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Literature summary for 2.7.1.1 extracted from
- Glucokinase and molecular aspects of liver glycogen metabolism (2008), Biochem. J., 414, 1-18.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Mus musculus | |
| 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Homo sapiens | |
| 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Rattus norvegicus | |
| glucokinase-associated protein | stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess | Mus musculus | |
| glucokinase-associated protein | stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess | Homo sapiens | |
| glucokinase-associated protein | stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess | Rattus norvegicus | |
| polyubiquitin | causes modest activation | Mus musculus | |
| polyubiquitin | causes modest activation | Homo sapiens | |
| polyubiquitin | causes modest activation | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glucokinase regulatory protein | competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein | Homo sapiens | |
| glucokinase regulatory protein | competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein | Mus musculus | |
| glucokinase regulatory protein | competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | free glucokinase is localized in the cytosol | Mus musculus | 5829 | - |
| cytosol | free glucokinase is localized in the cytosol | Homo sapiens | 5829 | - |
| cytosol | free glucokinase is localized in the cytosol | Rattus norvegicus | 5829 | - |
| nucleus | glucokinase regulatory protein causes accumulation of glucokinase in the nucleus | Mus musculus | 5634 | - |
| nucleus | glucokinase regulatory protein causes accumulation of glucokinase in the nucleus | Homo sapiens | 5634 | - |
| nucleus | glucokinase regulatory protein causes accumulation of glucokinase in the nucleus | Rattus norvegicus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for activity | Mus musculus |  |
| Mg2+ | required for activity | Homo sapiens | |
| Mg2+ | required for activity | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-glucose | - |
Mus musculus | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Homo sapiens | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Rattus norvegicus | ADP + D-glucose 6-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glucokinase | - |
Mus musculus |
| glucokinase | - |
Homo sapiens |
| glucokinase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes | Mus musculus |
| malfunction | defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes | Homo sapiens |
| malfunction | defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes | Rattus norvegicus |
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