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Literature summary for 3.1.6.2 extracted from

  • Miki, Y.; Nakata, T.; Suzuki, T.; Darnel, A.D.; Moriya, T.; Kaneko, C.; Hidaka, K.; Shiotsu, Y.; Kusaka, H.; Sasano, H.
    Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues (2002), J. Clin. Endocrinol. Metab., 87, 5760-5768.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone sulfate + H2O Homo sapiens STS converts the major circulating plasma estrogen estrone sulfate into the biologically active estrogene estrone, STS plays an important role in the in situ estrogen actions of various sex steroid-dependent tumors, peripheral STS plays a very important role in peripheral estrogen metabolism and actions in the human fetus estrone + sulfate
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland adult, relatively high STS activity Homo sapiens
-
aorta adult Homo sapiens
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liver adult, relatively high STS activity Homo sapiens
-
lung adult Homo sapiens
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additional information distribution of STS mRNA in human adult and fetal tissues Homo sapiens
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placenta adult, highest STS activity Homo sapiens
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testis adult Homo sapiens
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thyroid gland adult Homo sapiens
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uterus 1-3.7% of the mRNA levels of placenta, adult Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone sulfate + H2O
-
Homo sapiens estrone + sulfate
-
?
estrone sulfate + H2O STS converts the major circulating plasma estrogen estrone sulfate into the biologically active estrogene estrone, STS plays an important role in the in situ estrogen actions of various sex steroid-dependent tumors, peripheral STS plays a very important role in peripheral estrogen metabolism and actions in the human fetus Homo sapiens estrone + sulfate
-
?

Synonyms

Synonyms Comment Organism
estrone sulfatase
-
Homo sapiens
STS
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens