Inhibitors | Comment | Organism | Structure |
---|---|---|---|
estrone-3-O-sulfamate | highly potent, specific STS inhibitor, complete inhibition at 0.001 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.072 | - |
Estrone sulfate | pH 7.5, 37°C, POGS-5 microsomes | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | from POGS-5 cell line | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | ovarian estrogen synthesis, the relative contribution of STS activity to ovarian steroidogenesis is unclear but may have important physiological and pathophysiological implications | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
immature female Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
granulosa cell | primary cultures of granulosa cells matured in vitro with follicle-stimulating hormone and testosterone | Rattus norvegicus | - |
additional information | no STS activity in the immortalized rat granulosa cell line POGRS-1 | Rattus norvegicus | - |
ovary | crude homogenate, from immature female Sprague-Dawley rats treated with gonadotropin in vivo | Rattus norvegicus | - |
POGS-5 cell | immortalized rat granulosa cell line | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | - |
Rattus norvegicus | dehydroepiandrosterone + sulfate | - |
? | |
estrone sulfate + H2O | - |
Rattus norvegicus | estrone + sulfate | - |
? | |
additional information | ovarian estrogen synthesis, the relative contribution of STS activity to ovarian steroidogenesis is unclear but may have important physiological and pathophysiological implications | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
STS | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |