Information on EC 1.1.1.1 - alcohol dehydrogenase

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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

EC NUMBER
COMMENTARY
1.1.1.1
-
RECOMMENDED NAME
GeneOntology No.
alcohol dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
ordered bi bi mechanism with cofactor adding first to form a binary enzyme complex
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
ordered bi-bi mechanism
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
isoenzyme EE and SS: ordered bi bi mechanism
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
Theorell-Chance mechanism
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
kinetic mechanism is random for ethanol oxidation and compulsory ordered for acetaldehyde reduction
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
ordered bi-bi mechanism
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
rapid equilibrium random mechanism
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
Theorell-Chance mechanism
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
Theorell-Chance mechanism
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
oxidizes ethanol in an ordered bi-bi mechanism with NAD+ as the first substrate fixed
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
compulsory-order mechanism with the rate-limiting step being the dissociation of the product enzyme-NAD+ complex
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
mechanism is predominantly ordered with ethanol, but partially random with butanol
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
Ser48 is involved in catalysis, isozyme gamma(2)gamma(2)
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
ordered bibi mechanism, structural and functional implications of amino acid residue 47
Q9QYY9
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
reaction mechanism, His51 is involved, but not essential, in catalysis facilitating the deprotonation of the hydroxyl group of water or alcohol ligated to the catalytic zinc
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
sequential reaction mechanism
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
ordered sequential bibi reaction mechanism, modeling of oxidation kinetic mechanism
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
detailed determination of the reaction and kinetic mechanisms, active site structure and determination of amino acid residues involved in catalysis, 3 isozymes
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
class IV alcohol dehydrogenase also functions as retinol dehydrogenase, reaction and kinetic mechanism: asymmetric rapid equilibrium random mechanism with 2 dead-end ternary complexes fro retinol oxidation and a rapid equilibrium ordered mechanism with one dead-end ternary complex for retinal reduction, a unique mechanistic form fro zinc-containing ADH in the medium chain dehydrogenase/reductase superfamily of enzymes
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
active site structure
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
the catalytic triad consists of Cys44, His67, and Cys154, active site structure
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
catalytic mechanism involves a proton relay modulated by the coupled ionization of the active site Lys155/Tyr151 pair, and a NAD+ ribose 2'-OH switch, other active site residues are Ser138 and Trp144, ionization properties, substrate binding, overview
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
oxidizes ethanol in an ordered bi-bi mechanism with NAD+ as the first substrate fixed
Meyerozyma guilliermondii B10-05
-
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
the catalytic triad consists of Cys44, His67, and Cys154, active site structure
Pseudomonas aeruginosa PaADH
-
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
sequential reaction mechanism
Rhodococcus ruber DSM44541
-
-
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
-
-
-
-
a secondary alcohol + NAD+ = a ketone + NADH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
redox reaction
-
-
redox reaction
-
-
redox reaction
-
-
redox reaction
-
-
redox reaction
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
3-methylbutanol biosynthesis
-
acetaldehyde biosynthesis I
-
acetoin degradation
-
acetylene degradation
-
Biosynthesis of secondary metabolites
-
butanol and isobutanol biosynthesis (engineered)
-
chitin degradation to ethanol
-
Chloroalkane and chloroalkene degradation
-
Drug metabolism - cytochrome P450
-
ethanol degradation I
-
ethanol degradation II
-
Fatty acid degradation
-
Glycine, serine and threonine metabolism
-
Glycolysis / Gluconeogenesis
-
heterolactic fermentation
-
isoleucine degradation II
-
L-1,2-propanediol degradation
-
leucine degradation III
-
Metabolic pathways
-
Metabolism of xenobiotics by cytochrome P450
-
methionine degradation III
-
Microbial metabolism in diverse environments
-
mixed acid fermentation
-
Naphthalene degradation
-
noradrenaline and adrenaline degradation
-
phenylalanine degradation III
-
phenylethanol biosynthesis
-
phytol degradation
-
pyruvate fermentation to ethanol I
-
pyruvate fermentation to ethanol II
-
pyruvate fermentation to ethanol III
-
pyruvate fermentation to isobutanol (engineered)
-
Retinol metabolism
-
salidroside biosynthesis
-
serotonin degradation
-
superpathway of fermentation (Chlamydomonas reinhardtii)
-
tryptophan degradation V (side chain pathway)
-
tyrosine degradation III
-
Tyrosine metabolism
-
valine degradation II
-
SYSTEMATIC NAME
IUBMB Comments
alcohol:NAD+ oxidoreductase
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
(R)-specific alcohol dehydrogenase
-
-
(R)-specific alcohol dehydrogenase
Candida maris IFO10003
-
-
-
40 kDa allergen
-
-
-
-
ADH
-
-
-
-
ADH
Acetobacter pasteurianus SKU1108
-
-
-
ADH
Q1G151
-
ADH
Q9ZT38
-
ADH
Glycine max Enrei
Q9ZT38
-
-
ADH
Pseudomonas aeruginosa PaADH
-
-
-
ADH
Sulfolobus solfataricus DSM1617, Sulfolobus solfataricus Gtheta
-
-
-
ADH
P50381
-
ADH
P50381
-
-
ADH
B2ZRE3
-
ADH
B2ZRE3
-
-
ADH 1
-
-
ADH class III
P86884
-
ADH-10
P39462
-
-
ADH-A2
-
-
-
-
ADH-B2
-
-
-
-
ADH-C2
-
-
-
-
ADH-HT
-
-
-
-
ADH-I
Geobacillus thermoglucosidasius M10EXG
Q6RS93
-
-
ADH1
-
-
ADH1
Q9P6C8
-
ADH1
Neurospora crassa FGSC2489
Q9P6C8
-
-
ADH1
Q76HN6
-
ADH1
Pseudomonas putida S-5
Q76HN6
-
-
ADH1
Saccharomyces carlsbergensis Y379-50
B6UQD0
-
-
ADH1C
P00326
isozyme
ADH1C*1
-
-
ADH1C*2
-
-
ADH2
Entamoeba histolytica HM1, Entamoeba histolytica HM1:1MSS
-
-
-
ADH2
Q9ZT38
-
ADH2
Glycine max Enrei
Q9ZT38
-
-
ADH2
P00326
isozyme
ADH2
-
-
ADH2
Q9UXF1
-
-
ADH3
-
-
-
-
ADH3
P00326
isozyme
ADH3
Neurospora crassa FGSC2489
-
-
-
ADH4
-
-
ADH4
P08319
isozyme
ADH6Hp
Rhodococcus ruber 219
-
-
-
ADH8
-
-
AdhC
Q8U259
-
AdhE
Q0PH30
the purified AdhE exhibits high enzymatic activity attributed to aldehyde dehydrogenase and low alcohol dehydrogenase activity
AdhE
Thermoanaerobacter ethanolicus JW200
Q0PH30
the purified AdhE exhibits high enzymatic activity attributed to aldehyde dehydrogenase and low alcohol dehydrogenase activity
-
AFPDH
-
-
AFPDH
Candida maris IFO10003
-
-
-
alcohol dehydrogenase
-
-
alcohol dehydrogenase (NAD)
-
-
-
-
alcohol dehydrogenase 1
-
-
alcohol dehydrogenase 1
-
-
alcohol dehydrogenase 1
-
-
alcohol dehydrogenase 1
-
mutant enzyme S109P/L116S/Y294C
alcohol dehydrogenase 10
P39462
-
alcohol dehydrogenase 10
P39462
-
-
alcohol dehydrogenase 3
-
-
alcohol dehydrogenase 3
H9ZGN0
-
alcohol dehydrogenase 3
Ogataea angusta DL-1, ATCC 26012
H9ZGN0
-
-
alcohol dehydrogenase 5
-
-
alcohol dehydrogenase I
-
-
alcohol dehydrogenase II
-
-
alcohol dehydrogenase II
-
-
Alcohol dehydrogenase-B2
-
-
-
-
alcohol dependent dehydrogenase
-
-
alcohol-aldehyde/ketone oxidoreductase, NAD+-dependent
-
the enzyme transfers the pro-R hydrogen from coenzyme to substrate and is therefore an A-specific dehydrogenase
alcohol:NAD+ oxidoreductase
-
-
aldehyde dehydrogenase
-
-
aldehyde reductase
-
-
-
-
aldehyde/alcohol dehydrogenase
Q0PH30
-
aldehyde/alcohol dehydrogenase
Thermoanaerobacter ethanolicus JW200
Q0PH30
-
-
ALDH
-
-
aliphatic alcohol dehydrogenase
-
-
-
-
class I ADH
-
-
class I ADH
-
isoenzyme
class I ADH
-
isozyme
class I ALDH
P86883
-
class II ADH
-
-
class II ADH
-
isoenzyme
class II ADH
-
isozyme
class III ADH
-
-
class III alcohol dehydrogenase
-
-
class IV ADH
-
-
class IV ADH
-
isozyme
Cm-ADH2
-
-
dehydrogenase, alcohol
-
-
-
-
ethanol dehydrogenase
-
-
-
-
FALDH
-
-
-
-
FDH
-
-
-
-
Gastric alcohol dehydrogenase
-
-
-
-
Glutathione-dependent formaldehyde dehydrogenase
-
-
-
-
GSH-FDH
-
-
-
-
HpADH3
H9ZGN0
-
HpADH3
Ogataea angusta DL-1, ATCC 26012
H9ZGN0
-
-
long-chain alkyl alcohol dehydrogenase
A4IP64, A4ISB9
-
long-chain alkyl alcohol dehydrogenase
A4IP64, A4ISB9
-
-
LSADH
Leifsonia sp.
-
-
LSADH
-
-
-
medium chain alcohol dehydrogenase
-
-
medium-chain NAD+-dependent ADH
-
-
medium-chain secondary alcohol dehydrogenase
-
-
medium-chain secondary alcohol dehydrogenase
Rhodococcus ruber DSM44541
-
-
-
NAD(H)-dependent alcohol dehydrogenase
-
-
NAD+-ADH
-
-
NAD+-dependent (S)-stereospecific alcohol dehydrogenase
P39462
-
NAD+-dependent alcohol dehydrogenase
-
-
NAD+-dependent alcohol dehydrogenase
Oenococcus oeni DSM20252
-
-
-
NAD-dependent alcohol dehydrogenase
-
-
-
-
NAD-dependent medium-chain ADH
F9VMI9
-
NAD-specific aromatic alcohol dehydrogenase
-
-
-
-
NADH-alcohol dehydrogenase
-
-
-
-
NADH-aldehyde dehydrogenase
-
-
-
-
NADH-dependent alcohol dehydrogenase
-
-
NADH-dependent alcohol dehydrogenase
Candida maris IFO10003
-
-
-
Octanol dehydrogenase
-
-
-
-
PF0991 protein
Q8U259
-
primary alcohol dehydrogenase
-
-
-
-
Retinol dehydrogenase
-
-
-
-
sec-ADH A
-
-
sec-ADH A
Rhodococcus ruber DSM44541
-
-
-
short-chain ADH
Q4J702
-
short-chain ADH
Q4J702
-
-
short-chain dehydrogenase/reductase
C6A190
-
short-chain dehydrogenase/reductase
C6A190
-
-
short-chain NAD(H)-dependent dehydrogenase/reductase
Q4J702
-
short-chain NAD(H)-dependent dehydrogenase/reductase
Q4J702
-
-
SsADH-10
P39462
-
SsADH-10
P39462
-
-
SSO2536
P39462
locus name
SSO2536
P39462
locus name
-
ST0053
F9VMI9
-
Ta1316 ADH
Q9HIM3
-
TaDH
-
-
TsAdh319
C6A190
-
TsAdh319
C6A190
-
-
yeast alcohol dehydrogenase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9031-72-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain SKU1108, 2 soluble isozymes
-
-
Manually annotated by BRENDA team
Acetobacter pasteurianus SKU1108
strain SKU1108, 2 soluble isozymes
-
-
Manually annotated by BRENDA team
Brevibacterium sp. KU 1309
KU 1309
-
-
Manually annotated by BRENDA team
Candida maris IFO10003
-
-
-
Manually annotated by BRENDA team
fragment; CCTCC M203011
B2KJ46
UniProt
Manually annotated by BRENDA team
Candida parapsilosis CCTCC M203011
fragment; CCTCC M203011
B2KJ46
UniProt
Manually annotated by BRENDA team
Candida sp.
