Reference on EC 2.7.11.1 - non-specific serine/threonine protein kinase and Organism(s) Homo sapiens and UniProt Accession Q8WZ42
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (O15530), Schizosaccharomyces pombe (Q12701)
Deloukas, P.; Matthews, L.H.; Ashurst, J.; Burton, J.; Gilbert, J.G.; et al.
The DNA sequence and comparative analysis of human chromosome 20
Nature
414
865-871
2001
Homo sapiens (P68400), Homo sapiens (Q96S44), Homo sapiens (Q9P286)
Edwards, D.C.; Gill, G.N.
Structural features of LIM kinase that control effects on the actin cytoskeleton
J. Biol. Chem.
274
11352-11361
1999
Homo sapiens (P53667)
Frangiskakis, J.M.; Ewart, A.K.; Morris, C.A.; Mervis, C.B.; Bertrand, J.; Robinson, B.F.; Klein, B.P.; Ensing, G.J.; Everett, L.A.; Green, E.D.; Proschel, C.; Gutowski, N.J.; Noble, M.; Atkinson, D.L.; Odelberg, S.J.; Keating, M.T.
LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition
Cell
86
59-69
1996
Homo sapiens (P53667)
Mizuno, K.; Okano, I.; Ohashi, K.; Nunoue, K.; Kuma, K.; Miyata, T.; Nakamura, T.
Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif
Oncogene
9
1605-1612
1994
Homo sapiens (P53667)
Osborne, L.R.; Martindale, D.; Scherer, S.W.; Shi, X.M.; Huizenga, J.; Heng, H.H.; Costa, T.; Pober, B.; Lew, L.; Brinkman, J.; Rommens, J.; Koop, B.; Tsui, L.C.
Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients
Genomics
36
328-336
1996
Homo sapiens (P53667)
Dunham, I.; Shimizu, N.; Roe, B.A.; Chissoe, S.; Hunt, A.R.; Collins, J.E.; Bruskiewich, R.; Beare, D.M.; Clamp, M.; Smink, L.J.; Ainscough, R.; Almeida, J.P.; Babbage, A.; Bagguley, C.; Bailey, J.; Barlow, K.; Bates, K.N.; Beasley, O.; Bird, C.P.; Blakey, S.; Bridgeman, A.M.; Buck, D.; Burgess, J.; Burrill, W.D.; O'Brien, K.P.; et al.
The DNA sequence of human chromosome 22
Nature
402
489-495
1999
Homo sapiens (O96017), Homo sapiens (P49674)
Gamper, N.; Fillon, S.; Feng, Y.; Friedrich, B.; Lang, P.A.; Henke, G.; Huber, S.M.; Kobayashi, T.; Cohen, P.; Lang, F.
K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK
Pflugers Arch.
445
60-66
2002
Homo sapiens (O00141), Homo sapiens
Conus, N.M.; Hannan, K.M.; Cristiano, B.E.; Hemmings, B.A.; Pearson, R.B.
Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase
J. Biol. Chem.
277
38021-38028
2002
Homo sapiens (P31749)
Wiemann, S.; Weil, B.; Wellenreuther, R.; et al
Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs
Genome Res.
11
422-435
2001
Homo sapiens (Q9Y243)
Matsubara, A.; Wasson, J.C.; Donelan, S.S.; Welling, C.M.; Glaser, B.; Permutt, M.A.
Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes
Diabetologia
44
910-913
2001
Homo sapiens (P31749), Homo sapiens
Brunet, A.; Park, J.; Tran, H.; Hu, L.S.; Hemmings, B.A.; Greenberg, M.E.
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
Mol. Cell. Biol.
21
952-965
2001
Homo sapiens (O00141)
Lang, F.; Klingel, K.; Wagner, C.A.; et al
Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy
Proc. Natl. Acad. Sci. USA
97
8157-8162
2000
Homo sapiens (O00141)
Kobayashi, T.; Cohen, P.
Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
Biochem. J.
339
319-328
1999
Homo sapiens (O00141)
-
Kobayashi, T.; Deak, M.; Morrice, N.; Cohen, P.
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase
Biochem. J.
344
189-197
1999
Homo sapiens (O00141)
-
Waldegger, S.; Erdel, M.; Nagl, U.O.; Barth, P.; Raber, G.; Steuer, S.; Utermann, G.; Paulmichl, M.; Lang, F.
Genomic organization and chromosomal localization of the human SGK protein kinase gene
Genomics
51
299-302
1998
Homo sapiens (O00141), Homo sapiens
Waldegger, S.; Barth, P.; Raber, G.; Lang, F.
Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume
Proc. Natl. Acad. Sci. USA
94
4440-4445
1997
Homo sapiens (O00141), Homo sapiens
Delcommenne, M.; Tan, C.; Gray, V.; Rue, L.; Woodgett, J.; Dedhar, S.
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
Proc. Natl. Acad. Sci. USA
95
11211-11216
1998
Homo sapiens (P31749)
Alessi, D.R.; Andjelkovic, M.; Caudwell, B.; Cron, P.; Morrice, N.; Cohen, P.; Hemmings, B.A.
Mechanism of activation of protein kinase B by insulin and IGF-1
EMBO J.
15
6541-6551
1996
Homo sapiens (P31749)
Coffer, P.J.; Woodgett, J.R.
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
Eur. J. Biochem.
205
1217
1992
Homo sapiens (P31749), Bos taurus (Q01314)
Jones, P.F.; Jakubowicz, T.; Pitossi, F.J.; Maurer, F.; Hemmings, B.A.
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
Proc. Natl. Acad. Sci. USA
88
4171-4175
1991
Homo sapiens (P31749), Homo sapiens
Coffer, P.J.; Woodgett, J.R.
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
Eur. J. Biochem.
201
475-481
1991
Homo sapiens (P31749), Homo sapiens, Bos taurus (Q01314), Bos taurus
Brodbeck, D.; Hill, M.M.; Hemmings, B.A.
Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain
J. Biol. Chem.
276
29550-29558
2001
Mus musculus (Q9WUA6), Mus musculus, Homo sapiens (Q9Y243), Homo sapiens
Nakatani, K.; Sakaue, H.; Thompson, D.A.; Weigel, R.J.; Roth, R.A.
Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site
Biochem. Biophys. Res. Commun.
257
906-910
1999
Homo sapiens (Q9Y243), Homo sapiens
Masure, S.; Haefner, B.; Wesselink, J.J.; Hoefnagel, E.; Mortier, E.; Verhasselt, P.; Tuytelaars, A.; Gordon, R.; Richardson, A.
Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3
Eur. J. Biochem.
265
353-360
1999
Homo sapiens (Q9Y243), Homo sapiens
Brodbeck, D.; Cron, P.; Hemmings, B.A.
A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
J. Biol. Chem.
274
9133-9136
1999
Mus musculus (Q9WUA6), Mus musculus, Homo sapiens (Q9Y243), Homo sapiens
Grove, J.R.; Banerjee, P.; Balasubramanyam, A.; Coffer, P.J.; Price, D.J.; Avruch, J.; Woodgett, J.R.
