Information on EC 1.1.1.1 - alcohol dehydrogenase

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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

EC NUMBER
COMMENTARY hide
1.1.1.1
-
RECOMMENDED NAME
GeneOntology No.
alcohol dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
a secondary alcohol + NAD+ = a ketone + NADH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-methylbutanol biosynthesis (engineered)
-
-
acetaldehyde biosynthesis I
-
-
acetylene degradation
-
-
alpha-Linolenic acid metabolism
-
-
Biosynthesis of antibiotics
-
-
Biosynthesis of secondary metabolites
-
-
butanol and isobutanol biosynthesis (engineered)
-
-
chitin degradation to ethanol
-
-
Chloroalkane and chloroalkene degradation
-
-
Drug metabolism - cytochrome P450
-
-
ethanol degradation I
-
-
ethanol degradation II
-
-
Fatty acid degradation
-
-
Glycine, serine and threonine metabolism
-
-
Glycolysis / Gluconeogenesis
-
-
heterolactic fermentation
-
-
L-1,2-propanediol degradation
-
-
L-isoleucine degradation II
-
-
L-leucine degradation III
-
-
L-methionine degradation III
-
-
L-phenylalanine degradation III
-
-
L-tryptophan degradation V (side chain pathway)
-
-
L-tyrosine degradation III
-
-
L-valine degradation II
-
-
Metabolic pathways
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Metabolism of xenobiotics by cytochrome P450
-
-
Microbial metabolism in diverse environments
-
-
mixed acid fermentation
-
-
Naphthalene degradation
-
-
noradrenaline and adrenaline degradation
-
-
phenylethanol biosynthesis
-
-
phytol degradation
-
-
pyruvate fermentation to ethanol I
-
-
pyruvate fermentation to ethanol II
-
-
pyruvate fermentation to ethanol III
-
-
pyruvate fermentation to isobutanol (engineered)
-
-
Retinol metabolism
-
-
salidroside biosynthesis
-
-
serotonin degradation
-
-
superpathway of fermentation (Chlamydomonas reinhardtii)
-
-
Tyrosine metabolism
-
-
ethanol fermentation
-
-
leucine metabolism
-
-
methionine metabolism
-
-
phenylalanine metabolism
-
-
propanol degradation
-
-
tryptophan metabolism
-
-
tyrosine metabolism
-
-
valine metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
alcohol:NAD+ oxidoreductase
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
CAS REGISTRY NUMBER
COMMENTARY hide
9031-72-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain SKU1108, 2 soluble isozymes
-
-
Manually annotated by BRENDA team
strain SKU1108, 2 soluble isozymes
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
KU 1309
-
-
Manually annotated by BRENDA team
KU 1309
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
fragment; CCTCC M203011
UniProt
Manually annotated by BRENDA team
fragment; CCTCC M203011
UniProt
Manually annotated by BRENDA team
N-16
-
-
Manually annotated by BRENDA team
N-16
-
-
Manually annotated by BRENDA team
gene chy1186
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
japonica. ADH-1, ADH-2, ADH-3 and ADH-An
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
var. Cantalupensis
-
-
Manually annotated by BRENDA team
KNK10702
-
-
Manually annotated by BRENDA team
KNK10702
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-
Manually annotated by BRENDA team
strain HM1
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-
Manually annotated by BRENDA team
strain HM1:1MSS, alcohol dehydrogenase 2
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain Z
Uniprot
Manually annotated by BRENDA team
strain Z
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain KUC-1
SwissProt
Manually annotated by BRENDA team
strain KUC-1
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain LLD-R
Uniprot
Manually annotated by BRENDA team
gene GmAdh2
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
3 isoenzymes
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-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain S749
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Manually annotated by BRENDA team
strain S749
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-
Manually annotated by BRENDA team
cationic pyrazole-sensitive isoenzyme, anodic pyrazole-sensitive isoenzyme and cathionic pyrazole-in sensitive isoenzyme
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain B10-05
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-
Manually annotated by BRENDA team
strain B10-05
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
strain YR-1
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-
Manually annotated by BRENDA team
strain YR-1
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-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene adh3
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-
Manually annotated by BRENDA team
gene adh3
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-
Manually annotated by BRENDA team
i.e. Pichia angusta, HpADH3 is not the major ADH in strain DL-1, gene ADH3
UniProt
Manually annotated by BRENDA team
i.e. Pichia angusta, HpADH3 is not the major ADH in strain DL-1, gene ADH3
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain DSM 50106, stereoselective enzyme
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-
Manually annotated by BRENDA team
probable alcohol dehydrogenase; strain S-5
UniProt
Manually annotated by BRENDA team
probable alcohol dehydrogenase; strain S-5
UniProt
Manually annotated by BRENDA team
DSM44514
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-
Manually annotated by BRENDA team
strain DSM44541
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
strain Y379-50
UniProt
Manually annotated by BRENDA team
strain Y379-50
UniProt
Manually annotated by BRENDA team
pyrazole-insensitive isoenzyme and pyrazole-sensitive isoenzyme
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-
Manually annotated by BRENDA team
Sporotrichum pulverulentum
-
-
-
Manually annotated by BRENDA team
strain DSM1617
-
-
Manually annotated by BRENDA team
strain Gtheta
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-
Manually annotated by BRENDA team
strain RC3
UniProt
Manually annotated by BRENDA team
strain RC3
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
ATCC 27502
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-
Manually annotated by BRENDA team
strain DSM 1728
UniProt
Manually annotated by BRENDA team
strain ATN1
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
3 isoenzymes
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(-)-carvone + NADH + H+
? + NAD+
show the reaction diagram
1% activity compared to cyclohexanone
-
-
?
(1S,3S)-3-methylcyclohexanol + NAD+
(rac)-3-methylcyclohexanone + NADH + H+
show the reaction diagram
125% activity compared to cyclohexanol
163% activity compared to cyclohexanone
-
r
(2E)-2-methylpent-2-enal + NADPH + H+
(2E)-2-methylpent-2-en-1-ol + NADP+
show the reaction diagram
41.5% of the activity with (2E)-but-2-enal, yield 95% after 12 h
-
-
?
(2E)-3,7-dimethylocta-2,6-dienal + NADPH + H+
(2E)-3,7-dimethylocta-2,6-dien-1-ol + NADP+
show the reaction diagram
37.4% of the activity with (2E)-but-2-enal, yield 87% after 12 h
-
-
?
(2E)-but-2-en-1-ol + NADP+
(2E)-but-2-enal + NADPH + H+
show the reaction diagram
-
-
-
r
(2E)-but-2-enal + NADPH + H+
(2E)-but-2-en-1-ol + NADP+
show the reaction diagram
yield 96% after 12 h
-
-
r
(2E)-dec-2-enal + NADPH + H+
(2E)-dec-2-en-1-ol + NADP+
show the reaction diagram
16.7% of the activity with (2E)-but-2-enal, yield 91% after 12 h
-
-
?
