Information on EC 1.1.1.1 - alcohol dehydrogenase

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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

EC NUMBER
COMMENTARY hide
1.1.1.1
-
RECOMMENDED NAME
GeneOntology No.
alcohol dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
a secondary alcohol + NAD+ = a ketone + NADH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-methylbutanol biosynthesis (engineered)
-
-
acetaldehyde biosynthesis I
-
-
acetylene degradation
-
-
alpha-Linolenic acid metabolism
-
-
Biosynthesis of antibiotics
-
-
Biosynthesis of secondary metabolites
-
-
butanol and isobutanol biosynthesis (engineered)
-
-
chitin degradation to ethanol
-
-
Chloroalkane and chloroalkene degradation
-
-
Drug metabolism - cytochrome P450
-
-
ethanol degradation I
-
-
ethanol degradation II
-
-
ethanol fermentation
-
-
Fatty acid degradation
-
-
Glycine, serine and threonine metabolism
-
-
Glycolysis / Gluconeogenesis
-
-
heterolactic fermentation
-
-
L-1,2-propanediol degradation
-
-
L-isoleucine degradation II
-
-
L-leucine degradation III
-
-
L-methionine degradation III
-
-
L-phenylalanine degradation III
-
-
L-tryptophan degradation V (side chain pathway)
-
-
L-tyrosine degradation III
-
-
L-valine degradation II
-
-
leucine metabolism
-
-
Metabolic pathways
-
-
Metabolism of xenobiotics by cytochrome P450
-
-
methionine metabolism
-
-
Microbial metabolism in diverse environments
-
-
mixed acid fermentation
-
-
Naphthalene degradation
-
-
noradrenaline and adrenaline degradation
-
-
phenylalanine metabolism
-
-
phenylethanol biosynthesis
-
-
phytol degradation
-
-
propanol degradation
-
-
pyruvate fermentation to ethanol I
-
-
pyruvate fermentation to ethanol II
-
-
pyruvate fermentation to ethanol III
-
-
pyruvate fermentation to isobutanol (engineered)
-
-
Retinol metabolism
-
-
salidroside biosynthesis
-
-
serotonin degradation
-
-
superpathway of fermentation (Chlamydomonas reinhardtii)
-
-
tryptophan metabolism
-
-
tyrosine metabolism
-
-
Tyrosine metabolism
-
-
valine metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
alcohol:NAD+ oxidoreductase
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
CAS REGISTRY NUMBER
COMMENTARY hide
9031-72-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain SKU1108, 2 soluble isozymes
-
-
Manually annotated by BRENDA team
strain SKU1108, 2 soluble isozymes
-
-
Manually annotated by BRENDA team
Aeropyrum pernix DSM 11879
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
KU 1309
-
-
Manually annotated by BRENDA team
KU 1309
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Candida maris IFO10003
-
-
-
Manually annotated by BRENDA team
fragment; CCTCC M203011
UniProt
Manually annotated by BRENDA team
Candida parapsilosis CCTCC M203011
fragment; CCTCC M203011
UniProt
Manually annotated by BRENDA team
Candida sp.
N-16
-
-
Manually annotated by BRENDA team
Candida sp. N-16
N-16
-
-
Manually annotated by BRENDA team
gene chy1186
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
japonica. ADH-1, ADH-2, ADH-3 and ADH-An
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
var. Cantalupensis
-
-
Manually annotated by BRENDA team
KNK10702
-
-
Manually annotated by BRENDA team
KNK10702
-
-
Manually annotated by BRENDA team
strain HM1
-
-
Manually annotated by BRENDA team
strain HM1:1MSS, alcohol dehydrogenase 2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain Z
Uniprot
Manually annotated by BRENDA team
strain Z
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain KUC-1
SwissProt
Manually annotated by BRENDA team
strain KUC-1
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain LLD-R
Uniprot
Manually annotated by BRENDA team
strain M10EXG
UniProt
Manually annotated by BRENDA team
strain M10EXG
UniProt
Manually annotated by BRENDA team
gene GmAdh2
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
3 isoenzymes
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Leifsonia sp.
strain S749
-
-
Manually annotated by BRENDA team
strain S749
-
-
Manually annotated by BRENDA team
cationic pyrazole-sensitive isoenzyme, anodic pyrazole-sensitive isoenzyme and cathionic pyrazole-in sensitive isoenzyme
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain B10-05
-
-
Manually annotated by BRENDA team
strain B10-05
-
-
Manually annotated by BRENDA team
strain YR-1
-
-
Manually annotated by BRENDA team
strain YR-1
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene adh3
-
-
Manually annotated by BRENDA team
Oenococcus oeni DSM20252
gene adh3
-
-
Manually annotated by BRENDA team
i.e. Pichia angusta, HpADH3 is not the major ADH in strain DL-1, gene ADH3
UniProt
Manually annotated by BRENDA team
i.e. Pichia angusta, HpADH3 is not the major ADH in strain DL-1, gene ADH3
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
PaADH
-
-
Manually annotated by BRENDA team
strain DSM 50106, stereoselective enzyme
-
-
Manually annotated by BRENDA team
probable alcohol dehydrogenase; strain S-5
UniProt
Manually annotated by BRENDA team
probable alcohol dehydrogenase; strain S-5
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
DSM44514
-
-
Manually annotated by BRENDA team
strain DSM44541
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain Y379-50
UniProt
Manually annotated by BRENDA team
strain Y379-50
UniProt
Manually annotated by BRENDA team
pyrazole-insensitive isoenzyme and pyrazole-sensitive isoenzyme
-
-
Manually annotated by BRENDA team
Sporotrichum pulverulentum
-
-
-
Manually annotated by BRENDA team
strain DSM1617
-
-
Manually annotated by BRENDA team
strain Gtheta
-
-
Manually annotated by BRENDA team
strain RC3
UniProt
Manually annotated by BRENDA team
strain RC3
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain JW200
UniProt
Manually annotated by BRENDA team
strain JW200
UniProt
Manually annotated by BRENDA team
ATCC 27502
-
-
Manually annotated by BRENDA team
strain DSM 1728
UniProt
Manually annotated by BRENDA team
strain ATN1
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
3 isoenzymes
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
metabolism
-
enzyme is involved in phytol degradation
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(-)-carvone + NADH + H+
? + NAD+
show the reaction diagram
1% activity compared to cyclohexanone
-
-
?
(1S,3S)-3-methylcyclohexanol + NAD+
(rac)-3-methylcyclohexanone + NADH + H+
show the reaction diagram
125% activity compared to cyclohexanol
163% activity compared to cyclohexanone
-
r
(6S)-5,6-dihydro-6-methyl-4H-thieno[2,3b]thiopyran-4-one-7,7-dioxide + NADH + H+
(4S,6S)-5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3b]thiopyran-7,7-dioxide + NAD+
show the reaction diagram
-
-
-
-
-
(E)-hex-2-en-1-ol + NAD+
(E)-hex-2-en-1-one + NADH
show the reaction diagram
(R)-1-indanol + NAD+
?
show the reaction diagram
62% of activity compared to (S)-1-indanol
-
-
?
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
(R)-2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
(R)-2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
(R)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
(R)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
(R)-2-phenylpropanol + NAD+
(R)-2-phenylpropanal + NADH + H+
show the reaction diagram
(R)-3-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
(R)-alpha-tetralol + NAD+
?
show the reaction diagram
58% of activity compared to (S)-1-indanol
-
-
?
(R,S)-2-methylbutan-1-ol + NAD+
(R,S)-2-methyl-butan-1-one + NADH + H+
show the reaction diagram
(S)-(+)-1-indanol + NAD+
indanone + NADH + H+
show the reaction diagram
-
-
-
-
?
(S)-1-indanol + NAD+
?
show the reaction diagram
-
-
-
?
(S)-1-phenyl-2-propanol + NAD+
phenylacetone + NADH + H+
show the reaction diagram
-
9% activity compared to cyclohexanone
-
r
(S)-2-butanol + NAD+
2-butanone + NADH
show the reaction diagram
-
-
-
-
r
(S)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
(S)-2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
331% of the activity with 2-propanol
-
-
r
(S)-2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
38% of the activity with 2-propanol
-
-
r
(S)-2-methylbutan-1-ol + NAD+
(S)-2-methyl-butanal + NADH + H+
show the reaction diagram
(S)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
(S)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
(S)-2-pentanol + NAD+
?
show the reaction diagram
11% of activity compared to (S)-1-indanol
-
-
?
(S)-2-phenylpropanol + NAD+
(S)-2-phenylpropanal + NADH + H+
show the reaction diagram
-
156% of the activity with 2-phenylethanol
-
-
?