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini
Mol. Cell. Biol.
11
5541-5550
1991
Homo sapiens (P23443), Homo sapiens
Cheng, J.Q.; Godwin, A.K.; Bellacosa, A.; Taguchi, T.; Franke, T.F.; Hamilton, T.C.; Tsichlis, P.N.; Testa, J.R.
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
Proc. Natl. Acad. Sci. USA
89
9267-9271
1992
Homo sapiens (P31751)
Jones, P.F.; Jakubowicz, T.; Hemmings, B.A.
Molecular cloning of a second form of rac protein kinase
Cell Regul.
2
1001-1009
1991
Homo sapiens (P31751), Homo sapiens
Abidi, F.; Jacquot, S.; Lassiter, C.; Trivier, E.; Hanauer, A.; Schwartz, C.E.
Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome (CLS)
Eur. J. Hum. Genet.
7
20-26
1999
Homo sapiens (P51812), Homo sapiens
Jacquot, S.; Merienne, K.; De Cesare, D.; Pannetier, S.; Mandel, J.L.; Sassone-Corsi, P.; Hanauer, A.
Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations
Am. J. Hum. Genet.
63
1631-1640
1998
Homo sapiens (P51812), Homo sapiens
Trivier, E.; De Cesare, D.; Jacquot, S.; Pannetier, S.; Zackai, E.; Young, I.; Mandel, J.L.; Sassone-Corsi, P.; Hanauer, A.
Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome
Nature
384
567-570
1996
Homo sapiens (P51812)
Bjorbaek, C.; Vik, T.A.; Echwald, S.M.; et al.
Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients
Diabetes
44
90-97
1995
Homo sapiens (P51812), Homo sapiens
Moller, D.E.; Xia, C.H.; Tang, W.; Zhu, A.X.; Jakubowski, M.
Human rsk isoforms: cloning and characterization of tissue-specific expression
Am. J. Physiol.
266
C351-359
1994
Homo sapiens (P51812), Homo sapiens (Q15349), Homo sapiens (Q15418)
Klink, A.; Schiebel, K.; Winkelmann, M.; et al.
The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability
Hum. Mol. Genet.
4
869-878
1995
Homo sapiens (P51817)
Mahadevan, M.S.; Amemiya, C.; Jansen, G.; Sabourin, L.; Baird, S.; Neville, C.E.; Wormskamp, N.; Segers, B.; Batzer, M.; Lamerdin, J.; et al.
Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene
Hum. Mol. Genet.
2
299-304
1993
Mus musculus (P54265), Mus musculus, Homo sapiens (Q09013), Homo sapiens
Jansen, G.; Mahadevan, M.; Amemiya, C.; Wormskamp, N.; Segers, B.; Hendriks, W.; O'Hoy, K.; Baird, S.; Sabourin, L.; Lennon, G.; et al.
Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs
Nat. Genet.
1
261-266
1992
Mus musculus (P54265), Mus musculus, Homo sapiens (Q09013), Homo sapiens
Gennarelli, M.; Lucarelli, M.; Zelano, G.; Pizzuti, A.; Novelli, G.; Dallapiccola, B.
Different expression of the myotonin protein kinase gene in discrete areas of human brain
Biochem. Biophys. Res. Commun.
216
489-494
1995
Homo sapiens (Q09013), Homo sapiens
Sasagawa, N.; Sorimachi, H.; Maruyama, K.; Arahata, K.; Ishiura, S.; Suzuki, K.
Expression of a novel human myotonin protein kinase (MtPK) cDNA clone which encodes a protein with a thymopoietin-like domain in COS cells
FEBS Lett.
351
22-26
1994
Homo sapiens (Q09013)
Shaw, D.J.; McCurrach, M.; Rundle, S.A.; Harley, H.G.; Crow, S.R.; Sohn, R.; Thirion, J.P.; Hamshere, M.G.; Buckler, A.J.; Harper, P.S.; et al.
Genomic organization and transcriptional units at the myotonic dystrophy locus
Genomics
18
673-679
1993
Homo sapiens (Q09013)
Fu, Y.H.; Friedman, D.L.; Richards, S.; Pearlman, J.A.; Gibbs, R.A.; Pizzuti, A.; Ashizawa, T.; Perryman, M.B.; Scarlato, G.; Fenwick, R.G., Jr.; et al.
Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy
Science
260
235-238
1993
Homo sapiens (Q09013)
Fu, Y.H.; Pizzuti, A.; Fenwick, R.G., Jr.; King, J.; Rajnarayan, S.; Dunne, P.W.; Dubel, J.; Nasser, G.A.; Ashizawa, T.; de Jong, P.; et al.
An unstable triplet repeat in a gene related to myotonic muscular dystrophy
Science
255
1256-1258
1992
Homo sapiens (Q09013)
Brook, J.D.; McCurrach, M.E.; Harley, H.G.; Buckler, A.J.; Church, D.; Aburatani, H.; Hunter, K.; Stanton, V.P.; Thirion, J.P.; Hudson, T.; et al.
Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member
Cell
68
799-808
1992
Homo sapiens (Q09013)
Zhao, Y.; Bjorbaek, C.; Weremowicz, S.; Morton, C.C.; Moller, D.E.
RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation
Mol. Cell. Biol.
15
4353-4363
1995
Homo sapiens (Q15349), Homo sapiens
Lee-Fruman, K.K.; Kuo, C.J.; Lippincott, J.; Terada, N.; Blenis, J.
Characterization of S6K2, a novel kinase homologous to S6K1
Oncogene
18
5108-5114
1999
Homo sapiens (Q9UBS0)
Saitoh, M.; ten Dijke, P.; Miyazono, K.; Ichijo, H.
Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases
Biochem. Biophys. Res. Commun.
253
470-476
1998
Homo sapiens (Q9UBS0), Homo sapiens
Gout, I.; Minami, T.; Hara, K.; Tsujishita, Y.; Filonenko, V.; Waterfield, M.D.; Yonezawa, K.
Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region
J. Biol. Chem.
273
30061-30064
1998
Homo sapiens (Q9UBS0)
Yntema, H.G.; van den Helm, B.; Kissing, J.; et al.
A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation
Genomics
62
332-343
1999
Homo sapiens (Q9UK32)
Brede, G.; Solheim, J.; Troen, G.; Prydz, H.
Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization
Genomics
70
82-92
2000
Homo sapiens (P11801), Homo sapiens
Hanks, S.K.
Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family
Proc. Natl. Acad. Sci. USA
84
388-392
1987
Homo sapiens (P11801)
Semba, S.; Ouyang, H.; Han, S.Y.; Kato, Y.; Horii, A.
Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium
Int. J. Oncol.
16
731-737
2000
Homo sapiens (O14757)
Sanchez, Y.; Wong, C.; Thoma, R.S.; Richman, R.; Wu, Z.; Piwnica-Worms, H.; Elledge, S.J.