(2E)-hex-2-enal + NADPH + H+
(2E)-hex-2-en-1-ol + NADP+
show the reaction diagram
41.7% of the activity with (2E)-but-2-enal, yield 98% after 12 h
-
-
?
(2E)-oct-2-enal + NADPH + H+
(2E)-oct-2-en-1-ol + NADP+
show the reaction diagram
30.2% of the activity with (2E)-but-2-enal, yield 69% after 12 h
plus 27% oct-2-enyl ester
-
?
(6S)-5,6-dihydro-6-methyl-4H-thieno[2,3b]thiopyran-4-one-7,7-dioxide + NADH + H+
(4S,6S)-5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3b]thiopyran-7,7-dioxide + NAD+
show the reaction diagram
-
-
-
-
-
(E)-hex-2-en-1-ol + NAD+
(E)-hex-2-en-1-one + NADH
show the reaction diagram
(R)-1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
-
-
-
r
(R)-1-indanol + NAD+
?
show the reaction diagram
62% of activity compared to (S)-1-indanol
-
-
?
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
(R)-2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
(R)-2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
(R)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
(R)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
(R)-2-phenylpropanol + NAD+
(R)-2-phenylpropanal + NADH + H+
show the reaction diagram
(R)-3-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
(R)-alpha-tetralol + NAD+
?
show the reaction diagram
58% of activity compared to (S)-1-indanol
-
-
?
(R)-alpha-tetralol + NAD+
alpha-tetralone + NADH + H+
show the reaction diagram
-
-
-
r
(R,S)-2-methylbutan-1-ol + NAD+
(R,S)-2-methyl-butan-1-one + NADH + H+
show the reaction diagram
(S)-(+)-1-indanol + NAD+
indanone + NADH + H+
show the reaction diagram
-
-
-
-
?
(S)-1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
(S)-1-indanol + NAD+
?
show the reaction diagram
-
-
-
?
(S)-1-phenyl-2-propanol + NAD+
phenylacetone + NADH + H+
show the reaction diagram
-
9% activity compared to cyclohexanone
-
r
(S)-1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
show the reaction diagram
-
-
-
-
r
(S)-2-butanol + NAD+
2-butanone + NADH
show the reaction diagram
-
-
-
-
r
(S)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
(S)-2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
-
331% of the activity with 2-propanol
-
-
r
(S)-2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
-
38% of the activity with 2-propanol
-
-
r
(S)-2-methylbutan-1-ol + NAD+
(S)-2-methyl-butanal + NADH + H+
show the reaction diagram
(S)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
(S)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
(S)-2-pentanol + NAD+
?
show the reaction diagram
11% of activity compared to (S)-1-indanol
-
-
?
(S)-2-phenylpropanol + NAD+
(S)-2-phenylpropanal + NADH + H+
show the reaction diagram
-
156% of the activity with 2-phenylethanol
-
-
?
(S)-4-phenylbutan-2-ol + NAD+
benzylacetone + NADH + H+
show the reaction diagram
-
3% activity compared to cyclohexanone
-
r
(S)-alpha-tetralol + NAD+
?
show the reaction diagram
12% of activity compared to (S)-1-indanol
-
-
?
(S)-alpha-tetralol + NAD+
alpha-tetralone + NADH + H+
show the reaction diagram
(S)-heptan-2-ol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
-
-
-
r
(S)-pentan-2-ol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-
-
-
r
(S)-perillylalcohol + NAD+
(S)-perillaldehyde + NADH + H+
show the reaction diagram
52% activity compared to cyclohexanol
-
-
?
(Z)-hex-2-en-1-ol + NAD+
(Z)-hex-2-en-1-one + NADH
show the reaction diagram
-
9.7% of the activity with ethanol
-
-
?
1,1-dichloroacetone + NADH + H+
1,1-dichloropropan-2-ol + NADH
show the reaction diagram
-
1078% of the activity with phenyl trifluoromethyl ketone
-
-
?
1,2-butanediol + NAD+
?
show the reaction diagram
1,2-hexanediol + NAD+
?
show the reaction diagram
-
20% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,2-pentanediol + NAD+
?
show the reaction diagram
-
12% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,2-propanediol + NAD+
?
show the reaction diagram
1,2-propanediol + NAD+
hydroxyacetone + NADH
show the reaction diagram
-
-
-
-
?
1,2-propanediol + NAD+
hydroxyacetone + NADH + H+
show the reaction diagram
-
-
-
-
?
1,3-butanediol + NAD+
?
show the reaction diagram
-
39% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,3-propanediol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
1,3-propanediol + NAD+
?
show the reaction diagram
1,3-propanediol + NAD+
? + NADH
show the reaction diagram
-
7% of the activity with ethanol
-
-
?
1,5-pentanediol + NAD+
? + NADH + H+
show the reaction diagram
1-(3-bromophenyl)ethanol + NAD+
1-(3-bromophenyl)ethanone + NADH + H+
show the reaction diagram
315% of the activity with 1-phenylethanol
-
-
?
1-(3-chlorophenyl)ethanol + NAD+
1-(3-chlorophenyl)ethanone + NADH + H+
show the reaction diagram
205% of the activity with 1-phenylethanol
-
-
?
1-(4'-chlorophenyl)ethanol + NAD+
1-(4'-chlorophenyl)ethanone + NADH + H+
show the reaction diagram
-
26% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-(4'-fluorophenyl)ethanol + NAD+
1-(4'-fluorophenyl)ethanone + NADH + H+
show the reaction diagram
-
45% of the activity with (S)-1-phenylethanol
-
-
r
1-(4-bromophenyl)ethanol + NAD+
1-(4-bromophenyl)ethanone + NADH + H+
show the reaction diagram
167% of the activity with 1-phenylethanol
-
-
?
1-(4-chlorophenyl)ethanol + NAD+
1-(4-chlorophenyl)ethanone + NADH + H+
show the reaction diagram
151% of the activity with 1-phenylethanol
-
-
?
1-(4-fluorophenyl)ethanol + NAD+
1-(4-fluorophenyl)ethanone + NADH + H+
show the reaction diagram
1-(4-methylphenyl)ethanol + NAD+
1-(4-methylphenyl)ethanone + NADH + H+
show the reaction diagram
189% of the activity with 1-phenylethanol
-
-
?
1-(p-tolyl)-ethanol + NAD+
1-(4-methylphenyl)ethanone + NADH + H+
show the reaction diagram
19% activity compared to cyclohexanol
26% activity compared to cyclohexanone
-
?
