Reference on EC 2.7.1.1 - hexokinase and Organism(s) Homo sapiens and UniProt Accession P35557
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liu, F.; Dong, Q.; Myers, A.M.; Fromm, H.J.
Expression of human brain hexokinase in Escherichia coli: Purification and characterization of the expressed enzyme
Biochem. Biophys. Res. Commun.
177
305-311
1991
Homo sapiens
Haritos, A.A.; Rosemeyer, M.A.
Purification and physical properties of hexokinase from human erythrocytes
Biochim. Biophys. Acta
873
335-339
1986
Homo sapiens
Siebenlist, K.R.; Taketa, F.
Inhibition of red cell and yeast hexokinase by triethyltin bromide [(C2H5)3SnBr]
Biochem. Biophys. Res. Commun.
95
758-764
1980
Saccharomyces cerevisiae, Homo sapiens
Haritos, A.A.; Rosemeyer, M.A.
The purification and properties of human hexokinase
Biochem. Soc. Trans.
9
245
1981
Homo sapiens
-
Stocchi, V.; Magnani, M.; Canestrari, F.; Dacha, M.; Fornaini, G.
Multiple forms of human red blood cell hexokinase. Preparation, characterization, and age dependence
J. Biol. Chem.
257
2357-2364
1982
Homo sapiens
Magnani, M.; Stocchi, V.; Serafini, G.; Chiarantini, L.; Fornaini, G.
Purification, properties, and evidence for two subtypes of human placenta hexokinase type I
Arch. Biochem. Biophys.
260
388-399
1988
Homo sapiens
Rijksen, G.; Staal, G.E.J.; Beks, P.J.; Streefkerk, M.; Akkerman, J.W.N.
Compartmentation of hexokinase in human blood cells. Characterization of soluble and particulate enzymes
Biochim. Biophys. Acta
719
431-437
1982
Homo sapiens
Aleshin, A.E.; Zeng, C.; Bourenkov, G.P.; Bartunik, H.D.; Fromm, H.J.; Honzatko, R.B.
The mechanism of regulation of hexokinase: New insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate
Structure
6
39-50
1998
Homo sapiens
Aleshin, A.E.; Fromm, H.J.; Honzatko, R.B.
Multiple crystal forms of hexokinase I: New insights regarding conformational dynamics, subunit interactions, and membrane association
FEBS Lett.
434
42-46
1998
Homo sapiens
Aleshin, A.E.; Malfois, M.; Liu, X.; Kim, C.S.; Fromm, H.J.; Honzatko, R.B.; Koch, M.H.J.; Svergun, D.I.
Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution
Biochemistry
38
8359-8366
1999
Homo sapiens (P19367), Homo sapiens
Muzi, M.; Freeman, S.D.; Burrows, R.C.; Wiseman, R.W.; Link, J.M.; Krohn, K.A.; Graham, M.M.; Spence, A.M.
Kinetic characterization of hexokinase isoenzymes from glioma cells: Implications for FDG imaging of human brain tumors
Nucl. Med. Biol.
28
107-116
2001
Bos taurus, Homo sapiens, Rattus norvegicus
Palma, F.; Agostini, D.; Mason, P.; Dacha, M.; Piccoli, G.; Biagiarelli, B.; Fiorani, M.; Stocchi, V.
Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein
Mol. Cell. Biochem.
155
23-29
1996
Homo sapiens
Bianchi, M.; Serafini, G.; Bartolucci, E.; Giammarini, C.; Magnani, M.
Enzymatic properties of overexpressed human hexokinase fragments
Mol. Cell. Biochem.
189
185-193
1998
Homo sapiens
Sener, A.; Malaisse, W.J.
Kinetics and specificity of human B-cell glucokinase: relevance to hexose-induced insulin release
Biochim. Biophys. Acta
1312
73-78
1996
Homo sapiens
Xu, L.Z.; Harrison, R.W.; Weber, I.T.; Pilkis, S.J.
Human beta-cell glucokinase. Dual role of Ser-151 in catalysis and hexose affinity
J. Biol. Chem.
270
9939-9946
1995
Homo sapiens
Marotta, D.E.; Anand, G.R.; Anderson, T.A.; Miller, S.P.; Okar, D.A.; Levitt, D.G.; Lange, A.J.