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
Science
277
1497-1501
1997
Homo sapiens (O14757), Homo sapiens, Mus musculus (O35280)
Flaggs, G.; Plug, A.W.; Dunks, K.M.; Mundt, K.E.; Ford, J.C.; Quiggle, M.R.; Taylor, E.M.; Westphal, C.H.; Ashley, T.; Hoekstra, M.F.; Carr, A.M.
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
Curr. Biol.
7
977-986
1997
Homo sapiens (O14757), Mus musculus (O35280)
Stevenson, D.; Laverty, H.G.; Wenwieser, S.; Douglas, M.; Wilson, J.B.
Mapping and expression analysis of the human CASK gene
Mamm. Genome
11
934-937
2000
Homo sapiens (O14936)
Daniels, D.L.; Cohen, A.R.; Anderson, J.M.; Brunger, A.T.
Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition
Nat. Struct. Biol.
5
317-325
1998
Homo sapiens (O14936)
Cohen, A.R.; Woods, D.F.; Marfatia, S.M.; Walther, Z.; Chishti, A.H.; Anderson, J.M.; Wood, D.F.
Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells
J. Cell Biol.
142
129-138
1998
Homo sapiens (O14936)
Sossey-Alaoui, K.; Srivastava, A.K.
DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)
Genomics
56
121-126
1999
Homo sapiens (O15075), Homo sapiens
Matsumoto, N.; Pilz, D.T.; Ledbetter, D.H.
Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS)
Genomics
56
179-183
1999
Homo sapiens (O15075), Homo sapiens
Omori, Y.; Suzuki, M.; Ozaki, K.; Harada, Y.; Nakamura, Y.; Takahashi, E.; Fujiwara, T.
Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin
J. Hum. Genet.
43
169-177
1998
Homo sapiens (O15075), Homo sapiens
Nagase, T.; Ishikawa, K.; Nakajima, D.; Ohira, M.; Seki, N.; Miyajima, N.; Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
DNA Res.
4
141-150
1997
Homo sapiens (O15075)
Okazaki, N.; Yan, J.; Yuasa, S.; Ueno, T.; Kominami, E.; Masuho, Y.; Koga, H.; Muramatsu, M.
Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation
Brain Res. Mol. Brain Res.
85
1-12
2000
Homo sapiens (O75385)
Kuroyanagi, H.; Yan, J.; Seki, N.; Yamanouchi, Y.; Suzuki, Y.; Takano, T.; Muramatsu, M.; Shirasawa, T.
Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment
Genomics
51
76-85
1998
Homo sapiens (O75385), Homo sapiens
Sanjo, H.; Kawai, T.; Akira, S.
DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis
J. Biol. Chem.
273
29066-29071
1998
Homo sapiens (O94768), Homo sapiens (Q9UEE5)
Brown, A.L.; Lee, C.H.; Schwarz, J.K.; Mitiku, N.; Piwnica-Worms, H.; Chung, J.H.
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
Proc. Natl. Acad. Sci. USA
96
3745-3750
1999
Homo sapiens (O96017), Homo sapiens
Blasina, A.; de Weyer, I.V.; Laus, M.C.; Luyten, W.H.; Parker, A.E.; McGowan, C.H.
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Curr. Biol.
9
1-10
1999
Homo sapiens (O96017), Homo sapiens
Bell, D.W.; Varley, J.M.; Szydlo, T.E.; Kang, D.H.; Wahrer, D.C.; Shannon, K.E.; Lubratovich, M.; Verselis, S.J.; Isselbacher, K.J.; Fraumeni, J.F.; Birch, J.M.; Li, F.P.; Garber, J.E.; Haber, D.A.
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
Science
286
2528-2531
1999
Homo sapiens (O96017)
Matsuoka, S.; Huang, M.; Elledge, S.J.
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
Science
282
1893-1897
1998
Homo sapiens (O96017), Mus musculus (Q9Z265)
Zu, Y.L.; Wu, F.; Gilchrist, A.; Ai, Y.; Labadia, M.E.; Huang, C.K.
The primary structure of a human MAP kinase activated protein kinase 2
Biochem. Biophys. Res. Commun.
200
1118-1124
1994
Homo sapiens (P49137), Homo sapiens
Stokoe, D.; Caudwell, B.; Cohen, P.T.; Cohen, P.
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2
Biochem. J.
296
843-849
1993
Homo sapiens (P49137), Homo sapiens
Deiss, L.P.; Feinstein, E.; Berissi, H.; Cohen, O.; Kimchi, A.
Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death
Genes Dev.
9
15-30
1995
Homo sapiens (P53355)
Stapleton, D.; Mitchelhill, K.I.; Gao, G.; Widmer, J.; Michell, B.J.; Teh, T.; House, C.M.; Fernandez, C.S.; Cox, T.; Witters, L.A.; Kemp, B.E.
Mammalian AMP-activated protein kinase subfamily
J. Biol. Chem.
271
611-614
1996
Rattus norvegicus (P54645), Homo sapiens (Q13131)
Beri, R.K.; Marley, A.E.; See, C.G.; Sopwith, W.F.; Aguan, K.; Carling, D.; Scott, J.; Carey, F.
Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase
FEBS Lett.
356
117-121
1994
Homo sapiens (P54646)
Aguan, K.; Scott, J.; See, C.G.; Sarkar, N.H.
Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals
Gene
149
345-350
1994
Homo sapiens (P54646)
Westerman, A.M.; Entius, M.M.; Boor, P.P.; Koole, R.; de Baar, E.; Offerhaus, G.J.; Lubinski, J.; Lindhout, D.; Halley, D.J.; de Rooij, F.W.; Wilson, J.H.
Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families
Hum. Mutat.
13
476-481
1999
Homo sapiens (Q15831)
Nakagawa, H.; Koyama, K.; Miyoshi, Y.; Ando, H.; Baba, S.; Watatani, M.; Yasutomi, M.; Matsuura, N.; Monden, M.; Nakamura, Y.
Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome
Hum. Genet.
103
168-172
1998
Homo sapiens (Q15831)
Jenne, D.E.; Reimann, H.; Nezu, J.; Friedel, W.; Loff, S.; Jeschke, R.; Muller, O.; Back, W.; Zimmer, M.
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
Nat. Genet.
18
38-43
1998
Homo sapiens (Q15831), Homo sapiens
Hemminki, A.; Markie, D.; Tomlinson, I.; et al.
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
Nature
391
184-187
1998
Homo sapiens (Q15831)
Bignell, G.R.; Barfoot, R.; Seal, S.; Collins, N.; Warren, W.; Stratton, M.R.
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer
Cancer Res.
58
1384-1386
1998
Homo sapiens (Q15831)
Fish, K.J.; Cegielska, A.; Getman, M.E.; Landes, G.M.; Virshup, D.M.
Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family
J. Biol. Chem.
270
14875-14883
1995
Homo sapiens (P48729), Homo sapiens (P49674), Homo sapiens
Tapia, C.; Featherstone, T.; Gomez, C.; Taillon-Miller, P.; Allende, C.C.; Allende, J.E.
Cloning and chromosomal localization of the gene coding for human protein kinase CK1
FEBS Lett.
349
307-312
1994
Homo sapiens (P48729)
Kusuda, J.; Hidari, N.; Hirai, M.; Hashimoto, K.
Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization
Genomics
32
140-143
1996
Homo sapiens (P48730), Homo sapiens
Kitabayashi, A.N.; Kusuda, J.; Hirai, M.; Hashimoto, K.
Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2)
Genomics
46
133-137
1997
Homo sapiens (P78368), Homo sapiens
Kusuda, J.; Hirai, M.; Tanuma, R.; Hashimoto, K.
Cloning, expression analysis and chromosome mapping of human casein kinase 1 gamma1 (CSNK1G1): identification of two types of cDNA encoding the kinase protein associated with heterologous carboxy-terminal sequences
Cytogenet. Cell Genet.
90
298-302
2000
Homo sapiens (Q9HCP0), Homo sapiens
Kusuda, J.; Hirai, M.; Toyoda, A.; Tanuma, R.; Hashimoto, K.
Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3)
Cytogenet. Cell Genet.
83
101-103
1998
Homo sapiens (Q9Y6M4), Homo sapiens
Devilat, I.; Carvallo, P.
Structure and sequence of an intronless gene for human casein kinase II-alpha subunit
FEBS Lett.
316
114-118
1993
Homo sapiens (P68400), Homo sapiens
Litchfield, D.W.; Lozeman, F.J.; Piening, C.; Sommercorn, J.; Takio, K.; Walsh, K.A.; Krebs, E.G.
Subunit structure of casein kinase II from bovine testis. Demonstration that the alpha and alpha' subunits are distinct polypeptides
J. Biol. Chem.
265
7638-7644
1990
Bos taurus (P20427), Bos taurus, Homo sapiens (P68400)
Lozeman, F.J.; Litchfield, D.W.; Piening, C.; Takio, K.; Walsh, K.A.; Krebs, E.G.
Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II
Biochemistry
29
8436-8447
1990
Homo sapiens (P19784), Homo sapiens (P68400), Homo sapiens
Meisner, H.; Heller-Harrison, R.; Buxton, J.; Czech, M.P.
Molecular cloning of the human casein kinase II alpha subunit
Biochemistry
28
4072-4076
1989
Rattus norvegicus (P19139), Homo sapiens (P68400), Homo sapiens
ole-MoiYoi, O.K.; Brown, W.C.; Iams, K.P.; Nayar, A.; Tsukamoto, T.; Macklin, M.D.
Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva
EMBO J.
12
1621-1631
1993
Homo sapiens (P68400)
Allen, K.M.; Gleeson, J.G.; Bagrodia, S.; Partington, M.W.; MacMillan, J.C.; Cerione, R.A.; Mulley, J.C.; Walsh, C.A.
PAK3 mutation in nonsyndromic X-linked mental retardation
Nat. Genet.
20
25-30
1998
Homo sapiens (O75914), Homo sapiens
Johnston, A.M.; Naselli, G.; Gonez, L.J.; Martin, R.M.; Harrison, L.C.; DeAizpurua, H.J.
SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
Oncogene
19
4290-4297
2000
Rattus norvegicus (O88506), Homo sapiens (Q9UEW8), Mus musculus (Q9Z1W9)
Abo, A.; Qu, J.; Cammarano, M.S.; Dan, C.; Fritsch, A.; Baud, V.; Belisle, B.; Minden, A.
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
EMBO J.
17
6527-6540
1998
Homo sapiens (O96013)
Brown, J.L.; Stowers, L.; Baer, M.; Trejo, J.; Coughlin, S.; Chant, J.
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway
Curr. Biol.
6
598-605
1996
Homo sapiens (Q13153), Homo sapiens
Sells, M.A.; Knaus, U.G.; Bagrodia, S.; Ambrose, D.M.; Bokoch, G.M.; Chernoff, J.
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
Curr. Biol.
7
202-210
1997
Homo sapiens (Q13153), Homo sapiens
Benner, G.E.; Dennis, P.B.; Masaracchia, R.A.
Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation
J. Biol. Chem.
270
21121-21128
1995
Homo sapiens (Q13177)
Martin, G.A.; Bollag, G.; McCormick, F.; Abo, A.
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
EMBO J.
14
1970-1978
1995
Homo sapiens (Q13177), Homo sapiens
Martin, G.A.; Bollag, G.; McCormick, F.; Abo, A.
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
EMBO J.
14
4385
1995
Homo sapiens (Q13177)
Kojima, T.; Zama, T.; Wada, K.; Onogi, H.; Hagiwara, M.
Cloning of human PRP4 reveals interaction with Clk1
J. Biol. Chem.
276
32247-32256
2001
Homo sapiens (Q13523)
Grunau, C.; Hindermann, W.; Rosenthal, A.
Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes
Hum. Mol. Genet.
9
2651-2663
2000
Homo sapiens (Q9UPE1)
Nagase, T.; Ishikawa, K.; Miyajima, N.; Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
DNA Res.
5
31-39
1998
Homo sapiens (Q13523)
Gross, T.; Lutzelberger, M.; Weigmann, H.; Klingenhoff, A.; Shenoy, S.; Kaufer, N.F.
Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue
Nucleic Acids Res.
25
1028-1035
1997
Homo sapiens (Q13523), Mus musculus (Q61136)
Wang, Y.; Hofmann, T.G.; Runkel, L.; Haaf, T.; Schaller, H.; Debatin, K.; Hug, H.
Isolation and characterization of cDNAs for the protein kinase HIPK2
Biochim. Biophys. Acta
1518
168-172
2001
Homo sapiens (Q9H2X6), Homo sapiens, Mus musculus (Q9QZR5), Mus musculus
Li, X.; Wang, Y.; Debatin, K.M.; Hug, H.
The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells
Biochem. Biophys. Res. Commun.
277
513-517
2000
Homo sapiens (Q9H2X6)
Labeit, S.; Kolmerer, B.
Titins: giant proteins in charge of muscle ultrastructure and elasticity
Science
270
293-296
1995
Homo sapiens (Q8WZ42)
Gautel, M.; Castiglione Morelli, M.A.; Pfuhl, M.; Motta, A.; Pastore, A.
A calmodulin-binding sequence in the C-terminus of human cardiac titin kinase
Eur. J. Biochem.
230
752-759
1995
Homo sapiens (Q8WZ42), Homo sapiens
Taylor, L.K.; Wang, H.C.; Erikson, R.L.
Newly identified stress-responsive protein kinases, Krs-1 and Krs-2
Proc. Natl. Acad. Sci. USA
93
10099-10104
1996
Homo sapiens (Q13043), Homo sapiens (Q13188)
Schultz, S.J.; Fry, A.M.; Sutterlin, C.; Ried, T.; Nigg, E.A.
Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans
Cell Growth Differ.
5
625-635
1994
Homo sapiens (P51955), Homo sapiens (P51956), Homo sapiens (Q13188), Homo sapiens
Schultz, S.J.; Nigg, E.A.
Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans
Cell Growth Differ.
4
821-830
1993
Homo sapiens (P51955), Homo sapiens (P51956), Homo sapiens (Q13188), Homo sapiens
Pangilinan, F.; Li, Q.; Weaver, T.; Lewis, B.C.; Dang, C.V.; Spencer, F.
Mammalian BUB1 protein kinases: map positions and in vivo expression
Genomics
46
379-388
1997
Mus musculus (O08901), Homo sapiens (O43683)
Cahill, D.P.; da Costa, L.T.; Carson-Walter, E.B.; Kinzler, K.W.; Vogelstein, B.; Lengauer, C.
Characterization of MAD2B and other mitotic spindle checkpoint genes
Genomics
58
181-187
1999
Homo sapiens (O43683), Homo sapiens (O60566)
Taylor, S.S.; Ha, E.; McKeon, F.
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
J. Cell. Biol.
142
1-11
1998
Homo sapiens (O43683), Homo sapiens (O60566), Homo sapiens
Ouyang, B.; Lan, Z.; Meadows, J.; Pan, H.; Fukasawa, K.; Li, W.; Dai, W.
Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation
Cell Growth Differ.
9
877-885
1998
Homo sapiens (O43683)
Cahill, D.P.; Lengauer, C.; Yu, J.; Riggins, G.J.; Willson, J.K.; Markowitz, S.D.; Kinzler, K.W.; Vogelstein, B.
Mutations of mitotic checkpoint genes in human cancers
Nature
392
300-303
1998
Homo sapiens (O43683), Homo sapiens (O60566)
Davenport, J.W.; Fernandes, E.R.; Harris, L.D.; Neale, G.A.; Goorha, R.
The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner
Genomics
55
113-117
1999
Homo sapiens (O60566), Homo sapiens, Mus musculus (Q9Z1S0), Mus musculus
Chan, G.K.; Schaar, B.T.; Yen, T.J.
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
J. Cell. Biol.
143
49-63
1998
Homo sapiens (O60566)
Ohta, S.; Takeuchi, M.; Deguchi, M.; Tsuji, T.; Gahara, Y.; Nagata, K.
A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway
Biochem. J.
350
395-404
2000
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Rattus norvegicus (P57760)
Berson, A.E.; Young, C.; Morrison, S.L.; Fujii, G.H.; Sheung, J.; Wu, B.; Bolen, J.B.; Burkhardt, A.L.
Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase
Biochem. Biophys. Res. Commun.
259
533-538
1999
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Mus musculus
Ligos, J.M.; Gerwin, N.; Fernandez, P.; Gutierrez-Ramos, J.C.; Bernad, A.
Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases
Biochem. Biophys. Res. Commun.
249
380-384
1998
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Mus musculus
Hess, G.F.; Drong, R.F.; Weiland, K.L.; Slightom, J.L.; Sclafani, R.A.; Hollingsworth, R.E.
A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines
Gene
211
133-140
1998
Homo sapiens (O00311), Homo sapiens
Jiang, W.; Hunter, T.
Identification and characterization of a human protein kinase related to budding yeast Cdc7p
Proc. Natl. Acad. Sci. USA
94
14320-14325
1997
Homo sapiens (O00311), Homo sapiens
Sato, N.; Arai, K.; Masai, H.
Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7
EMBO J.
16
4340-4351
1997
Homo sapiens (O00311), Homo sapiens
Wang, P.J.; McCarrey, J.R.; Yang, F.; Page, D.C.
An abundance of X-linked genes expressed in spermatogonia
Nat. Genet.
27
422-426
2001
Mus musculus (Q99mw1), Homo sapiens (Q9BXU1)
Aoki, M.; Yokota, T.; Sugiura, I.; Sasaki, C.; Hasegawa, T.; Okumura, C.; Ishiguro, K.; Kohno, T.; Sugio, S.; Matsuzaki, T.
Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta
Acta Crystallogr. Sect. D
60
439-446
2004
Homo sapiens
Chen, X.; Lin, G.; Wei, Y.; Hexige, S.; Niu, Y.; Liu, L.; Yang, C.; Yu, L.
TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway
Biochem. Biophys. Res. Commun.
333
742-749
2005
Homo sapiens (Q6SA08), Homo sapiens
Bain, J.; McLauchlan, H.; Elliott, M.; Cohen, P.
The specificities of protein kinase inhibitors: an update
Biochem. J.
371
199-204
2003
Homo sapiens, Rattus norvegicus
Biondi, R.M.; Nebreda, A.R.
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
Biochem. J.
372
1-13
2003
Homo sapiens (Q13153)
Hofmann, T.G.; Stollberg, N.; Schmitz, M.L.; Will, H.
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells
Cancer Res.
63
8271-8277
2003
Homo sapiens
Mottet, D.; Ruys, S.P.; Demazy, C.; Raes, M.; Michiels, C.
Role for casein kinase 2 in the regulation of HIF-1 activity
Int. J. Cancer
117
764-774
2005
Homo sapiens
Mukai, H.
The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC
J. Biochem.
133
17-27
2003
Asteroidea, Bos taurus, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis
Cho, J.H.; Johnson, G.V.
Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding
J. Biol. Chem.
278
187-193
2003
Homo sapiens
Tamaskovic, R.; Bichsel, S.J.; Rogniaux, H.; Stegert, M.R.; Hemmings, B.A.
Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase
J. Biol. Chem.
278
6710-6718
2003
Homo sapiens
Roosbeek, S.; Peelman, F.; Verhee, A.; Labeur, C.; Caster, H.; Lensink, M.F.; Cirulli, C.; Grooten, J.; Cochet, C.; Vandekerckhove, J.; Amoresano, A.; Chimini, G.; Tavernier, J.; Rosseneu, M.
Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter
J. Biol. Chem.
279
37779-37788
2004
Homo sapiens
Hernandez, F.; Perez, M.; Lucas, J.J.; Mata, A.M.; Bhat, R.; Avila, J.
Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease
J. Biol. Chem.
279
3801-3806
2004
Homo sapiens
Cho, J.H.; Johnson, G.V.
Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ
J. Biol. Chem.
279
54716-54723
2004
Homo sapiens
Stoothoff, W.H.; Cho, J.H.; McDonald, R.P.; Johnson, G.V.
FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation
J. Biol. Chem.
280
270-276
2005
Homo sapiens
Kenyon, T.K.; Homan, E.; Storlie, J.; Ikoma, M.; Grose, C.
