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Literature summary for 3.1.6.2 extracted from

  • Gibson, D.A.; Foster, P.A.; Simitsidellis, I.; Critchley, H.O.D.; Kelepouri, O.; Collins, F.; Saunders, P.T.K.
    Sulfation pathways A role for steroid sulphatase in intracrine regulation of endometrial decidualisation (2018), J. Mol. Endocrinol., 61, M57-M65 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.6.2

Inhibitors

Inhibitors Comment Organism Structure
irosustat
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08842
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast endometrial stromal fibroblast Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens expression increases upon stimulation with decidualisation media up

General Information

General Information Comment Organism
physiological function both expression and activity of STS increase in response to a decidualisation stimulus. Inhibition of STS activity disrupts bioavailability of estrogens and inhibits decidualisation responses consistent with stromal utilisation of sulfated steroids as precursors to active hormones during decidualisation Homo sapiens