Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor sulfamic acid 2-bromo-4-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]methyl]phenyl ester | Homo sapiens |
in complex with inhibitor sulfamic acid 2-bromo-4-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]methyl]phenyl ester | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sulfamic acid 2-bromo-4-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]methyl]phenyl ester | dual aromatase-sulfatase inhibitor, IC50 value for aromatase 0.82 nM | Homo sapiens | |
sulfamic acid 2-bromo-4-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]methyl]phenyl ester | dual aromatase-sulfatase inhibitor. Alomst complete inhibition of both aromates and sulfatase in pregnant mare's serum gonadotropin pretreated female rats 3 h after a single oral dose. No inhibition of aldosterone synthesis | Rattus norvegicus | |
sulfamic acid 5-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]-methyl]-2-fluorophenyl ester | dual aromatase-sulfatase inhibitor, IC50 value for aromatase 0.77 nM | Homo sapiens | |
sulfamic acid 5-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]-methyl]-2-fluorophenyl ester | dual aromatase-sulfatase inhibitor. Potent inhibition of both aromates and sulfatase in pregnant mare's serum gonadotropin pretreated female rats 3 h after a single oral dose | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JEG-3 cell | - |
Homo sapiens | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000039 | - |
- |
Homo sapiens | sulfamic acid 2-bromo-4-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]methyl]phenyl ester | |
0.00059 | - |
- |
Homo sapiens | sulfamic acid 5-[[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]-methyl]-2-fluorophenyl ester |