Identification and characterization of the ATP-binding site in human pancreatic glucokinase
Arch. Biochem. Biophys.
436
23-31
2005
Homo sapiens
Brocklehurst, K.J.; Davies, R.A.; Agius, L.
Differences in regulatory properties between human and rat glucokinase regulatory protein
Biochem. J.
378
693-697
2004
Homo sapiens, Rattus norvegicus
Grimsby, J.; Sarabu, R.; Corbett, W.L.; Haynes, N.E.; Bizzarro, F.T.; Coffey, J.W.; Guertin, K.R.; Hilliard, D.W.; Kester, R.F.; Mahaney, P.E.; Marcus, L.; Qi, L.; Spence, C.L.; Tengi, J.; Magnuson, M.A.; Chu, C.A.; Dvorozniak, M.T.; Matschinsky, F.M.; Grippo, J.F.
Allosteric activators of glucokinase: potential role in diabetes therapy
Science
301
370-373
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Kamata, K.; Mitsuya, M.; Nishimura, T.; Eiki, J.; Nagata, Y.
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase
Structure
12
429-438
2004
Homo sapiens (P35557)
Heredia, V.V.; Thomson, J.; Nettleton, D.; Sun, S.
Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysis
Biochemistry
45
7553-7562
2006
Homo sapiens
Kim, Y.B.; Kalinowski, S.S.; Marcinkeviciene, J.
A pre-steady state analysis of ligand binding to human glucokinase: evidence for a preexisting equilibrium
Biochemistry
46
1423-1431
2007
Homo sapiens
Jeong, E.J.; Park, K.; Joung, H.A.; Lee, C.S.; Seol, D.W.; Chung, B.H.; Kim, M.
Detection of glucose-induced conformational change in hexokinase II using fluorescence complementation assay
Biotechnol. Lett.
29
797-802
2007
Homo sapiens
Marin-Hernandez, A.; Rodriguez-Enriquez, S.; Vital-Gonzalez, P.A.; Flores-Rodriguez, F.L.; Macias-Silva, M.; Sosa-Garrocho, M.; Moreno-Sanchez, R.
Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase
FEBS J.
273
1975-1988
2006
Homo sapiens, Rattus norvegicus
Gloyn, A.L.; Odili, S.; Zelent, D.; Buettger, C.; Castleden, H.A.; Steele, A.M.; Stride, A.; Shiota, C.; Magnuson, M.A.; Lorini, R.; dAnnunzio, G.; Stanley, C.A.; Kwagh, J.; van Schaftingen, E.; Veiga-da-Cunha, M.; Barbetti, F.; Dunten, P.; Han, Y.; Grimsby, J.; Taub, R.; Ellard, S.; Hattersley, A.T.
Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young
J. Biol. Chem.
280
14105-14113
2005
Homo sapiens
Bjorkhaug, L.; Molnes, J.; Sovik, O.; Njolstad, P.R.; Flatmark, T.
Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation
J. Biol. Chem.
282
22757-22764
2007
Homo sapiens
Tsai, H.J.
Function of interdomain alpha-helix in human brain hexokinase: covalent linkage and catalytic regulation between N- and C-terminal halves
J. Biomed. Sci.
14
195-202
2007
Homo sapiens
Pedelini, L.; Garcia-Gimeno, M.A.; Marina, A.; Gomez-Zumaquero, J.M.; Rodriguez-Bada, P.; Lopez-Enriquez, S.; Soriguer, F.C.; Cuesta-Munoz, A.L.; Sanz, P.
Structure-function analysis of the alpha5 and the alpha13 helices of human glucokinase: description of two novel activating mutations
Protein Sci.
14
2080-2086
2005
Homo sapiens
Zelent, B.; Odili, S.; Buettger, C.; Shiota, C.; Grimsby, J.; Taub, R.; Magnuson, M.A.; Vanderkooi, J.M.; Matschinsky, F.M.
Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
Biochem. J.