1-butanal + NADH + H+
1-butanol + NAD+
show the reaction diagram
-
-
-
-
r
1-butanol + 2 NAD+ + H2O
butanoic acid + 2 NADH + 2 H+
show the reaction diagram
1-butanol + NAD+
butanal + NADH
show the reaction diagram
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
1-chloro-5-acetylfuro[2,3-c]pyridine + NADH + H+
1-chloro-5-(1-hydroxyethyl)furo[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
1-decalone + NADH + H+
decahydronaphthalen-1-ol + NAD+
show the reaction diagram
85% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
1-decanol + NAD+
decanal + NADH + H+
show the reaction diagram
1-dodecanol + NAD+
dodecanal + NADH
show the reaction diagram
1-heptanol + NAD+
1-heptanal + NADH + H+
show the reaction diagram
-
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
1-heptanol + NAD+
heptanol + NADH + H+
show the reaction diagram
-
56% of the activity with 2-propanol, in the reverse reaction 755% of the activity with phenyl trifluoromethyl ketone
-
-
r
1-hexanal + NADH + H+
1-hexanol + NAD+
show the reaction diagram
-
-
-
-
r
1-hexanol + 2 NAD+ + H2O
hexanoic acid + 2 NADH + 2 H+
show the reaction diagram
1-hexanol + NAD+
1-hexanal + NADH + H+
show the reaction diagram
1-hexanol + NAD+
?
show the reaction diagram
-
15% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
1-hydroxy-2-butanone + NADH + H+
butane-1,2-diol + NAD+
show the reaction diagram
-
59% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
1-hydroxymethyl-6-methylpyrene + NAD+
1-formyl-6-methylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
1-hydroxymethyl-8-methylpyrene + NAD+
1-formyl-8-methylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
1-hydroxymethylpyrene + NAD+
1-formylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
1-indanone + NADH + H+
(S)-1-indanol + NAD+
show the reaction diagram
1-indanone + NADH + H+
1-indanol + NAD+
show the reaction diagram
-
-
-
-
r
1-nonanol + NAD+
nonanal + NADH + H+
show the reaction diagram
1-octanol + 2 NAD+ + H2O
octanoic acid + 2 NADH + 2 H+
show the reaction diagram
1-octanol + 2 NADP+ + H2O
octanoic acid + 2 NADPH + 2 H+
show the reaction diagram
-
-
-
r
1-octanol + NAD+
1-octanal + NADH + H+
show the reaction diagram
-
6% of activity with N-benzyl-3-pyrrolidinol
-
-
?
1-octanol + NAD+
octanal + NADH
show the reaction diagram
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
1-pentanol + NAD+
1-pentanal + NADH + H+
show the reaction diagram
1-pentanol + NAD+
pentanal + NADH + H*
show the reaction diagram
-
8% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
1-phenyl-1,2-ethanediol + NAD+
1-phenyl-2-propanone + NADH + H+
show the reaction diagram
1% activity compared to cyclohexanol
-
-
r
1-phenyl-1,2-propandione + NADH + H+
1-phenyl-2-hydroxy-1-propanone + NAD+
show the reaction diagram
-
146% of the activity with 2,2,2-trifluoroacetophenone
-
-
r
1-phenyl-1,2-propanedione + NADH
?
show the reaction diagram
about 25% of the activity compared to isatin
-
-
?
1-phenyl-1,2-propanedione + NADH + H+
?
show the reaction diagram
1-phenyl-1-propanol + NAD+
1-phenyl-1-propanone + NADH + H+
show the reaction diagram
-
59% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-phenyl-1-propanol + NAD+
1-phenylpropanal + NADH + H+
show the reaction diagram
-
59% of the activity with (S)-1-phenylethanol
-
-
r
1-phenyl-1-propanol + NAD+
?
show the reaction diagram
-
31% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-phenyl-2-butanone + NADH + H+
1-phenylbutan-2-ol + NAD+
show the reaction diagram
1-phenyl-2-propanol + NAD+
1-phenyl-2-propanone + NADH + H+
show the reaction diagram
1-phenyl-2-propanone + NADH + H+
(S)-1-phenyl-2-propanol + NAD+
show the reaction diagram
-
-
-
-
-
1-phenyl-3-butanone + NADH + H+
1-phenylbutan-3-ol + NAD+
show the reaction diagram
-
353% of the activity with phenyl trifluoromethyl ketone
-
-
?
1-phenylethanol + NAD+
1-phenylethanone + NADH
show the reaction diagram
1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
show the reaction diagram
1-phenylethanol + NAD+
acetophenone + NADH + H+
show the reaction diagram
-
1% activity compared to cyclohexanone
-
?
1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
show the reaction diagram
-
-
-
?
1-propanol + NAD+
propanal + NADH
show the reaction diagram
-
-
-
-
?
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
1-propanol + NAD+
propanaldehyde + NADH + H+
show the reaction diagram
11-cis-retinal + NADH + H+
11-cis-retinol + NAD+
show the reaction diagram
-
-
-
-
?
11-cis-retinol + NAD+
11-cis-retinal + NADH
show the reaction diagram
12-hydroxydodecanoate + NAD+
12-oxododecanoic acid + NADH
show the reaction diagram
12-hydroxylauric acid methyl ester + NAD+
12-oxo lauricacid methyl ester + NADH + H+
show the reaction diagram
-
-
product is a key intermediate for biobased polyamide 12 production
-
?
12-oxolauric acid methyl ester + NADH + H+
12-hydroxylauric acid methyl ester + NAD+
show the reaction diagram
-
-
-
-
?
13-cis-retinal + NADH + H+
13-cis-retinol + NAD+
show the reaction diagram
-
-
-
-
?
13-cis-retinol + NAD+
13-cis-retinal + NADH
show the reaction diagram
16-hydroxyhexadecanoate + NAD+
16-oxohexadecanoic acid + NADH
show the reaction diagram
-
-
-
-
?
17beta-hydroxyetiocholan-3-one + NAD+
ethiocholan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
?
2',3',4',5',6'-pentafluoroacetophenone + NADH + H+
1-(2,3,4,5,6-pentafluorophenyl)ethanol + NAD+
show the reaction diagram
45% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2,2'-dichlorobenzil + NADH + H+
1,2-bis(2-chlorophenyl)-2-hydroxyethanone + NAD+
show the reaction diagram
-
-
-
?
2,2,2-trichloroethanol + NAD+
trichloroacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
2,2,2-trifluoro-1-phenylethanone + propan-2-ol
(1R)-2,2,2-trifluoro-1-phenylethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 99% enantiomeric excess
-
?
2,2,2-trifluoroacetophenone + NADH
2,2,2-trifluoro-1-phenylethanol + NAD+
show the reaction diagram
about 35% of the activity compared to isatin
-
-
?
2,2,2-trifluoroacetophenone + NADH + H+
(R)-alpha-(trifluoromethyl)benzyl alcohol + NAD+
show the reaction diagram
2,2,2-trifluoroacetophenone + NADH + H+
2,2,2-trifluoro-1-phenylethanol + NAD+
show the reaction diagram
2,2,2-trifluoroacetophenone + NADPH + H+
(R)-2,2,2-trifluoro-1-phenylethanol + NADP+
show the reaction diagram
180% of the activity with acetoin
-
-
r
2,2-dichloroacetophenone + NADH + H+
2,2-dichloro-1-phenylethanol + NAD+
show the reaction diagram
2,2-difluoro-1-phenylethanone + propan-2-ol
(1R)-2,2-difluoro-1-phenylethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 94% enantiomeric excess
-
?
