction |
catalytic preference and insulin-regulated traffic of IRAP in adipocytes are disturbed by obesity and are interrelated with comprehensive roles of endogenous substrates with N-terminal cysteine pair in energy metabolism homeostasis |
-, 754445 |
| 3.4.11.3 | malfunction |
diabetes insipidus (DI) is a rare complication of pregnancy occurring in pregnancy, it is associated with excessive vasopressinase activity, secreted by placental trophoblasts, which increases the rate of degradation of anti-diuretic hormone. It is responsive to synthetic desmopressin 1-deamino-8-D-arginine vasopressin as this form is not degraded by placental vasopressinase. Vasopressinase-induced diabetes insipidus is associated with pre-eclampsia |
753436 |
| 3.4.11.3 | malfunction |
in IRAP knockout mice, the half-life of circulating vasopressin is increased 3fold, and plasma concentrations are increased 2fold. Transgenic mice with constitutive TUG proteolysis in muscle consume much more water than wild-type control mice. The transgenic mice lose more body weight during water restriction, and the abundance of renal AQP2 water channels is reduced, implying that vasopressin activity is decreased. To compensate for accelerated vasopressin degradation, vasopressin secretion is increased, as assessed by the cosecreted protein copeptin. IRAP abundance is increased in T-tubule fractions of fasting transgenic mice, when compared with controls |
-, 754109 |
| 3.4.11.3 | malfunction |
inhibition of central enzyme activity by injection of amastatin in anaesthetised suckling mothers increases the frequency of reflex milk ejections |
732363 |
| 3.4.11.3 | malfunction |
peptide inhibitor DG026 is able to selectively downregulate IRAP-dependent cross-presentation by dendritic cells but leave ERAP1-dependent cross-presentation unaffected |
754389 |
| 3.4.11.3 | malfunction |
protein S-acylation (also referred to as palmitoylation) is a post-translational modification (PTM) involving the attachment of palmitate and other fatty acids to cysteine residues of proteins via thioester linkage, no effects of mutating the modified cysteines on the plasma membrane localisation of IRAP in transfected HEK-293T cells are detected |
755404 |