413
269-280
2008
Homo sapiens
Peng, Q.; Zhou, Q.; Zhou, J.; Zhong, D.; Pan, F.; Liang, H.
Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo
Cancer Biol. Ther.
7
1128-1135
2008
Homo sapiens (P52789), Homo sapiens
Christesen, H.B.; Tribble, N.D.; Molven, A.; Siddiqui, J.; Sandal, T.; Brusgaard, K.; Ellard, S.; Nj?lstad, P.R.; Alm, J.; Brock Jacobsen, B.; Hussain, K.; Gloyn, A.L.
Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation
Eur. J. Endocrinol.
159
27-34
2008
Homo sapiens
Anderka, O.; Boyken, J.; Aschenbach, U.; Batzer, A.; Boscheinen, O.; Schmoll, D.
Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein - impact of physiological and pharmacological effectors
J. Biol. Chem.
283
31333-31340
2008
Homo sapiens
Estalella, I.; Garcia-Gimeno, M.A.; Marina, A.; Castano, L.; Sanz, P.
Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients
J. Hum. Genet.
53
460-466
2008
Homo sapiens (Q53Y25)
Jeong, E.J.; Park, K.; Yi, S.Y.; Kang, H.J.; Chung, S.J.; Lee, C.S.; Chung, J.W.; Seol, D.W.; Chung, B.H.; Kim, M.
Stress-governed expression and purification of human type II hexokinase in Escherichia coli
J. Microbiol. Biotechnol.
17
638-643
2007
Homo sapiens (P52789), Homo sapiens
Agius, L.
Glucokinase and molecular aspects of liver glycogen metabolism
Biochem. J.
414
1-18
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Riera, A.; Ahuatzi, D.; Herrero, P.; Garcia-Gimeno, M.A.; Sanz, P.; Moreno, F.
Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell
Biochem. J.
415
233-239
2008
Homo sapiens
Veiga-da-Cunha, M.; Sokolova, T.; Opperdoes, F.; Van Schaftingen, E.
Evolution of vertebrate glucokinase regulatory protein from a bacterial N-acetylmuramate 6-phosphate etherase
Biochem. J.
423
323-332
2009
Homo sapiens, Xenopus laevis
Ralph, E.C.; Thomson, J.; Almaden, J.; Sun, S.
Glucose modulation of glucokinase activation by small molecules
Biochemistry
47
5028-5036
2008
Homo sapiens
Sun, S.
Biochemical characterization of MODY2 glucokinase variants V62M and G72R reveals reduced enzymatic activities relative to wild-type
Biochemistry
48
2514-2521
2009
Homo sapiens (P35557), Homo sapiens
Antoine, M.; Boutin, J.A.; Ferry, G.
Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states
Biochemistry
48
5466-5482
2009
Homo sapiens
Larion, M.; Miller, B.G.
23-Residue C-terminal alpha-helix governs kinetic cooperativity in monomeric human glucokinase
Biochemistry
48
6157-6165
2009
Homo sapiens
Pfefferkorn, J.A.; Lou, J.; Minich, M.L.; Filipski, K.J.; He, M.; Zhou, R.; Ahmed, S.; Benbow, J.; Perez, A.G.; Tu, M.; Litchfield, J.; Sharma, R.; Metzler, K.; Bourbonais, F.; Huang, C.; Beebe, D.A.; Oates, P.J.
Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
Bioorg. Med. Chem. Lett.
19
3247-3252
2009
Homo sapiens
Zhang, L.; Li, H.; Zhu, Q.; Liu, J.; Chen, L.; Leng, Y.; Jiang, H.; Liu, H.
Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase
Bioorg. Med. Chem.
17
7301-7312
2009
Homo sapiens
Ahn, K.J.; Kim, J.; Yun, M.; Park, J.H.; Lee, J.D.
Enzymatic properties of the N- and C-terminal halves of human hexokinase II
BMB Rep.
42
350-355
2009
Homo sapiens
Christesen, H.B.; Brusgaard, K.; Beck Nielsen, H.; Brock Jacobsen, B.
Non-insulinoma persistent hyperinsulinaemic hypoglycaemia caused by an activating glucokinase mutation: hypoglycaemia unawareness and attacks
Clin. Endocrinol. (Oxf.)
