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3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + biotinylated [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + biotinylated [histone H3]-N6-methyl-L-lysine9
-
-
-
?
biotinyl-MARTKQTARKSTGGKAPRKQ + S-adenosyl-L-methionine
?
-
Dim-5 methylates the histone H3 tail at position Lys9
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-
?
L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine
N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-methionine + ACINUS
?
-
-
-
?
S-adenosyl-L-methionine + CDYL1
?
-
-
-
?
S-adenosyl-L-methionine + dimethylated histone H3(K9)
S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
-
the activity on dimethylated histone H3(K9) peptides is several folds lower than when monomethylated histone H3(K9) peptides are used
-
-
?
S-adenosyl-L-methionine + DNA methyltransferase 1
?
-
-
-
-
?
S-adenosyl-L-methionine + H2B ubiquitinated nucleosome
?
-
-
-
?
S-adenosyl-L-methionine + histone H2A
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + histone H2B
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3 (1-13)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3 (S10phos)
?
-
phosphorylation of the proximal amino acids impairs Lys-9 methylation via impairing enzyme-substrate interaction
-
-
?
S-adenosyl-L-methionine + histone H3 (T11phos)
?
-
phosphorylation of the proximal amino acids impairs Lys-9 methylation via impairing enzyme-substrate interaction
-
-
?
S-adenosyl-L-methionine + histone H3(K27A)
?
-
mutation in the unstructured amino-terminal tail of histone H3 does not affect the central globular domain, but reduces the turnover numbers of the substrates
-
-
?
S-adenosyl-L-methionine + histone H3(K4A)
?
-
mutation in the unstructured amino-terminal tail of histone H3 does not affect the central globular domain, but reduces the turnover numbers of the substrates
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
?
S-adenosyl-L-methionine + histone H3(K9)
S-adenosyl-L-homocysteine + ?
S-adenosyl-L-methionine + histone H4
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + histone K4-acetylK9
?
-
-
-
-
?
S-adenosyl-L-methionine + histone K4-trimethylK9
?
-
-
-
-
?
S-adenosyl-L-methionine + histone K4AK9
?
-
-
-
-
?
S-adenosyl-L-methionine + histone L-lysine
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
S-adenosyl-L-methionine + monomethylated histone H3(K9)
S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
-
the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin. SUVR4 in vivo specifically converts monomethylated histone H3(K9) to trimethylated histone H3(K9) at transposons and pseudogenes
-
-
?
S-adenosyl-L-methionine + p53
?
the enzyme is responsible for p53 methylation at lysine 373
-
-
?
S-adenosyl-L-methionine + reptin
?
the enzyme is responsible for reptin methylation at lysine 67
-
-
?
S-adenosyl-L-methionine + WIZ
?
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine9
-
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
-
?
additional information
?
-
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
r
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
overall reaction
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
r
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
preferred substrate
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
r
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
r
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
?
-
Dim-5 recognizes R8-G12 of the H3 tail with T11 and G12 being the most important specificity determinants, phosphorylation of H3 tail residues S10 and T11may regulate the activity of Dim-5
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
?
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
S-adenosyl-L-homocysteine + ?
-
SETDB1 is mainly responsible for mono- and trimethylation of histone H3 lysine 9 and SU (VAR)3-9 for monomethylation of histone H3 lysine 9 during spermatogenesis
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
S-adenosyl-L-homocysteine + ?
-
PRDM8 specifically methylates H3(K9) of histones
-
-
?
S-adenosyl-L-methionine + histone L-lysine
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
-
-
-
?
S-adenosyl-L-methionine + histone L-lysine
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
Lys9 of histone H3
-
?
S-adenosyl-L-methionine + histone L-lysine
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
Lys9 of histone 3
-
?
S-adenosyl-L-methionine + histone L-lysine
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
-
-
?
additional information
?
-
-
no activity is observed on trimethylated histone H3(K9) peptides either with or without ubiquitin
-
-
?
additional information
?
-
SETDB1 specifically methylates H3K9, but not H3K4 or H3K27. SETDB1 methylates H3 to generate K9me1, K9me2, and K9me3 in a sequential manner
-
-
-
additional information
?
-
-
SETDB1 specifically methylates H3K9, but not H3K4 or H3K27. SETDB1 methylates H3 to generate K9me1, K9me2, and K9me3 in a sequential manner
-
-
-
additional information
?
-
-
growth factor independent 1 and G9a complex methylates the wild-type H3 substrate as well as the mutants replaced at K4, K36, and K79, substitution at K27 slightly reduces methylation of the H3 substrate, whereas substitution at K9 blocks methylation
-
-
?
additional information
?
-
-
the NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance
-
-
?
additional information
?
-
the enzyme is able to add methyl groups to lysine 27 as well as 9 in histone H3
-
-
?
additional information
?
-
-
histone methylation has significant effects on heterochromatin formation and transcriptional regulation
-
-
?
additional information
?
-
-
minimal substrate methylated by G9a contains seven amino acids (TARKSTG) of the histone H3 tail
-
-
?
additional information
?
-
the enzyme is automethylated at K239
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-
?