2,3'-dichloroacetophenone + NADH + H+
1-(2,3-dichlorophenyl)ethanol + NAD+
show the reaction diagram
-
67% of the activity with phenyl trifluoromethyl ketone
-
-
?
2,3'-dichloroacetophenone + NADH + H+
2-chloro-1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
2,3-butanediol + H2O
?
show the reaction diagram
-
-
-
?
2,3-butanediol + NAD+
?
show the reaction diagram
-
83% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
2,3-butanediol + NAD+
acetoin + NADH + H+
show the reaction diagram
2,3-butanedione + NADH + H+
?
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
2,3-pentanedione + NADH
? + NADH
show the reaction diagram
-
5.5% of the activity with acetaldehyde
-
-
?
2,4-pentanediol + NAD+
?
show the reaction diagram
2-(3,5-dimethylphenyl)propanal + NADH + H+
(S)-2-(3,5-dimethylphenyl)propanol + NAD+
show the reaction diagram
2-(3-benzoylphenyl)propanal + NADH + H+
(S)-2-(3-benzoylphenyl)propanol + NAD+
show the reaction diagram
2-(3-fluorobiphenyl-4-yl)propanal + NADH + H+
(S)-2-(3-(fluoro)biphenyl-4-yl)propanol + NAD+
show the reaction diagram
2-(3-phenoxyphenyl)propanal + NADH + H+
(S)-2-((3-phenoxy)phenyl)propanol + NAD+
show the reaction diagram
2-(4-isobutylphenyl)propanal + NADH + H+
(S)-2-(4-isobutylphenyl)propanol + NAD+
show the reaction diagram
2-(4-trifluoromethylphenyl)propanal + NADH + H+
(S)-2-(4-trifluoromethyl)phenylpropanol + NAD+
show the reaction diagram
-
18 h, 55% yield, 98% enantiomeric excess
-
-
?
2-(6-methoxynaphthalen-2-yl)propanal + NADH + H+
(S)-2-(6-methoxynaphthalen-2-yl)propan-1-ol + NAD+
show the reaction diagram
-
18 h, 96% yield, 98% enantiomeric excess
-
-
?
2-(naphthalen-1-yl)propanal + NADH + H+
(S)-2-(naphthalen-1-yl)propanol + NAD+
show the reaction diagram
-
18 h, 90% yield, 80% enantiomeric excess
-
-
?
2-(naphthalen-2-yl)propanal + NADH + H+
(S)-2-(naphthalen-2-yl)propanol + NAD+
show the reaction diagram
-
18 h, 57% yield, 94% enantiomeric excess
-
-
?
2-acetylcyclohexanone + NADH + H+
2-acetylcyclohexanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylcyclopentanone + NADH + H+
2-acetylcyclopentanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylfuran + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylpyridine + NADH + H+
(R)-1-(2-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylpyrrole + NADH + H+
1-(1H-pyrrol-2-yl)ethanol + NAD+
show the reaction diagram
-
70% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-acetylpyrrole + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylthiazole + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylthiophene + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-aminoethanol + NAD+
?
show the reaction diagram
-
-
-
?
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
2-butanone + NADH + H+
2-butanol + NAD+
show the reaction diagram
2-butanone + NADH + H+
butan-2-ol + NAD+
show the reaction diagram
-
2.8fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
2-butanone + NADPH + H+
butan-2-ol + NADP+
show the reaction diagram
2-butene-1-ol + NAD+
? + NADH
show the reaction diagram
2-chloroacetophenone + NADH + H+
1-(2-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
low activity
-
-
r
2-chlorocyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
3% activity compared to cyclohexanone
-
-
?
2-decalone + NADH + H+
? + NAD+
show the reaction diagram
28% activity compared to cyclohexanone
-
-
?
2-decanol + NAD+
2-decanone + NADH + H+
show the reaction diagram
weak activity
-
-
r
2-decanone + NADH
(S)-2-decanol + NAD+ + H+
show the reaction diagram
-
-
92% enantiomeric excess
-
?
2-deoxy-D-ribose + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-ethoxyethanol + NAD+
2-ethoxyacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
2-ethylhexan-1-ol + NAD+
2-ethylhexanal + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
weak activity
-
-
?
2-fluoro-1-(4-chlorophenyl)ethanone + propan-2-ol
(1R)-2-fluoro-1-(4-chlorophenyl)ethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 98% enantiomeric excess
-
?
2-fluoro-1-(4-fluorophenyl)ethanone + propan-2-ol
(1R)-2-fluoro-1-(4-fluorophenyl)ethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 97% enantiomeric excess
-
?
2-fluoro-1-(4-iodophenyl)ethanone + propan-2-ol
(1R)-2-fluoro-1-(4-iodophenyl)ethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 99% enantiomeric excess
-
?
2-fluoro-1-phenylethanone + propan-2-ol
(1R)-2-fluoro-1-phenylethanol + acetone
show the reaction diagram
in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH
99% conversion, 99% enantiomeric excess
-
?
2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
2-heptanol + NAD+
heptan-2-one + NADH + H+
show the reaction diagram
62% of the activity with 1-phenylethanol
-
-
?
2-heptanone + NADH
(S)-2-heptanol + NAD+ + H+
show the reaction diagram
-
-
79% enantiomeric excess
-
?
2-heptanone + NADH + H+
(R)-2-heptanol + NAD+
show the reaction diagram
-
229% of the activity with phenyl trifluoromethyl ketone
99% enantiomeric excess
-
?
2-heptanone + NADPH + H+
heptan-2-ol + NADP+
show the reaction diagram
2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
2-hexanone + NADH
(S)-2-hexanol + NAD+ + H+
show the reaction diagram
-
-
37% enantiomeric excess
-
?
2-hexanone + NADH + H+
2-hexanol + NAD+
show the reaction diagram
-
-
-
-
r
2-hexanone + NADH + H+
?
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
2-hexanone + NADH + H+
hexan-2-ol + NAD+
show the reaction diagram
-
50.4fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
2-hexanone + NADPH + H+
hexan-2-ol + NADP+
show the reaction diagram
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
show the reaction diagram
2-hydroxyacetophenone + NADPH + H+
(S)-1-phenyl-1,2-ethanediol + NADP+
show the reaction diagram
-
-
-
?
2-hydroxymethylpyrene + NAD+
2-formylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
2-mercaptoethanol + NAD+
?
show the reaction diagram
2-methoxybenzaldehyde + NADH + H+
2-methoxybenzylalcohol + NAD+
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
2-methoxybenzyl alcohol + NAD+
2-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
25% of the activity with (S)-(-)-1-phenylethanol
-
-
?
