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2.1.1.355: [histone H3]-lysine9 N-trimethyltransferase

This is an abbreviated version!
For detailed information about [histone H3]-lysine9 N-trimethyltransferase, go to the full flat file.

Word Map on EC 2.1.1.355

Reaction

3 S-adenosyl-L-methionine +

a [histone H3]-L-lysine9
= 3 S-adenosyl-L-homocysteine +
a [histone H3]-N6,N6,N6-trimethyl-L-lysine9

Synonyms

Clr4, dG9a, Dim-5, Dim-5 histone lysine methyltransferase, Dim-5 histone-3 lysine-9 methyltransferase, Dim5, DOT1L, EC 2.1.1.43, EHMT1, EHMT2, ESET, G9a, G9a histone methyltransferase, G9a HMT, G9a lysine 9 histone H3 methyltransferase, G9a-like protein lysine methyltransferase, G9a/G9a-like protein lysine dimethyltransferase complex, GLP, H3-K9 methyltransferase, H3K9 histone methyltransferase, H3K9 histone methyltransferases, H3K9 HMT, H3K9 methyltransferase, H3K9-specific histone methyltransferase, H3K9-specific SET domain methyltransferase, histone H3 Lys79 methyltransferase, histone H3 lysine 9 methyltransferase, histone H3 lysine methyltransferase G9a, histone H3 methyltransferase, histone H3K9 methyltransferase, histone H3K9 trimethylase, histone lysine methyltransferase, histone lysine methyltransferase G9a, histone methyltransferase, histone methyltransferase G9a, HKMT, HKMTase, HMTase, KHMTase, KMT1A, KMT1B, KMT1C, KMT1D, KMT1F, lysine methyltransferase G9a, lysine-preferring HMTase, MT8, PRDM2, PRDM8, SETDB1, SU (VAR)3-9, SU(VAR)3-9, SUV39H1, SUVR4

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase

Inhibitors

Inhibitors on EC 2.1.1.355 - [histone H3]-lysine9 N-trimethyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(4,4-difluoropiperidin-1-yl)-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine
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2-(azepan-1-yl)-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-quinazolin-4-amine
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2-cyclohexyl-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-quinazolin-4-amine
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2-cyclohexyl-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine
MS0124, selective inhibitor
6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
-
6,7-dimethoxy-2-morpholino-N-(1-propylpiperidin-4-yl)-quinazolin-4-amine
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6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(piperidin-1-yl)-quinazolin-4-amine
-
6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(pyrrolidin-1-yl)-quinazolin-4-amine
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6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)quinazolin-4-amine
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6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine
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6,7-dimethoxy-N2-methyl-N4-(1-methylpiperidin-4-yl)-N2-pentyl-quinazoline-2,4-diamine
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6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)-N2-pentylquinazoline-2,4-diamine
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6-ethoxy-7-methoxy-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine
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6-fluoro-7-methoxy-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine
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6-isopropoxy-7-methoxy-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine
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6-methoxy-7-methyl-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine
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7-ethoxy-6-methoxy-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine
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7-fluoro-6-methoxy-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine
-
7-isopropoxy-6-methoxy-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine
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7-methoxy-6-methyl-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine
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7-[(5-aminopentyl)oxy]-N4-[1-(5-aminopentyl)piperidin-4-yl]-N2-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine
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7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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BIX-01294
chaetocin
cyclohexamide
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decreases nuclear G9a protein but does not prevent its relative increase during hypoxic stress
E72
i.e. 7-[(5-aminopentyl)oxy]-N4-[-1-(5-aminopentyl)piperidin-4-yl]-N2-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
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N-(1-cyclopropylpiperidin-4-yl)-6,7-dimethoxy-2-morpholinoquinazolin-4-amine
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N-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-2-morpholinoquinazolin-4-amine
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N-(1-isopropylpiperidin-4-yl)-6,7-dimethoxy-2-morpholinoquinazolin-4-amine
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N2-butyl-6,7-dimethoxy-N2-methyl-N4-(1-methylpiperidin-4-yl)-quinazoline-2,4-diamine
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N2-heptyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)-quinazoline-2,4-diamine
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N2-hexyl-6,7-dimethoxy-N2-methyl-N4-(1-methylpiperidin-4-yl)-quinazoline-2,4-diamine
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N2-hexyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine
MS012, selective inhibitor
RNA
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the presence of RNA strongly inhibits enzyme activity in vitro
trimethylated histone H3(K4)
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UNC0638
UNC0642
additional information
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