BRENDA - Enzyme Database
show all sequences of 2.7.1.1

Glucokinase and molecular aspects of liver glycogen metabolism

Agius, L.; Biochem. J. 414, 1-18 (2008)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
Homo sapiens
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
Mus musculus
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
Rattus norvegicus
glucokinase-associated protein
stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess
Homo sapiens
glucokinase-associated protein
stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess
Mus musculus
glucokinase-associated protein
stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess
Rattus norvegicus
polyubiquitin
causes modest activation
Homo sapiens
polyubiquitin
causes modest activation
Mus musculus
polyubiquitin
causes modest activation
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
glucokinase regulatory protein
competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein
Homo sapiens
glucokinase regulatory protein
competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein
Mus musculus
glucokinase regulatory protein
competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
free glucokinase is localized in the cytosol
Homo sapiens
5829
-
cytosol
free glucokinase is localized in the cytosol
Mus musculus
5829
-
cytosol
free glucokinase is localized in the cytosol
Rattus norvegicus
5829
-
nucleus
glucokinase regulatory protein causes accumulation of glucokinase in the nucleus
Homo sapiens
5634
-
nucleus
glucokinase regulatory protein causes accumulation of glucokinase in the nucleus
Mus musculus
5634
-
nucleus
glucokinase regulatory protein causes accumulation of glucokinase in the nucleus
Rattus norvegicus
5634
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required for activity
Homo sapiens
Mg2+
required for activity
Mus musculus
Mg2+
required for activity
Rattus norvegicus
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
liver
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ATP + D-glucose
-
702116
Mus musculus
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
-
702116
Homo sapiens
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
-
702116
Rattus norvegicus
ADP + D-glucose 6-phosphate
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
glucokinase
-
Mus musculus
glucokinase
-
Homo sapiens
glucokinase
-
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Rattus norvegicus
ATP
-
Homo sapiens
ATP
-
Mus musculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
Homo sapiens
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
Mus musculus
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
Rattus norvegicus
glucokinase-associated protein
stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess
Homo sapiens
glucokinase-associated protein
stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess
Mus musculus
glucokinase-associated protein
stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess
Rattus norvegicus
polyubiquitin
causes modest activation
Homo sapiens
polyubiquitin
causes modest activation
Mus musculus
polyubiquitin
causes modest activation
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Rattus norvegicus
ATP
-
Homo sapiens
ATP
-
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
glucokinase regulatory protein
competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein
Homo sapiens
glucokinase regulatory protein
competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein
Mus musculus
glucokinase regulatory protein
competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
free glucokinase is localized in the cytosol
Homo sapiens
5829
-
cytosol
free glucokinase is localized in the cytosol
Mus musculus
5829
-
cytosol
free glucokinase is localized in the cytosol
Rattus norvegicus
5829
-
nucleus
glucokinase regulatory protein causes accumulation of glucokinase in the nucleus
Homo sapiens
5634
-
nucleus
glucokinase regulatory protein causes accumulation of glucokinase in the nucleus
Mus musculus
5634
-
nucleus
glucokinase regulatory protein causes accumulation of glucokinase in the nucleus
Rattus norvegicus
5634
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required for activity
Homo sapiens
Mg2+
required for activity
Mus musculus
Mg2+
required for activity
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
liver
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ATP + D-glucose
-
702116
Mus musculus
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
-
702116
Homo sapiens
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
-
702116
Rattus norvegicus
ADP + D-glucose 6-phosphate
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes
Homo sapiens
malfunction
defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes
Mus musculus
malfunction
defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes
Homo sapiens
malfunction
defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes
Mus musculus
malfunction
defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes
Rattus norvegicus
Other publictions for EC 2.7.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)