2-methoxyethanol + NAD+
2-methoxyacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
r
2-methyl-2,4-pentanediol + NAD+
?
show the reaction diagram
1% activity compared to cyclohexanol
-
-
?
2-methylbutan-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-methylbutyraldehyde + NADH + H+
2-methylbutanol + NAD+
show the reaction diagram
-
1.4% of the activity with acetaldehyde
-
-
?
2-methylcyclohexanone + NADH + H+
2-methylcyclohexanol + NAD+
show the reaction diagram
13% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
46% activity compared to cyclohexanone
-
-
?
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH
show the reaction diagram
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH + H+
show the reaction diagram
2-methylpropionaldehyde + NADH + H+
2-methylpropanal + NAD+
show the reaction diagram
-
3.3% of the activity with acetaldehyde
-
-
?
2-nitrobenzaldehyde + NADH + H+
(2-nitrophenyl)methanol + NAD+
show the reaction diagram
-
33% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-nitrobenzaldehyde + NADH + H+
2-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
low activity
-
-
r
2-nonanol + NAD+
2-nonanone + NADH + H+
show the reaction diagram
weak activity
-
-
r
2-nonanone + NADH
(S)-2-nonanol + NAD+ + H+
show the reaction diagram
-
-
95% enantiomeric excess
-
?
2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
2-octanone + NADH
(S)-2-octanol + NAD+ + H+
show the reaction diagram
-
-
92% enantiomeric excess
-
?
2-octanone + NADH + H+
2-octanol + NAD+
show the reaction diagram
-
-
-
-
r
2-octanone + NADPH + H+
octan-2-ol + NADP+
show the reaction diagram
11.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-oxo-3-methylpentane + NADH
3-methylpentan-2-ol + NAD+
show the reaction diagram
2-oxo-3-phenylpropane + NADH
2-hydroxy-3-phenylpropane + NAD+
show the reaction diagram
2-oxo-4-methylpentane + NADH
4-methylpentan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-butyric acid + NADH + H+
2-hydroxybutyric acid + NAD+
show the reaction diagram
-
15% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-oxohexane + NADH
2-hydroxyhexane + NAD+
show the reaction diagram
-
-
-
-
?
2-oxopentane + NADH
2-pentanol + NAD+
show the reaction diagram
-
-
-
-
?
2-oxopentanoate + NADH + H+
2-hydroxypentanoate + NAD+
show the reaction diagram
-
low activity
-
-
r
2-oxopropanal + NADH + H+
? + NAD+
show the reaction diagram
328% of the activity with acetoin
-
-
r
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
2-pentanone + NADH
(S)-2-pentanol + NAD+ + H+
show the reaction diagram
-
-
60% enantiomeric excess
-
?
2-pentanone + NADH
pentan-2-ol + NAD+
show the reaction diagram
-
-
-
r
2-pentanone + NADH + H+
2-pentanol + NAD+
show the reaction diagram
2-pentanone + NADPH + H+
pentan-2-ol + NADP+
show the reaction diagram
11.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-phenylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
2-phenylethanol + NAD+
2-phenylethanone + NADH + H+
show the reaction diagram
57% activity compared to cyclohexanol
-
-
r
2-phenylethanol + NAD+
phenylacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
2-phenylpropanal + NADH + H+
(S)-2-phenylpropanol + NAD+
show the reaction diagram
-
18 h, 74% yield, 98% enantiomeric excess
-
-
?
2-propanol + NAD(P)+
acetone + NAD(P)H
show the reaction diagram
2-propanol + NAD+
2-propanone + NADH
show the reaction diagram
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
2-propanol + NAD+
aceton + NADH + H+
show the reaction diagram
-
-
irreversible, no measurable activity with acetone
-
ir
2-propanol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
2-propanol + NAD+
propanone + NADH + H+
show the reaction diagram
-
-
-
-
r
2-[3-(2-phenyl-1,3-dioxolan-2-yl)phenyl]propanal + NADH + H+
(S)-2-(3-(2-phenyl-1,3-dioxolan-2-yl)phenyl)propanol + NAD+
show the reaction diagram
-
18 h, 95% yield, 61% enantiomeric excess
-
-
?
3',4'-dimethoxyphenylacetone + NADH + H+
1-(3,4-dimethoxyphenyl)propan-2-ol + NAD+
show the reaction diagram
-
24% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-bromoacetophenone + NADH + H+
1-(3-bromophenyl)ethanol + NAD+
show the reaction diagram
-
151% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-chloroacetophenone + NADH + H+
1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
70% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-methoxyacetophenone + NADH + H+
1-(3-methoxyphenyl)ethanol + NAD+
show the reaction diagram
-
51% of the activity with phenyl trifluoromethyl ketone
-
-
?
3,3,5-trimethylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
3,4-dihydro-retinol + NAD+
3,4-dihydro-retinal
show the reaction diagram
-
-
-
-
r
3,4-dimethylbenzyl alcohol + NAD+
3,4-dimethylbenzaldehyde + NADH + H+
show the reaction diagram
45% activity compared to cyclohexanol
-
-
r
3,4-hexanedione + NADH + H+
?
show the reaction diagram
-
77% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
3,4-methylenedioxyphenyl acetone + NADH
(S)-(3,4-methylenedioxyphenyl)-2-propanol + NAD+ + H+
show the reaction diagram
-
-
-
-
-
3,5-dimethylcyclohexanol + NAD+
3,5-dimethylcyclohexanone + NADH + H+
show the reaction diagram
1% activity compared to cyclohexanol
-
-
r
3-acetylpyridine + NADH + H+
(R)-1-(3-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
3-acetylpyridine + NADH + H+
1-pyridin-3-ylethanol + NAD+
show the reaction diagram
-
7.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
3-aminobenzyl alcohol + NAD+
3-aminobenzaldehyde + NADH + H+
show the reaction diagram
8% activity compared to cyclohexanol
-
-
r
3-bromobenzyl alcohol + NAD+
3-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-bromobenzylalcohol + NAD+
3-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-butene-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-chloro-2-butanone + NADH + H+
3-chlorobutan-2-ol + NAD+
show the reaction diagram
-
151% of the activity with phenyl trifluoromethyl ketone
-
-
?
3-chlorobenzaldehyde + NADH + H+
3-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
3-heptanol + NAD+
3-heptanone + NADH + H+
show the reaction diagram
-
93% of the activity with 2-propanol
-
-
r
3-methoxy-1-phenylpropan-1-one + NADH
3-methoxy-1-phenylpropan-1-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methoxybenzaldehyde + NADH + H+
3-methoxybenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
3-methoxybenzaldehyde + NADH + H+
3-methoxybenzylalcohol + NAD+
show the reaction diagram
-
14% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
show the reaction diagram
3-methoxybenzylalcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-methyl-1-butanol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-methyl-2-cyclohexenone + NADH + H+
? + NAD+
show the reaction diagram
1% activity compared to cyclohexanone
-
-
?
