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Information on EC 3.1.6.2 - steryl-sulfatase
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EC Tree
3.1.6.2 steryl-sulfataseIUBMB Comments
Also acts on some related steryl sulfates.
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Word Map
- 3.1.6.2
- women
- testosterone
- androgen
- adrenal
- cortisol
- estradiol
- estrogen
- androstenedione
- sulphate
- globulin
-
polycystic
- ovary
- fsh
-
x-linked
- ovarian
-
postmenopausal
- ichthyosis
- progesterone
- acth
- aromatase
- hyperandrogenism
-
neurosteroids
- hirsutism
-
menstrual
-
hormone-binding
- prolactin
-
luteinizing
- 17-hydroxyprogesterone
-
premenopausal
-
adrenarche
-
sulfotransferase
-
hormone-dependent
- sulfamate
-
endocrinology
-
hyperandrogenemia
-
17beta-hydroxysteroid
-
hypothalamic-pituitary-adrenal
-
pubertal
- pharmacology
- 21-hydroxylase
-
alpha-hydroxyprogesterone
- 17beta-hsds
-
dhea-s
-
virilization
-
tanner
- 11-deoxycortisol
- allopregnanolone
-
sulfatases
-
kallmann
- medicine
- analysis
-
pregs
-
incidentalomas
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
dheas, steroid sulfatase, steroid sulphatase, estrone sulfatase, arylsulfatase c, e1-sts, sterol sulfatase, dehydroepiandrosterone sulfatase, steryl-sulfatase, arylsufatase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-beta-hydroxysteroid sulfate sulfatase
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arylsulfatase C
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ASC
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AtsA
dehydroepiandrosterone sulfatase
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-
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dehydroepiandrosterone sulfate sulfatase
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estrone sulfatase
phenolic steroid sulfatase
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pregnenolone sulfatase
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steroid 3-sulfatase
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steroid sulfatase
steroid sulfate sulfohydrolase
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sterol sulfatase
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Steryl-sulfate sulfohydrolase
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STS
sulfatase, sterol
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additional information
steroid sulfatase
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steroid sulfatase
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STS
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additional information
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arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
additional information
-
arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of sulfuric ester
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-
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-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
steryl-sulfate sulfohydrolase
Also acts on some related steryl sulfates.
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CAS REGISTRY NUMBER
COMMENTARY
9025-62-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
16alpha-hydroxydehydroepiandrosterone 3-sulfate + H2O
16alpha-hydroxydehydroepiandrosterone + sulfate
-
-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferol + sulfate
-
-
-
-
?
4-methylumbelliferyl-6-O-sulfate + H2O
4-methylumbelliferone + sulfate
-
-
-
-
?
7-dehydroepiandrosterone sulfate + H2O
7-dehydroepiandrosterone + sulfate
-
-
-
-
?
arylsulfates + H2O
? + sulfate
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e.g. 3alpha sulfates of: 5alpha-androstane-17-one, 5beta-androstane-17-one, 3beta sulfates of: 5alpha-androstane-17-one, DELTA5-androstene 17-one, 5alpha-pregnane-20-one, DELTA5-pregnene-20-one
-
-
?
arzoxifene sulfate + H2O
arzoxifene + sulfate
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product of sulfotransferase reaction on arzoxifene used in hormone replacement therapy
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-
?
dehydroisoandrosterone 3-sulfate + H2O
dehydroisoandrosterone + sulfate
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-
-
-
?
epitestosterone 17-sulfate + H2O
epitestosterone + sulfate
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-
-
?
etiocholanolone 3-sulfate + H2O
etiocholanolone + sulfate
-
-
-
?
phenolphthalein disulfate + H2O
phenolphthalein monosulfate + sulfate
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-
-
-
?
raloxifene sulfate + H2O
raloxifene + sulfate
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product of sulfotransferase reaction on raloxifene used in hormone replacement therapy, the benzothiophene sulfate is substrate, the 4'-phenolic sulfate is no substrate for enzyme
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-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
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-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
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-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
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-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
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-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
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-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
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-
-
-
?
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
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-
-
?
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
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both s-form and f-form
-
-
?
cholesterol sulfate + H2O
cholesterol + sulfate
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cholesterol sulfate metabolism, steroid sulfohydrolase pathway
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-
?
cholesterol sulfate + H2O
cholesterol + sulfate
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highly specific for cholesterol sulfate
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-
?