N-16
-
-
Manually annotated by BRENDA team
Candida sp. N-16
N-16
-
-
Manually annotated by BRENDA team
japonica. ADH-1, ADH-2, ADH-3 and ADH-An
-
-
Manually annotated by BRENDA team
var. Cantalupensis
-
-
Manually annotated by BRENDA team
Devosia riboflavina KNK10702
KNK10702
-
-
Manually annotated by BRENDA team
alleloenzyme AdhS
-
-
Manually annotated by BRENDA team
alleloenzymes Adhf and Adhus
-
-
Manually annotated by BRENDA team
alleloenzymes AdhS and AdhF
-
-
Manually annotated by BRENDA team
strain HM1
-
-
Manually annotated by BRENDA team
strain HM1:1MSS, alcohol dehydrogenase 2
-
-
Manually annotated by BRENDA team
Entamoeba histolytica HM1
strain HM1
-
-
Manually annotated by BRENDA team
Entamoeba histolytica HM1:1MSS
strain HM1:1MSS, alcohol dehydrogenase 2
-
-
Manually annotated by BRENDA team
isoenzymes EE, ES, and SS
-
-
Manually annotated by BRENDA team
strain Z
Uniprot
Manually annotated by BRENDA team
Euglena gracilis Z
strain Z
Uniprot
Manually annotated by BRENDA team
strain KUC-1
SwissProt
Manually annotated by BRENDA team
Flavobacterium frigidimaris KUC-1
strain KUC-1
SwissProt
Manually annotated by BRENDA team
Geobacillus stearothermophilus LLD-R
strain LLD-R
Uniprot
Manually annotated by BRENDA team
Geobacillus thermoglucosidasius M10EXG
strain M10EXG
UniProt
Manually annotated by BRENDA team
4 isoenzymes
-
-
Manually annotated by BRENDA team
gene GmAdh2
UniProt
Manually annotated by BRENDA team
Glycine max Enrei
gene GmAdh2
UniProt
Manually annotated by BRENDA team
ADHIndianapolis form 1 and 2 and 3
-
-
Manually annotated by BRENDA team
alcohol dehydrogenase 2, 2 allelic forms
-
-
Manually annotated by BRENDA team
anodic enzyme form
-
-
Manually annotated by BRENDA team
anodic enzyme form; chi-ADH
-
-
Manually annotated by BRENDA team
class I enzyme, several isozymes
-
-
Manually annotated by BRENDA team
class I isoenzymes: alpha,gamma2, gamma2gamma2, alpha,gamma1, alpha,beta1, beta1,gamma2, gamma1,gamma1, beta1,gamma1, beta1,beta1
-
-
Manually annotated by BRENDA team
class II isoenzyme: pi-ADH
-
-
Manually annotated by BRENDA team
class III isoenzyme
-
-
Manually annotated by BRENDA team
class III isoenzyme; isoenzyme chi-ADH
-
-
Manually annotated by BRENDA team
class IV alcohol dehydrogenase
-
-
Manually annotated by BRENDA team
class IV enzyme, sigma-ADH
-
-
Manually annotated by BRENDA team
isoenzyme alpha,alpha, beta1,beta1, gamma1,gamma1 and gamma2,gamma2
-
-
Manually annotated by BRENDA team
isoenzyme pi
-
-
Manually annotated by BRENDA team
isoenzymes beta1,beta1, beta2,beta2 and beta3,beta3
-
-
Manually annotated by BRENDA team
isoenzymes: beta2beta2, beta2beta1, alphabeta2 and beta2gamma1
-
-
Manually annotated by BRENDA team
isozyme 1C*2 (gamma2gamma2)
-
-
Manually annotated by BRENDA team
isozymes ADH1B1, ADH1B2, and ADH4
-
-
Manually annotated by BRENDA team
mue-alcolhol dehydrogenase
-
-
Manually annotated by BRENDA team
3 isoenzymes
-
-
Manually annotated by BRENDA team
Leifsonia sp.
strain S749
-
-
Manually annotated by BRENDA team
strain S749
-
-
Manually annotated by BRENDA team
cationic pyrazole-sensitive isoenzyme, anodic pyrazole-sensitive isoenzyme and cathionic pyrazole-in sensitive isoenzyme
-
-
Manually annotated by BRENDA team
3 major isoenzymes: TT-ADH, AA-ADH and BB-ADH
-
-
Manually annotated by BRENDA team
strain B10-05
-
-
Manually annotated by BRENDA team
Meyerozyma guilliermondii B10-05
strain B10-05
-
-
Manually annotated by BRENDA team
strain YR-1
-
-
Manually annotated by BRENDA team
Mucor circinelloides YR-1
strain YR-1
-
-
Manually annotated by BRENDA team
class III enzyme
-
-
Manually annotated by BRENDA team
isoenzyme A2, B2 and C2
-
-
Manually annotated by BRENDA team
isozymes ADH1 and ADH4
-
-
Manually annotated by BRENDA team
low-activity isozyme ADH2
Uniprot
Manually annotated by BRENDA team
FGSC2489
-
-
Manually annotated by BRENDA team
FGSC2489
SwissProt
Manually annotated by BRENDA team
Neurospora crassa FGSC2489
FGSC2489
-
-
Manually annotated by BRENDA team
Neurospora crassa FGSC2489
FGSC2489
SwissProt
Manually annotated by BRENDA team
gene adh3
-
-
Manually annotated by BRENDA team
Oenococcus oeni DSM20252
gene adh3
-
-
Manually annotated by BRENDA team
i.e. Pichia angusta, HpADH3 is not the major ADH in strain DL-1, gene ADH3
H9ZGN0
UniProt
Manually annotated by BRENDA team
Ogataea angusta DL-1, ATCC 26012
i.e. Pichia angusta, HpADH3 is not the major ADH in strain DL-1, gene ADH3
H9ZGN0
UniProt
Manually annotated by BRENDA team
Pseudomonas aeruginosa PaADH
PaADH
-
-
Manually annotated by BRENDA team
strain DSM 50106, stereoselective enzyme
-
-
Manually annotated by BRENDA team
probable alcohol dehydrogenase; strain S-5
UniProt
Manually annotated by BRENDA team
Pseudomonas putida S-5
probable alcohol dehydrogenase; strain S-5
UniProt
Manually annotated by BRENDA team
class IV enzyme
-
-
Manually annotated by BRENDA team
isoenzyme 1, 2, 3 and 4
-
-
Manually annotated by BRENDA team
DSM44514
-
-
Manually annotated by BRENDA team
strain DSM44541
-
-
Manually annotated by BRENDA team
Rhodococcus ruber 219
DSM44514
-
-
Manually annotated by BRENDA team
Rhodococcus ruber DSM44541
strain DSM44541
-
-
Manually annotated by BRENDA team
strain Y379-50
UniProt
Manually annotated by BRENDA team
Saccharomyces carlsbergensis Y379-50
strain Y379-50
UniProt
Manually annotated by BRENDA team
alcohol dehydrogenase IV
-
-
Manually annotated by BRENDA team
isoenzyme I, II and III
-
-
Manually annotated by BRENDA team
isozyme YADH-1, YADH-2, and YADH-3
-
-
Manually annotated by BRENDA team
pyrazole-insensitive isoenzyme and pyrazole-sensitive isoenzyme
-
-
Manually annotated by BRENDA team
Sporotrichum pulverulentum
-
-
-
Manually annotated by BRENDA team
strain DSM 1617
-
-
Manually annotated by BRENDA team
strain DSM1617
-
-
Manually annotated by BRENDA team
strain Gtheta
-
-
Manually annotated by BRENDA team
Sulfolobus solfataricus DSM1617
strain DSM1617
-
-
Manually annotated by BRENDA team
Sulfolobus solfataricus Gtheta
strain Gtheta
-
-
Manually annotated by BRENDA team
strain RC3
UniProt
Manually annotated by BRENDA team
strain RC3
UniProt
Manually annotated by BRENDA team
-
F9VMI9
SwissProt
Manually annotated by BRENDA team
Thermoanaerobacter ethanolicus JW200
strain JW200
UniProt
Manually annotated by BRENDA team
strain DSM 1728
UniProt
Manually annotated by BRENDA team
recombinantly produced in Escherichia coli
-
-
Manually annotated by BRENDA team
strain ATN1
UniProt
Manually annotated by BRENDA team
strain ATN1
UniProt
Manually annotated by BRENDA team
3 isoenzymes
-
-
Manually annotated by BRENDA team
3 non-allelic alcohol dehydrogenase isoenzymes
-
-
Manually annotated by BRENDA team
wild-type enzyme Adh1-1S and mutant enzyme Adh1-1S1108
-
-
Manually annotated by BRENDA team
ADH I and ADH II
-
-
Manually annotated by BRENDA team
ATCC 29191
-
-
Manually annotated by BRENDA team
enzyme form ADH-I and ADH-II
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
evolution
-
the enzyme ADH3 belongs to the group III alcohol dehydrogenases
evolution
-
the enzyme belongs to the short-chain alcohol dehydrogenases
evolution
P86883
the class I type enzyme belongs to the medium-chain alcohol dehydrogenases, structural and evolutionary relationships of the pigeon enzyme, phylogenetic tree, overview
evolution
P86884
the class III type enzyme belongs to the medium-chain alcohol dehydrogenases, structural and evolutionary relationships of the dogfish enzyme, phylogenetic tree, overview
evolution
Q9ZT38
alcohol dehydrogenase is a fermentative enzyme that is highly conserved across species, from prokaryotes to fungi, plants, and animals
evolution
-
the enzyme belongs to the short-chain alcohol dehydrogenases
-
evolution
Glycine max Enrei
-
alcohol dehydrogenase is a fermentative enzyme that is highly conserved across species, from prokaryotes to fungi, plants, and animals
-
evolution
Oenococcus oeni DSM20252
-
the enzyme ADH3 belongs to the group III alcohol dehydrogenases
-
physiological function
Q9ZT38
key enzyme in alcohol fermentation
physiological function
Glycine max Enrei
-
key enzyme in alcohol fermentation
-
metabolism
-
enzyme is involved in phytol degradation
additional information
-
ADH1 molecular modeling and molecular dynamics simulations, and comparison to rat ADH5 enzyme, overview
additional information
-
ADH5 molecular modeling and molecular dynamics simulations, and comparison to human ADH1 enzyme, overview
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(-)-carvone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
1% activity compared to cyclohexanone
-
-
?
(1S,3S)-3-methylcyclohexanol + NAD+
(rac)-3-methylcyclohexanone + NADH + H+
show the reaction diagram
B2ZRE3
125% activity compared to cyclohexanol
163% activity compared to cyclohexanone
-
r
(6S)-5,6-dihydro-6-methyl-4H-thieno[2,3b]thiopyran-4-one-7,7-dioxide + NADH + H+
(4S,6S)-5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3b]thiopyran-7,7-dioxide + NAD+
show the reaction diagram
-
-
-
-
-
(E)-hex-2-en-1-ol + NAD+
(E)-hex-2-en-1-one + NADH
show the reaction diagram
-
-
-
-
?
(E)-hex-2-en-1-ol + NAD+
(E)-hex-2-en-1-one + NADH
show the reaction diagram
-
43.2% of the activity with ethanol
-
-
?
(R)-1-indanol + NAD+
?
show the reaction diagram
Q4J702
62% of activity compared to (S)-1-indanol
-
-
?
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
-
-
-
-
?
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
-
-
-
-
r
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
?
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
50% of the activity with 2-propanol
-
-
ir
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
Devosia riboflavina, Devosia riboflavina KNK10702
-
55% of activity with N-benzyl-3-pyrrolidinol
-
-
?
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
Saccharomyces carlsbergensis Y379-50
B6UQD0
-
-
-
?
(R)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
-
50% of the activity with 2-propanol
-
-
ir
(R)-2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
Leifsonia sp., Leifsonia sp. S749
-
2469% of the activity with 2-propanol
-
-
r
(R)-2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
Leifsonia sp., Leifsonia sp. S749
-
1906% of the activity with 2-propanol
-
-
r
(R)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
-
-
-
-
-
(R)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
Leifsonia sp., Leifsonia sp. S749
-
2406% of the activity with 2-propanol
-
-
r
(R)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-
-
-
-
-
(R)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-
-
-
-
r
(R)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
75% of the activity with 2-propanol
-
-
r
(R)-2-phenylpropanol + NAD+
(R)-2-phenylpropanal + NADH + H+
show the reaction diagram
Brevibacterium sp., Brevibacterium sp. KU 1309
-
63% of the activity with 2-phenylethanol
-
-
?
(R)-3-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
2% activity compared to cyclohexanone
-
-
?
(R)-alpha-tetralol + NAD+
?
show the reaction diagram
Q4J702
58% of activity compared to (S)-1-indanol
-
-
?
(R,S)-2-methylbutan-1-ol + NAD+
(R,S)-2-methyl-butan-1-one + NADH + H+
show the reaction diagram
-
-
-
-
?
(R,S)-2-methylbutan-1-ol + NAD+
(R,S)-2-methyl-butan-1-one + NADH + H+
show the reaction diagram
Saccharomyces carlsbergensis, Saccharomyces carlsbergensis Y379-50
B6UQD0
-
-
-
?
