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Literature summary for 3.1.6.2 extracted from

  • Ahmed, V.; Liu, Y.; Silvestro, C.; Taylor, S.D.
    Boronic acids as inhibitors of steroid sulfatase (2006), Bioorg. Med. Chem., 14, 8564-8573.
    View publication on PubMed
Search for more literature for 3.1.6.2

Inhibitors

Inhibitors Comment Organism Structure
17alpha-benzyl-17beta-hydroxyestra-1,3,5-(10)-triene-3-boronic acid
-
 Homo sapiens
17alpha-benzyl-3,17beta-dihydroxyestra-1,3,5-(10)-triene
-
 Homo sapiens
2-t-butyl-4H-1-benzopyran-4-one-6-boronic acid
-
 Homo sapiens
2-tert-butyl-6-hydroxy-4H-chromen-4-one
-
 Homo sapiens
6-oxo-8,9,10,11-tetrahydro-7H-cylohepta-[c][1]benzopyran-boronic acid
-
 Homo sapiens
estra-1,3,5-(10)-triene-17-one-3-boronic acid competitive Homo sapiens
estrone
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-6-O-sulfate + H2O
-
 Homo sapiens 4-methylumbelliferone + sulfate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00025
-
 17alpha-benzyl-3,17beta-dihydroxyestra-1,3,5-(10)-triene 30°C, pH 7.0 Homo sapiens
0.00025
-
 17alpha-benzyl-17beta-hydroxyestra-1,3,5-(10)-triene-3-boronic acid 30°C, pH 7.0 Homo sapiens
0.0021
-
 estra-1,3,5-(10)-triene-17-one-3-boronic acid 30°C, pH 7.5 Homo sapiens
0.0028
-
 estra-1,3,5-(10)-triene-17-one-3-boronic acid 30°C, pH 7.0 Homo sapiens
0.0038
-
 estra-1,3,5-(10)-triene-17-one-3-boronic acid 30°C, pH 8.0 Homo sapiens
0.0046
-
 2-tert-butyl-6-hydroxy-4H-chromen-4-one 30°C, pH 7.0 Homo sapiens
0.0068
-
 estra-1,3,5-(10)-triene-17-one-3-boronic acid 30°C, pH 8.8 Homo sapiens
0.007
-
 estra-1,3,5-(10)-triene-17-one-3-boronic acid 30°C, pH 8.5 Homo sapiens
0.063
-
 estrone 30°C, pH 7.0 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.086
-
 30°C, pH 7.0 Homo sapiens 2-t-butyl-4H-1-benzopyran-4-one-6-boronic acid
0.171
-
 30°C, pH 7.0 Homo sapiens 6-oxo-8,9,10,11-tetrahydro-7H-cylohepta-[c][1]benzopyran-boronic acid