dehydroandrosterone 3-sulfate + H2O
dehydroandrosterone + sulfate
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-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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only s-form
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?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
in adipose tissue, further concersion to bioactive androgens and estrogens
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-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
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?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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conversion to androstenediol by 17beta-hydroxysteroid dehydrogenase type 1, androstenediol supports mammary tumor growth in rodents, or conversion to androstenedione, main substrate for aromatase in postmenopausal women
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?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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-
subsequent conversion to andgrogen testosterone or androstenediol, androgens stimulate growth of prostate cancer cells
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?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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subsequent conversion to androst-5-ene-3beta,17beta-diol (Adiol), an androgen with estrogenic properties, and thus a mitogen for the growth and development of hormome-dependent breast cancer
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?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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subsequent conversion to androst-5-ene-3beta,17beta-diol, an androgen with estrogenic properties, stimulating breast cancer growth
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?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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subsequent conversion to estradiol with 3beta-hydroxysteroid dehydrogenase, aromatase and 17beta-hydroxysteroid dehydrogenase
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?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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subsequent conversion to testosterone
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?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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androgen metabolism, dehydroepiandrosterone sulfate may play a part in the pathogenesis of androgenic alopecia
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-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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hydrolyzes dehydroepiandrosterone sulfate to its active, unsulfated form
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-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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oestrogen biosynthesis
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-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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1.5% of the activity with cholesterol sulfate
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-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol
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-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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subsequent conversion to testosterone or aromatisation to estrone
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?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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-
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
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conversion to androstenediol by 17beta-hydroxysteroid dehydrogenase type 1, androstenediol supports mammary tumor growth in rodents, or conversion to androstenedione, main substrate for aromatase in postmenopausal women
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
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subsequent conversion to androst-5-ene-3beta,17beta-diol (Adiol), an androgen with estrogenic properties, and thus a mitogen for the growth and development of hormome-dependent breast cancer
-
?
epiandrosterone 3-sulfate + H2O
epiandrosterone + sulfate
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-
-
?
estrone 3-sulfate + H2O
estrone + sulfate
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hydrolyzes estrone 3-sulfate to its active, unsulfated form
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-
?
estrone sulfate + H2O
estrone + sulfate
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135600, 135602, 135604, 135611, 135619, 135622, 135624, 645740, 645797, 656640, 656641, 656649, 656658, 681648, 691630, 702979, 703195, 705062, 705709, 714750, 714821, 714906, 716213, 716214
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-
?
estrone sulfate + H2O
estrone + sulfate
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conversion to estradiol by 17beta-hydroxysteroid dehydrogenase type 1
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?
estrone sulfate + H2O
estrone + sulfate
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estrogen estrone formed from androstenedione by cytochrome P450 enzyme aromatase, estrogen is a mitogen for growth and development of hormone-dependent breast cancer
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?
estrone sulfate + H2O
estrone + sulfate
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in breast cancer tissue 10 times more estrone originates from estrone sulfate than from androstenedione
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?
estrone sulfate + H2O
estrone + sulfate
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subsequent conversion to biologically active estrogen estradiol, increased activity and expression of STS in hormone-dependent cancer cells, estradiol prerequisite for Ishikawa cell tumorgenesis in ovariectomized mouse model, estrogens are suggested as growth stimulators in prostate cancer cells as well, subsequent conversion to estradiol
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?
estrone sulfate + H2O
estrone + sulfate
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subsequent conversion to estradiol
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?
estrone sulfate + H2O
estrone + sulfate
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subsequent conversion to estradiol with 17beta-hydroxysteroid dehydrogenase
-
?
estrone sulfate + H2O
estrone + sulfate
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STS converts the major circulating plasma estrogen estrone sulfate into the biologically active estrogene estrone, STS plays an important role in the in situ estrogen actions of various sex steroid-dependent tumors, peripheral STS plays a very important role in peripheral estrogen metabolism and actions in the human fetus
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-
?
estrone sulfate + H2O
estrone + sulfate
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STS plays an important role in the in situ estrogen actions of estrogen-dependent human tissues and various sex steroid-dependent tumors, STS may be associated with the degree of atherosclerotic changes in the female aorta, transformation of the biologically inactive form of plasma estrogen in its active form
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
0.6% of the activity with cholesterol sulfate
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
subsequent conversion to estradiol
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
conversion to estradiol by 17beta-hydroxysteroid dehydrogenase type 1
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
estrogen estrone formed from androstenedione by cytochrome P450 enzyme aromatase, estrogen is a mitogen for growth and development of hormone-dependent breast cancer
-
?
estrone sulfate + H2O
estrone + sulfate
STS within the Leydig cells of Sus scrofa is involved in modulation of testicular estrogen bioavailability
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
pregnenolone sulfate + H2O
pregnenolone + sulfate
-
8.7% of the activity with cholesterol sulfate
-
-
?
steroid sulfate + H2O
steroid + sulfate
-
steroid sulfatase converts all steroid sulfates into their free steroid forms
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
135595, 135598, 135599, 135600, 135601, 135602, 135603, 135604, 135605, 135606, 135611, 135612, 135614, 135615, 135616, 135617, 135619, 135622, 135624, 135625, 135626, 135628
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?