Comparison of varicella-zoster virus ORF47 protein kinase and casein kinase II and their substrates
J. Med. Virol.
70 Suppl 1
S95-102
2003
Homo sapiens, Human alphaherpesvirus 3
Zhang, Y.; Li, H.L.; Wang, D.L.; Liu, S.J.; Wang, J.Z.
A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology
J. Neural Transm.
2
1-11
2006
Homo sapiens
Coito, C.; Diamond, D.L.; Neddermann, P.; Korth, M.J.; Katze, M.G.
High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein
J. Virol.
78
3502-3513
2004
Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus
Auer, A.; von Blume, J.; Sturany, S.; von Wichert, G.; Van Lint, J.; Vandenheede, J.; Adler, G.; Seufferlein, T.
Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling
Mol. Biol. Cell
16
4375-4385
2005
Homo sapiens
Lambourne, S.L.; Sellers, L.A.; Bush, T.G.; Choudhury, S.K.; Emson, P.C.; Suh, Y.H.; Wilkinson, L.S.
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities
Mol. Cell. Biol.
25
278-293
2005
Homo sapiens, Mus musculus
Spiridonov, N.A.; Wong, L.; Zerfas, P.M.; Starost, M.F.; Pack, S.D.; Paweletz, C.P.; Johnson, G.R.
Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility
Mol. Cell. Biol.
25
4250-4261
2005
Mus musculus (Q925K9), Mus musculus, Homo sapiens (Q9BXA6), Homo sapiens
Willets, J.M.; Mistry, R.; Nahorski, S.R.; Challiss, R.A.
Specificity of G protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell M3 muscarinic acetylcholine receptor signaling
Mol. Pharmacol.
64
1059-1068
2003
Homo sapiens
Ahn, B.H.; Min, G.; Bae, Y.S.; Min do, S.
Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells
Exp. Mol. Med.
38
55-62
2006
Homo sapiens
Pagano, M.A.; Cesaro, L.; Meggio, F.; Pinna, L.A.
Protein kinase CK2: a newcomer in the druggable kinome
Biochem. Soc. Trans.
34
1303-1306
2006
Homo sapiens
Yan, Y.; Nguyen, H.; Dalmasso, G.; Sitaraman, S.V.; Merlin, D.
Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform
Biochim. Biophys. Acta
1769
106-116
2007
Homo sapiens (Q6E0B2)
Duncan, J.S.; Litchfield, D.W.
Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2
Biochim. Biophys. Acta
1784
33-47
2008
Homo sapiens
Haraga, A.; Miller, S.I.
A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1
Cell. Microbiol.
8
837-846
2006
Homo sapiens
Laramas, M.; Pasquier, D.; Filhol, O.; Ringeisen, F.; Descotes, J.L.; Cochet, C.
Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer
Eur. J. Cancer
43
928-934
2007
Homo sapiens
Price, M.A.
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling
Genes Dev.
20
399-410
2006
Drosophila melanogaster, Homo sapiens, Xenopus laevis
Guerra, B.
Protein kinase CK2 subunits are positive regulators of AKT kinase
Int. J. Oncol.
28
685-693
2006
Homo sapiens
Hanger, D.P.; Byers, H.L.; Wray, S.; Leung, K.Y.; Saxton, M.J.; Seereeram, A.; Reynolds, C.H.; Ward, M.A.; Anderton, B.H.
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
J. Biol. Chem.
282
23645-23654
2007
Homo sapiens
Foster, K.S.; McCrary, W.J.; Ross, J.S.; Wright, C.F.
Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt
Oncogene
25
4605-4612
2006
Homo sapiens
Bolanos-Garcia, V.M.; Fernandez-Recio, J.; Allende, J.E.; Blundell, T.L.
Identifying interaction motifs in CK2beta - a ubiquitous kinase regulatory subunit
Trends Biochem. Sci.
31
654-661
2006
Homo sapiens
Caples, M.J.; Clements, J.E.; Barber, S.A.
Protein kinase CK2 phosphorylates the Nef protein from a neurovirulent simian immunodeficiency virus
Virology
348
156-164
2006
Homo sapiens
Akita, S.; Umezawa, N.; Kato, N.; Higuchi, T.
Array-based fluorescence assay for serine/threonine kinases using specific chemical reaction
Bioorg. Med. Chem.
16
7788-7794
2008
Bos taurus, Homo sapiens (P31749)
Yoo, J.H.; Yoo, J.H.; Choi, Y.J.; Kang, J.G.; Sun, Y.K.; Ki, C.S.; Lee, K.A.; Choi, J.R.
A novel de novo mutation in the serine-threonine kinase STK11 gene in a Korean patient with Peutz-Jeghers syndrome
BMC Med. genet.
9
44
2008
Homo sapiens (Q15831), Homo sapiens
Kotliarova, S.; Pastorino, S.; Kovell, L.C.; Kotliarov, Y.; Song, H.; Zhang, W.; Bailey, R.; Maric, D.; Zenklusen, J.C.; Lee, J.; Fine, H.A.
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation
Cancer Res.
68
6643-6651
2008
Homo sapiens
Mills, S.J.; Vandeput, F.; Trusselle, M.N.; Safrany, S.T.; Erneux, C.; Potter, B.V.
Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the pH domain of protein kinase Balpha
ChemBioChem
9
1757-1766
2008
Homo sapiens
Cozzone, D.; Froejdoe, S.; Disse, E.; Debard, C.; Laville, M.; Pirola, L.; Vidal, H.
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients
Diabetologia
51
512-521
2008
Homo sapiens (P31749), Homo sapiens (P31751), Homo sapiens (Q9Y243), Homo sapiens
Oh, Y.; Herbst, R.S.; Burris, H.; Cleverly, A.; Musib, L.; Lahn, M.; Bepler, G.
Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer
J. Clin. Oncol.
26
1135-1141
2008
Homo sapiens
Enomoto, A.; Kido, N.; Ito, M.; Morita, A.; Matsumoto, Y.; Takamatsu, N.; Hosoi, Y.; Miyagawa, K.
Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38)
Oncogene
27
1930-1938
2008
Homo sapiens (Q15208)
Ragan, T.J.; Ross, D.B.; Keshwani, M.M.; Harris, T.K.
Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1)
Protein Expr. Purif.
57
271-279
2008
Homo sapiens (P23443)
Keshwani, M.M.; Ross, D.B.; Ragan, T.J.; Harris, T.K.
Baculovirus-mediated expression, purification, and characterization of a fully activated catalytic kinase domain construct of the 70 kDa 40S ribosomal protein S6 kinase-1 alphaII isoform (S6K1alphaII)
Protein Expr. Purif.
58
32-41
2008
Homo sapiens
Chen, H.; Van Duyne, R.; Zhang, N.; Kashanchi, F.; Zeng, C.
A novel binding pocket of cyclin-dependent kinase 2
Proteins
74
122-132
2008
Homo sapiens
Brown, D.A.; Yule, D.I.