(S)-(+)-1-indanol + NAD+
indanone + NADH + H+
show the reaction diagram
-
-
-
-
?
(S)-1-indanol + NAD+
?
show the reaction diagram
Q4J702
-
-
-
?
(S)-1-phenyl-2-propanol + NAD+
phenylacetone + NADH + H+
show the reaction diagram
B2ZRE3
-
9% activity compared to cyclohexanone
-
r
(S)-2-butanol + NAD+
2-butanone + NADH
show the reaction diagram
-
-
-
-
r
(S)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
-
-
-
-
?
(S)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
-
-
-
-
r
(S)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
?
(S)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
275% of the activity with 2-propanol
-
-
ir
(S)-2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
Saccharomyces carlsbergensis Y379-50
B6UQD0
-
-
-
?
(S)-2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
331% of the activity with 2-propanol
-
-
r
(S)-2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
38% of the activity with 2-propanol
-
-
r
(S)-2-methylbutan-1-ol + NAD+
(S)-2-methyl-butanal + NADH + H+
show the reaction diagram
-
-
-
-
?
(S)-2-methylbutan-1-ol + NAD+
(S)-2-methyl-butanal + NADH + H+
show the reaction diagram
-
-
-
-
-
(S)-2-methylbutan-1-ol + NAD+
(S)-2-methyl-butanal + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
?
(S)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
-
-
-
-
-
(S)-2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
81% of the activity with 2-propanol
-
-
r
(S)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-
-
-
-
-
(S)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-
-
-
-
r
(S)-2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
25% of the activity with 2-propanol
-
-
r
(S)-2-pentanol + NAD+
?
show the reaction diagram
Q4J702
11% of activity compared to (S)-1-indanol
-
-
?
(S)-2-phenylpropanol + NAD+
(S)-2-phenylpropanal + NADH + H+
show the reaction diagram
-
156% of the activity with 2-phenylethanol
-
-
?
(S)-4-phenylbutan-2-ol + NAD+
benzylacetone + NADH + H+
show the reaction diagram
B2ZRE3
-
3% activity compared to cyclohexanone
-
r
(S)-alpha-tetralol + NAD+
?
show the reaction diagram
Q4J702
12% of activity compared to (S)-1-indanol
-
-
?
(S)-heptan-2-ol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
B2ZRE3
-
-
-
r
(S)-pentan-2-ol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
B2ZRE3
-
-
-
r
(S)-perillylalcohol + NAD+
(S)-perillaldehyde + NADH + H+
show the reaction diagram
B2ZRE3
52% activity compared to cyclohexanol
-
-
?
(Z)-hex-2-en-1-ol + NAD+
(Z)-hex-2-en-1-one + NADH
show the reaction diagram
-
9.7% of the activity with ethanol
-
-
?
1,1-dichloroacetone + NADH + H+
1,1-dichloropropan-2-ol + NADH
show the reaction diagram
Leifsonia sp.
-
1078% of the activity with phenyl trifluoromethyl ketone
-
-
?
1,2-butanediol + NAD+
?
show the reaction diagram
H9ZGN0
low activity
-
-
?
1,2-butanediol + NAD+
?
show the reaction diagram
-
35% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,2-butanediol + NAD+
?
show the reaction diagram
Ogataea angusta DL-1, ATCC 26012
H9ZGN0
low activity
-
-
?
1,2-hexanediol + NAD+
?
show the reaction diagram
-
20% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,2-pentanediol + NAD+
?
show the reaction diagram
-
12% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,2-propanediol + NAD+
?
show the reaction diagram
Oenococcus oeni, Oenococcus oeni DSM20252
-
-
-
-
?
1,2-propanediol + NAD+
hydroxyacetone + NADH
show the reaction diagram
-
-
-
-
?
1,2-propanediol + NAD+
hydroxyacetone + NADH + H+
show the reaction diagram
-
-
-
-
?
1,3-butanediol + NAD+
?
show the reaction diagram
-
39% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1,3-propanediol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 45% of the activity with ethanol
-
-
r
1,3-propanediol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 5% of the activity with 1-octanol
-
-
r
1,3-propanediol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9, -
about 45% of the activity with ethanol
-
-
r
1,3-propanediol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9, -
about 5% of the activity with 1-octanol
-
-
r
1,3-propanediol + NAD+
? + NADH
show the reaction diagram
-
7% of the activity with ethanol
-
-
?
1,3-propanediol + NAD+
?
show the reaction diagram
Oenococcus oeni, Oenococcus oeni DSM20252
-
-
-
-
?
1-(4'-chlorophenyl)ethanol + NAD+
1-(4'-chlorophenyl)ethanone + NADH + H+
show the reaction diagram
-
26% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-(4-fluorophenyl)ethanol + NAD+
1-(4-fluorophenyl)ethanone + NADH + H+
show the reaction diagram
-
45% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-(p-tolyl)-ethanol + NAD+
1-(4-methylphenyl)ethanone + NADH + H+
show the reaction diagram
B2ZRE3
19% activity compared to cyclohexanol
26% activity compared to cyclohexanone
-
?
1-butanal + NADH + H+
1-butanol + NAD+
show the reaction diagram
-
-
-
-
r
1-butanol + 2 NAD+ + H2O
butanoic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 45% of the activity with ethanol
-
-
r
1-butanol + 2 NAD+ + H2O
butanoic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 50% of the activity with 1-octanol
-
-
r
1-butanol + 2 NAD+ + H2O
butanoic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9, -
about 45% of the activity with ethanol
-
-
r
1-butanol + 2 NAD+ + H2O
butanoic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9, -
about 50% of the activity with 1-octanol
-
-
r
1-butanol + NAD+
butanal + NADH
show the reaction diagram
-
-
-
-
?
1-butanol + NAD+
butanal + NADH
show the reaction diagram
Brevibacterium sp., Brevibacterium sp. KU 1309
-
111% of the activity with 2-phenylethanol
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-
-
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-
-
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-, Q6RS93
-
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
H9ZGN0
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-, Q76HN6
30% activity compared to benzyl alcohol
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-
15.7% of the activity with ethanol
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-, Q9P6C8
about 80% of activity with ethanol, ADH1
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
B2ZRE3
142% activity compared to cyclohexanol
-
-
r
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
Q9HIM3, -
67.7% activity compared to ethanol
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
B2ZRE3
142% activity compared to cyclohexanol
-
-
r
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
Oenococcus oeni DSM20252
-
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
Flavobacterium frigidimaris KUC-1
Q8L3C9
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
Geobacillus thermoglucosidasius M10EXG
Q6RS93
-
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
Ogataea angusta DL-1, ATCC 26012
H9ZGN0
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
Neurospora crassa FGSC2489
-, Q9P6C8
about 80% of activity with ethanol, ADH1
-
-
?
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
Pseudomonas putida S-5
Q76HN6
30% activity compared to benzyl alcohol
-
-
?
1-chloro-5-acetylfuro[2,3-c]pyridine + NADH + H+
1-chloro-5-(1-hydroxyethyl)furo[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
1-decalone + NADH + H+
decahydronaphthalen-1-ol + NAD+
show the reaction diagram
Q4J9F2, -
85% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
1-decanol + NAD+
decanal + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
1-decanol + NAD+
decanal + NADH + H+
show the reaction diagram
-, Q76HN6
13% activity compared to benzyl alcohol
-
-
?
1-decanol + NAD+
decanal + NADH + H+
show the reaction diagram
Flavobacterium frigidimaris KUC-1
Q8L3C9
-
-
-
r
1-decanol + NAD+
decanal + NADH + H+
show the reaction diagram
Pseudomonas putida S-5
Q76HN6
13% activity compared to benzyl alcohol
-
-
?
1-dodecanol + NAD+
dodecanal + NADH
show the reaction diagram
Brevibacterium sp., Brevibacterium sp. KU 1309
-
68% of the activity with 2-phenylethanol
-
-
?
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
-, Q6RS93
-
-
-
?
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
-, Q76HN6
25% activity compared to benzyl alcohol
-
-
?
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
B2ZRE3
80% activity compared to cyclohexanol
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
Flavobacterium frigidimaris KUC-1
Q8L3C9
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
Geobacillus thermoglucosidasius M10EXG
Q6RS93
-
-
-
?
1-heptanol + NAD+
heptanal + NADH + H+
show the reaction diagram
Pseudomonas putida S-5
Q76HN6
25% activity compared to benzyl alcohol
-
-
?
1-heptanol + NAD+
heptanol + NADH + H+
show the reaction diagram
Leifsonia sp.
-
56% of the activity with 2-propanol, in the reverse reaction 755% of the activity with phenyl trifluoromethyl ketone
-
-
r
1-heptanol + NAD+
1-heptanal + NADH + H+
show the reaction diagram
-
-
-
-
r
1-hexanal + NADH + H+
1-hexanol + NAD+
show the reaction diagram
-
-
-
-
r
1-hexanol + 2 NAD+ + H2O
hexanoic acid acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 55% of the activity with 1-octanol
-
-
r
1-hexanol + 2 NAD+ + H2O
hexanoic acid acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 70% of the activity with ethanol
-
-
r
1-hexanol + 2 NAD+ + H2O
hexanoic acid acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9, -
about 70% of the activity with ethanol
-
-
r
1-hexanol + 2 NAD+ + H2O
hexanoic acid acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9, -
about 55% of the activity with 1-octanol
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
-, Q6RS93
-
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
F9VMI9, -
-
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
Leifsonia sp.
-
44% of the activity with 2-propanol, in the reverse reaction 1029% of the activity with phenyl trifluoromethyl ketone
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
-, Q76HN6
61% activity compared to benzyl alcohol
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
-, Q9P6C8
about 90% of activity with ethanol, ADH1
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
B2ZRE3
109% activity compared to cyclohexanol
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
Q9HIM3, -
15.3% activity compared to ethanol
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
B2ZRE3
109% activity compared to cyclohexanol
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
Geobacillus thermoglucosidasius M10EXG
Q6RS93
-
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
Neurospora crassa FGSC2489
-, Q9P6C8
about 90% of activity with ethanol, ADH1
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
Pseudomonas putida S-5
Q76HN6
61% activity compared to benzyl alcohol
-
-
?
1-hexanol + NAD+
?
show the reaction diagram
-
15% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-hexanol + NAD+
1-hexanal + NADH + H+
show the reaction diagram
-
-
-
-
r
1-hydroxy-2-butanone + NADH + H+
butane-1,2-diol + NAD+
show the reaction diagram
-
59% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
1-hydroxymethyl-6-methylpyrene + NAD+
1-formyl-6-methylpyrene + NADH + H+
show the reaction diagram
P00326, P08319
-
-
-
r
1-hydroxymethyl-8-methylpyrene + NAD+
1-formyl-8-methylpyrene + NADH + H+
show the reaction diagram
P00326, P08319
-
-
-
r
1-hydroxymethylpyrene + NAD+
1-formylpyrene + NADH + H+
show the reaction diagram
P00326, P08319
-
-
-
r
1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
-
-
-
-
?
1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
B2ZRE3
-
1% activity compared to cyclohexanone
-
r
1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
Q4J9F2, -
26% of the activity compared to isoborneol
-
-
?
1-indanol + NAD+
1-indanone + NADH + H+
show the reaction diagram
Q4J9F2
26% of the activity compared to isoborneol
-
-
?
1-nonanol + NAD+
nonanal + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
1-nonanol + NAD+
nonanal + NADH + H+
show the reaction diagram
-, Q76HN6
12% activity compared to benzyl alcohol
-
-
?
1-octanol + 2 NAD+ + H2O
octanoic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
best substrate
-
-
r
1-octanol + 2 NAD+ + H2O
octanoic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 30% of the activity with ethanol
-
-
r
1-octanol + 2 NAD+ + H2O
octanoic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9, -
best substrate
-
-
r
1-octanol + 2 NADP+ + H2O
octanoic acid + 2 NADPH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
-
-
-
r
1-octanol + NAD+
octanal + NADH
show the reaction diagram
Brevibacterium sp., Brevibacterium sp. KU 1309
-
101% of the activity with 2-phenylethanol
-
-
?
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
-, Q6RS93
-
-
-
?
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
H9ZGN0
-
-
-
r
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
Leifsonia sp.
-
33% of the activity with 2-propanol, in the reverse reaction 435% of the activity with phenyl trifluoromethyl ketone
-
-
r
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
-, Q76HN6
11% activity compared to benzyl alcohol
-
-
?
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
-, Q9P6C8
about 85% of activity with ethanol, ADH1
-
-
?
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
B2ZRE3
57% activity compared to cyclohexanol
-
-
r
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
P00326, P08319
substrate for isozyme ADH3
-
-
r
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
Geobacillus thermoglucosidasius M10EXG
Q6RS93
-
-
-
?