68
747-755
2008
Homo sapiens
Grimsby, J.; Berthel, S.J.; Sarabu, R.
Glucokinase activators for the potential treatment of type 2 diabetes
Curr. Top. Med. Chem.
8
1524-1532
2008
Homo sapiens
Coghlan, M.; Leighton, B.
Glucokinase activators in diabetes management
Expert Opin. Investig. Drugs
17
145-167
2008
Homo sapiens
Molnes, J.; Bjorkhaug, L.; Sovik, O.; Njolstad, P.R.; Flatmark, T.
Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions
FEBS J.
275
2467-2481
2008
Homo sapiens (P35557), Homo sapiens
Beer, N.L.; Tribble, N.D.; McCulloch, L.J.; Roos, C.; Johnson, P.R.; Orho-Melander, M.; Gloyn, A.L.
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
Hum. Mol. Genet.
18
4081-4088
2009
Homo sapiens
Osbak, K.K.; Colclough, K.; Saint-Martin, C.; Beer, N.L.; Bellanne-Chantelot, C.; Ellard, S.; Gloyn, A.L.
Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia
Hum. Mutat.
30
1512-1526
2009
Homo sapiens
Zhang, J.; Li, C.; Shi, T.; Chen, K.; Shen, X.; Jiang, H.
Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis
PLoS ONE
4
e6304
2009
Homo sapiens (P19367)
Petit, P.; Antoine, M.; Ferry, G.; Boutin, J.A.; Lagarde, A.; Gluais, L.; Vincentelli, R.; Vuillard, L.
The active conformation of human glucokinase is not altered by allosteric activators
Acta Crystallogr. Sect. D
67
929-935
2011
Homo sapiens (P35557)
Zelent, B.; Odili, S.; Buettger, C.; Zelent, D.K.; Chen, P.; Fenner, D.; Bass, J.; Stanley, C.; Laberge, M.; Vanderkooi, J.M.; Sarabu, R.; Grimsby, J.; Matschinsky, F.M.
Mutational analysis of allosteric activation and inhibition of glucokinase
Biochem. J.
440
203-215
2011
Homo sapiens (P35557)
Bourbonais, F.J.; Chen, J.; Huang, C.; Zhang, Y.; Pfefferkorn, J.A.; Landro, J.A.
Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis
Biochem. J.
441
881-887
2012
Homo sapiens
Zelent, B.; Buettger, C.; Grimsby, J.; Sarabu, R.; Vanderkooi, J.M.; Wand, A.J.; Matschinsky, F.M.
Thermal stabilty of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea
Biochim. Biophys. Acta
1824
769-784
2012
Homo sapiens
Li, F.; Zhu, Q.; Zhang, Y.; Feng, Y.; Leng, Y.; Zhang, A.
Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators
Bioorg. Med. Chem.
18
3875-3884
2010
Homo sapiens
Mao, W.; Ning, M.; Liu, Z.; Zhu, Q.; Leng, Y.; Zhang, A.
Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators
Bioorg. Med. Chem.
20
2982-2991
2012
Homo sapiens
Molnes, J.; Teigen, K.; Aukrust, I.; Bjorkhaug, L.; Sovik, O.; Flatmark, T.; Njolstad, P.R.
Binding of ATP at the active site of human pancreatic glucokinase--nucleotide-induced conformational changes with possible implications for its kinetic cooperativity
FEBS J.
278
2372-2386
2011
Homo sapiens
Liu, Q.; Shen, Y.; Liu, S.; Weng, J.; Liu, J.
Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site
FEBS Lett.
585
1175-1179
2011
Homo sapiens (P35557)
Wolf, A.; Agnihotri, S.; Micallef, J.; Mukherjee, J.; Sabha, N.; Cairns, R.; Hawkins, C.; Guha, A.
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
J. Exp. Med.
208
313-326
2011
Homo sapiens
Larion, M.; Salinas, R.; Bruschweiler-Li, L.; Miller, B.; Brschweiler, R.
Order-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase
PLoS Biol.
