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Literature summary for 3.4.11.3 extracted from

  • Axen, A.; Lindeberg, G.; Demaegdt, H.; Vauquelin, G.; Karlen, A.; Hallberg, M.
    Cyclic insulin-regulated aminopeptidase (IRAP)/AT4 receptor ligands (2006), J. Pept. Sci., 12, 705-713.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-Val-L-Tyr-L-Ile-L-Cys-L-Pro-L-Cys cyclic disulfide, angiotensin IV analog, considerably more stable than angiotensin IV toward enzymatic degradation Homo sapiens
L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-cyclohexylalanine
-
Homo sapiens
L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe i.e.angiotensin IV Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform IRAP is identical to angiotensin IV receptor
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000046
-
L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe pH 7.4, 37°C Homo sapiens
0.0000065
-
L-Val-L-Tyr-L-Ile-L-Cys-L-Pro-L-Cys pH 7.4, 37°C Homo sapiens
0.0000079
-
L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-cyclohexylalanine pH 7.4, 37°C Homo sapiens