3-methylbutan-1-ol + NAD+
3-methyl-butan-1-one + NADH + H+
show the reaction diagram
3-methylbutan-2-ol + NAD+
3-methylbutan-2-one + NADH
show the reaction diagram
-
R-(-)-3-methylbutan-2-ol and S-(+)-3-methylbutan-2-ol
-
-
?
3-methylbutan-2-one + NADH
3-methylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methylbutan-2-one + NADH + H+
3-methyl-2-butanol + NAD+
show the reaction diagram
-
-
-
-
r
3-methylbutan-2-one + NADH + H+
3-methylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methylbutanal + NAD+
? + NADH + H+
show the reaction diagram
3-methylbutanol + NAD+
3-methylbutanone + NADH + H+
show the reaction diagram
133% activity compared to cyclohexanol
-
-
r
3-methylbutanol + NAD+
? + NADH
show the reaction diagram
3-methylbutyraldehyde + NADH + H+
3-methylbutanol + NAD+
show the reaction diagram
-
2.9% of the activity with acetaldehyde
-
-
?
3-methylcyclohexanol + NAD+
3-methylcyclohexanone + NADH
show the reaction diagram
-
-
-
-
r
3-methylcyclohexanol + NAD+
3-methylcyclohexanone + NADH + H+
show the reaction diagram
14% of activity compared to (S)-1-indanol
-
-
?
3-methylcyclohexanol + NAD+
?
show the reaction diagram
10% of the activity compared to isoborneol
-
-
?
3-methylcyclohexanone + NADH
3-methylcyclohexanol + NAD+
show the reaction diagram
3-methylcyclohexanone + NADH + H+
3-methylcyclohexanol + NAD+
show the reaction diagram
33% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
3-methylphenylethyl alcohol + NAD+
?
show the reaction diagram
64% activity compared to cyclohexanol
-
-
?
3-nitroacetophenone + NADH + H+
1-(3-nitrophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
3-nitrobenzaldehyde + NADH + H+
3-nitrobenzyl alcohol + NAD+
show the reaction diagram
3-oxo-5beta-androstan-17beta-ol + NADH
3beta,17beta-dihydroxy-5beta-androstane + NAD+
show the reaction diagram
3-oxoheptane + NADH
3-hydroxyheptane + NAD+
show the reaction diagram
-
-
-
-
?
3-pentanol + NAD+
3-pentanone + NADH + H+
show the reaction diagram
3-pentanone + NADH
pentan-3-ol + NAD+
show the reaction diagram
-
-
-
r
3-pentanone + NADPH + H+
pentan-3-ol + NADP+
show the reaction diagram
7.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
3-penten-2-one + NADH + H+
? + NAD+
show the reaction diagram
2% activity compared to cyclohexanone
-
-
?
3-phenyl-1-propanol + NAD+
3-phenyl-1-propanone + NADH
show the reaction diagram
3-phenyl-2-propen-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-phenylpropanol + NAD+
3-phenylpropanal + NADH + H+
show the reaction diagram
-
135% of the activity with 2-phenylethanol
-
-
?
3-phenylpropionaldehyde + NADH
3-phenylpropan-1-ol + NAD+
show the reaction diagram
-
1218% of the activity with phenyl trifluoromethyl ketone
-
-
?
3-phenylpropionaldehyde + NADH + H+
3-phenylpropanol + NAD+
show the reaction diagram
-
6.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
3-pyridylcarbinol + NAD+
pyridine-3-carbaldehyde + NADH
show the reaction diagram
-
-
-
-
?
3beta,12alpha-dihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta,17beta-dihydroxy-5beta-androstane + NAD+
5beta-androstan-3,17dione + NADH
show the reaction diagram
-
-
-
-
?
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta,7alpha-dihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta-hxdroxy-5alpha-cholanoate + NAD+
3-oxo-5alpha-cholanoate + NADH
show the reaction diagram
-
-
-
-
?
3beta-hydroxy-5beta-androstan-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
3beta-hydroxy-5beta-cholanoate + NAD+
3-oxo-5beta-cholanoate + NADH
show the reaction diagram
-
-
-
-
?
4'-bromoacetophenone + NADH + H+
1-(4-bromophenyl)ethanol + NAD+
show the reaction diagram
-
77% of the activity with phenyl trifluoromethyl ketone
-
-
?
4'-chloroacetophenone + NADH + H+
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
60% of the activity with phenyl trifluoromethyl ketone
-
-
?
4'-chlorobutyrophenone + NADH + H+
1-(4-chlorophenyl)butan-1-ol + NAD+
show the reaction diagram
-
10% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
4-acetylpyridine + NADH + H+
(R)-1-(4-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-acetylpyridine + NADH + H+
1-pyridin-4-ylethanol + NAD+
show the reaction diagram
-
64.5fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
4-bromobenzyl alcohol + NAD+
4-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
4-bromobenzylalcohol + NAD+
4-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADH + H+
4-carboxybenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADH + H+
4-carboxybenzylalcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-chloroacetophenone + NADH
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
4-chloroacetophenone + NADH + H+
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-chlorobenzaldehyde + NADH + H+
4-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
4-ethylcyclohexanol + NAD+
4-ethylcyclohexanone + NADH + H+
show the reaction diagram
60% activity compared to cyclohexanol
-
-
r
4-ethylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
22% activity compared to cyclohexanone
-
-
?
4-fluoroacetophenone + NADH + H+
1-(4-fluorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-hydroxy-2-butanone + NADH + H+
2,4-dihydroxybutane + NAD+
show the reaction diagram
-
26% of the activity with phenyl trifluoromethyl ketone
-
-
?
4-hydroxy-retinol + NAD+
4-oxo-retinal + NADH
show the reaction diagram
-
-
-
-
r
4-hydroxymethylpyrene + NAD+
4-formylpyrene + NADH + H+
show the reaction diagram
-
-
-
r
4-hydroxynonenal + NADH + H+
4-hydroxynonenol + NAD+
show the reaction diagram
-
substrate of isozyme ADH4
-
-
r
4-methoxy-1-naphthaldehyde + NAD+
4-methoxy-1-naphthol + NADH + H+
show the reaction diagram
-
fluorogenic substrate of class I and II isozymes
-
-
?
4-methoxy-1-naphthaldehyde + NAD+
4-methoxy-1-naphthyl alcohol + NADH + H+
show the reaction diagram
-
substrate for class I ADH
-
-
?
4-methoxy-1-naphthaldehyde + NADH + H+
4-methoxynaphthalene-1-carbaldehyde + NAD+
show the reaction diagram
-
substrate for class I ADH
-
-
r
4-methoxybenzaldehyde + NADH + H+
4-methoxybenzyl alcohol + NAD+
show the reaction diagram
-
-
51% of the activity with butan-2-ol
-
?