Protein kinase A regulation of P2X(4) receptors: Requirement for a specific motif in the C-terminus
Biochim. Biophys. Acta
1803
275-287
2010
Homo sapiens
Bialik, S.; Kimchi, A.
Lethal weapons: DAP-kinase, autophagy and cell death DAP-kinase regulates autophagy
Curr. Opin. Cell Biol.
22
199-205
2010
Homo sapiens
Swords, R.; Mahalingam, D.; ODwyer, M.; Santocanale, C.; Kelly, K.; Carew, J.; Giles, F.
Cdc7 kinase - a new target for drug development
Eur. J. Cancer
46
33-40
2010
Homo sapiens
Anand, V.S.; Reichling, L.J.; Lipinski, K.; Stochaj, W.; Duan, W.; Kelleher, K.; Pungaliya, P.; Brown, E.L.; Reinhart, P.H.; Somberg, R.; Hirst, W.D.; Riddle, S.M.; Braithwaite, S.P.
Investigation of leucine-rich repeat kinase 2: enzymological properties and novel assays
FEBS J.
276
466-478
2009
Homo sapiens
Bi, J.; Lau, S.H.; Hu, L.; Rao, H.L.; Liu, H.B.; Zhan, W.H.; Chen, G.; Wen, J.M.; Wang, Q.; Li, B.; Guan, X.Y.
Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer
Int. J. Cancer
124
1587-1593
2009
Homo sapiens
Lee, C.H.; Liu, C.M.; Wen, C.C.; Chang, S.M.; Hwu, H.G.
Genetic copy number variants in sib pairs both affected with schizophrenia
J. Biomed. Sci.
17
2-2
2010
Homo sapiens
Aliagas-Martin, I.; Burdick, D.; Corson, L.; Dotson, J.; Drummond, J.; Fields, C.; Huang, O.W.; Hunsaker, T.; Kleinheinz, T.; Krueger, E.; Liang, J.; Moffat, J.; Phillips, G.; Pulk, R.; Rawson, T.E.; Ultsch, M.; Walker, L.; Wiesmann, C.; Zhang, B.; Zhu, B.Y.; Cochran, A.G.
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B
J. Med. Chem.
52
3300-3307
2009
Homo sapiens (O14965)
Eiseler, T.; Doeppler, H.; Yan, I.K.; Kitatani, K.; Mizuno, K.; Storz, P.
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility via slingshot
Nat. Cell Biol.
11
545-556
2009
Homo sapiens
Maloverjan, A.; Piirsoo, M.; Michelson, P.; Kogerman, P.; Osterlund, T.
Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway
Exp. Cell Res.
316
627-637
2010
Homo sapiens (Q6PHR2), Homo sapiens
Cheong, J.; Virshup, D.
Casein kinase 1: complexity in the family
Int. J. Biochem. Cell Biol.
43
465-469
2011
Homo sapiens
Lin C.; Tsai S.C.; Tseng M.T.; Peng S.F.; Kuo S.C.; Lin M.W.; Hsu Y.M.; Lee M.R.; Amagaya S.; Huang W.W.; Wu T.S.; Yang J.S.
AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells
Int. J. Oncol.
42
993-1000
2013
Homo sapiens
Calamaras, T.; Lee, C.; Lan, F.; Ido, Y.; Siwik, D.; Colucci, W.
Post-translational modification of serine/threonine kinase LKB1 via adduction of the reactive lipid species 4-hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity
J. Biol. Chem.
287
42400-42406
2012
Homo sapiens
Asano, J.; Nakano, A.; Oda, A.; Amou, H.; Hiasa, M.; Takeuchi, K.; Miki, H.; Nakamura, S.; Harada, T.; Fujii, S.; Kagawa, K.; Endo, I.; Yata, K.; Sakai, A.; Ozaki, S.; Matsumoto, T.; Abe, M.
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells
Leukemia
25
1182-1188
2011
Homo sapiens
Matheny, R.W.; Geddis, A.V.; Abdalla, M.N.; Leandry, L.A.
Phosphatidylinositol 3-kinase p110alpha mediates phosphorylation of AMP-activated protein kinase in myoblasts
Biochem. Biophys. Res. Commun.
469
1117-1122
2016
Homo sapiens (P42336)
Hu, L.; Chen, H.; Cai, J.; Zhang, Y.; Qi, C.; Gong, H.; Zhai, Y.; Fu, H.; Yang, G.; Gao, C.
Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer
BMC Cancer
15
246
2015
Homo sapiens
Kim, S.; Ezhilarasan, R.; Phillips, E.; Gallego-Perez, D.; Sparks, A.; Taylor, D.; Ladner, K.; Furuta, T.; Sabit, H.; Chhipa, R.; Cho, J.; Mohyeldin, A.; Beck, S.; Kurozumi, K.; Kuroiwa, T.; Iwata, R.; Asai, A.; Kim, J.; Sulman, E.; Cheng, S.; Lee, L.; Na
Serine/threonine kinase MLK4 determines mesenchymal identity in glioma stem cells in an NF-kappaB-dependent manner
Cancer Cell
29
201-213
2016
Homo sapiens
Enerbaeck, S.
Casein kinase 2 - A kinase that inhibits brown fat formation
Cell Metab.
22
958-959
2015
Homo sapiens
Fukasawa, T.; Enomoto, A.; Miyagawa, K.
Serine-threonine kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint
Cell. Signal.
27
1569-1575
2015
Homo sapiens (Q15208)
Watson, L.J.; Alexander, K.M.; Mohan, M.L.; Bowman, A.L.; Mangmool, S.; Xiao, K.; Naga Prasad, S.V.; Rockman, H.A.
Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation
Cell. Signal.
28
1580-1592
2016
Homo sapiens (P48736)
Sommer, L.; Schaad, M.; Dames, S.
NMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK)
J. Biol. Chem.
288
20046-20063
2013
Homo sapiens (P78527), Homo sapiens (Q13315), Homo sapiens (Q13535), Homo sapiens (Q96Q15)
Somoza, J.R.; Koditek, D.; Villasenor, A.G.; Novikov, N.; Wong, M.H.; Liclican, A.; Xing, W.; Lagpacan, L.; Wang, R.; Schultz, B.E.; Papalia, G.A.; Samuel, D.; Lad, L.; McGrath, M.E.
Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase delta
J. Biol. Chem.
290
8439-8446
2015
Homo sapiens (O00329)
Mohl, B.; Roy, P.
Cellular casein kinase 2 and protein phosphatase 2A modulate replication site assembly of bluetongue virus
J. Biol. Chem.
291
14566-14574
2016
Homo sapiens
Chan, T.; Cheung, F.; Zheng, J.; Lu, X.; Zhu, L.; Grewal, T.; Murray, M.; Zhou, F.
Casein kinase 2 is a novel regulator of the human organic anion transporting polypeptide 1A2 (OATP1A2) trafficking
Mol. Pharm.