(S)-4-phenylbutan-2-ol + NAD+
benzylacetone + NADH + H+
show the reaction diagram
-
3% activity compared to cyclohexanone
-
r
(S)-alpha-tetralol + NAD+
?
show the reaction diagram
12% of activity compared to (S)-1-indanol
-
-
?
(S)-heptan-2-ol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
-
-
-
r
(S)-pentan-2-ol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-
-
-
r
(S)-perillylalcohol + NAD+
(S)-perillaldehyde + NADH + H+
show the reaction diagram
52% activity compared to cyclohexanol
-
-
?
(Z)-hex-2-en-1-ol + NAD+
(Z)-hex-2-en-1-one + NADH
show the reaction diagram
-
9.7% of the activity with ethanol
-
-
?
1,1-dichloroacetone + NADH + H+
1,1-dichloropropan-2-ol + NADH
show the reaction diagram
Leifsonia sp.
-
1078% of the activity with phenyl trifluoromethyl ketone
-
-
?
1,2-butanediol + NAD+
?
show the reaction diagram
1,2-hexanediol + NAD+
?
show the reaction diagram
-
20% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,2-pentanediol + NAD+
?
show the reaction diagram
-
12% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,2-propanediol + NAD+
?
show the reaction diagram
1,2-propanediol + NAD+
hydroxyacetone + NADH
show the reaction diagram
-
-
-
-
?
1,2-propanediol + NAD+
hydroxyacetone + NADH + H+
show the reaction diagram
-
-
-
-
?
1,3-butanediol + NAD+
?
show the reaction diagram
-
39% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,3-propanediol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
1,3-propanediol + NAD+
?
show the reaction diagram
1,3-propanediol + NAD+
? + NADH
show the reaction diagram
-
7% of the activity with ethanol
-
-
?
1-(4'-chlorophenyl)ethanol + NAD+
1-(4'-chlorophenyl)ethanone + NADH + H+
show the reaction diagram
-
26% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-(4-fluorophenyl)ethanol + NAD+
1-(4-fluorophenyl)ethanone + NADH + H+
show the reaction diagram
-
45% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-(p-tolyl)-ethanol + NAD+
1-(4-methylphenyl)ethanone + NADH + H+
show the reaction diagram
19% activity compared to cyclohexanol
26% activity compared to cyclohexanone
-
?
1-butanal + NADH + H+
1-butanol + NAD+
show the reaction diagram
-
-
-
-
r
1-butanol + 2 NAD+ + H2O
butanoic acid + 2 NADH + 2 H+
show the reaction diagram
1-butanol + NAD+
butanal + NADH
show the reaction diagram
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
1-chloro-5-acetylfuro[2,3-c]pyridine + NADH + H+
1-chloro-5-(1-hydroxyethyl)furo[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
1-decalone + NADH + H+
decahydronaphthalen-1-ol + NAD+
show the reaction diagram
85% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
1-decanol + NAD+
decanal + NADH + H+
show the reaction diagram
1-dodecanol + NAD+
dodecanal + NADH
show the reaction diagram
1-heptanol + NAD+
1-heptanal + NADH + H+
show the reaction diagram
-
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
1-heptanol + NAD+
heptanol + NADH + H+
show the reaction diagram
Leifsonia sp.
-
56% of the activity with 2-propanol, in the reverse reaction 755% of the activity with phenyl trifluoromethyl ketone
-
-
r
1-hexanal + NADH + H+
1-hexanol + NAD+
show the reaction diagram
-
-
-
-
r
1-hexanol + 2 NAD+ + H2O
hexanoic acid + 2 NADH + 2 H+
show the reaction diagram
1-hexanol + NAD+
1-hexanal + NADH + H+
show the reaction diagram
1-hexanol + NAD+
?
show the reaction diagram
-
15% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
1-hydroxy-2-butanone + NADH + H+
butane-1,2-diol + NAD+
show the reaction diagram
-
59% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
1-hydroxymethyl-6-methylpyrene + NAD+
1-formyl-6-methylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
1-hydroxymethyl-8-methylpyrene + NAD+
1-formyl-8-methylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
1-hydroxymethylpyrene + NAD+
1-formylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
1-nonanol + NAD+
nonanal + NADH + H+
show the reaction diagram
1-octanol + 2 NAD+ + H2O
octanoic acid + 2 NADH + 2 H+
show the reaction diagram
1-octanol + 2 NADP+ + H2O
octanoic acid + 2 NADPH + 2 H+
show the reaction diagram
-
-
-
r
1-octanol + NAD+
1-octanal + NADH + H+
show the reaction diagram
-
6% of activity with N-benzyl-3-pyrrolidinol
-
-
?
1-octanol + NAD+
octanal + NADH
show the reaction diagram
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
1-pentanol + NAD+
1-pentanal + NADH + H+
show the reaction diagram
1-pentanol + NAD+
pentanal + NADH + H*
show the reaction diagram
-
8% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
1-phenyl-1,2-ethanediol + NAD+
1-phenyl-2-propanone + NADH + H+
show the reaction diagram
1% activity compared to cyclohexanol
-
-
r
1-phenyl-1,2-propanedione + NADH
?
show the reaction diagram
about 25% of the activity compared to isatin
-
-
?
1-phenyl-1,2-propanedione + NADH + H+
?
show the reaction diagram
1-phenyl-1-propanol + NAD+
1-phenyl-1-propanone + NADH + H+
show the reaction diagram
-
59% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-phenyl-1-propanol + NAD+
?
show the reaction diagram
-
31% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-phenyl-2-butanone + NADH + H+
1-phenylbutan-2-ol + NAD+
show the reaction diagram
1-phenyl-2-propanol + NAD+
1-phenyl-2-propanone + NADH + H+
show the reaction diagram
1-phenyl-2-propanone + NADH + H+
(S)-1-phenyl-2-propanol + NAD+
show the reaction diagram
-
-
-
-
-
1-phenyl-3-butanone + NADH + H+
1-phenylbutan-3-ol + NAD+
show the reaction diagram
Leifsonia sp.
-
353% of the activity with phenyl trifluoromethyl ketone
-
-
?
1-phenylethanol + NAD+
1-phenylethanone + NADH
show the reaction diagram
1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
show the reaction diagram
3% activity compared to cyclohexanol
-
-
r
1-phenylethanol + NAD+
acetophenone + NADH + H+
show the reaction diagram
-
1% activity compared to cyclohexanone
-
?
1-propanol + NAD+
propanal + NADH
show the reaction diagram
-
-
-
-
?
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
1-propanol + NAD+
propanaldehyde + NADH + H+
show the reaction diagram
11-cis-retinal + NADH + H+
11-cis-retinol + NAD+
show the reaction diagram
-
-
-
-
?
11-cis-retinol + NAD+
11-cis-retinal + NADH
show the reaction diagram
12-hydroxydodecanoate + NAD+
12-oxododecanoic acid + NADH
show the reaction diagram
13-cis-retinal + NADH + H+
13-cis-retinol + NAD+
show the reaction diagram
-
-
-
-
?
13-cis-retinol + NAD+
13-cis-retinal + NADH
show the reaction diagram
16-hydroxyhexadecanoate + NAD+
16-oxohexadecanoic acid + NADH
show the reaction diagram
-
-
-
-
?
17beta-hydroxyetiocholan-3-one + NAD+
ethiocholan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
?
2',3',4',5',6'-pentafluoroacetophenone + NADH + H+
1-(2,3,4,5,6-pentafluorophenyl)ethanol + NAD+
show the reaction diagram
45% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2,2'-dichlorobenzil + NADH + H+
1,2-bis(2-chlorophenyl)-2-hydroxyethanone + NAD+
show the reaction diagram
-
-
-
?
2,2,2-trichloroethanol + NAD+
trichloroacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
2,2,2-trifluoroacetophenone + NADH
2,2,2-trifluoro-1-phenylethanol + NAD+
show the reaction diagram
about 35% of the activity compared to isatin
-
-
?
2,2,2-trifluoroacetophenone + NADH + H+
(R)-alpha-(trifluoromethyl)benzyl alcohol + NAD+
show the reaction diagram
-
93% enantiomeric excess
-
-
?
2,2,2-trifluoroacetophenone + NADH + H+
2,2,2-trifluoro-1-phenylethanol + NAD+
show the reaction diagram
35% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2,2-dichloroacetophenone + NADH + H+
2,2-dichloro-1-phenylethanol + NAD+
show the reaction diagram
2,3'-dichloroacetophenone + NADH + H+
1-(2,3-dichlorophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
67% of the activity with phenyl trifluoromethyl ketone
-
-
?
2,3'-dichloroacetophenone + NADH + H+
2-chloro-1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
2,3-butanediol + H2O
?
show the reaction diagram
-
-
-
?