4-methoxybenzaldehyde + NADH + H+
4-methoxybenzylalcohol + NAD+
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
4-methoxybenzyl alcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
show the reaction diagram
4-methoxybenzylalcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
4-methoxyphenylacetone + NADH
(2S)-1-(4-methoxyphenyl)propan-2-ol + NAD+ + H+
show the reaction diagram
-
-
-
-
?
4-methyl-1-pentanol + NAD+
4-methyl-1-pentanal + NADH
show the reaction diagram
4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH + H+
show the reaction diagram
56% activity compared to cyclohexanol
-
-
r
4-methylcyclohexanone + NADH + H+
4-methylcyclohexanol + NAD+
show the reaction diagram
60% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
4-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
25% activity compared to cyclohexanone
-
-
?
4-methylpentan-2-one + NADH + H+
4-methyl-2-pentanol + NAD+
show the reaction diagram
-
-
-
-
r
4-nitrobenzaldehyde + NADH + H+
4-nitrobenzyl alcohol + NAD+
show the reaction diagram
4-nitrobenzaldehyde + NADH + H+
4-nitrobenzylalcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-nitrobenzyl alcohol + NAD+
4-nitrobenzaldehyde + NADH + H+
show the reaction diagram
94% activity compared to benzyl alcohol
-
-
?
4-nitrosodimethylaniline + NAD+
? + NADH + H+
show the reaction diagram
-
photometric assay substrate
-
-
?
4-phenylbutan-2-one + NADH
4-phenylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
5-acetyl-7-chlorofuro[2,3-c]pyridine + NADH + H+
5-(1-hydroxyethyl)-7-chlorofuro[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
5-acetylfuro[2,3-c]pyridine + NADH + H+
5-(1-hydroxyethyl)furo[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
5-hydroxymethylfurfural + NADH + H+
(furan-2,5-diyl)dimethanol + NAD+
show the reaction diagram
5alpha-androstan-17beta-ol-3-one + NADH + H+
3beta,17beta-dihydroxy-5alpha-androstan + NAD+
show the reaction diagram
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH
show the reaction diagram
-
low activity
-
-
?
5beta-androstan-17beta-ol-3-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
5beta-androstan-3beta-ol-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
5beta-cholanic acid-3-one + NAD+
5beta-cholanic acid-3-ol + NAD+
show the reaction diagram
-
-
-
-
?
5beta-cholanic acid-3-one + NADH
5beta-cholanic acid-3-ol + NAD+
show the reaction diagram
-
low activity
-
-
?
5beta-pregnan-21-ol-3,20-dione hemisuccinate + NADH
5beta-pregnan-3,20,21-trione hemisuccinate + NADH
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3,20-dione + NADH
?
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3beta-ol-20-one + NAD+
5beta-pregnan-3,20-dione + NADH
show the reaction diagram
-
-
-
-
?
6-benzyloxy-3,5-dioxo-hexanoic acid ethyl ester + NADH + H+
(3R,5S)-6-benzyloxy-3,5-dihydroxy-hexanoic acid ethyl ester + NAD+
show the reaction diagram
-
-
-
-
-
6-methoxy-2-naphthaldehyde + NADH + H+
(6-methoxynaphthalen-2-yl)methanol + NAD+
show the reaction diagram
-
substrate for class II ADH
-
-
r
6-methoxy-2-naphthaldehyde + NADH + H+
6-methoxy-2-naphthyl alcohol + NAD+
show the reaction diagram
-
substrate for class II ADH
-
-
?
6-methoxy-2-naphthaldehyde + NADH + H+
6-methoxy-2-naphtol + NAD+
show the reaction diagram
-
class II isozyme, reductive activity
-
-
?
7-cis-retinol + NAD+
7-cis-retinal + NADH
show the reaction diagram
9-cis-retinol + NAD+
9-cis-retinal + NADH
show the reaction diagram
a primary alcohol + NAD+
an aldehyde + NADH + H+
show the reaction diagram
-
ADH3 is involved in multiple cellular pathways, as diverse as formaldehyde detoxification, retinoid metabolism and NO homeostasis, ADH3 is considered to play only a minor role in hepatic alcohol metabolism because ethanol concentrations rarely exceed 50 mM
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
acetaldehyde + NADH + H+
ethanol + NAD+ + H+
show the reaction diagram
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
acetoin + NAD+
diacetyl + NADH
show the reaction diagram
18% of the activity with 2,3-butanediol
-
-
?
acetoin + NADH + H+
2,3-butanediol + NAD+
show the reaction diagram
-
-
-
r
acetoin + NADH + H+
3-hydroxy-2-butanol + NAD+
show the reaction diagram
-
-
-
-
r
acetoin + NADH + H+
butan-2,3-diol + NAD+
show the reaction diagram
-
-
-
?
acetone + NAD+ + H2O
? + NADH + H+
show the reaction diagram
about 5% of the activity with 1-octanol
-
-
r
acetone + NADH
isopropanol + NAD+
show the reaction diagram
acetone + NADH + H+
2-propanol + NAD+
show the reaction diagram
-
-
-
-
?
acetone + NADH + H+
propan-2-ol + NAD+
show the reaction diagram
-
1.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
acetone + NADPH + H+
propan-2-ol + NADP+
show the reaction diagram
14.7% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
acetophenone + NADH
(R)-alpha-phenyl ethanol + NAD+
show the reaction diagram
-
the enzyme exhibits high stereoselectivity in the desymmetrization of the prochiral ketone acetophenone, producing optically pure (R)-alpha-phenyl ethanol at high conversion
-
-
?
acetophenone + NADH + H+
(R)-1-phenylethanol + NAD+
show the reaction diagram
-
6% of the activity with phenyl trifluoromethyl ketone, in the reverse reaction 87% of the activity with 2-propanol
99% enantiomeric excess
-
?
acetophenone + NADH + H+
(S)-(-)-1-phenylethanol + NAD+
show the reaction diagram
-
more than 99% enantiomeric excess
-
-
r
acetophenone + NADH + H+
(S)-1-phenylethanol + NAD+
show the reaction diagram
-
-
99% enantiomeric excess
-
r
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
acetophenone + NADPH + H+
1-phenylethanol + NADP+
show the reaction diagram
acetylacetone + 2 NADH + 2 H+
2,4-pentanediol + 2 NAD+
show the reaction diagram
-
-
-
-
r
acetylacetone + NADH + H+
?
show the reaction diagram
-
63% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
acetylacetone + NADH + H+
acetophenone + NADH + H+
show the reaction diagram
1% activity compared to cyclohexanone
1% activity compared to cyclohexanone
-
r
acetylpyrazine + NADH + H+
(R)-1-(pyrazyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
alcohol + NAD+
aldehyde or ketone + NADH
show the reaction diagram
all-trans retinal + NADH + H+
all-trans retinol + NAD+
show the reaction diagram
26.8% of the activity with butan-1-ol
-
-
?
