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2.1.1.355: [histone H3]-lysine9 N-trimethyltransferase

This is an abbreviated version!
For detailed information about [histone H3]-lysine9 N-trimethyltransferase, go to the full flat file.

Word Map on EC 2.1.1.355

Reaction

3 S-adenosyl-L-methionine +

a [histone H3]-L-lysine9
= 3 S-adenosyl-L-homocysteine +
a [histone H3]-N6,N6,N6-trimethyl-L-lysine9

Synonyms

Clr4, dG9a, Dim-5, Dim-5 histone lysine methyltransferase, Dim-5 histone-3 lysine-9 methyltransferase, Dim5, DOT1L, EC 2.1.1.43, EHMT1, EHMT2, ESET, G9a, G9a histone methyltransferase, G9a HMT, G9a lysine 9 histone H3 methyltransferase, G9a-like protein lysine methyltransferase, G9a/G9a-like protein lysine dimethyltransferase complex, GLP, H3-K9 methyltransferase, H3K9 histone methyltransferase, H3K9 histone methyltransferases, H3K9 HMT, H3K9 methyltransferase, H3K9-specific histone methyltransferase, H3K9-specific SET domain methyltransferase, histone H3 Lys79 methyltransferase, histone H3 lysine 9 methyltransferase, histone H3 lysine methyltransferase G9a, histone H3 methyltransferase, histone H3K9 methyltransferase, histone H3K9 trimethylase, histone lysine methyltransferase, histone lysine methyltransferase G9a, histone methyltransferase, histone methyltransferase G9a, HKMT, HKMTase, HMTase, KHMTase, KMT1A, KMT1B, KMT1C, KMT1D, KMT1F, lysine methyltransferase G9a, lysine-preferring HMTase, MT8, PRDM2, PRDM8, SETDB1, SU (VAR)3-9, SU(VAR)3-9, SUV39H1, SUVR4

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase

Cloned

Cloned on EC 2.1.1.355 - [histone H3]-lysine9 N-trimethyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cotransfection of growth factor independent 1 with both HA epitope-tagged G9a and Myc epitope-tagged Suv39H1 into HeLa cells
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expressed in Escherichia coli BL21 codon-plus RIL cells
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli strain XL1 blue
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expressed in Mus musculus
expressed in Sf9 insect cells
PCR-amplified EcoRI-XhoI insert encoding the murine long form of G9a cloned into the EcoRI-XhoI sites of pSG5.HA and pSG5.FLAG, PCR-amplified EcoRI-SalI inserts of G9a residues 1-333, 72-333, 330-690, 685-1018, 936-1263 (deltaANK), 1-1088 (deltaSET), 730-1263, and 464-1263 cloned into the EcoRI-SalI sites of the vector pM for Gal4 DNA binding domain fusions and into the EcoRI-XhoI sites of pSG5.HA or pSG5.FLAG, expression in CV-1 and Cos-7 cells
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the 70 kDa full-length form is expressed in HEK-293T cells
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