2,3-butanediol + NAD+
?
show the reaction diagram
-
83% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
2,3-butanediol + NAD+
acetoin + NADH + H+
show the reaction diagram
-
-
-
?
2,3-butanedione + NADH + H+
?
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
2,3-pentanedione + NADH
? + NADH
show the reaction diagram
-
5.5% of the activity with acetaldehyde
-
-
?
2,4-pentanediol + NAD+
?
show the reaction diagram
2-(3,5-dimethylphenyl)propanal + NADH + H+
(S)-2-(3,5-dimethylphenyl)propanol + NAD+
show the reaction diagram
2-(3-benzoylphenyl)propanal + NADH + H+
(S)-2-(3-benzoylphenyl)propanol + NAD+
show the reaction diagram
2-(3-fluorobiphenyl-4-yl)propanal + NADH + H+
(S)-2-(3-(fluoro)biphenyl-4-yl)propanol + NAD+
show the reaction diagram
2-(3-phenoxyphenyl)propanal + NADH + H+
(S)-2-((3-phenoxy)phenyl)propanol + NAD+
show the reaction diagram
2-(4-isobutylphenyl)propanal + NADH + H+
(S)-2-(4-isobutylphenyl)propanol + NAD+
show the reaction diagram
2-(4-trifluoromethylphenyl)propanal + NADH + H+
(S)-2-(4-trifluoromethyl)phenylpropanol + NAD+
show the reaction diagram
-
18 h, 55% yield, 98% enantiomeric excess
-
-
?
2-(6-methoxynaphthalen-2-yl)propanal + NADH + H+
(S)-2-(6-methoxynaphthalen-2-yl)propan-1-ol + NAD+
show the reaction diagram
-
18 h, 96% yield, 98% enantiomeric excess
-
-
?
2-(naphthalen-1-yl)propanal + NADH + H+
(S)-2-(naphthalen-1-yl)propanol + NAD+
show the reaction diagram
-
18 h, 90% yield, 80% enantiomeric excess
-
-
?
2-(naphthalen-2-yl)propanal + NADH + H+
(S)-2-(naphthalen-2-yl)propanol + NAD+
show the reaction diagram
-
18 h, 57% yield, 94% enantiomeric excess
-
-
?
2-acetylcyclohexanone + NADH + H+
2-acetylcyclohexanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylcyclopentanone + NADH + H+
2-acetylcyclopentanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylfuran + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylpyridine + NADH + H+
(R)-1-(2-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylpyrrole + NADH + H+
1-(1H-pyrrol-2-yl)ethanol + NAD+
show the reaction diagram
-
70% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-acetylpyrrole + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylthiazole + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylthiophene + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-aminoethanol + NAD+
?
show the reaction diagram
-
-
-
?
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
2-butanone + NADH + H+
2-butanol + NAD+
show the reaction diagram
2-butanone + NADH + H+
butan-2-ol + NAD+
show the reaction diagram
-
2.8fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
2-butanone + NADPH + H+
butan-2-ol + NADP+
show the reaction diagram
2-butene-1-ol + NAD+
? + NADH
show the reaction diagram
2-chloroacetophenone + NADH + H+
1-(2-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
low activity
-
-
r
2-chlorocyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
3% activity compared to cyclohexanone
-
-
?
2-decalone + NADH + H+
? + NAD+
show the reaction diagram
28% activity compared to cyclohexanone
-
-
?
2-decanol + NAD+
2-decanone + NADH + H+
show the reaction diagram
weak activity
-
-
r
2-decanone + NADH
(S)-2-decanol + NAD+ + H+
show the reaction diagram
-
-
92% enantiomeric excess
-
?
2-deoxy-D-ribose + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-ethoxyethanol + NAD+
2-ethoxyacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
2-ethylhexan-1-ol + NAD+
2-ethylhexanal + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
weak activity
-
-
?
2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
2-heptanone + NADH
(S)-2-heptanol + NAD+ + H+
show the reaction diagram
-
-
79% enantiomeric excess
-
?
2-heptanone + NADH + H+
(R)-2-heptanol + NAD+
show the reaction diagram
Leifsonia sp.
-
229% of the activity with phenyl trifluoromethyl ketone
99% enantiomeric excess
-
?
2-heptanone + NADPH + H+
heptan-2-ol + NADP+
show the reaction diagram
2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
2-hexanone + NADH
(S)-2-hexanol + NAD+ + H+
show the reaction diagram
-
-
37% enantiomeric excess
-
?
2-hexanone + NADH + H+
2-hexanol + NAD+
show the reaction diagram
-
-
-
-
r
2-hexanone + NADH + H+
?
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
2-hexanone + NADH + H+
hexan-2-ol + NAD+
show the reaction diagram
-
50.4fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
2-hexanone + NADPH + H+
hexan-2-ol + NADP+
show the reaction diagram
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
show the reaction diagram
2-hydroxyacetophenone + NADPH + H+
(S)-1-phenyl-1,2-ethanediol + NADP+
show the reaction diagram
-
-
-
?
2-hydroxymethylpyrene + NAD+
2-formylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
2-mercaptoethanol + NAD+
?
show the reaction diagram
2-methoxybenzaldehyde + NADH + H+
2-methoxybenzylalcohol + NAD+
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
2-methoxybenzyl alcohol + NAD+
2-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
25% of the activity with (S)-(-)-1-phenylethanol
-
-
?
2-methoxyethanol + NAD+
2-methoxyacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
r
2-methyl-2,4-pentanediol + NAD+
?
show the reaction diagram
1% activity compared to cyclohexanol
-
-
?
2-methylbutan-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-methylbutyraldehyde + NADH + H+
2-methylbutanol + NAD+
show the reaction diagram
-
1.4% of the activity with acetaldehyde
-
-
?
2-methylcyclohexanone + NADH + H+
2-methylcyclohexanol + NAD+
show the reaction diagram
13% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
46% activity compared to cyclohexanone
-
-
?
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH
show the reaction diagram
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH + H+
show the reaction diagram
2-methylpropionaldehyde + NADH + H+
2-methylpropanal + NAD+
show the reaction diagram
-
3.3% of the activity with acetaldehyde
-
-
?
2-nitrobenzaldehyde + NADH + H+
(2-nitrophenyl)methanol + NAD+
show the reaction diagram
-
33% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-nitrobenzaldehyde + NADH + H+
2-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
low activity
-
-
r
2-nonanol + NAD+
2-nonanone + NADH + H+
show the reaction diagram
weak activity
-
-
r
2-nonanone + NADH
(S)-2-nonanol + NAD+ + H+
show the reaction diagram
-
-
95% enantiomeric excess
-
?
2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
2-octanone + NADH
(S)-2-octanol + NAD+ + H+
show the reaction diagram
-
-
92% enantiomeric excess
-
?
2-octanone + NADH + H+
2-octanol + NAD+
show the reaction diagram
-
-
-
-
r
2-octanone + NADPH + H+
octan-2-ol + NADP+
show the reaction diagram
11.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-oxo-3-methylpentane + NADH
3-methylpentan-2-ol + NAD+
show the reaction diagram
2-oxo-3-phenylpropane + NADH
2-hydroxy-3-phenylpropane + NAD+
show the reaction diagram
2-oxo-4-methylpentane + NADH
4-methylpentan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-butyric acid + NADH + H+
2-hydroxybutyric acid + NAD+
show the reaction diagram
-
15% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-oxohexane + NADH
2-hydroxyhexane + NAD+
show the reaction diagram
-
-
-
-
?
2-oxopentane + NADH
2-pentanol + NAD+
show the reaction diagram
-
-
-
-
?
2-oxopentanoate + NADH + H+
2-hydroxypentanoate + NAD+
show the reaction diagram
-
low activity
-
-
r
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
2-pentanone + NADH
(S)-2-pentanol + NAD+ + H+
show the reaction diagram
-
-
60% enantiomeric excess
-
?
2-pentanone + NADH
pentan-2-ol + NAD+
show the reaction diagram
-
-
-
r
2-pentanone + NADH + H+
2-pentanol + NAD+
show the reaction diagram
2-pentanone + NADPH + H+
pentan-2-ol + NADP+
show the reaction diagram
11.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-phenylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
2-phenylethanol + NAD+
2-phenylethanone + NADH + H+
show the reaction diagram
57% activity compared to cyclohexanol
-
-
r
2-phenylethanol + NAD+
phenylacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
2-phenylpropanal + NADH + H+
(S)-2-phenylpropanol + NAD+
show the reaction diagram
-
18 h, 74% yield, 98% enantiomeric excess
-
-
?