all-trans-retinal + NADH + H+
all-trans-retinol + NAD+
show the reaction diagram
-
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
allyl alcohol + NAD+
acrolein + NADH
show the reaction diagram
allyl alcohol + NAD+
prop-2-en-1-al + NADH
show the reaction diagram
allylalcohol + NAD+
prop-2-enal + NADH + H+
show the reaction diagram
-
-
-
?
alpha-ethyl benzoylformate + NADH + H+
ethyl (R)-()-mandelate + NAD+
show the reaction diagram
-
-
95% enantiomeric excess
-
r
alpha-methyl benzoylformate + NADH + H+
methyl (R)-mandelate + NAD+
show the reaction diagram
-
-
92% enantiomeric excess
-
r
alpha-tetralone + NADH + H+
(S)-alpha-tetralol + NAD+
show the reaction diagram
alpha-tetralone + NADH + H+
alpha-tetralol + NAD+
show the reaction diagram
-
-
-
-
r
anisaldehyde + NADH
anisic alcohol + NADH
show the reaction diagram
-
-
-
-
?
anisaldehyde + NADH + H+
anisic alcohol + NAD+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADH
benzyl alcohol + NAD+
show the reaction diagram
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
show the reaction diagram
107% of the activity with (2E)-but-2-enal, yield 99% after 12 h
-
-
r
benzil + NADH + H+
(R)-benzoin + NAD+
show the reaction diagram
62% of the activity compared to 1-phenyl-1,2-propanedione. The enzyme catalyses the asymmetric reduction of benzil to (R)-benzoin with both excellent conversion (98%) and optical purity (98%) by way of an efficient in situ NADH-recycling system involving a second thermophilic ADH
-
-
?
benzoin + NADH + H+
1,2-diphenylethane-1,2-diol
show the reaction diagram
-
13% of activity with N-benzyl-3-pyrrolidinone
-
-
?
benzoylformic acid + NADPH + H+
mandelate + NADP+
show the reaction diagram
2.4% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
benzyl aclohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + acycloNADH + H+
show the reaction diagram
-
acycloNAD+ i.e. NAD+-analogue, where the nicotinamide ribosyl moiety has been replaced by the nicotinamide (2-hydroxyethoxy)methyl moiety
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
show the reaction diagram
-
-
-
r
benzylacetone + NADH + H+
4-phenylbutan-2-ol + NAD+
show the reaction diagram
benzylalcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
benzyloxycarbonyl-3-pyrrolidinone + NADH + H+
(S)-benzyloxycarbonyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
production with 99.6% enantiomeric excess
-
-
?
butan-1-ol + NAD+
butanal + acycloNADH + H+
show the reaction diagram
-
acycloNAD+ i.e. NAD+-analogue, where the nicotinamide ribosyl moiety has been replaced by the nicotinamide (2-hydroxyethoxy)methyl moiety
-
-
?
butan-1-ol + NAD+
butanal + NADH + H+
show the reaction diagram
butan-2,3-diol + NAD+
acetoin + NADH + H+
show the reaction diagram
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
butan-2-ol + NAD+
butanone + NADH + H+
show the reaction diagram
-
-
83% of the activity with butan-2-ol
-
?
butan-2-one + NADH
butan-2-ol + NAD+
show the reaction diagram
butanal + NADH
1-butanol + NAD+ + H+
show the reaction diagram
-
% of the activity with phenyl trifluoromethyl ketone
-
-
ir
butanal + NADH + H+
butan-1-ol + NAD+
show the reaction diagram
-
-
-
r
butanol + NAD+
1-butanal + NADH + H+
show the reaction diagram
butanol + NAD+
butanal + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
butanol + NAD+
butyraldehyde + NADH + H+
show the reaction diagram
butanol + NAD+
n-butanal + NADH
show the reaction diagram
-
-
-
?
butyraldehyde + NAD+
n-butanol + NADH + H+
show the reaction diagram
-
-
-
-
r
butyraldehyde + NADH
n-butanol + NAD+
show the reaction diagram
butyraldehyde + NADH + H+
butanol + NAD+
show the reaction diagram
-
56% of the activity with acetaldehyde
-
-
?
butyraldehyde + NADH + H+
n-butanol + NAD+
show the reaction diagram
butyraldehyde + NADPH + H+
butanol + NADP+
show the reaction diagram
-
22% of the activity with NADH
-
-
?
capronaldehyde + NADH
1-hexanol + NAD+
show the reaction diagram
chloroacetone + NADH + H+
1-chloro-2-propanol + NAD+
show the reaction diagram
-
-
-
-
r
chloroacetone + NADH + H+
1-chloropropan-2-ol + NAD+
show the reaction diagram
choline + NAD+
? + NADH + H+
show the reaction diagram
3% activity compared to benzyl alcohol
-
-
?
cinnamaldehyde + NADH + H+
cinnamyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
cinnamyl alcohol + NAD+
cinnamaldehyde + NADH
show the reaction diagram
cinnamyl alcohol + NAD+
cinnamaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
cis-4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cis-decahydro-1-naphthol + NAD+
?
show the reaction diagram
11% of activity compared to (S)-1-indanol
-
-
?
crotyl alcohol + NAD+
crotonaldehyde + NADH
show the reaction diagram
cycloheptanol + NAD+
cycloheptanone + NADH + H+
show the reaction diagram
cycloheptanone + NADH
cycloheptanol + NAD+
show the reaction diagram
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
cyclohexanol + NAD+
cyclohexanone + NADH + H+
show the reaction diagram
cyclohexanone + NADH
cyclohexanol + NAD+
show the reaction diagram
cyclohexanone + NADH + H+
?
show the reaction diagram
-
activity is 2.1fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
cyclohexanone + NADH + H+
cyclohexanol + NAD+
show the reaction diagram
cyclooctanone + NADH
cyclooctanol + NAD+
show the reaction diagram
-
-
-
-
?
cyclopentanol + NAD+
? + NADH
show the reaction diagram
cyclopentanol + NAD+
cyclopentanone + NADH + H+
show the reaction diagram
cyclopentanone + NADH
cyclopentanol + NAD+
show the reaction diagram
-
-
-
-
?
cyclopentanone + NADH + H+
? + NAD+
show the reaction diagram
1% activity compared to cyclohexanone
-
-
?
cyclopetanone + NADH
cyclopentanol + NADH
show the reaction diagram
-
-
-
-
?
D-arabinose + NADH + H+
D-arabitol + NAD+
show the reaction diagram
66% of the activity with 2,3-butanediol
-
-
?
D-glucitol + NAD+
? + NADH
show the reaction diagram
decahydro-2-naphthol + NAD+
?
show the reaction diagram
37% activity compared to cyclohexanol
-
-
?
decyl aldehyde + NADH + H+
1-decanol + NAD+
show the reaction diagram
21% activity compared to benzyl alcohol
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?
diacetyl + NADH + H+
2,3-butandiol + NAD+
show the reaction diagram
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r
diacetyl + NADH + H+
?
show the reaction diagram
diacetyl + NADH + H+
acetoin + NAD+
show the reaction diagram
150% of the activity with acetoin
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?