10
e1001452
2012
Homo sapiens
Bowler, J.; Hervert, K.; Kearley, M.; Miller, B.
Small-molecule allosteric activation of human glucokinase in the absence of glucose
ACS Med. Chem. Lett.
4
580-584
2013
Homo sapiens
Lin, H.; Zeng, J., Xie, R.; Schulz, M.J.; Tedesco, R.; Qu, J.; Erhard, K.F.; Mack, J.F.; Raha, K.; Rendina, A.R.; Szewczuk, L.M.; Kratz, P.M.; Jurewicz, A.J.; Cecconie, T.; Martens, S.; McDevitt, P.J.; Martin, J.D.; Chen, S.B.; Jiang, Y.; Nickels, L.; Schwartz, B.J.; Smallwood, A.; Zhao, B.; Campobasso, N.; Qian, Y.; Briand, J.; Rominger, C.M.; Oleykowski, C.; Hardwicke, M.A.; Luengo, J.I.
Discovery of a novel 2,6-disubstituted glucosamine series of potent and selective hexokinase 2 inhibitors
ACS Med. Chem. Lett.
7
217-22
2015
Homo sapiens (P19367), Homo sapiens (P52789)
Dransfield, P.J.; Pattaropong, V.; Lai, S.; Fu, Z.; Kohn, T.J.; Du, X.; Cheng, A.; Xiong, Y.; Komorowski, R.; Jin, L.; Conn, M.; Tien, E.; DeWolf, W.E.; Hinklin, R.J.; Aicher, T.D.; Kraser, C.F.; Boyd, S.A.; Voegtli, W.C.; Condroski, K.R.; Veniant-Ellison, M.; Medina, J.C.; Houze, J.; Coward, P.
Novel series of potent glucokinase activators leading to the discovery of AM-2394
ACS Med. Chem. Lett.
7
714-718
2016
Homo sapiens (P52789)
Zhuo, B.; Li, Y.; Li, Z.; Qin, H.; Sun, Q.; Zhang, F.; Shen, Y.; Shi, Y.; Wang, R.
PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma
Biochem. Biophys. Res. Commun.
464
401-406
2015
Homo sapiens
Kumar, S.; Parameswaran, S.; Sharma, R.K.
Novel myristoylation of the sperm-specific hexokinase 1 isoform regulates its atypical localization
Biol. Open
4
1679-1687
2015
Homo sapiens (P19367)
Bryan, N.; Raisch, K.
Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II
Biosci. Rep.
35
e00205
2015
Homo sapiens
Sen, S.; Kaminiski, R.; Deshmane, S.; Langford, D.; Khalili, K.; Amini, S.; Datta, P.K.
Role of hexokinase-1 in the survival of HIV-1-infected macrophages
Cell Cycle
14
980-989
2015
Homo sapiens
Ermakova, E.
Structural insight into the glucokinase-ligands interactions. Molecular docking study
Comput. Biol. Chem.
64
281-296
2016
Homo sapiens (P35557)
Yellapu, N.; Mahto, M.K.; Valasani, K.R.; Sarma, P.V.; Matcha, B.
Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding - explains hyperglycemia in type 2 diabetic patients
J. Biomol. Struct. Dyn.
33
820-833
2015
Homo sapiens
Pandurangan, M.; Enkhtaivan, G.; Kim, D.H.
Homobrassinolide induced conformational changes in hexokinase: a possible mechanism for its antidiabetic potential
J. Mol. Recognit.
29
276-280
2016
Homo sapiens (P35557), Homo sapiens
Martinez, J.A.; Larion, M.; Conejo, M.S.; Porter, C.M.; Miller, B.G.
Role of connecting loop I in catalysis and allosteric regulation of human glucokinase
Protein Sci.
23
915-922
2014
Homo sapiens (P35557), Homo sapiens
Milanes, J.E.; Suryadi, J.; Abendroth, J.; Van Voorhis, W.C.; Barrett, K.F.; Dranow, D.M.; Phan, I.Q.; Patrick, S.L.; Rozema, S.D.; Khalifa, M.M.; Golden, J.E.; Morris, J.C.
Enzymatic and structural characterization of the Naegleria fowleri glucokinase
Antimicrob. Agents Chemother.
