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2.1.1.355: [histone H3]-lysine9 N-trimethyltransferase

This is an abbreviated version!
For detailed information about [histone H3]-lysine9 N-trimethyltransferase, go to the full flat file.

Word Map on EC 2.1.1.355

Reaction

3 S-adenosyl-L-methionine +

a [histone H3]-L-lysine9
= 3 S-adenosyl-L-homocysteine +
a [histone H3]-N6,N6,N6-trimethyl-L-lysine9

Synonyms

Clr4, dG9a, Dim-5, Dim-5 histone lysine methyltransferase, Dim-5 histone-3 lysine-9 methyltransferase, Dim5, DOT1L, EC 2.1.1.43, EHMT1, EHMT2, ESET, G9a, G9a histone methyltransferase, G9a HMT, G9a lysine 9 histone H3 methyltransferase, G9a-like protein lysine methyltransferase, G9a/G9a-like protein lysine dimethyltransferase complex, GLP, H3-K9 methyltransferase, H3K9 histone methyltransferase, H3K9 histone methyltransferases, H3K9 HMT, H3K9 methyltransferase, H3K9-specific histone methyltransferase, H3K9-specific SET domain methyltransferase, histone H3 Lys79 methyltransferase, histone H3 lysine 9 methyltransferase, histone H3 lysine methyltransferase G9a, histone H3 methyltransferase, histone H3K9 methyltransferase, histone H3K9 trimethylase, histone lysine methyltransferase, histone lysine methyltransferase G9a, histone methyltransferase, histone methyltransferase G9a, HKMT, HKMTase, HMTase, KHMTase, KMT1A, KMT1B, KMT1C, KMT1D, KMT1F, lysine methyltransferase G9a, lysine-preferring HMTase, MT8, PRDM2, PRDM8, SETDB1, SU (VAR)3-9, SU(VAR)3-9, SUV39H1, SUVR4

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase

Substrates Products

Substrates Products on EC 2.1.1.355 - [histone H3]-lysine9 N-trimethyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
show the reaction diagram
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine9
show the reaction diagram
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + biotinylated [histone H3]-L-lysine9
3 S-adenosyl-L-homocysteine + biotinylated [histone H3]-N6-methyl-L-lysine9
show the reaction diagram
-
-
-
?
biotinyl-MARTKQTARKSTGGKAPRKQ + S-adenosyl-L-methionine
?
show the reaction diagram
-
Dim-5 methylates the histone H3 tail at position Lys9
-
-
?
L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine
N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
show the reaction diagram
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
show the reaction diagram
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
show the reaction diagram
S-adenosyl-L-methionine + ACINUS
?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + CDYL1
?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethylated histone H3(K9)
S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
show the reaction diagram
-
the activity on dimethylated histone H3(K9) peptides is several folds lower than when monomethylated histone H3(K9) peptides are used
-
-
?
S-adenosyl-L-methionine + DNA methyltransferase 1
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + H2B ubiquitinated nucleosome
?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + histone H2A
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H2B
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H3
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H3 (1-13)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H3 (S10phos)
?
show the reaction diagram
-
phosphorylation of the proximal amino acids impairs Lys-9 methylation via impairing enzyme-substrate interaction
-
-
?
S-adenosyl-L-methionine + histone H3 (T11phos)
?
show the reaction diagram
-
phosphorylation of the proximal amino acids impairs Lys-9 methylation via impairing enzyme-substrate interaction
-
-
?
S-adenosyl-L-methionine + histone H3(K27A)
?
show the reaction diagram
-
mutation in the unstructured amino-terminal tail of histone H3 does not affect the central globular domain, but reduces the turnover numbers of the substrates
-
-
?
S-adenosyl-L-methionine + histone H3(K4A)
?
show the reaction diagram
-
mutation in the unstructured amino-terminal tail of histone H3 does not affect the central globular domain, but reduces the turnover numbers of the substrates
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K9)
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + histone H4
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone K4-acetylK9
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone K4-trimethylK9
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone K4AK9
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone L-lysine
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
show the reaction diagram
S-adenosyl-L-methionine + monomethylated histone H3(K9)
S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
show the reaction diagram
-
the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin. SUVR4 in vivo specifically converts monomethylated histone H3(K9) to trimethylated histone H3(K9) at transposons and pseudogenes
-
-
?
S-adenosyl-L-methionine + p53
?
show the reaction diagram
the enzyme is responsible for p53 methylation at lysine 373
-
-
?
S-adenosyl-L-methionine + reptin
?
show the reaction diagram
the enzyme is responsible for reptin methylation at lysine 67
-
-
?
S-adenosyl-L-methionine + WIZ
?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-L-lysine9
S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine9
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine9
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine9
show the reaction diagram
-
-
-
-
?
additional information
?
-