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Literature summary for 3.1.6.2 extracted from
- Purification and properties of arylsulfatase C from human placenta (1987), Enzyme, 37, 115-126.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dehydroepiandrosterone | - |
Homo sapiens |  |
| Estrone 3-sulfate | competitive inhibitor | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
dehydroepiandrosterone 3-sulfate | - |
Homo sapiens | |
| 0.1 | - |
methylumbelliferyl sulfate | esterone 3-sulfate | Homo sapiens | |
| 1 | - |
p-nitrophenylsulfate | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 78000 | - |
1 * 78000, solubilized in Triton X-100 | Homo sapiens |
| 78000 | - |
alpha, 3 * 78000, SDS-PAGE,solubilized in Triton X-100 | Homo sapiens |
| 238000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| steroid sulfates + H2O | Homo sapiens | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dehydroepiandrosterone 3-sulfate + H2O | - |
Homo sapiens | dehydroepiandrosterone + sulfate | - |
? | |
| estrone sulfate + H2O | - |
Homo sapiens | estrone + sulfate | - |
? | |
| p-nitrophenyl-sulfate + H2O | arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein | Homo sapiens | p-nitrophenol + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Homo sapiens | steroid + sulfate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 78000, solubilized in Triton X-100 | Homo sapiens |
| trimer | alpha, 3 * 78000, SDS-PAGE,solubilized in Triton X-100 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
5 h, 20% loss of activity | Homo sapiens |
| 50 | - |
3 h, 50% loss of activity | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
4-methylumbelliferyl sulfate | Homo sapiens |
| 7.3 | - |
p-nitrophenyl sulfate | Homo sapiens |
| 8 | - |
dehydroepiandrosterone 3-sulfate | Homo sapiens |
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Release 2023.1 (January 2023)
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