1-octanol + NAD+
1-octanal + NADH + H+
show the reaction diagram
-
6% of activity with N-benzyl-3-pyrrolidinol
-
-
?
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
-, Q6RS93
-
-
-
?
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
H9ZGN0
-
-
-
r
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
-, Q76HN6
152% activity compared to benzyl alcohol
-
-
?
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
-, Q9P6C8
about 85% of activity with ethanol, ADH1
-
-
?
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
B2ZRE3
121% activity compared to cyclohexanol
-
-
r
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
Q9HIM3, -
19.1% activity compared to ethanol
-
-
?
1-pentanol + NAD+
pentanal + NADH + H*
show the reaction diagram
-
8% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-pentanol + NAD+
1-pentanal + NADH + H+
show the reaction diagram
-
-
-
-
r
1-phenyl-1,2-ethanediol + NAD+
1-phenyl-2-propanone + NADH + H+
show the reaction diagram
B2ZRE3
1% activity compared to cyclohexanol
-
-
r
1-phenyl-1,2-propanedione + NADH
?
show the reaction diagram
Q4J702
about 25% of the activity compared to isatin
-
-
?
1-phenyl-1,2-propanedione + NADH + H+
?
show the reaction diagram
-
activity is 1.46fold higher than with 2,2,2-trifluoroacetophenone
-
-
?
1-phenyl-1,2-propanedione + NADH + H+
?
show the reaction diagram
Q4J9F2, -
1-phenyl-1,2-propanedione and ethyl 3-methyl-2-oxobutyrate are the best substrate in the reduction reaction
-
-
?
1-phenyl-1,2-propanedione + NADH + H+
?
show the reaction diagram
Q4J9F2
1-phenyl-1,2-propanedione and ethyl 3-methyl-2-oxobutyrate are the best substrate in the reduction reaction
-
-
?
1-phenyl-1-propanol + NAD+
1-phenyl-1-propanone + NADH + H+
show the reaction diagram
-
59% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-phenyl-1-propanol + NAD+
?
show the reaction diagram
-
31% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
1-phenyl-2-butanone + NADH + H+
1-phenylbutan-2-ol + NAD+
show the reaction diagram
Leifsonia sp.
-
12% of the activity with phenyl trifluoromethyl ketone
-
-
?
1-phenyl-2-butanone + NADH + H+
1-phenylbutan-2-ol + NAD+
show the reaction diagram
Devosia riboflavina, Devosia riboflavina KNK10702
-
1.5fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
1-phenyl-2-propanol + NAD+
1-phenyl-2-propanone + NADH + H+
show the reaction diagram
-
16% of the activity with (S)-(-)-1-phenylethanol
-
-
?
1-phenyl-2-propanol + NAD+
1-phenyl-2-propanone + NADH + H+
show the reaction diagram
B2ZRE3
3% activity compared to cyclohexanol
-
-
r
1-phenyl-2-propanone + NADH + H+
(S)-1-phenyl-2-propanol + NAD+
show the reaction diagram
-
-
-
-
-
1-phenyl-3-butanone + NADH + H+
1-phenylbutan-3-ol + NAD+
show the reaction diagram
Leifsonia sp.
-
353% of the activity with phenyl trifluoromethyl ketone
-
-
?
1-phenylethanol + NAD+
1-phenylethanone + NADH
show the reaction diagram
-, Q6L0S1
-
-
-
?
1-phenylethanol + NAD+
1-phenylethanone + NADH
show the reaction diagram
-
46% of the activity with 2-phenylethanol
-
-
?
1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
show the reaction diagram
B2ZRE3
3% activity compared to cyclohexanol
-
-
r
1-phenylethanol + NAD+
acetophenone + NADH + H+
show the reaction diagram
B2ZRE3
-
1% activity compared to cyclohexanone
-
?
1-propanol + NAD+
propanal + NADH
show the reaction diagram
-
-
-
-
?
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
-
-
-
-
?
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
-
-
-
-
?
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
-, Q9P6C8
about 75% of activity with ethanol, ADH1
-
-
?
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
B2ZRE3
153% activity compared to cyclohexanol
-
-
r
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
Sulfolobus solfataricus DSM1617
-
-
-
-
?
1-propanol + NAD+
propanaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
1-propanol + NAD+
propanaldehyde + NADH + H+
show the reaction diagram
H9ZGN0
-
-
-
r
11-cis-retinal + NADH + H+
11-cis-retinol + NAD+
show the reaction diagram
-
-
-
-
?
11-cis-retinol + NAD+
11-cis-retinal + NADH
show the reaction diagram
-
-
-
-
?
11-cis-retinol + NAD+
11-cis-retinal + NADH
show the reaction diagram
-
-
-
?
12-hydroxydodecanoate + NAD+
12-oxododecanoic acid + NADH
show the reaction diagram
-
-
-
-
?
12-hydroxydodecanoate + NAD+
12-oxododecanoic acid + NADH
show the reaction diagram
-
-
-
-
?
12-hydroxydodecanoate + NAD+
12-oxododecanoic acid + NADH
show the reaction diagram
-
-
-
-
?
12-hydroxydodecanoate + NAD+
12-oxododecanoic acid + NADH
show the reaction diagram
-
-
-
-
?
12-hydroxydodecanoate + NAD+
12-oxododecanoic acid + NADH
show the reaction diagram
-
oxidized at pH 10, not oxidized at pH 7.5
-
-
-
13-cis-retinal + NAD+
13-cis-retinol + NADH
show the reaction diagram
-
-
-
-
?
13-cis-retinol + NAD+
13-cis-retinal + NADH
show the reaction diagram
-
-
-
?
13-cis-retinol + NAD+
13-cis-retinal + NADH
show the reaction diagram
-
no activity with isozyme ADH1
-
-
?
16-hydroxyhexadecanoate + NAD+
16-oxohexadecanoic acid + NADH
show the reaction diagram
-
-
-
-
?
17beta-hydroxyetiocholan-3-one + NAD+
ethiocholan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
?
2',3',4',5',6'-pentafluoroacetophenone + NADH + H+
1-(2,3,4,5,6-pentafluorophenyl)ethanol + NAD+
show the reaction diagram
Q4J9F2, -
45% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2,2'-dichlorobenzil + NADH + H+
1,2-bis(2-chlorophenyl)-2-hydroxyethanone + NAD+
show the reaction diagram
Q4J9F2, -
-
-
-
?
2,2,2-trichloroethanol + NAD+
trichloroacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
2,2,2-trifluoroacetophenone + NADH
2,2,2-trifluoro-1-phenylethanol + NAD+
show the reaction diagram
Q4J702
about 35% of the activity compared to isatin
-
-
?
2,2,2-trifluoroacetophenone + NADH + H+
(R)-alpha-(trifluoromethyl)benzyl alcohol + NAD+
show the reaction diagram
-
93% enantiomeric excess
-
-
?
2,2,2-trifluoroacetophenone + NADH + H+
2,2,2-trifluoro-1-phenylethanol + NAD+
show the reaction diagram
Q4J9F2, -
35% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2,2-dichloroacetophenone + NADH + H+
2,2-dichloro-1-phenylethanol + NAD+
show the reaction diagram
-
32% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
2,2-dichloroacetophenone + NADH + H+
2,2-dichloro-1-phenylethanol + NAD+
show the reaction diagram
Q4J9F2, -
30% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2,2-dichloroacetophenone + NADH + H+
2,2-dichloro-1-phenylethanol + NAD+
show the reaction diagram
Q4J9F2
30% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2,3'-dichloroacetophenone + NADH + H+
1-(2,3-dichlorophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
67% of the activity with phenyl trifluoromethyl ketone
-
-
?
2,3'-dichloroacetophenone + NADH + H+
2-chloro-1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
2,3-butanediol + H2O
?
show the reaction diagram
-, Q6L0S1
-
-
-
?
2,3-butanediol + NAD+
acetoin + NADH + H+
show the reaction diagram
-, Q8U259
-
-
-
?
2,3-butanediol + NAD+
?
show the reaction diagram
-
83% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
2,3-butanedione + NADH + H+
?
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
2,3-pentanedione + NADH
? + NADH
show the reaction diagram
-
5.5% of the activity with acetaldehyde
-
-
?
2,4-pentanediol + NAD+
?
show the reaction diagram
-
21% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
2,4-pentanediol + NAD+
?
show the reaction diagram
B2ZRE3
4% activity compared to cyclohexanol
-
-
?
2-(3,5-dimethylphenyl)propanal + NADH + H+
(S)-2-(3,5-dimethylphenyl)propanol + NAD+
show the reaction diagram
-
18 h, 99% yield, 90% enantiomeric excess
-
-
?
2-(3,5-dimethylphenyl)propanal + NADH + H+
(S)-2-(3,5-dimethylphenyl)propanol + NAD+
show the reaction diagram
P39462
18 h, 99% yield, 90% enantiomeric excess
-
-
?
2-(3-benzoylphenyl)propanal + NADH + H+
(S)-2-(3-benzoylphenyl)propanol + NAD+
show the reaction diagram
-
18 h, 85% yield, 95% enantiomeric excess
-
-
?
2-(3-benzoylphenyl)propanal + NADH + H+
(S)-2-(3-benzoylphenyl)propanol + NAD+
show the reaction diagram
P39462
18 h, 85% yield, 95% enantiomeric excess
-
-
?
2-(3-fluorobiphenyl-4-yl)propanal + NADH + H+
(S)-2-(3-(fluoro)biphenyl-4-yl)propanol + NAD+
show the reaction diagram
-
18 h, 77% yield, 97% enantiomeric excess
-
-
?
2-(3-fluorobiphenyl-4-yl)propanal + NADH + H+
(S)-2-(3-(fluoro)biphenyl-4-yl)propanol + NAD+
show the reaction diagram
P39462
18 h, 77% yield, 97% enantiomeric excess
-
-
?
2-(3-phenoxyphenyl)propanal + NADH + H+
(S)-2-((3-phenoxy)phenyl)propanol + NAD+
show the reaction diagram
-
18 h, 85% yield, 95% enantiomeric excess
-
-
?
2-(3-phenoxyphenyl)propanal + NADH + H+
(S)-2-((3-phenoxy)phenyl)propanol + NAD+
show the reaction diagram
P39462
18 h, 85% yield, 95% enantiomeric excess
-
-
?
2-(4-isobutylphenyl)propanal + NADH + H+
(S)-2-(4-isobutylphenyl)propanol + NAD+
show the reaction diagram
-
18 h, 92% yield, 99% enantiomeric excess
-
-
?
2-(4-isobutylphenyl)propanal + NADH + H+
(S)-2-(4-isobutylphenyl)propanol + NAD+
show the reaction diagram
P39462
18 h, 92% yield, 99% enantiomeric excess
-
-
?
2-(4-trifluoromethylphenyl)propanal + NADH + H+
(S)-2-(4-trifluoromethyl)phenylpropanol + NAD+
show the reaction diagram
-
18 h, 55% yield, 98% enantiomeric excess
-
-
?
2-(6-methoxynaphthalen-2-yl)propanal + NADH + H+
(S)-2-(6-methoxynaphthalen-2-yl)propan-1-ol + NAD+
show the reaction diagram
-
18 h, 96% yield, 98% enantiomeric excess
-
-
?
2-(naphthalen-1-yl)propanal + NADH + H+
(S)-2-(naphthalen-1-yl)propanol + NAD+
show the reaction diagram
-
18 h, 90% yield, 80% enantiomeric excess
-
-
?
2-(naphthalen-2-yl)propanal + NADH + H+
(S)-2-(naphthalen-2-yl)propanol + NAD+
show the reaction diagram
-
18 h, 57% yield, 94% enantiomeric excess
-
-
?
2-acetylcyclohexanone + NADH + H+
2-acetylcyclohexanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylcyclopentanone + NADH + H+
2-acetylcyclopentanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylfuran + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylpyridine + NADH + H+
(R)-1-(2-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylpyrrole + NADH + H+
1-(1H-pyrrol-2-yl)ethanol + NAD+
show the reaction diagram
-
70% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-acetylpyrrole + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylthiazole + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-acetylthiophene + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-aminoethanol + NAD+
?
show the reaction diagram
-, Q6L0S1
-
-
-
?
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
-
-
-
-
?
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
-, Q8L3C9
weak activity
-
-
r
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
-, Q9P6C8
about 25% of activity with ethanol, ADH1
-
-
?
