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Literature summary for 2.7.1.1 extracted from

  • Kumar, S.; Parameswaran, S.; Sharma, R.K.
    Novel myristoylation of the sperm-specific hexokinase 1 isoform regulates its atypical localization (2015), Biol. Open, 4, 1679-1687.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.1

Protein Variants

Protein Variants Comment Organism
C5A mutation abrogates palmitoylation of protein Homo sapiens
C5S mutation abrogates palmitoylation of protein Homo sapiens
G2A mutant protein lacks myristoylation Homo sapiens
G2A/C5S mutation abrogates both myristoylation and palmitoylation of protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane compartmentalization of hexokinase-1 to plasma membrane of sperm cells is swappable to somatic HEK-293 cells Homo sapiens 5886
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Organism

Organism UniProt Comment Textmining
Homo sapiens P19367
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
lipoprotein The N-terminal MGQICQ motif in the unique germ cell-specific domain of hexokinase acquires hydrophobicity by N-myristoylation and palmitoylation. The mutation of the myristoyl recipient Gly2 impedes plasma membrane association and relocates the enzyme to the cytosol but not the nucleus. Substitution of the putatively palmitoylated Cys5 is reflected in a similar loss of compartmentalization of the protein Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
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sperm
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
hexokinase-1
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 Homo sapiens