Literature summary for 2.7.1.1 extracted from

Bourbonais, F.J.; Chen, J.; Huang, C.; Zhang, Y.; Pfefferkorn, J.A.; Landro, J.A.
Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis (2012), Biochem. J., 441, 881-887.

Search for more literature for 2.7.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
(S)-6-(3-cyclopentyl-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propanamido)nicotinic acid	in the presence of liver-specific GKA, progress curves at 1 mM glucose are similar to those at 5 mM, reflecting activation of GK. With steady-state kinetic methods it is shown that there are at least two kinetically distinct forms of glucokinase that interconvert through a slow conformational change and that this interconversion is affected by glucose concentration and a liver-specific GKA	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli as a His-tagged fusion protein	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
GK regulatory protein	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-glucose	-	Homo sapiens	ADP + D-glucose 6-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
glucokinase 1	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.1	-	assay at	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000128	-	GK regulatory protein	steady-state Ki value, pH 7.1, 25°C	Homo sapiens
0.000113	-	GK regulatory protein	initial Ki value, pH 7.1, 25°C	Homo sapiens

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Release 2023.1 (January 2023)