2-propanol + NAD(P)+
acetone + NAD(P)H
show the reaction diagram
2-propanol + NAD+
2-propanone + NADH
show the reaction diagram
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
2-propanol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
2-propanol + NAD+
propanone + NADH + H+
show the reaction diagram
-
-
-
-
r
2-[3-(2-phenyl-1,3-dioxolan-2-yl)phenyl]propanal + NADH + H+
(S)-2-(3-(2-phenyl-1,3-dioxolan-2-yl)phenyl)propanol + NAD+
show the reaction diagram
-
18 h, 95% yield, 61% enantiomeric excess
-
-
?
3',4'-dimethoxyphenylacetone + NADH + H+
1-(3,4-dimethoxyphenyl)propan-2-ol + NAD+
show the reaction diagram
Leifsonia sp.
-
24% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-bromoacetophenone + NADH + H+
1-(3-bromophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
151% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-chloroacetophenone + NADH + H+
1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
70% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-methoxyacetophenone + NADH + H+
1-(3-methoxyphenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
51% of the activity with phenyl trifluoromethyl ketone
-
-
?
3,3,5-trimethylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
3,4-dihydro-retinol + NAD+
3,4-dihydro-retinal
show the reaction diagram
-
-
-
-
r
3,4-dimethylbenzyl alcohol + NAD+
3,4-dimethylbenzaldehyde + NADH + H+
show the reaction diagram
45% activity compared to cyclohexanol
-
-
r
3,4-hexanedione + NADH + H+
?
show the reaction diagram
-
77% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
3,4-methylenedioxyphenyl acetone + NADH
(S)-(3,4-methylenedioxyphenyl)-2-propanol + NAD+ + H+
show the reaction diagram
-
-
-
-
-
3,5-dimethylcyclohexanol + NAD+
3,5-dimethylcyclohexanone + NADH + H+
show the reaction diagram
1% activity compared to cyclohexanol
-
-
r
3-acetylpyridine + NADH + H+
(R)-1-(3-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
3-acetylpyridine + NADH + H+
1-pyridin-3-ylethanol + NAD+
show the reaction diagram
-
7.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
3-aminobenzyl alcohol + NAD+
3-aminobenzaldehyde + NADH + H+
show the reaction diagram
8% activity compared to cyclohexanol
-
-
r
3-bromobenzyl alcohol + NAD+
3-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-bromobenzylalcohol + NAD+
3-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-butene-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-chloro-2-butanone + NADH + H+
3-chlorobutan-2-ol + NAD+
show the reaction diagram
Leifsonia sp.
-
151% of the activity with phenyl trifluoromethyl ketone
-
-
?
3-chlorobenzaldehyde + NADH + H+
3-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
3-heptanol + NAD+
3-heptanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
93% of the activity with 2-propanol
-
-
r
3-methoxy-1-phenylpropan-1-one + NADH
3-methoxy-1-phenylpropan-1-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methoxybenzaldehyde + NADH + H+
3-methoxybenzylalcohol + NAD+
show the reaction diagram
-
14% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
show the reaction diagram
3-methoxybenzylalcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-methyl-1-butanol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-methyl-2-cyclohexenone + NADH + H+
? + NAD+
show the reaction diagram
1% activity compared to cyclohexanone
-
-
?
3-methylbutan-1-ol + NAD+
3-methyl-butan-1-one + NADH + H+
show the reaction diagram
3-methylbutan-2-ol + NAD+
3-methylbutan-2-one + NADH
show the reaction diagram
-
R-(-)-3-methylbutan-2-ol and S-(+)-3-methylbutan-2-ol
-
-
?
3-methylbutan-2-one + NADH
3-methylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methylbutan-2-one + NADH + H+
3-methyl-2-butanol + NAD+
show the reaction diagram
-
-
-
-
r
3-methylbutan-2-one + NADH + H+
3-methylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methylbutanal + NAD+
? + NADH + H+
show the reaction diagram
3-methylbutanol + NAD+
3-methylbutanone + NADH + H+
show the reaction diagram
133% activity compared to cyclohexanol
-
-
r
3-methylbutanol + NAD+
? + NADH
show the reaction diagram
3-methylbutyraldehyde + NADH + H+
3-methylbutanol + NAD+
show the reaction diagram
-
2.9% of the activity with acetaldehyde
-
-
?
3-methylcyclohexanol + NAD+
3-methylcyclohexanone + NADH
show the reaction diagram
-
-
-
-
r
3-methylcyclohexanol + NAD+
3-methylcyclohexanone + NADH + H+
show the reaction diagram
14% of activity compared to (S)-1-indanol
-
-
?
3-methylcyclohexanol + NAD+
?
show the reaction diagram
10% of the activity compared to isoborneol
-
-
?
3-methylcyclohexanone + NADH
3-methylcyclohexanol + NAD+
show the reaction diagram
3-methylcyclohexanone + NADH + H+
3-methylcyclohexanol + NAD+
show the reaction diagram
33% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
3-methylphenylethyl alcohol + NAD+
?
show the reaction diagram
64% activity compared to cyclohexanol
-
-
?
3-nitroacetophenone + NADH + H+
1-(3-nitrophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
3-nitrobenzaldehyde + NADH + H+
3-nitrobenzyl alcohol + NAD+
show the reaction diagram
3-oxo-5beta-androstan-17beta-ol + NADH
3beta,17beta-dihydroxy-5beta-androstane + NAD+
show the reaction diagram
3-oxoheptane + NADH
3-hydroxyheptane + NAD+
show the reaction diagram
-
-
-
-
?
3-pentanol + NAD+
3-pentanone + NADH + H+
show the reaction diagram
3-pentanone + NADH
pentan-3-ol + NAD+
show the reaction diagram
-
-
-
r
3-pentanone + NADPH + H+
pentan-3-ol + NADP+
show the reaction diagram
7.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
3-penten-2-one + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
3-phenyl-1-propanol + NAD+
3-phenyl-1-propanone + NADH
show the reaction diagram
3-phenyl-2-propen-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-phenylpropanol + NAD+
3-phenylpropanal + NADH + H+
show the reaction diagram
-
135% of the activity with 2-phenylethanol
-
-
?
3-phenylpropionaldehyde + NADH
3-phenylpropan-1-ol + NAD+
show the reaction diagram
Leifsonia sp.
-
1218% of the activity with phenyl trifluoromethyl ketone
-
-
?
3-phenylpropionaldehyde + NADH + H+
3-phenylpropanol + NAD+
show the reaction diagram
-
6.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
3-pyridylcarbinol + NAD+
pyridine-3-carbaldehyde + NADH
show the reaction diagram
-
-
-
-
?
3beta,12alpha-dihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta,17beta-dihydroxy-5beta-androstane + NAD+
5beta-androstan-3,17dione + NADH
show the reaction diagram
-
-
-
-
?
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta,7alpha-dihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta-hxdroxy-5alpha-cholanoate + NAD+
3-oxo-5alpha-cholanoate + NADH
show the reaction diagram
-
-
-
-
?
3beta-hydroxy-5beta-androstan-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
3beta-hydroxy-5beta-cholanoate + NAD+
3-oxo-5beta-cholanoate + NADH
show the reaction diagram
-
-
-
-
?
4'-bromoacetophenone + NADH + H+
1-(4-bromophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
77% of the activity with phenyl trifluoromethyl ketone
-
-
?
4'-chloroacetophenone + NADH + H+
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
60% of the activity with phenyl trifluoromethyl ketone
-
-
?
4'-chlorobutyrophenone + NADH + H+
1-(4-chlorophenyl)butan-1-ol + NAD+
show the reaction diagram
-
10% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
4-acetylpyridine + NADH + H+
(R)-1-(4-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-acetylpyridine + NADH + H+
1-pyridin-4-ylethanol + NAD+
show the reaction diagram
-
64.5fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
4-bromobenzyl alcohol + NAD+
4-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
4-bromobenzylalcohol + NAD+
4-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADH + H+
4-carboxybenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADH + H+
4-carboxybenzylalcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-chloroacetophenone + NADH
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
4-chloroacetophenone + NADH + H+
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-chlorobenzaldehyde + NADH + H+
4-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
4-ethylcyclohexanol + NAD+
4-ethylcyclohexanone + NADH + H+
show the reaction diagram
60% activity compared to cyclohexanol
-
-
r
4-ethylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
22% activity compared to cyclohexanone
-
-
?
4-fluoroacetophenone + NADH + H+
1-(4-fluorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-hydroxy-2-butanone + NADH + H+
2,4-dihydroxybutane + NAD+
show the reaction diagram
Leifsonia sp.
-
26% of the activity with phenyl trifluoromethyl ketone
-
-
?