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
-
activity is 3.7fold higher than with (S)-N-benzyl-3-pyrrolidinol
-
-
r
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
B2ZRE3
39% activity compared to cyclohexanol
4% activity compared to cyclohexanone
-
r
2-butanone + NADH + H+
2-butanol + NAD+
show the reaction diagram
-
-
-
-
r
2-butanone + NADH + H+
2-butanol + NAD+
show the reaction diagram
-
40% of the activity with N-benzyl-3-pyrrolidinone
-
-
r
2-butanone + NADH + H+
butan-2-ol + NAD+
show the reaction diagram
-
2.8fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
2-butanone + NADPH + H+
butan-2-ol + NADP+
show the reaction diagram
B2KJ46, -
12.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-butanone + NADPH + H+
butan-2-ol + NADP+
show the reaction diagram
Candida parapsilosis CCTCC M203011
B2KJ46
12.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-butene-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-butene-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-chloroacetophenone + NADH + H+
1-(2-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
low activity
-
-
r
2-chlorocyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
3% activity compared to cyclohexanone
-
-
?
2-decalone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
28% activity compared to cyclohexanone
-
-
?
2-decanol + NAD+
2-decanone + NADH + H+
show the reaction diagram
-, Q8L3C9
weak activity
-
-
r
2-deoxy-D-ribose + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-ethoxyethanol + NAD+
2-ethoxyacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
2-ethylhexan-1-ol + NAD+
2-ethylhexanal + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
weak activity
-
-
?
2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
-, Q8L3C9
weak activity
-
-
r
2-heptanol + NAD+
2-heptanone + NADH + H+
show the reaction diagram
B2ZRE3
63% activity compared to cyclohexanol
5% activity compared to cyclohexanone
-
r
2-heptanone + NADH + H+
(R)-2-heptanol + NAD+
show the reaction diagram
Leifsonia sp.
-
229% of the activity with phenyl trifluoromethyl ketone
99% enantiomeric excess
-
?
2-heptanone + NADPH + H+
heptan-2-ol + NADP+
show the reaction diagram
B2KJ46, -
6.8% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-heptanone + NADPH + H+
heptan-2-ol + NADP+
show the reaction diagram
Candida parapsilosis CCTCC M203011
B2KJ46
6.8% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
-, Q8L3C9
weak activity
-
-
r
2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
-
activity is 11.2fold higher than with (S)-N-benzyl-3-pyrrolidinol
-
-
?
2-hexanol + NAD+
2-hexanone + NADH + H+
show the reaction diagram
B2ZRE3
64% activity compared to cyclohexanol
4% activity compared to cyclohexanone
-
r
2-hexanone + NADH + H+
?
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
2-hexanone + NADH + H+
hexan-2-ol + NAD+
show the reaction diagram
-
50.4fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
2-hexanone + NADH + H+
2-hexanol + NAD+
show the reaction diagram
-
-
-
-
r
2-hexanone + NADPH + H+
hexan-2-ol + NADP+
show the reaction diagram
B2KJ46, -
5.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-hexanone + NADPH + H+
hexan-2-ol + NADP+
show the reaction diagram
Candida parapsilosis CCTCC M203011
B2KJ46
5.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
show the reaction diagram
B2KJ46, -
2.4% of the activity with NADPH
-
-
?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
show the reaction diagram
Candida parapsilosis CCTCC M203011
B2KJ46
2.4% of the activity with NADPH
-
-
?
2-hydroxyacetophenone + NADPH + H+
(S)-1-phenyl-1,2-ethanediol + NADP+
show the reaction diagram
B2KJ46, -
-
-
-
?
2-hydroxymethylpyrene + NAD+
2-formylpyrene + NADH + H+
show the reaction diagram
P00326, P08319
-
-
-
r
2-mercaptoethanol + NAD+
?
show the reaction diagram
-
-
-
-
?
2-mercaptoethanol + NAD+
?
show the reaction diagram
B2ZRE3
11% activity compared to cyclohexanol
-
-
?
2-methoxybenzaldehyde + NADH + H+
2-methoxybenzylalcohol + NAD+
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
2-methoxybenzyl alcohol + NAD+
2-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
25% of the activity with (S)-(-)-1-phenylethanol
-
-
?
2-methoxyethanol + NAD+
2-methoxyacetaldehyde + NADH + H+
show the reaction diagram
H9ZGN0
-
-
-
r
2-methyl-2,4-pentanediol + NAD+
?
show the reaction diagram
B2ZRE3
1% activity compared to cyclohexanol
-
-
?
2-methylbutan-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
2-methylbutyraldehyde + NADH + H+
2-methylbutanol + NAD+
show the reaction diagram
-
1.4% of the activity with acetaldehyde
-
-
?
2-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
46% activity compared to cyclohexanone
-
-
?
2-methylcyclohexanone + NADH + H+
2-methylcyclohexanol + NAD+
show the reaction diagram
Q4J9F2, -
13% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH
show the reaction diagram
-
-
-
-
?
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH
show the reaction diagram
-
-
-
-
-
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
-
-
-
?
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH
show the reaction diagram
-
-
-
-
?
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH
show the reaction diagram
-
-
-
-
-
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH
show the reaction diagram
-
weak activity
-
-
?
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH + H+
show the reaction diagram
-
-
-
-
?
2-methylpropan-1-ol + NAD+
2-methyl-propan-1-one + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
?
2-methylpropionaldehyde + NADH + H+
2-methylpropanal + NAD+
show the reaction diagram
-
3.3% of the activity with acetaldehyde
-
-
?
2-nitrobenzaldehyde + NADH + H+
(2-nitrophenyl)methanol + NAD+
show the reaction diagram
-
33% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-nitrobenzaldehyde + NADH + H+
2-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
low activity
-
-
r
2-nonanol + NAD+
2-nonanone + NADH + H+
show the reaction diagram
-, Q8L3C9
weak activity
-
-
r
2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
-, Q8L3C9
weak activity
-
-
r
2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
H9ZGN0
low activity
-
-
r
2-octanol + NAD+
2-octanone + NADH + H+
show the reaction diagram
B2ZRE3
43% activity compared to cyclohexanol
4% activity compared to cyclohexanone
-
r
2-octanone + NADH + H+
2-octanol + NAD+
show the reaction diagram
-
-
-
-
r
2-octanone + NADPH + H+
octan-2-ol + NADP+
show the reaction diagram
B2KJ46, -
11.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-oxo-3-methylpentane + NADH
3-methylpentan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-3-phenylpropane + NADH
2-hydroxy-3-phenylpropane + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-4-methylpentane + NADH
4-methylpentan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-butyric acid + NADH + H+
2-hydroxybutyric acid + NAD+
show the reaction diagram
-
15% of activity with N-benzyl-3-pyrrolidinone
-
-
?
2-oxohexane + NADH
2-hydroxyhexane + NAD+
show the reaction diagram
-
-
-
-
?
2-oxopentane + NADH
2-pentanol + NAD+
show the reaction diagram
-
-
-
-
?
2-oxopentanoate + NADH + H+
2-hydroxypentanoate + NAD+
show the reaction diagram
-
low activity
-
-
r
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-, Q8L3C9
weak activity
-
-
r
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
H9ZGN0
low activity
-
-
r
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-
45% of activity with N-benzyl-3-pyrrolidinol
-
-
?
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
-
activity is 9fold higher than with (S)-N-benzyl-3-pyrrolidinol
-
-
?
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
Q9HIM3, -
5.7% activity compared to ethanol
-
-
?
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
Devosia riboflavina KNK10702
-
45% of activity with N-benzyl-3-pyrrolidinol
-
-
?
2-pentanone + NADH
pentan-2-ol + NAD+
show the reaction diagram
-
-
-
r
2-pentanone + NADH + H+
2-pentanol + NAD+
show the reaction diagram
-
-
-
-
r
2-pentanone + NADH + H+
2-pentanol + NAD+
show the reaction diagram
B2ZRE3
6% activity compared to cyclohexanol
-
-
r
2-pentanone + NADPH + H+
pentan-2-ol + NADP+
show the reaction diagram
B2KJ46, -
11.9% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
2-phenylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
2% activity compared to cyclohexanone
-
-
?
2-phenylethanol + NAD+
phenylacetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
2-phenylethanol + NAD+
2-phenylethanone + NADH + H+
show the reaction diagram
B2ZRE3
57% activity compared to cyclohexanol
-
-
r
2-phenylpropanal + NADH + H+
(S)-2-phenylpropanol + NAD+
show the reaction diagram
-
18 h, 74% yield, 98% enantiomeric excess
-
-
?
2-propanol + NAD(P)+
acetone + NAD(P)H
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
-
-
-
ir
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
-, Q9P6C8
about 50% of activity with ethanol, ADH1
-
-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
Flavobacterium frigidimaris KUC-1
Q8L3C9
-
-
-
r
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
Saccharomyces carlsbergensis Y379-50
B6UQD0
-
-
-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
Neurospora crassa FGSC2489
-, Q9P6C8
about 50% of activity with ethanol, ADH1
-
-
?
2-propanol + NAD+
2-propanone + NADH
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
2-propanone + NADH
show the reaction diagram
-, Q6L0S1
-
-
-
?
2-propanol + NAD+
2-propanone + NADH
show the reaction diagram
-
54% of the activity with 2-phenylethanol
-
-
?
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
-
-
-
-
?
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
-, Q6RS93
-
-
-
?
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
H9ZGN0
-
-
-
r
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
-
activity is 3.1fold higher than with (S)-N-benzyl-3-pyrrolidinol
-
-
?
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
B2ZRE3
6% activity compared to cyclohexanol
-
-
r
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
Q9HIM3, -
73.5% activity compared to ethanol
-
-
?
2-propanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
Sulfolobus solfataricus DSM1617
-
-
-
-
?
2-propanol + NAD+
propanone + NADH + H+
show the reaction diagram
-
-
-
-
r
2-[3-(2-phenyl-1,3-dioxolan-2-yl)phenyl]propanal + NADH + H+
(S)-2-(3-(2-phenyl-1,3-dioxolan-2-yl)phenyl)propanol + NAD+
show the reaction diagram
-
18 h, 95% yield, 61% enantiomeric excess
-
-
?
3',4'dimethoxyphenylacetone + NADH + H+
1-(3,4-dimethoxyphenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
24% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-bromoacetophenone + NADH + H+
1-(3-bromophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
151% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-chloroacetophenone + NADH + H+
1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
70% of the activity with phenyl trifluoromethyl ketone
-
-
?
3'-methoxyacetophenone + NADH + H+
1-(3-methoxyphenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
51% of the activity with phenyl trifluoromethyl ketone
-
-
?
3,3,5-trimethylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
2% activity compared to cyclohexanone
-
-
?
3,4-dihydro-retinol + NAD+
3,4-dihydro-retinal
show the reaction diagram
-
-
-
-
r
3,4-dimethylbenzyl alcohol + NAD+
3,4-dimethylbenzaldehyde + NADH + H+
show the reaction diagram
B2ZRE3
45% activity compared to cyclohexanol
-
-
r
3,4-hexanedione + NADH + H+
?
show the reaction diagram
-
77% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
3,4-methylenedioxyphenyl acetone + NADH
(S)-(3,4-methylenedioxyphenyl)-2-propanol + NAD+ + H+
show the reaction diagram
-
-
-
-
-
3,5-dimethylcyclohexanol + NAD+
3,5-dimethylcyclohexanone + NADH + H+
show the reaction diagram
B2ZRE3
1% activity compared to cyclohexanol
-
-
r
3-acetylpyridine + NADH + H+
1-pyridin-3-ylethanol + NAD+
show the reaction diagram
-
7.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
3-acetylpyridine + NADH + H+
(R)-1-(3-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
3-aminobenzyl alcohol + NAD+
3-aminobenzaldehyde + NADH + H+
show the reaction diagram
B2ZRE3
8% activity compared to cyclohexanol
-
-
r
3-bromobenzyl alcohol + NAD+
3-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-bromobenzylalcohol + NAD+
3-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-butene-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-chloro-2-butanone + NADH + H+
3-chlorobutan-2-ol + NAD+
show the reaction diagram
Leifsonia sp.
-
151% of the activity with phenyl trifluoromethyl ketone
-
-
?
3-chlorobenzaldehyde + NADH + H+
3-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
3-heptanol + NAD+
3-heptanone + NADH + H+
show the reaction diagram
Leifsonia sp.
-
93% of the activity with 2-propanol
-
-
r
3-methoxybenzaldehyde + NADH + H+
3-methoxybenzylalcohol + NAD+
show the reaction diagram
-
14% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
13% of the activity with (S)-(-)-1-phenylethanol
-
-
?
3-methoxybenzylalcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
3-methyl-1-butanol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-methyl-2-cyclohexenone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
1% activity compared to cyclohexanone
-
-
?
3-methylbutan-1-ol + NAD+
3-methyl-butan-1-one + NADH + H+
show the reaction diagram
-
-
-
-
?
3-methylbutan-1-ol + NAD+
3-methyl-butan-1-one + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
?
3-methylbutan-2-ol + NAD+
3-methylbutan-2-one + NADH
show the reaction diagram
-
R-(-)-3-methylbutan-2-ol and S-(+)-3-methylbutan-2-ol
-
-
?
