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Literature summary for 3.4.11.3 extracted from

  • Habtemichael, E.N.; Alcazar-Roman, A.; Rubin, B.R.; Grossi, L.R.; Belman, J.P.; Julca, O.; Loeffler, M.G.; Li, H.; Chi, N.W.; Samuel, V.T.; Bogan, J.S.
    Coordinated regulation of vasopressin inactivation and glucose uptake by action of TUG protein in muscle (2015), J. Biol. Chem., 290, 14454-14461 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.3

Protein Variants

Protein Variants Comment Organism
additional information construction of IRAP knockout mice, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface TUG regulates IRAP cell surface targeting in 3T3-L1 adipocytes Mus musculus 9986
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membrane IRAP is a transmembrane aminopeptidase Mus musculus 16020
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vesicle in adipose and muscle cells, insulin stimulates the exocytic translocation of vesicles containing GLUT4, a glucose transporter, and insulin-regulated aminopeptidase (IRAP), a transmembrane aminopeptidase. TUG regulates IRAP cell surface targeting in 3T3-L1 adipocytes Mus musculus 31982
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4 ?
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 ?
additional information Mus musculus C57BL/6J recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4 ?
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 ?
Vasopressin + H2O Mus musculus inactivation of vasopressin ?
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 ?
Vasopressin + H2O Mus musculus C57BL/6J inactivation of vasopressin ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8C129
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Mus musculus C57BL/6J Q8C129
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Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
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 Mus musculus
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adipocyte
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 Mus musculus
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adipose tissue
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 Mus musculus
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skeletal muscle T-tubule-enriched membrane fractions from quadriceps muscles isolated of fasting mice Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4 Mus musculus ?
-
 ?
additional information recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4 Mus musculus C57BL/6J ?
-
 ?
Vasopressin + H2O
-
 Mus musculus ?
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 ?
Vasopressin + H2O inactivation of vasopressin Mus musculus ?
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 ?
Vasopressin + H2O
-
 Mus musculus C57BL/6J ?
-
 ?
Vasopressin + H2O inactivation of vasopressin Mus musculus C57BL/6J ?
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 ?

Synonyms

Synonyms Comment Organism
insulin-regulated aminopeptidase
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 Mus musculus
IRAP
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 Mus musculus

General Information

General Information Comment Organism
malfunction in IRAP knockout mice, the half-life of circulating vasopressin is increased 3fold, and plasma concentrations are increased 2fold. Transgenic mice with constitutive TUG proteolysis in muscle consume much more water than wild-type control mice. The transgenic mice lose more body weight during water restriction, and the abundance of renal AQP2 water channels is reduced, implying that vasopressin activity is decreased. To compensate for accelerated vasopressin degradation, vasopressin secretion is increased, as assessed by the cosecreted protein copeptin. IRAP abundance is increased in T-tubule fractions of fasting transgenic mice, when compared with controls Mus musculus
metabolism insulin stimulates the exocytic translocation of vesicles containing GLUT4 glucose transporters and insulin-regulated aminopeptidase (IRAP). Insulin acts through TUG proteins to control IRAP targeting, similar to GLUT4, the activity of vasopressin, an IRAP substrate, is reduced in mice with disrupted TUG action in muscle. TUG regulates vasopressin action. Exocytic translocation of vesicles in muscle coordinates vasopressin inactivation by IRAP with glucose uptake Mus musculus
physiological function the enzyme inactivates vasopressin in the muscle and adipose tissue regulated by TUG. Vasopressin regulates water permeability in the renal collecting system by both minute-to-minute effects on AQP2 targeting and hour-to-daylong effects on AQP2 abundance. Recombinant IRAP binds to TUG, and this interaction is mapped to a short peptide in IRAP that is critical for GLUT4 intracellular retention Mus musculus