4-hydroxy-retinol + NAD+
4-oxo-retinal + NADH
show the reaction diagram
-
-
-
-
r
4-hydroxymethylpyrene + NAD+
4-formylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
4-hydroxynonenal + NADH + H+
4-hydroxynonenol + NAD+
show the reaction diagram
-
substrate of isozyme ADH4
-
-
r
4-methoxy-1-naphthaldehyde + NAD+
4-methoxy-1-naphthol + NADH + H+
show the reaction diagram
-
fluorogenic substrate of class I and II isozymes
-
-
?
4-methoxy-1-naphthaldehyde + NAD+
4-methoxy-1-naphthyl alcohol + NADH + H+
show the reaction diagram
-
substrate for class I ADH
-
-
?
4-methoxy-1-naphthaldehyde + NADH + H+
4-methoxynaphthalene-1-carbaldehyde + NAD+
show the reaction diagram
-
substrate for class I ADH
-
-
r
4-methoxybenzaldehyde + NADH + H+
4-methoxybenzylalcohol + NAD+
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
4-methoxybenzyl alcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
show the reaction diagram
4-methoxybenzylalcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
4-methoxyphenylacetone + NADH
(2S)-1-(4-methoxyphenyl)propan-2-ol + NAD+ + H+
show the reaction diagram
-
-
-
-
?
4-methyl-1-pentanol + NAD+
4-methyl-1-pentanal + NADH
show the reaction diagram
4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH + H+
show the reaction diagram
56% activity compared to cyclohexanol
-
-
r
4-methylcyclohexanone + NADH + H+
4-methylcyclohexanol + NAD+
show the reaction diagram
60% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
4-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
25% activity compared to cyclohexanone
-
-
?
4-methylpentan-2-one + NADH + H+
4-methyl-2-pentanol + NAD+
show the reaction diagram
-
-
-
-
r
4-nitrobenzaldehyde + NADH + H+
4-nitrobenzyl alcohol + NAD+
show the reaction diagram
4-nitrobenzaldehyde + NADH + H+
4-nitrobenzylalcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-nitrobenzyl alcohol + NAD+
4-nitrobenzaldehyde + NADH + H+
show the reaction diagram
94% activity compared to benzyl alcohol
-
-
?
4-nitrosodimethylaniline + NAD+
? + NADH + H+
show the reaction diagram
-
photometric assay substrate
-
-
?
4-phenylbutan-2-one + NADH
4-phenylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
5-acetyl-7-chlorofuro[2,3-c]pyridine + NADH + H+
5-(1-hydroxyethyl)-7-chlorofuro[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
5-acetylfuro[2,3-c]pyridine + NADH + H+
5-(1-hydroxyethyl)furo[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
5-hydroxymethylfurfural + NADH + H+
?
show the reaction diagram
mutant enzyme S109P/L116S/Y294C
-
-
?
5alpha-androstan-17beta-ol-3-one + NADH + H+
3beta,17beta-dihydroxy-5alpha-androstan + NAD+
show the reaction diagram
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH
show the reaction diagram
-
low activity
-
-
?
5beta-androstan-17beta-ol-3-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
5beta-androstan-3beta-ol-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
5beta-cholanic acid-3-one + NAD+
5beta-cholanic acid-3-ol + NAD+
show the reaction diagram
-
-
-
-
?
5beta-cholanic acid-3-one + NADH
5beta-cholanic acid-3-ol + NAD+
show the reaction diagram
-
low activity
-
-
?
5beta-pregnan-21-ol-3,20-dione hemisuccinate + NADH
5beta-pregnan-3,20,21-trione hemisuccinate + NADH
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3,20-dione + NADH
?
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3beta-ol-20-one + NAD+
5beta-pregnan-3,20-dione + NADH
show the reaction diagram
-
-
-
-
?
6-benzyloxy-3,5-dioxo-hexanoic acid ethyl ester + NADH + H+
(3R,5S)-6-benzyloxy-3,5-dihydroxy-hexanoic acid ethyl ester + NAD+
show the reaction diagram
-
-
-
-
-
6-methoxy-2-naphthaldehyde + NAD+
6-methoxy-2-naphthyl alcohol + NADH + H+
show the reaction diagram
-
substrate for class II ADH
-
-
?
6-methoxy-2-naphthaldehyde + NADH + H+
(6-methoxynaphthalen-2-yl)methanol + NAD+
show the reaction diagram
-
substrate for class II ADH
-
-
r
6-methoxy-2-naphthaldehyde + NADH + H+
6-methoxy-2-naphtol + NAD+
show the reaction diagram
-
class II isozyme, reductive activity
-
-
?
7-cis-retinol + NAD+
7-cis-retinal + NADH
show the reaction diagram
9-cis-retinol + NAD+
9-cis-retinal + NADH
show the reaction diagram
a primary alcohol + NAD+
an aldehyde + NADH + H+
show the reaction diagram
-
ADH3 is involved in multiple cellular pathways, as diverse as formaldehyde detoxification, retinoid metabolism and NO homeostasis, ADH3 is considered to play only a minor role in hepatic alcohol metabolism because ethanol concentrations rarely exceed 50 mM
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
acetaldehyde + NADH + H+
ethanol + NAD+ + H+
show the reaction diagram
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
-
16% of the activity with NADH
-
-
r
acetoin + NADH + H+
3-hydroxy-2-butanol + NAD+
show the reaction diagram
-
-
-
-
r
acetone + NAD+ + H2O
? + NADH + H+
show the reaction diagram
about 5% of the activity with 1-octanol
-
-
r
acetone + NADH
isopropanol + NAD+
show the reaction diagram
acetone + NADH + H+
2-propanol + NAD+
show the reaction diagram
-
-
-
-
?
acetone + NADH + H+
propan-2-ol + NAD+
show the reaction diagram
-
1.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
acetone + NADPH + H+
propan-2-ol + NADP+
show the reaction diagram
14.7% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
acetophenone + NADH
(R)-alpha-phenyl ethanol + NAD+
show the reaction diagram
-
the enzyme exhibits high stereoselectivity in the desymmetrization of the prochiral ketone acetophenone, producing optically pure (R)-alpha-phenyl ethanol at high conversion
-
-
?
acetophenone + NADH + H+
(R)-1-phenylethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
6% of the activity with phenyl trifluoromethyl ketone, in the reverse reaction 87% of the activity with 2-propanol
99% enantiomeric excess
-
?
acetophenone + NADH + H+
(S)-(-)-1-phenylethanol + NAD+
show the reaction diagram
-
more than 99% enantiomeric excess
-
-
r
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
acetophenone + NADPH + H+
1-phenylethanol + NADP+
show the reaction diagram
acetylacetone + 2 NADH + 2 H+
2,4-pentanediol + 2 NAD+
show the reaction diagram
-
-
-
-
r
acetylacetone + NADH + H+
?
show the reaction diagram
-
63% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
acetylacetone + NADH + H+
acetophenone + NADH + H+
show the reaction diagram
1% activity compared to cyclohexanone
1% activity compared to cyclohexanone
-
r
acetylpyrazine + NADH + H+
(R)-1-(pyrazyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
alcohol + NAD+
aldehyde or ketone + NADH
show the reaction diagram
all-trans-retinal + NADH + H+
all-trans-retinol + NAD+
show the reaction diagram
-
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
allyl alcohol + NAD+
acrolein + NADH
show the reaction diagram
allyl alcohol + NAD+
prop-2-en-1-al + NADH
show the reaction diagram
allylalcohol + NAD+
prop-2-enal + NADH + H+
show the reaction diagram
-
-
-
?
alpha-tetralone + NADH + H+
(S)-alpha-tetralol + NAD+
show the reaction diagram
-
more than 99% enantiomeric excess
-
-
?
anisaldehyde + NADH
anisic alcohol + NADH
show the reaction diagram
-
-
-
-
?
anisaldehyde + NADH + H+
anisic alcohol + NAD+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADH
benzyl alcohol + NAD+
show the reaction diagram
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
benzil + NADH + H+
(R)-benzoin + NAD+
show the reaction diagram
62% of the activity compared to 1-phenyl-1,2-propanedione. The enzyme catalyses the asymmetric reduction of benzil to (R)-benzoin with both excellent conversion (98%) and optical purity (98%) by way of an efficient in situ NADH-recycling system involving a second thermophilic ADH
-
-
?
benzoin + NADH + H+
1,2-diphenylethane-1,2-diol
show the reaction diagram
-
13% of activity with N-benzyl-3-pyrrolidinone
-
-
?
benzoylformic acid + NADPH + H+
mandelate + NADP+
show the reaction diagram
2.4% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
benzyl aclohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
benzylacetone + NADH + H+
4-phenylbutan-2-ol + NAD+
show the reaction diagram
benzylalcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
benzyloxycarbonyl-3-pyrrolidinone + NADH + H+
(S)-benzyloxycarbonyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
production with 99.6% enantiomeric excess
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
butan-2-one + NADH
butan-2-ol + NAD+
show the reaction diagram
butanal + NADH
1-butanol + NAD+ + H+
show the reaction diagram
Leifsonia sp.