3-methylbutan-2-one + NADH
3-methylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methylbutan-2-one + NADH + H+
3-methylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
3-methylbutan-2-one + NADH + H+
3-methyl-2-butanol + NAD+
show the reaction diagram
-
-
-
-
r
3-methylbutanol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-methylbutanol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-methylbutanol + NAD+
3-methylbutanone + NADH + H+
show the reaction diagram
B2ZRE3
133% activity compared to cyclohexanol
-
-
r
3-methylbutyraldehyde + NADH + H+
3-methylbutanol + NAD+
show the reaction diagram
-
2.9% of the activity with acetaldehyde
-
-
?
3-methylcyclohexanol + NAD+
3-methylcyclohexanone + NADH
show the reaction diagram
-
-
-
-
r
3-methylcyclohexanol + NAD+
?
show the reaction diagram
Q4J9F2, -
10% of the activity compared to isoborneol
-
-
?
3-methylcyclohexanone + NADH
3-methylcyclohexanol + NAD+
show the reaction diagram
-
-
-
-
r
3-methylcyclohexanone + NADH
3-methylcyclohexanol + NAD+
show the reaction diagram
Q4J702
about 10% of the activity compared to isatin
-
-
?
3-methylcyclohexanone + NADH + H+
3-methylcyclohexanol + NAD+
show the reaction diagram
Q4J9F2, -
33% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
3-methylcylohexanol + NAD+
3-methylcyclohexanone + NADH
show the reaction diagram
Q4J702
14% of activity compared to (S)-1-indanol
-
-
?
3-methylphenylethyl alcohol + NAD+
?
show the reaction diagram
B2ZRE3
64% activity compared to cyclohexanol
-
-
?
3-nitroacetophenone + NADH + H+
1-(3-nitrophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
3-nitrobenzaldehyde + NADH + H+
3-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
3-nitrobenzaldehyde + NADH + H+
3-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
class IV isozyme, reductive activity
-
-
?
3-oxo-5beta-androstan-17beta-ol + NADH
3beta,17beta-dihydroxy-5beta-androstane + NAD+
show the reaction diagram
-
-
-
-
?
3-oxo-5beta-androstan-17beta-ol + NADH
3beta,17beta-dihydroxy-5beta-androstane + NAD+
show the reaction diagram
-
-
-
-
?
3-oxoheptane + NADH
3-hydroxyheptane + NAD+
show the reaction diagram
-
-
-
-
?
3-pentanol + NAD+
3-pentanone + NADH + H+
show the reaction diagram
-
-
-
-
r
3-pentanol + NAD+
3-pentanone + NADH + H+
show the reaction diagram
B2ZRE3
2% activity compared to cyclohexanol
2% activity compared to cyclohexanone
-
r
3-pentanone + NADH
pentan-3-ol + NAD+
show the reaction diagram
-
-
-
r
3-pentanone + NADPH + H+
pentan-3-ol + NADP+
show the reaction diagram
B2KJ46, -
7.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
3-penten-2-one + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
2% activity compared to cyclohexanone
-
-
?
3-phenyl-1-propanol + NAD+
3-phenyl-1-propanone + NADH
show the reaction diagram
-
-
-
-
-
3-phenyl-1-propanol + NAD+
3-phenyl-1-propanone + NADH
show the reaction diagram
-
-
-
-
?
3-phenyl-2-propen-1-ol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3-phenylpropanol + NAD+
3-phenylpropanal + NADH + H+
show the reaction diagram
-
135% of the activity with 2-phenylethanol
-
-
?
3-phenylpropionaldehyde + NADH
3-phenylpropan-1-ol + NAD+
show the reaction diagram
Leifsonia sp.
-
1218% of the activity with phenyl trifluoromethyl ketone
-
-
?
3-phenylpropionaldehyde + NADH + H+
3-phenylpropanol + NAD+
show the reaction diagram
-
6.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
3-pyridylcarbinol + NAD+
pyridine-3-carbaldehyde + NADH
show the reaction diagram
-
-
-
-
?
3beta,12alpha-dihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta,17beta-dihydroxy-5beta-androstane + NAD+
5beta-androstan-3,17dione + NADH
show the reaction diagram
-
-
-
-
?
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta,7alpha-dihydroxy-5beta-cholanoic acid + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
3beta-hxdroxy-5alpha-cholanoate + NAD+
3-oxo-5alpha-cholanoate + NADH
show the reaction diagram
-
-
-
-
?
3beta-hydroxy-5beta-androstan-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
-
3beta-hydroxy-5beta-androstan-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
?
3beta-hydroxy-5beta-androstan-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
-
catalyzed by isoenzyme BB-ADH, no activity with isoenzyme AA-ADH and TT-ADH
-
-
?
3beta-hydroxy-5beta-cholanoate + NAD+
3-oxo-5beta-cholanoate + NADH
show the reaction diagram
-
-
-
-
?
4'-bromoacetophenone + NADH + H+
1-(4-bromophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
77% of the activity with phenyl trifluoromethyl ketone
-
-
?
4'-chloroacetophenone + NADH + H+
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
60% of the activity with phenyl trifluoromethyl ketone
-
-
?
4'-chlorobutyrophenone + NADH + H+
1-(4-chlorophenyl)butan-1-ol + NAD+
show the reaction diagram
-
10% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
4-acetylpyridine + NADH + H+
1-pyridin-4-ylethanol + NAD+
show the reaction diagram
-
64.5fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
4-acetylpyridine + NADH + H+
(R)-1-(4-pyridyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-bromobenzyl alcohol + NAD+
4-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
4-bromobenzylalcohol + NAD+
4-bromobenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADH + H+
4-carboxybenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADH + H+
4-carboxybenzylalcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-chloroacetophenone + NADH
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
Rhodococcus ruber, Rhodococcus ruber 219
-
-
-
-
r
4-chloroacetophenone + NADH + H+
1-(4-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-chlorobenzaldehyde + NADH + H+
4-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
4-ethylcyclohexanol + NAD+
4-ethylcyclohexanone + NADH + H+
show the reaction diagram
B2ZRE3
60% activity compared to cyclohexanol
-
-
r
4-ethylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
22% activity compared to cyclohexanone
-
-
?
4-fluoroacetophenone + NADH + H+
1-(4-fluorophenyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
4-hydroxy-2-butanone + NADH + H+
2,4-dihydroxybutane + NAD+
show the reaction diagram
Leifsonia sp.
-
26% of the activity with phenyl trifluoromethyl ketone
-
-
?
4-hydroxy-retinol + NAD+
4-oxo-retinal + NADH
show the reaction diagram
-
-
-
-
r
4-hydroxymethylpyrene + NAD+
4-formylpyrene + NADH + H+
show the reaction diagram
P00326, P08319
-
-
-
r
4-hydroxynonenal + NADH + H+
4-hydroxynonenol + NAD+
show the reaction diagram
-
substrate of isozyme ADH4
-
-
r
4-methoxy-1-naphthaldehyde + NAD+
4-methoxy-1-naphthyl alcohol + NADH + H+
show the reaction diagram
-
substrate for class I ADH
-
-
?
4-methoxy-1-naphthaldehyde + NAD+
4-methoxy-1-naphtol + NADH + H+
show the reaction diagram
-
fluorogenic substrate of class I and II isozymes
-
-
?
4-methoxy-1-naphthaldehyde + NADH + H+
4-methoxy-1-naphthyl alcohol + NAD+
show the reaction diagram
-
substrate for class I ADH
-
-
r
4-methoxybenzaldehyde + NADH + H+
4-methoxybenzylalcohol + NAD+
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
4-methoxybenzyl alcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
4-methoxybenzyl alcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
99% of the activity with (S)-(-)-1-phenylethanol
-
-
?
4-methoxybenzylalcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
4-methyl-1-pentanol + NAD+
4-methyl-1-pentanal + NADH
show the reaction diagram
-
-
-
-
-
4-methyl-1-pentanol + NAD+
4-methyl-1-pentanal + NADH
show the reaction diagram
-
-
-
-
?
4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH + H+
show the reaction diagram
B2ZRE3
56% activity compared to cyclohexanol
-
-
r
4-methylcyclohexanone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
25% activity compared to cyclohexanone
-
-
?
4-methylcyclohexanone + NADH + H+
4-methylcyclohexanol + NAD+
show the reaction diagram
Q4J9F2, -
60% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
4-methylpentan-2-one + NADH + H+
4-methyl-2-pentanol + NAD+
show the reaction diagram
-
-
-
-
r
4-nitrobenzaldehyde + NADH + H+
4-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NADH + H+
4-nitrobenzyl alcohol + NAD+
show the reaction diagram
Candida maris, Candida maris IFO10003
-
-
-
-
r
4-nitrobenzaldehyde + NADH + H+
4-nitrobenzylalcohol + NAD+
show the reaction diagram
-
-
-
-
?
4-nitrobenzyl alcohol + NAD+
4-nitrobenzaldehyde + NADH + H+
show the reaction diagram
-, Q76HN6
94% activity compared to benzyl alcohol
-
-
?
4-nitrosodimethylaniline + NAD+
? + NADH + H+
show the reaction diagram
-
photometric assay substrate
-
-
?
4-phenylbutan-2-one + NADH
4-phenylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
?
5-acetyl-7-chlorofuro[2,3-c]pyridine + NADH + H+
5-(1-hydroxyethyl)-7-chlorofuro[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
5-acetylfuro[2,3-c]pyridine + NADH + H+
5-(1-hydroxyethyl)furo[2,3-c]pyridine + NAD+
show the reaction diagram
-
-
-
-
r
5-hydroxymethylfurfural + NADH + H+
?
show the reaction diagram
P00330
mutant enzyme S109P/L116S/Y294C
-
-
?
5alpha-androstan-17beta-ol-3-one + NADH + H+
3beta,17beta-dihydroxy-5alpha-androstan + NAD+
show the reaction diagram
-
-
-
-
-
5alpha-androstan-17beta-ol-3-one + NADH + H+
3beta,17beta-dihydroxy-5alpha-androstan + NAD+
show the reaction diagram
-
-
-
-
?
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH
show the reaction diagram
-
low activity
-
-
?
5beta-androstan-17beta-ol-3-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
?
5beta-androstan-17beta-ol-3-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
-
low activity
-
-
?
5beta-androstan-3beta-ol-17-one + NAD+
5beta-androstan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
?
5beta-cholanic acid-3-one + NAD+
5beta-cholanic acid-3-ol + NAD+
show the reaction diagram
-
-
-
-
?
5beta-cholanic acid-3-one + NADH
5beta-cholanic acid-3-ol + NAD+
show the reaction diagram
-
low activity
-
-
?
5beta-pregnan-21-ol-3,20-dione hemisuccinate + NADH
5beta-pregnan-3,20,21-trione hemisuccinate + NADH
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3,20-dione + NADH
?
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3beta-ol-20-one + NAD+
5beta-pregnan-3,20-dione + NADH
show the reaction diagram
-
-
-
-
?
6-benzyloxy-3,5-dioxo-hexanoic acid ethyl ester + NADH + H+
(3R,5S)-6-benzyloxy-3,5-dihydroxy-hexanoic acid ethyl ester + NAD+
show the reaction diagram
-
-
-
-
-
6-methoxy-2-naphthaldehyde + NAD+
6-methoxy-2-naphthyl alcohol + NADH + H+
show the reaction diagram
-
substrate for class II ADH
-
-
?
6-methoxy-2-naphthaldehyde + NADH + H+
6-methoxy-2-naphthyl alcohol + NAD+
show the reaction diagram
-
substrate for class II ADH
-
-
r
6-methoxy-2-naphthaldehyde + NADH + H+
6-methoxy-2-naphtol + NAD+
show the reaction diagram
-
class II isozyme, reductive activity
-
-
?
7-cis-retinol + NAD+
7-cis-retinal + NADH
show the reaction diagram
-
-
-
-
?
9-cis-retinol + NAD+
9-cis-retinal + NADH
show the reaction diagram
-
-
-
-
?
9-cis-retinol + NAD+
9-cis-retinal + NADH
show the reaction diagram
-
-
-
?
a primary alcohol + NAD+
an aldehyde + NADH + H+
show the reaction diagram
-
ADH3 is involved in multiple cellular pathways, as diverse as formaldehyde detoxification, retinoid metabolism and NO homeostasis, ADH3 is considered to play only a minor role in hepatic alcohol metabolism because ethanol concentrations rarely exceed 50 mM
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
-
-
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
Candida sp.