13
144-154
2016
Homo sapiens
Cerda, O.; Caceres, M.; Park, K.; Leiva-Salcedo, E.; Romero, A.; Varela, D.; Trimmer, J.; Stutzin, A.
Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4
Pflugers Arch.
467
1723-1732
2015
Homo sapiens
Thomas, D.; Powell, J.A.; Green, B.D.; Barry, E.F.; Ma, Y.; Woodcock, J.; Fitter, S.; Zannettino, A.C.; Pitson, S.M.; Hughes, T.P.; Lopez, A.F.; Shepherd, P.R.; Wei, A.H.; Ekert, P.G.; Guthridge, M.A.
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival
PLoS Biol.
11
e1001515
2013
Homo sapiens (P42336)
Herhaus, L.; Perez-Oliva, A.; Cozza, G.; Gourlay, R.; Weidlich, S.; Campbell, D.; Pinna, L.; Sapkota, G.
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization
Sci. Signal.
8
ra35
2015
Homo sapiens
An, N.; Lin, Y.; Mahajan, S.; Kellner, J.; Wang, Y.; Li, Z.; Kraft, A.; Kang, Y.
Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells
Stem Cells
31
1202-1212
2013
Homo sapiens
Aramini, J.; Vorobiev, S.; Tuberty, L.; Janjua, H.; Campbell, E.; Seetharaman, J.; Su, M.; Huang, Y.; Acton, T.; Xiao, R.; Tong, L.; Montelione, G.
The RAS-binding domain of human BRAF protein serine/threonine kinase exhibits allosteric conformational changes upon binding HRAS
Structure
23
1382-1393
2015
Homo sapiens (P15056)
Chai, J.; Wang, S.; Han, D.; Dong, W.; Xie, C.; Guo, H.
MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase
Tumor Biol.
36
1313-1321
2015
Homo sapiens
Enerbaeck, S.
Casein kinase 2 - a kinase that inhibits brown fat formation
Cell Metab.
22
958-959
2015
Homo sapiens
Fukasawa, T.; Enomoto, A.; Miyagawa, K.
Serine-threonine kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint
Cell. Signal.
27
1569-1575
2015
Homo sapiens (Q15208)
-
Mohl, B.; Roy, P.
Cellular casein kinase 2 and protein phosphatase 2A modulate replication site assembly of bluetongue virus
J. Biol. Chem.
291
14566-14574
2016
Homo sapiens
Greer, Y.; Westlake, C.; Gao, B.; Bharti, K.; Shiba, Y.; Xavier, C.; Pazour, G.; Yang, Y.; Rubin, J.
Casein kinase 1delta functions at the centrosome and Golgi to promote ciliogenesis
Mol. Biol. Cell
25
1629-1640
2014
Homo sapiens (P48730), Mus musculus (Q9DC28)
-
Cerda, O.; Caceres, M.; Park, K.; Leiva-Salcedo, E.; Romero, A.; Varela, D.; Trimmer, J.; Stutzin, A.
Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4
Pflugers Arch.
467
1723-1732
2015
Homo sapiens
-
Herhaus, L.; Perez-Oliva, A.; Cozza, G.; Gourlay, R.; Weidlich, S.; Campbell, D.; Pinna, L.; Sapkota, G.
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization
Sci. Signal.
8
ra35
2015
Homo sapiens
-
An, N.; Lin, Y.; Mahajan, S.; Kellner, J.; Wang, Y.; Li, Z.; Kraft, A.; Kang, Y.
Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells
Stem Cells
31
1202-1212
2013
Mus musculus (P06803), Mus musculus, Homo sapiens (P11309), Homo sapiens
Chai, J.; Wang, S.; Han, D.; Dong, W.; Xie, C.; Guo, H.
MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase
Tumor Biol.
36
1313-1321
2015
Homo sapiens
-
Kim, H.; Han, Y.; Lee, J.; Lee, S.
Casein kinase 2alpha enhances 5-fluorouracil resistance in colorectal cancer cells by inhibiting endoplasmic reticulum stress
Anticancer Res.
40
1419-1426
2020
Homo sapiens
Roach, B.; Ngo, J.; Limso, C.; Oloja, K.; Bhandari, D.
Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5
Biochem. Biophys. Res. Commun.
504
753-758
2018
Homo sapiens (Q00535)
Meng, Z.; Bhm, T.; Xu, P.; Henne-Bruns, D.; Peifer, C.; Witt, L.; Knippschild, U.; Bischof, J.
Kinase activity of casein kinase 1 delta (CK1delta) is modulated by protein kinase Calpha (PKCalpha) by site-specific phosphorylation within the kinase domain of CK1delta
Biochim. Biophys. Acta Proteins Proteom.
1867
710-721
2019
Homo sapiens (P48730)
Karthikeyan, C.; Jharia, P.; Waiker, D.; Nusbaum, A.; Amawi, H.; Kirwen, E.; Christman, R.; Arudra, S.; Meijer, L.; Tiwari, A.; Trivedi, P.
N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1delta/epsion inhibitors synthesis, biological evaluation and molecular modeling studies
Bioorg. Med. Chem. Lett.
27
2663-2667
2017
Homo sapiens (P48730)
Hawkinson, J.; Sinville, R.; Mudaliar, D.; Shetty, J.; Ward, T.; Herr, J.; Georg, G.
Potent pyrimidine and pyrrolopyrimidine inhibitors of testis-specific serine/threonine kinase 2 (TSSK2)
ChemMedChem
12
1857-1865
2017
Homo sapiens (Q96PF2)
Rozpedek, W.; Pytel, D.; Nowak-Zdunczyk, A.; Lewko, D.; Wojtczak, R.; Diehl, J.; Majsterek, I.
Breaking the DNA damage response via serine/threonine kinase inhibitors to improve cancer treatment
Curr. Med. Chem.
26
1425-1445
2019
Homo sapiens (Q13315), Homo sapiens (Q13535), Homo sapiens (Q9NZJ5)
Gocher, A.; Azabdaftari, G.; Euscher, L.; Dai, S.; Karacosta, L.; Franke, T.; Edelman, A.
Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells
J. Biol. Chem.
292
14188-14204
2017
Homo sapiens (P31749)
Su, Y.; Song, P.; Wang, H.; Hu, B.; Wang, J.; Cheng, M.
Precise design of highly isoform-selective p21-activated kinase 4 inhibitors computational insights into the selectivity mechanism through molecular dynamics simulation and binding free energy calculation
J. Biomol. Struct. Dyn.
38
3825-3837
2020
Homo sapiens (O96013), Homo sapiens (Q13153)
Majumdar, A.; Ahmad, F.; Sheikh, T.; Bhagat, R.; Pathak, P.; Joshi, S.; Seth, P.; Tandon, V.; Tripathi, M.; Saratchandra, P.; Sarkar, C.; Sen, E.
miR-217-casein kinase-2 cross talk regulates ERK activation in ganglioglioma
J. Mol. Med.
95
1215-1226
2017
Homo sapiens (P68400), Homo sapiens