-
% of the activity with phenyl trifluoromethyl ketone
-
-
ir
butanol + NAD+
1-butanal + NADH + H+
show the reaction diagram
butanol + NAD+
butanal + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
butanol + NAD+
butyraldehyde + NADH + H+
show the reaction diagram
butanol + NAD+
n-butanal + NADH
show the reaction diagram
-
-
-
?
butyraldehyde + NADH
n-butanol + NAD+
show the reaction diagram
butyraldehyde + NADH + H+
butanol + NAD+
show the reaction diagram
-
56% of the activity with acetaldehyde
-
-
?
butyraldehyde + NADH + H+
n-butanol + NAD+
show the reaction diagram
butyraldehyde + NADPH + H+
butanol + NADP+
show the reaction diagram
-
22% of the activity with NADH
-
-
?
capronaldehyde + NADH
1-hexanol + NAD+
show the reaction diagram
chloroacetone + NADH + H+
1-chloro-2-propanol + NAD+
show the reaction diagram
-
-
-
-
r
chloroacetone + NADH + H+
1-chloropropan-2-ol + NAD+
show the reaction diagram
choline + NAD+
? + NADH + H+
show the reaction diagram
3% activity compared to benzyl alcohol
-
-
?
cinnamyl alcohol + NAD+
cinnamaldehyde + NADH
show the reaction diagram
cis-4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cis-decahydro-1-naphthol + NAD+
?
show the reaction diagram
11% of activity compared to (S)-1-indanol
-
-
?
crotyl alcohol + NAD+
crotonaldehyde + NADH
show the reaction diagram
cycloheptanol + NAD+
cycloheptanone + NADH + H+
show the reaction diagram
cycloheptanone + NADH
cycloheptanol + NAD+
show the reaction diagram
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
cyclohexanol + NAD+
cyclohexanone + NADH + H+
show the reaction diagram
cyclohexanone + NADH
cyclohexanol + NAD+
show the reaction diagram
cyclohexanone + NADH + H+
?
show the reaction diagram
-
activity is 2.1fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
cyclohexanone + NADH + H+
cyclohexanol + NAD+
show the reaction diagram
cyclooctanone + NADH
cyclooctanol + NAD+
show the reaction diagram
-
-
-
-
?
cyclopentanol + NAD+
? + NADH
show the reaction diagram
cyclopentanol + NAD+
cyclopentanone + NADH + H+
show the reaction diagram
55% of the activity compared to isoborneol
-
-
?
cyclopentanone + NADH
cyclopentanol + NAD+
show the reaction diagram
-
-
-
-
?
cyclopentanone + NADH + H+
? + NAD+
show the reaction diagram
1% activity compared to cyclohexanone
-
-
?
cyclopetanone + NADH
cyclopentanol + NADH
show the reaction diagram
-
-
-
-
?
D-glucitol + NAD+
? + NADH
show the reaction diagram
decahydro-2-naphthol + NAD+
?
show the reaction diagram
37% activity compared to cyclohexanol
-
-
?
decyl aldehyde + NADH + H+
1-decanol + NAD+
show the reaction diagram
21% activity compared to benzyl alcohol
-
-
?
diacetyl + NADH + H+
2,3-butandiol + NAD+
show the reaction diagram
-
-
-
-
r
diacetyl + NADH + H+
?
show the reaction diagram
diethylketone + NADH + H+
3-pentanol + NAD+
show the reaction diagram
-
-
-
-
r
digitose + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
dihydro-4,4-dimethyl-2,3-furandione + NADH + H+
?
show the reaction diagram
-
13.1fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
docosanol + NAD+
? + NADH + H+
show the reaction diagram
-
immobilized HLAD shows about 60% reaction rate and free HLAD shows about 20% reaction rate with docosanol compared to ethanol at pH 8.8 and 30C
-
-
?
dodecanol + NAD+
dodecanal + NADH + H+
show the reaction diagram
-
immobilized HLAD shows about 60% reaction rate and free HLAD shows about 35% reaction rate with dodecanol compared to ethanol at pH 8.8 and 30C
-
-
?
ethanol + 2 NAD+ + H2O
acetic acid + 2 NADH + 2 H+
show the reaction diagram
ethanol + 2 NADP+ + H2O
acetic acid + 2 NADPH + 2 H+
show the reaction diagram
-
-
-
r
ethanol + 3-benzoylpyridine-adenine dinucleotide
acetaldehyde + ?
show the reaction diagram
-
rapid equilibrium bi bi mechanism
-
-
-
ethanol + beta-NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
ethanol + NAD+
aldehyde + NADH + H+
show the reaction diagram
-
immobilized HLAD shows 100% reaction rate and free HLAD shows about 55% reaction rate with ethanol at pH 8.8 and 30C
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
show the reaction diagram
8.5% of the activity with ethanol and NAD+
-
-
?
ethyl 3-methyl-2-oxobutyrate + NADH + H+
?
show the reaction diagram
1-phenyl-1,2-propanedione and ethyl 3-methyl-2-oxobutyrate are the best substrate in the reduction reaction
-
-
?
ethyl 3-methyl-2-oxobutyrate + NADH + H+
ethyl-2-hydroxy-3-methylbutyrate + NAD+
show the reaction diagram
Leifsonia sp.
-
33% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl 3-oxobutanoate + NADH
ethyl 3-hydroxybutanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethyl 3-oxobutanoate + NADH + H+
ethyl 3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
309% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl 3-oxobutyrate + NADH + H+
ethyl (S)-3-hydroxybutyrate + NAD+
show the reaction diagram
-
-
-
-
-
ethyl 3-oxohexanoate + NADH
ethyl 3-hydroxyhexanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethyl 3-oxopentanoate + NADH
ethyl 3-hydroxypentanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethyl 3-phenyl-3-oxopropanoate + NADH
ethyl 3-phenyl-3-hydroxypropanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethyl 4-bromo-3-oxobutanoate + NADH + H+
ethyl 4-bromo-3-hydroxybutanoate
show the reaction diagram
Leifsonia sp.
-
511% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl 4-chloro-3-oxobutanoate + NADH + H+
ethyl 4-chloro-3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
809% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl 4-chloroacetoacetate + NADH + H+
?
show the reaction diagram
-
6.8fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
ethyl 4-chloroacetoacetate + NADH + H+
ethyl 4-chloro-3-hydroxybutanoate + NAD+
show the reaction diagram
-
-
-
-
r
ethyl 4-chloroacetoacetate + NADPH
?
show the reaction diagram
activity is 1.48fold higher than with 2-hydroxyacetophenone and NADPH
-
-
?
ethyl acetoacetate + NADH + H+
?
show the reaction diagram
-
42.4fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
ethyl acetoacetate + NADH + H+
ethyl 3-hydroxybutanoate + NAD+
show the reaction diagram
-
-
-
-
r
ethyl benzoylformate + NADH
?
show the reaction diagram
about 30% of the activity compared to isatin
-
-
?
ethyl benzoylformate + NADH
ethyl (R)-mandelate + NAD+
show the reaction diagram
-
enantiomeric excess of 99.9%
-
-
?
ethyl benzoylformate + NADH + H+
?
show the reaction diagram
23% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
ethyl benzoylformate + NADH + H+
ethyl (R)-(-)-mandelate + NAD+
show the reaction diagram
-
95% enantiomeric excess
-
-
?
ethyl pyruvate + NADH
?
show the reaction diagram
ethyl pyruvate + NADH
ethyl 2-hydroxypropanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethyl pyruvate + NADH + H+
ethyl 2-hydroxypropanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
488% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl pyruvate + NADH + H+
ethyl 2-hydroxypropionate + NAD+
show the reaction diagram
16% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
ethyl pyruvate + NADH + H+
ethyl lactate + NAD+
show the reaction diagram
-
-
-
-
r
ethyl trifluoroacetoacetate + NADPH + H+
1-ethoxy-2,2,2-trifluoroethanol + NADP+
show the reaction diagram
4.3% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
ethylene glycol + NAD+
?
show the reaction diagram
ethylene glycol + NAD+
? + NADH
show the reaction diagram
ethylenglycol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
r
formaldehyde + NADH + H+
methanol + NAD+
show the reaction diagram
furfural + NADH
furfuryl alcohol + NADH
show the reaction diagram
-
activity with enzyme form ADH I, no activity with enzyme form ADH II
-
r
furfural + NADH + H+
furfuryl alcohol + NADH
show the reaction diagram
mutant enzyme S109P/L116S/Y294C
-
-
?