-
-
-
-
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
Sporotrichum pulverulentum
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
A4IP64, A4ISB9
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
H9ZGN0
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
H9ZGN0
best substrate
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
the reduction of acetaldehyde is 4.9fold faster than the oxidation of ethanol
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
reduced by isoenzyme A2 and C2, no activity with isoenzyme B2
-
-
-
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
reduced at the highest rate of all aldehydes tested
-
-
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
cells with an extra copy of ADH1 display chronological life-span extension. Antioxidant enzymes are induced in 2xADH1 cells. Strains carrying an extra ADH1 copy show extended replicative life span and increased Sir2p activity
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
P00330
mutant enzyme S109P/L116S/Y294C
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
Oenococcus oeni DSM20252
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
Candida sp. N-16
-
-
-
-
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
Candida maris IFO10003
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
Ogataea angusta DL-1, ATCC 26012
H9ZGN0
-, best substrate
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
Entamoeba histolytica HM1:1MSS
-
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
A4IP64, A4ISB9, -
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+ + H+
show the reaction diagram
A4IP64, A4ISB9
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
-
16% of the activity with NADH
-
-
r
acetoin + NADH + H+
3-hydroxy-2-butanol + NAD+
show the reaction diagram
-
-
-
-
r
acetone + NAD+ + H2O
? + NADH + H+
show the reaction diagram
A4IP64, A4ISB9
about 5% of the activity with 1-octanol
-
-
r
acetone + NADH
isopropanol + NAD+
show the reaction diagram
-
-
-
r
acetone + NADH
isopropanol + NAD+
show the reaction diagram
-
-
-
r
acetone + NADH + H+
propan-2-ol + NAD+
show the reaction diagram
-
1.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
acetone + NADH + H+
2-propanol + NAD+
show the reaction diagram
-
-
-
-
?
acetone + NADPH + H+
propan-2-ol + NADP+
show the reaction diagram
B2KJ46, -
14.7% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
acetophenone + NADH
(R)-alpha-phenyl ethanol + NAD+
show the reaction diagram
-
the enzyme exhibits high stereoselectivity in the desymmetrization of the prochiral ketone acetophenone, producing optically pure (R)-alpha-phenyl ethanol at high conversion
-
-
?
acetophenone + NADH
acetophenol + NAD+
show the reaction diagram
Rhodococcus ruber, Rhodococcus ruber 219
-
-
-
-
r
acetophenone + NADH + H+
(R)-1-phenylethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
6% of the activity with phenyl trifluoromethyl ketone, in the reverse reaction 87% of the activity with 2-propanol
99% enantiomeric excess
-
?
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
Q4J9F2, -
-
-
-
?
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
-
-
-
-
r
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
-
1.8fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
-
40% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
Q4J9F2
-
-
-
?
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
Candida maris IFO10003
-
-
-
-
r
acetophenone + NADH + H+
(S)-(-)-1-phenylethanol + NAD+
show the reaction diagram
-
more than 99% enantiomeric excess
-
-
r
acetophenone + NADPH + H+
1-phenylethanol + NADP+
show the reaction diagram
B2KJ46, -
5.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
acetophenone + NADPH + H+
1-phenylethanol + NADP+
show the reaction diagram
Candida parapsilosis CCTCC M203011
B2KJ46
5.1% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
acetylacetone + 2 NADH + 2 H+
2,4-pentanediol + 2 NAD+
show the reaction diagram
-
-
-
-
r
acetylacetone + NADH + H+
?
show the reaction diagram
-
63% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
acetylacetone + NADH + H+
acetophenone + NADH + H+
show the reaction diagram
B2ZRE3
1% activity compared to cyclohexanone
1% activity compared to cyclohexanone
-
r
acetylpyrazine + NADH + H+
(R)-1-(pyrazyl)ethanol + NAD+
show the reaction diagram
-
-
-
-
r
alcohol + NAD+
aldehyde or ketone + NADH
show the reaction diagram
Rhodococcus ruber, Rhodococcus ruber DSM44541
-
medium chain sec-alcohols or (omega-1)-ketones, no activity with primary alcohols or aldehydes
-
-
r
all-trans-retinal + NADH + H+
all-trans-retinol + NAD+
show the reaction diagram
-
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
-
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
-
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
-
-
-
-
r
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
-
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
-
ADH4 might be involved in biosynthesis of retinoic acid
-
-
r
allyl alcohol + NAD+
prop-2-en-1-al + NADH
show the reaction diagram
-
-
-
-
?
allyl alcohol + NAD+
prop-2-en-1-al + NADH
show the reaction diagram
-
-
-
-
?
allyl alcohol + NAD+
prop-2-en-1-al + NADH
show the reaction diagram
-
-
-
-
?
allyl alcohol + NAD+
prop-2-en-1-al + NADH
show the reaction diagram
-
-
-
-
?
allyl alcohol + NAD+
prop-2-en-1-al + NADH
show the reaction diagram
-
-
-
-
?
allyl alcohol + NAD+
prop-2-en-1-al + NADH
show the reaction diagram
-
no activity
-
-
-
allyl alcohol + NAD+
acrolein + NADH
show the reaction diagram
-
-
-
-
?
allyl alcohol + NAD+
acrolein + NADH
show the reaction diagram
-
-
-
-
r
allyl alcohol + NAD+
acrolein + NADH
show the reaction diagram
-
-
-
-
?
allyl alcohol + NAD+
acrolein + NADH
show the reaction diagram
-
-
product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol
-
?
allylalcohol + NAD+
prop-2-enal + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
?
alpha-tetralone + NADH + H+
(S)-alpha-tetralol + NAD+
show the reaction diagram
-
more than 99% enantiomeric excess
-
-
?
alpha-tetraol + NAD+
?
show the reaction diagram
Q4J9F2, -
51% of the activity compared to isoborneol
-
-
?
anisaldehyde + NADH
anisic alcohol + NADH
show the reaction diagram
-
-
-
-
?
anisaldehyde + NADH + H+
anisic alcohol + NAD+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADH
benzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADH
benzyl alcohol + NAD+
show the reaction diagram
F9VMI9, -
-
-
-
?
benzaldehyde + NADH
benzyl alcohol + NAD+
show the reaction diagram
-
reduced by isoenzyme A2 and C2, no activity with isoenzyme B2
-
-
r
benzaldehyde + NADH
benzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
-
1.2% of the activity with acetaldehyde
-
-
?
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
-, Q76HN6
3% activity compared to benzyl alcohol
-
-
r
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
-
14% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
-
21% of activity with N-benzyl-3-pyrrolidinone
-
-
?
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
-
74% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
Candida maris IFO10003
-
-
-
-
r
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
show the reaction diagram
Sulfolobus solfataricus Gtheta
-
-
-
-
?
benzil + NADH + H+
(R)-benzoin + NAD+
show the reaction diagram
Q4J9F2, -
62% of the activity compared to 1-phenyl-1,2-propanedione. The enzyme catalyses the asymmetric reduction of benzil to (R)-benzoin with both excellent conversion (98%) and optical purity (98%) by way of an efficient in situ NADH-recycling system involving a second thermophilic ADH
-
-
?
benzoin + NADH + H+
1,2-diphenylethane-1,2-diol
show the reaction diagram
-
13% of activity with N-benzyl-3-pyrrolidinone
-
-
?
benzoylformic acid + NADPH + H+
mandelate + NADP+
show the reaction diagram
B2KJ46, -
2.4% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
benzyl aclohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
Q9QYY9
-
-
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
-
no activity
-
-
-
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
-
oxidized by isoenzyme A2 and C2 no activity with isoenzyme B2
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
show the reaction diagram
-
oxidation with isoenzyme ADH-1 and ADH-3, no activity with isoenzyme ADH-2
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
P50381, -
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
B2ZRE3
-
178% activity compared to cyclohexanone
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-, Q76HN6
100% activity
-
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
199% of the activity with 2-phenylethanol
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
B2ZRE3
47% activity compared to cyclohexanol
154% activity compared to cyclohexanone
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
P50381
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
Saccharomyces carlsbergensis Y379-50
B6UQD0
-
-
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
Sulfolobus solfataricus DSM1617
-
-
-
-
r
benzylacetone + NADH + H+
4-phenylbutan-2-ol + NAD+
show the reaction diagram
-
-
-
-
r
benzylacetone + NADH + H+
4-phenylbutan-2-ol + NAD+
show the reaction diagram
-
activity is 1.3fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
benzylalcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
benzylalcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
Q9UXF1, -
-
-
-
?
benzylalcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
-, Q8L3C9
weak activity
-
-
r
benzylalcohol + NAD+
benzaldehyde + NADH + H+
show the reaction diagram
Q9UXF1, -
-
-
-
?
benzyloxycarbonyl-3-pyrrolidinone + NADH + H+
(S)-benzyloxycarbonyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
production with 99.6% enantiomeric excess
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
-
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
no activity
-
-
-
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
weak activity
-
-
?
butan-2-ol + NAD+
butan-2-one + NADH
show the reaction diagram
-
(R)-2-butanol and (S)-2-butanol
-
?
butan-2-one + NADH
butan-2-ol + NAD+
show the reaction diagram
-
-
-
r
butan-2-one + NADH
butan-2-ol + NAD+
show the reaction diagram
-
-
-
-
r
butanal + NADH
1-butanol + NAD+ + H+
show the reaction diagram
Leifsonia sp.
-
% of the activity with phenyl trifluoromethyl ketone
-
-
ir
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
weak
-
-
-
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
activity with ADH I, no activity with ADH II
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
oxidized by enzyme form ADH-I, no activity with enzyme form ADH-II
-
-
-
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
pH 10.0: oxidized by ADH-1 and ADH-3, no activity with isoenzyme ADH-2
-
-
?
butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
Meyerozyma guilliermondii B10-05
-
-
-
-
?
butanol + NAD+
butanal + NADH
show the reaction diagram
-
-
-
-
?
butanol + NAD+
n-butanal + NADH
show the reaction diagram
P00327
-
-
-
?
butanol + NAD+
butyraldehyde + NADH + H+
show the reaction diagram
B2ZRE3
-
359% activity compared to cyclohexanone
-
r
butanol + NAD+
butyraldehyde + NADH + H+
show the reaction diagram
-
immobilized HLAD shows about 95% reaction rate and free HLAD shows about 90% reaction rate with butanol compared to ethanol at pH 8.8 and 30C
-
-
?
butyraldehyde + NADH
n-butanol + NAD+
show the reaction diagram
-
-
-
-
r
butyraldehyde + NADH
n-butanol + NAD+
show the reaction diagram
-
-
-
-
r
butyraldehyde + NADH
n-butanol + NAD+
show the reaction diagram
-
activity with enzyme form ADH I, no activity with enzyme form ADH II
-
r
butyraldehyde + NADH + H+
n-butanol + NAD+
show the reaction diagram
-
-
-
-
?
butyraldehyde + NADH + H+
n-butanol + NAD+
show the reaction diagram
Acetobacter pasteurianus, Acetobacter pasteurianus SKU1108
-
best substrate for isozyme ADH II
-
-
r
butyraldehyde + NADH + H+
n-butanol + NAD+
show the reaction diagram
Sulfolobus solfataricus Gtheta
-
-
-
-
?
butyraldehyde + NADH + H+
butanol + NAD+
show the reaction diagram
-
56% of the activity with acetaldehyde
-
-
?
butyraldehyde + NADPH + H+
butanol + NADP+
show the reaction diagram
-
22% of the activity with NADH
-
-
?
capronaldehyde + NADH
1-hexanol + NAD+
show the reaction diagram
Rhodococcus ruber, Rhodococcus ruber 219
-
best substrate
-
-
r
chloroacetone + NADH + H+
1-chloropropan-2-ol + NAD+
show the reaction diagram
Leifsonia sp.
