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Literature summary for 3.1.6.2 extracted from

  • Nakata, T.; Takashima, S.; Shiotsu, Y.; Murakata, C.; Ishida, H.; Akinaga, S.; Li, P.K.; Sasano, H.; Suzuki, T.; Saeki, T.
    Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients (2003), J. Steroid Biochem. Mol. Biol., 86, 455-460.
    View publication on PubMed
Search for more literature for 3.1.6.2

Application

Application Comment Organism
medicine the expression of STS is an independent prognostic factor in breast cancer, STS is a new molecular target for the treatment of estrogen-dependent breast tumor post-selective estrogen receptor modulator and/or aromatase inhibitors Homo sapiens
pharmacology the non-estrogenic STS inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine has anti-cancer activity and should be a potent therapeutic agent for treatment of estrogen-dependent breast cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of STS gene in human breast cancer MCF-7 cells, i.e. MCS-2 cells, transplanted in female nude mice Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(p-O-sulfamoyl)-N-tetradecanoyl tyramine non-estrogenic STS inhibitor, IC50: 56 nM/l, anti-cancer activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens biosynthesis of estrogens in breast tumor tissues of post-menopausal breast cancer patients, STS stimulates the growth and survival of estrogen-dependent breast tumors ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCS-2 cell the MCS-2 cell line is established by introduction of the human STS gene into estrogen-dependent human breast cancer MCF-7 cells, MCS-2 cells are transplanted into female nude mice Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androstenediol sulfate + H2O
-
 Homo sapiens androstenediol + sulfate
-
 ?
dehydroepiandrosterone sulfate + H2O
-
 Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
estrone 3-sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
additional information biosynthesis of estrogens in breast tumor tissues of post-menopausal breast cancer patients, STS stimulates the growth and survival of estrogen-dependent breast tumors Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
STS
-
 Homo sapiens