furfuryl alcohol + NAD+
furfural + NADH
show the reaction diagram
glutaraldehyde + NADH + H+
?
show the reaction diagram
-
70.8fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
glycerol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
about 45% of the activity with ethanol
-
-
r
glycerol + NAD+
dihydroxyacetone + NADH
show the reaction diagram
glycerol + NAD+
dihydroxyacetone + NADH + H+
show the reaction diagram
-
-
-
-
?
heptaldehyde + NADH + H+
? + NAD+
show the reaction diagram
33% activity compared to benzyl alcohol
-
-
?
heptan-2-ol + NAD+
heptan-2-one + NADH
show the reaction diagram
-
-
-
-
?
heptan-4-ol + NAD+
heptan-4-one + NADH
show the reaction diagram
-
-
-
-
?
hexadecanol + NAD+
hexadecanal + NADH
show the reaction diagram
-
very low activity
-
-
?
hexadecanol + NAD+
hexadecanal + NADH + H+
show the reaction diagram
-
immobilized HLAD shows about 60% reaction rate and free HLAD shows about 15% reaction rate with hexadecanol compared to ethanol at pH 8.8 and 30C
-
-
?
hexaldehyde + NADH + H+
1-hexanol + NAD+
show the reaction diagram
7% activity compared to benzyl alcohol
-
-
?
hexan-1-ol + NAD+
n-hexanal + NADH
show the reaction diagram
hexan-2-ol + NAD+
2-hexanone + NADH
show the reaction diagram
-
-
-
-
?
hexanal + NADH + H+
1-hexanone + NAD+
show the reaction diagram
-
49% of the activity with acetaldehyde
-
-
?
hexanal + NADH + H+
n-hexanol + NAD+
show the reaction diagram
-
22.3fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
hexanal + NADPH + H+
1-hexanone + NADP+
show the reaction diagram
-
24% of the activity with NADH
-
-
?
hexanol + NAD+
hexaldehyde + NADH
show the reaction diagram
-
-
-
-
?
hexanol + NAD+
hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
hydrocinnamaldehyde + NADH + H+
hydrocinnamyl alcohol + NAD+
show the reaction diagram
12% activity compared to benzyl alcohol
-
-
r
hydrocinnamyl alcohol + NAD+
hydrocinnamaldehyde + NADH + H+
show the reaction diagram
31% activity compared to benzyl alcohol
-
-
r
hydroxyacetone + NADH + H+
propane-1,2-diol + NAD+
show the reaction diagram
-
27% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
isatin + NADH
?
show the reaction diagram
-
-
-
?
iso-propanol + NAD+
isopropanal + NADH + H+
show the reaction diagram
isoamylalcohol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
about 5% of the activity with 1-octanol
-
-
r
isoborneol + NAD+
?
show the reaction diagram
isoborneol is the best substrate in the oxidation reaction
-
-
?
isobutyl alcohol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
isobutyraldehyde + NADH + H+
isobutanol + NAD+
show the reaction diagram
-
-
-
-
r
isobutyramide + NAD+
?
show the reaction diagram
-
-
-
-
r
isopentanol + NAD+
? + NADH + H+
show the reaction diagram
low affinity
-
-
?
isopentenyl alcohol + NAD+
isopentanone + NADH
show the reaction diagram
-
-
-
-
?
isopropanol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
isopropanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
-
-
-
r
isopropanol + NAD+
acetone + NADH + H+
show the reaction diagram
levulinic acid + NADH + H+
?
show the reaction diagram
-
11% of activity with N-benzyl-3-pyrrolidinone
-
-
?
m-chlorophenacyl chloride + NADH + H+
2-chloro-1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
4.6fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
m-nitrobenzaldehyde + NAD+
m-nitrobenzyl alcohol + NADH + H+
show the reaction diagram
-
substrate of class IV ADH
-
-
?
m-nitrobenzaldehyde + NADH + H+
m-nitrobenzyl alcohol + NAD+
show the reaction diagram
methanol + 2 NAD+ + H2o
formic acid + 2 NADH + 2 H+
show the reaction diagram
about 25% of the activity with 1-octanol
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
methyl 3-oxobutanoate + NADH + H+
methyl 3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
130% of the activity with phenyl trifluoromethyl ketone
-
-
?
methyl 4-bromo-3-oxobutanoate + NADH + H+
methyl 4-bromo-3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
164% of the activity with phenyl trifluoromethyl ketone
-
-
?
methyl acetoacetate + NADH + H+
methyl 3-hydroxybutanoate + NAD+
show the reaction diagram
-
-
-
-
r
methyl benzoylformate + NADH
?
show the reaction diagram
methyl benzoylformate + NADH + H+
methyl (R)-(-)-mandelate + NAD+
show the reaction diagram
-
92% enantiomeric excess
-
-
?
methyl glyoxal + NADH + H+
?
show the reaction diagram
-
3.5fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
methyl o-chlorobenzoylformate + NADH
?
show the reaction diagram
about 55% of the activity compared to isatin
-
-
?
methyl pyruvate + NADH + H+
methyl 2-hydroxypropanoate + NAD+
show the reaction diagram
-
18.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
methyl pyruvate + NADH + H+
methyl lactate + NAD+
show the reaction diagram
-
-
-
-
r
methylbenzoylformate + NADH + H+
?
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
methylcrotonyl alcohol + NAD+
methylcrotonaldehyde + NADH
show the reaction diagram
-
-
-
-
?
methylglyoxal + NADH
? + NADH
show the reaction diagram
-
11.9% of the activity with acetaldehyde
-
-
?
N-benzyl-3-piperidone + NADH + H+
N-benzylpiperidin-3-ol + NAD+
show the reaction diagram
-
2.3fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
N-benzyl-3-pyrrolidinol + NAD+
1-benzylpyrrolidin-3-one + NADH + H+
show the reaction diagram
-
33% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
N-benzyl-3-pyrrolidinone + NADH + H+
(R)-N-benzyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
(R)-stereoselectivity of the reduction carried out with the heat-treated cells
-
-
r
N-benzyl-3-pyrrolidinone + NADH + H+
(S)-N-benzyl-3-pyrrolidinol + NAD+
show the reaction diagram
N-benzyl-4-piperidone + NADH + H+
N-benzylpiperidin-4-ol + NAD+
show the reaction diagram
-
10.7fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
n-butanal + NADH + H+
n-butanol + NAD+
show the reaction diagram
-
-
-
-
?
n-butanol + NAD+
butanal + NADH
show the reaction diagram
-
low activity
-
-
?
n-butanol + NAD+
butylaldehyde + NADH + H+
show the reaction diagram
n-butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
n-butanol + NAD+
butyraldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
n-butanol + NAD+
n-butanal + NADH
show the reaction diagram
n-butanol + NAD+
n-butanal + NADH + H+
show the reaction diagram
-
-
-
-
?
n-butylaldehyde + NADH + H+
butanal + NAD+
show the reaction diagram
-
activity is 1.8fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
n-butyraldehyde + NADH + H+
n-butanol + NAD+
show the reaction diagram
-
7.3fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
n-decanol + NAD+
n-decanal + NADH
show the reaction diagram
-
-
-
-
r
n-hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
r
n-hexylaldehyde + NADH + H+
hexanal + NAD+
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
n-octylaldehyde + NADH + H+
n-octanol + NAD+
show the reaction diagram
-
activity is 1.7fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
n-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
-
-
-
-
?
n-pentylaldehyde + NADH + H+
n-pentanol + NAD+
show the reaction diagram
-
-
-
-
r
n-propanol + NAD+
n-propanal + NADH
show the reaction diagram
-
-
-
-
r
n-propanol + NAD+
propanal + NADH
show the reaction diagram
n-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
n-propanol + NAD+
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
N-tert-butoxycarbonyl-3-pyrrolidinone + NADH + H+
(S)-N-tert-butoxycarbonyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
production of (S)-N-tert-butoxycarbonyl-3-pyrrolidinol with 99.6% enantiomeric excess
-
-
?
n-valeraldehyde + NADH + H+
n-pentanol + NAD+
show the reaction diagram
-
activity is 2.8fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
nonyl aldehyde + NADH + H+
1-nonanol + NAD+
show the reaction diagram
25% activity compared to benzyl alcohol
-
-
?
nonylphenol polyethoxylate 9 + NAD+
? + NADH
show the reaction diagram
7% activity compared to benzyl alcohol
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
octan-2-ol + NAD+
octan-2-one + NADH
show the reaction diagram
octanal + NAD+ + H2O
octanoic acid + NADH + H+
show the reaction diagram
octanal + NADH + H+
octanol + NAD+
show the reaction diagram
octanoic acid + 2 NADH + 2 H+
1-octanol + 2 NAD+ + H2o
show the reaction diagram
-
-
-
r
octanol + NAD+
octanal + NADH
show the reaction diagram
octanol + NAD+
octanal + NADH + H+
show the reaction diagram
octyl aldehyde + NADH + H+
1-octanol + NAD+
show the reaction diagram
29% activity compared to benzyl alcohol
-
-
?