63
e02410-18
2019
Homo sapiens (P35557)
Heneberg, P.
Redox regulation of hexokinases
Antioxid. Redox Signal.
30
415-442
2019
Oryctolagus cuniculus, Trypanosoma brucei, Mus musculus (P17710), Homo sapiens (P19367), Homo sapiens (P52789), Homo sapiens (P52790), Plasmodium falciparum (Q02155)
Casey, A.K.; Miller, B.G.
Kinetic Basis of carbohydrate-mediated inhibition of human glucokinase by the glucokinase regulatory protein
Biochemistry
55
2899-2902
2016
Homo sapiens
Tesinsky, M.; Simcikova, D.; Heneberg, P.
First evidence of changes in enzyme kinetics and stability of glucokinase affected by somatic cancer-associated variations
Biochim. Biophys. Acta Proteins Proteom.
1867
213-218
2019
Homo sapiens
Cornish-Bowden, A.
Zacharias Dische and the discovery of feedback inhibition A landmark paper published in the forerunner of Biochimie
Biochimie
182
120-130
2021
Homo sapiens
Liu, Y.; Li, M.; Zhang, Y.; Wu, C.; Yang, K.; Gao, S.; Zheng, M.; Li, X.; Li, H.; Chen, L.
Structure based discovery of novel hexokinase 2 inhibitors
Bioorg. Chem.
96
103609
2020
Homo sapiens (P52789), Homo sapiens
Nawaz, M.H.; Ferreira, J.C.; Nedyalkova, L.; Zhu, H.; Carrasco-Lopez, C.; Kirmizialtin, S.; Rabeh, W.M.
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation
Biosci. Rep.
38
BSR20171666
2018
Homo sapiens (P52789), Homo sapiens
Dische, Z.
Sur l'interdependance des divers enzymes du systeme glycolytique et sur la regulation automatique de leur activite dans les cellules
Bull. Soc. Chim. Biol.
23
1140-1148
1941
Homo sapiens
-
Wang, Z.; Shi, X.; Zhang, H.; Yu, L.; Cheng, Y.; Zhang, H.; Zhang, H.; Zhou, J.; Chen, J.; Shen, X.; Duan, W.
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators Design, synthesis, and biological evaluation
Eur. J. Med. Chem.
139
128-152
2017
Homo sapiens
Bao, F.; Yang, K.; Wu, C.; Gao, S.; Wang, P.; Chen, L.; Li, H.
New natural inhibitors of hexokinase 2 (HK2) Steroids from Ganoderma sinense
Fitoterapia
125
123-129
2018
Homo sapiens (P52789)
Aljamal, J.; Badawneh, M.
In vitro inhibition of human erythrocyte hexokinase by various hyperglycemic drugs
J. Biochem. Mol. Toxicol.
31
e21910
2017
Homo sapiens (P19367), Homo sapiens
Khan, M.W.; Ding, X.; Cotler, S.J.; Clarke, M.; Layden, B.T.
Studies on the tissue localization of HKDC1, a putative novel fifth hexokinase, in humans
J. Histochem. Cytochem.
66
385-392
2018
Homo sapiens (Q2TB90), Homo sapiens
Roh, J.I.; Kim, Y.; Oh, J.; Kim, Y.; Lee, J.; Lee, J.; Chun, K.H.; Lee, H.W.
Hexokinase 2 is a molecular bridge linking telomerase and autophagy
PLoS ONE
13
e0193182
2018
Homo sapiens (P52789)
Simcikova, D.; Heneberg, P.
Identification of alkaline pH optimum of human glucokinase because of ATP-mediated bias correction in outcomes of enzyme assays
Sci. Rep.
9
11422
2019
Homo sapiens (P35557), Homo sapiens
Yin, X.; Choudhury, M.; Kang, J.H.; Schaefbauer, K.J.; Jung, M.Y.; Andrianifahanana, M.; Hernandez, D.M.; Leof, E.B.
Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-beta
Sci. Signal.
12
eaax4067
2019
Mus musculus (O08528), Mus musculus, Homo sapiens (P52789), Homo sapiens
