Literature summary for 2.7.1.1 extracted from

Pandurangan, M.; Enkhtaivan, G.; Kim, D.H.
Homobrassinolide induced conformational changes in hexokinase: a possible mechanism for its antidiabetic potential (2016), J. Mol. Recognit., 29, 276-280.

Search for more literature for 2.7.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
28-homobrassinolide	28-homobrassinolide is able to protect or restore the native structure of hexokinase when exposed to diabetic levels of glucose. The denatured hexokinase is renatured upon binding with homobrassinolide. Homobrassinolide is able to bind to the drug-binding pocket of glucokinase. The glide energy is -7.1 kcal/mol	Homo sapiens

Application

Application	Comment	Organism
medicine	28-homobrassinolide is able to protect or restore the native structure of hexokinase when exposed to diabetic levels of glucose	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking of 28-homobrassinolide. Homobrassinolide is able to bind to the drug-binding pocket of glucokinase. The glide energy is -7.1 kcal/mol	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35557	-	-

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Release 2023.1 (January 2023)