octylphenol polyethoxylate 2 + NAD+
? + NADH
show the reaction diagram
59% activity compared to benzyl alcohol
-
-
?
octylphenol polyethoxylate 8 + NAD+
? + NADH
show the reaction diagram
7% activity compared to benzyl alcohol
-
-
?
oxalacetic acid + NADH + H+
?
show the reaction diagram
-
14% of activity with N-benzyl-3-pyrrolidinone
-
-
?
oxaloacetate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
p-chlorobenzaldehyde + NADH + H+
p-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
1.2fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
p-methoxybenzyl alcohol + NAD+
p-methoxybenzaldehyde + NADH + H+
show the reaction diagram
p-nitrobenzaldehyde + NADH
p-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
p-nitrobenzaldehyde + NADH + H+
p-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
substrate of isozyme ADH4
-
-
r
p-nitrobenzyloxycarbonyl-3-pyrrolidinone + NADH + H+
(S)-N-p-nitrobenzyloxycarbonyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
production with 90.7% enantiomeric excess
-
-
?
p-nitrophenyl octanoate + H2O
p-nitrophenol + octanoate
show the reaction diagram
-
acid-assisted nucleophilic catalysis involving the ammonium ion of Lys and the thiolate of Cys in the acyl-oxygen cleavage
-
?
pentan-2-ol + NAD+
2-pentanone + NADH
show the reaction diagram
pentan-3-ol + NAD+
3-pentanone + NADH
show the reaction diagram
pentan-3-ol + NAD+
3-pentanone + NADH + H+
show the reaction diagram
-
-
-
-
r
pentanal + NADH
1-pentanol + NAD+ + H+
show the reaction diagram
Leifsonia sp.
-
132% of the activity with phenyl trifluoromethyl ketone, in the reverse reaction 5% of the activity with 2-propanol
-
-
?
pentanol + NAD+
1-pentanal + NADH + H+
show the reaction diagram
about 10% of the activity with ethanol or 1-propanol
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
pentanol + NAD+
pentanone + NADH
show the reaction diagram
pentanol + NAD+
valeraldehyde + NADH + H+
show the reaction diagram
-
240% activity compared to cyclohexanone
-
r
phenyl trifluoromethyl ketone + NADH + H+
(S)-1-phenyltrifluoroethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
-
more than 99% enantiomeric excess
-
?
phenylacetaldehyde + NADH
phenylethanol + NAD+
show the reaction diagram
phenylalaninol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
phenylethanol + NAD+
phenylacetaldehyde + NADH
show the reaction diagram
-
R-(+)-phenylethanol and S-(-)-phenylethanol
-
-
?
phenylethanol + NAD+
phenylacetaldehyde + NADH + H+
show the reaction diagram
-
15% of activity with N-benzyl-3-pyrrolidinol
-
-
?
phenylglyoxylic acid + NADH + H+
hydroxy(phenyl)acetic acid + NAD+
show the reaction diagram
-
enzyme covalently immobilized to magnetic Fe3O4 nanoparticles via glutaraldehyde retains 48.77% activity of its original activity
-
-
?
phytol + NAD+
phytenal + NADH + H+
show the reaction diagram
-
-
-
-
?
polyoxyethylene 8 decyl ether + NAD+
? + NADH
show the reaction diagram
12% activity compared to benzyl alcohol
-
-
?
primary or secondary alcohol + NAD+
aldehyde or ketone + NADH
show the reaction diagram
prop-2-en-1-ol + NAD+
? + NADH
show the reaction diagram
-
140.6% of the activity with ethanol
-
-
?
propan-1,2-diol + NAD+
? + NADH
show the reaction diagram
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
propan-2-ol + NAD+
acetone + NADH + H+
show the reaction diagram
-
6% activity compared to cyclohexanone
-
r
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
propionaldehyde + NADH
propanol + NAD+
show the reaction diagram
propionaldehyde + NADH + H+
1-propanol + NAD+
show the reaction diagram
-
-
-
-
r
propionaldehyde + NADH + H+
?
show the reaction diagram
-
activity is 1.1fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
propiophenone + NADH + H+
1-phenylpropan-1-ol + NAD+
show the reaction diagram
-
27% of activity with N-benzyl-3-pyrrolidinone
-
-
?
pyridine 2-aldehyde + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
pyridine 3-aldehyde + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
pyridine 4-aldehyde + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
pyridine-3-aldehyde + NADH + H+
pyridin-3-yl ethanol + NAD+
show the reaction diagram
-
82% of activity with N-benzyl-3-pyrrolidinone
-
-
?
pyridine-4-aldehyde + NADH + H+
pyridin-4-yl methanol + NAD+
show the reaction diagram
-
4.4fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
R-(+)-1-phenylethanol + NAD+
1-phenylethanone + NADH
show the reaction diagram
-
-
-
-
-
R-(+)-cis-verbenol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
R-(+)-trans-bicyclo(2.2.1)-heptanol + NAD+
R-(+)-trans-bicyclo(2.2.1)-heptanal + NADH
show the reaction diagram
-
R-(+)-trans-bicyclo(2.2.1)-heptanol and S-(-)-trans-bicyclo(2.2.1)-heptanol
-
-
?
rac-3-methylcyclohexanone + NADH + H+
(1S,3S)-3-methylcyclohexanol + NAD+
show the reaction diagram
-
-
-
-
?
retinal + NADH + H+
retinol + NAD+
show the reaction diagram
-
substrate of isozyme ADH4
-
-
r
retinol + NAD+
retinal + NADH
show the reaction diagram
-
-
-
-
?
S-(-)-1-phenylethanol + NAD+
1-phenylethanone + NADH
show the reaction diagram
-
-
-
-
-
S-(-)-cis-bicyclo(2.2.1)-heptanol + NAD+
S-(-)-cis-bicyclo(2.2.1)-heptanal + NADH
show the reaction diagram
-
-
-
-
?
secondary alcohol + NAD+
aldehyde + NADH
show the reaction diagram
-
-
-
-
?
tert-butyl 3-oxobutanoate + NADH + H+
tert butyl 3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
568% of the activity with phenyl trifluoromethyl ketone
-
-
?
tert-butyl acetoacetate + NADH + H+
?
show the reaction diagram
-
-
-
-
?
tetracosanol + NAD+
? + NADH + H+
show the reaction diagram
-
immobilized HLAD shows about 55% reaction rate and free HLAD shows about 15% reaction rate with tetracosanol compared to ethanol at pH 8.8 and 30C
-
-
?
tetrahydro-4H-pyran-4-one + NADH + H+
? + NAD+
show the reaction diagram
10% activity compared to cyclohexanone
-
-
?
tetralin-1-ol + NAD+
3,4-dihydronaphthalen-1(2H)-one + NADH + H+
show the reaction diagram
51% of the activity compared to isoborneol
-
-
?
trans-4-(N,N-dimethylamino)-cinnamaldehyde + NADH
trans-4-(N,N-dimethylamino)-cinnamyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
trans-4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
trans-cinnamaldehyde + NADH + H+
cinnamyl alcohol + NAD+
show the reaction diagram
trans-cinnamyl alcohol + NAD+
(2E)-3-phenylprop-2-enal + NADH + H+
show the reaction diagram
-
activity is 3.9fold higher than with (S)-(-)-1-phenylethanol
-
-
?
Tris + NAD+
? + NADH
show the reaction diagram
-
-
-
-
r
Triton X-100 + NAD+
? + NADH
show the reaction diagram
7% activity compared to benzyl alcohol
-
-
?
Triton X-114 + NAD+
? + NADH
show the reaction diagram
3% activity compared to benzyl alcohol
-
-
?
Triton X-165 + NAD+
? + NADH
show the reaction diagram
24% activity compared to benzyl alcohol
-
-
?
Triton X-35 + NAD+
? + NADH
show the reaction diagram
43% activity compared to benzyl alcohol
-
-
?
Triton X-405 + NAD+
? + NADH
show the reaction diagram
19% activity compared to benzyl alcohol
-
-
?
Triton X-45 + NAD+
? + NADH
show the reaction diagram
7% activity compared to benzyl alcohol
-
-
?
tryptophol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
valeraldehyde + NADH
1-pentanol + NAD+
show the reaction diagram
vanillyl alcohol + NAD+
vanillin + NADH
show the reaction diagram
-
-
-
-
?
additional information
?
-