-
238% of the activity with phenyl trifluoromethyl ketone
-
-
?
chloroacetone + NADH + H+
1-chloropropan-2-ol + NAD+
show the reaction diagram
-
41.7fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
chloroacetone + NADH + H+
1-chloro-2-propanol + NAD+
show the reaction diagram
-
-
-
-
r
choline + NAD+
? + NADH + H+
show the reaction diagram
-, Q76HN6
3% activity compared to benzyl alcohol
-
-
?
cinnamyl alcohol + NAD+
cinnamaldehyde + NADH
show the reaction diagram
-
-
-
-
?
cinnamyl alcohol + NAD+
cinnamaldehyde + NADH
show the reaction diagram
-
-
-
-
?
cinnamyl alcohol + NAD+
cinnamaldehyde + NADH
show the reaction diagram
-
-
-
-
?
cis-4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cis-decahydro-1-naphthol + NAD+
?
show the reaction diagram
Q4J702
11% of activity compared to (S)-1-indanol
-
-
?
crotyl alcohol + NAD+
crotonaldehyde + NADH
show the reaction diagram
-
-
-
-
?
crotyl alcohol + NAD+
crotonaldehyde + NADH
show the reaction diagram
-
-
-
-
?
crotyl alcohol + NAD+
crotonaldehyde + NADH
show the reaction diagram
-
-
product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol
-
?
crotyl alcohol + NAD+
crotonaldehyde + NADH
show the reaction diagram
-
product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol
-
-
?
cycloheptanol + NAD+
cycloheptanone + NADH + H+
show the reaction diagram
Q4J9F2, -
-
-
-
?
cycloheptanol + NAD+
cycloheptanone + NADH + H+
show the reaction diagram
Q4J702
37% of activity compared to (S)-1-indanol
-
-
?
cycloheptanone + NADH
cycloheptanol + NAD+
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
no activity
-
-
-
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
oxidized by isoenzyme A2, no activity with isoenzymes B2 and C2
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH
show the reaction diagram
-
reaction is catalyzed by the cathodic pyrazole-sensitive enzyme, no activity with the cathodic pyrazole-insensitive enzyme and by the anodic pyrazole-insensitive enzyme
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH + H+
show the reaction diagram
-
-
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH + H+
show the reaction diagram
-
-
-
-
r
cyclohexanol + NAD+
cyclohexanone + NADH + H+
show the reaction diagram
B2ZRE3
100% activity
100% activity
-
r
cyclohexanol + NAD+
cyclohexanone + NADH + H+
show the reaction diagram
-
13% of the activity with (S)-(-)-1-phenylethanol
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH + H+
show the reaction diagram
Sulfolobus solfataricus DSM1617
-
-
-
-
?
cyclohexanone + NADH
cyclohexanol + NAD+
show the reaction diagram
-
-
-
-
?
cyclohexanone + NADH
cyclohexanol + NAD+
show the reaction diagram
-
best cyclic ketone substrate
-
-
?
cyclohexanone + NADH
cyclohexanal + NAD+
show the reaction diagram
-
-
-
-
?
cyclohexanone + NADH + H+
?
show the reaction diagram
-
activity is 2.1fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
cyclohexanone + NADH + H+
cyclohexanol + NAD+
show the reaction diagram
Q4J9F2, -
-
-
-
?
cyclooctanone + NADH
cyclooctanol + NAD+
show the reaction diagram
-
-
-
-
?
cyclopentanol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
cyclopentanol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
cyclopentanol + NAD+
cyclopentanone + NADH + H+
show the reaction diagram
Q4J9F2, -
55% of the activity compared to isoborneol
-
-
?
cyclopentanone + NADH
cyclopentanol + NAD+
show the reaction diagram
-
-
-
-
?
cyclopentanone + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
1% activity compared to cyclohexanone
-
-
?
cyclopetanone + NADH
cyclopentanol + NADH
show the reaction diagram
-
-
-
-
?
D-glucitol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
D-glucitol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
decahydro-2-naphthol + NAD+
?
show the reaction diagram
B2ZRE3
37% activity compared to cyclohexanol
-
-
?
decyl aldehyde + NADH + H+
1-decanol + NAD+
show the reaction diagram
-, Q76HN6
21% activity compared to benzyl alcohol
-
-
?
diacetyl + NADH + H+
?
show the reaction diagram
Devosia riboflavina, Devosia riboflavina KNK10702
-
16.1fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
diacetyl + NADH + H+
2,3-butandiol + NAD+
show the reaction diagram
-
-
-
-
r
diethylketone + NADH + H+
3-pentanol + NAD+
show the reaction diagram
-
-
-
-
r
digitose + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
dihydro-4,4-dimethyl-2,3-furandione + NADH + H+
?
show the reaction diagram
-
13.1fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
docosanol + NAD+
? + NADH + H+
show the reaction diagram
-
immobilized HLAD shows about 60% reaction rate and free HLAD shows about 20% reaction rate with docosanol compared to ethanol at pH 8.8 and 30C
-
-
?
dodecanol + NAD+
dodecanal + NADH + H+
show the reaction diagram
-
immobilized HLAD shows about 60% reaction rate and free HLAD shows about 35% reaction rate with dodecanol compared to ethanol at pH 8.8 and 30C
-
-
?
ethanol + 2 NAD+ + H2O
acetic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
best substrate
-
-
r
ethanol + 2 NAD+ + H2O
acetic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 45% of the activity with 1-octanol
-
-
r
ethanol + 2 NADP+ + H2O
acetic acid + 2 NADPH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
-
-
-
r
ethanol + 3-benzoylpyridine-adenine dinucleotide
acetaldehyde + ?
show the reaction diagram
-
rapid equilibrium bi bi mechanism
-
-
-
ethanol + beta-NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
-
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
-
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
-
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
P00331
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
-
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
-
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
-
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-, Q9P6C8
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
acetaldehyde is the best substrate for isozyme ADH I
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
best substrate
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
class III isoenzyme chi-ADH oxidizes ethanol very poorly
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
no oxidation with class III enzyme
-
-
-
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
isoenzyme ADH-1 and ADH-3, no activity with isoenzyme ADH-2
-
-
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
the reduction of acetaldehyde is 4.9fold faster than the oxidation of ethanol
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
Candida sp.
-
the reduction of acetaldehyde of ADH-MII is about 7times higher than that of the oxidation of ethanol
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
no activity with isoenzyme B2, oxidized by isoenzyme A2 and C2, role of the major liver isoenzyme A2 in ethanol metabolism
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
plays an important role in the metabolism of ethanol
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
chi-ADH plays an important role in the metabolism of long chain alcohols and aldehydes
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
the anodic enzyme form may contribute significantly to alcohol elimination in man, particularly at high concentrations when the other enzyme species are saturated
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
the enzyme plays a significant role in first-pass metabolism of ethanol in human
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
enzyme is responsible for the major ethanol oxidation capacity in the body. The products acetaldehyde and NADH are responsible for the most of the toxic effects and metabolic disturbances produced by ethanol ingestion
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
rate-limiting step of the alcoholic fermentation
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
P00327
isomerization of the enzyme-NAD+ complex is the rate-limiting step for acetaldehyde reduction by the wild-type enzyme
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
no cooperativity between the 2 active sites of the enzyme
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
DH3 plays an important role in systemic ethanol metabolism at higher levels of blood ethanol through activation by cytoplasmic solution hydrophobicity
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
76% of the activity with 2-phenylethanol
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
P42328
proton and hydride equivalent transfer in the alcohol dehydrogenase enzymatic reaction are modulated by the correlated motions between NAD+ and the cofactor domain
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
Entamoeba histolytica HM1
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
Candida sp. N-16
-
the reduction of acetaldehyde of ADH-MII is about 7times higher than that of the oxidation of ethanol
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
Brevibacterium sp. KU 1309
-
76% of the activity with 2-phenylethanol
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
Acetobacter pasteurianus SKU1108
-
-
acetaldehyde is the best substrate for isozyme ADH I
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
Neurospora crassa FGSC2489
-, Q9P6C8
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
B8QU18
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
-
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-, Q8L3C9
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Q9UXF1, -
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
P50381, -
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-, Q6L0S1
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Q09669, -
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Q0PH30, -
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-, Q6RS93
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-, Q9ZT38
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Q1G151
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
H9ZGN0
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
best substrate
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Q9HIM3, -
100% activity
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
no activity with NADP+, in reverse reaction no activity with NADPH
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
the enzyme is highly specific for ethanol with NAD+ as the coenzyme
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
B2ZRE3
88% activity compared to cyclohexanol
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
P00326, P08319
substrate for isozyme ADH1C, extremely poor substrate for isozyme ADH3
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
P00326, P08319
substrate for isozyme ADH2
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
P00326, P08319
substrate for isozyme ADH4
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
P50381
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Mucor circinelloides YR-1
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Q9UXF1, -
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Sulfolobus solfataricus DSM1617
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Glycine max Enrei
Q9ZT38
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Thermoanaerobacter ethanolicus JW200
Q0PH30
-
-
-
?
ethanol + NAD+
aldehyde + NADH + H+
show the reaction diagram
-
immobilized HLAD shows 100% reaction rate and free HLAD shows about 55% reaction rate with ethanol at pH 8.8 and 30C
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
show the reaction diagram
-, Q6L0S1
8.5% of the activity with ethanol and NAD+
-
-
?
ethyl 3-methyl-2-oxobutyrate + NADH + H+
ethyl-2-hydroxy-3-methylbutyrate + NAD+
show the reaction diagram
Leifsonia sp.
-
33% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl 3-methyl-2-oxobutyrate + NADH + H+
?
show the reaction diagram
Q4J9F2, -
1-phenyl-1,2-propanedione and ethyl 3-methyl-2-oxobutyrate are the best substrate in the reduction reaction
-
-
?
ethyl 3-oxobutanoate + NADH + H+
ethyl 3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
309% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl 3-oxobutyrate + NADH + H+
ethyl (S)-3-hydroxybutyrate + NAD+
show the reaction diagram
-
-
-
-
-
ethyl 3-phenyl-3-oxopropanoate + NADH
ethyl 3-phenyl-3-hydroxypropanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethyl 4-bromo-3-oxobutanoate + NADH + H+
ethyl 4-bromo-3-hydroxybutanoate
show the reaction diagram
Leifsonia sp.
-
511% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl 4-chloro-3-oxobutanoate + NADH + H+
ethyl 4-chloro-3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
809% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl 4-chloroacetoacetate + NADH + H+
?
show the reaction diagram
-
6.8fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
ethyl 4-chloroacetoacetate + NADH + H+
ethyl 4-chloro-3-hydroxybutanoate + NAD+
show the reaction diagram
-
-
-
-
r
ethyl 4-chloroacetoacetate + NADPH
?
show the reaction diagram
B2KJ46, -
activity is 1.48fold higher than with 2-hydroxyacetophenone and NADPH
-
-
?
ethyl acetoacetate + NADH + H+
?
show the reaction diagram
-
42.4fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
ethyl acetoacetate + NADH + H+
ethyl 3-hydroxybutanoate + NAD+
show the reaction diagram
-
-
-
-
r
ethyl benzoylformate + NADH
?
show the reaction diagram
Q4J702
about 30% of the activity compared to isatin
-
-
?
ethyl benzoylformate + NADH
ethyl (R)-mandelate + NAD+
show the reaction diagram
-
enantiomeric excess of 99.9%
-
-
?
ethyl benzoylformate + NADH + H+
ethyl (R)-(-)-mandelate + NAD+
show the reaction diagram
-
95% enantiomeric excess
-
-
?
ethyl benzoylformate + NADH + H+
?
show the reaction diagram
Q4J9F2, -
23% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
ethyl pyruvate + NADH
?
show the reaction diagram
Q4J702
about 15% of the activity compared to isatin
-
-
?
ethyl pyruvate + NADH
ethyl 2-hydroxypropanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethyl pyruvate + NADH + H+
ethyl 2-hydroxypropanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
488% of the activity with phenyl trifluoromethyl ketone
-
-
?
ethyl pyruvate + NADH + H+
ethyl 2-hydroxypropionate + NAD+
show the reaction diagram
Q4J9F2, -
16% of the activity compared to 1-phenyl-1,2-propanedione
-
-
?
ethyl pyruvate + NADH + H+
ethyl lactate + NAD+
show the reaction diagram
-
-
-
-
r
ethyl trifluoroacetoacetate + NADPH + H+
1-ethoxy-2,2,2-trifluoroethanol + NADP+
show the reaction diagram
B2KJ46, -
4.3% of the activity with 2-hydroxyacetophenone and NADPH
-
-
?
ethyl-3-oxobutanoate + NADH
ethyl-3-hydroxybutanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethyl-3-oxohexanoate + NADH
ethyl-3-hydroxyhexanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethyl-3-oxopentanoate + NADH
ethyl-3-hydroxypentanoate + NAD+
show the reaction diagram
-
-
-
-
?
ethylene glycol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
ethylene glycol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
ethylene glycol + NAD+
? + NADH
show the reaction diagram
-
no activity
-
-
-
ethylene glycol + NAD+
? + NADH
show the reaction diagram
-
class III isoenzyme chi-ADH shows no activity
-
-
-
ethylene glycol + NAD+
? + NADH
show the reaction diagram
-
oxidized by isoenzyme A2, no activity with isoenzyme B2 and C2
-
-
?
ethylene glycol + NAD+
? + NADH
show the reaction diagram
Meyerozyma guilliermondii B10-05
-
-
-
-
?
ethylene glycol + NAD+
?
show the reaction diagram
Pseudomonas aeruginosa, Pseudomonas aeruginosa PaADH
-
poor substrate
-
-
r
ethylenglycol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
r
formaldehyde + NADH + H+
methanol + NAD+
show the reaction diagram
-
-
-
-
?
formaldehyde + NADH + H+
methanol + NAD+
show the reaction diagram
-
-
-
-
?
formaldehyde + NADH + H+
methanol + NAD+
show the reaction diagram
-
activity with ADH I, no activity with ADH II
-
-
?
formaldehyde + NADH + H+
methanol + NAD+
show the reaction diagram
-
reduced by isoenzyme A2, no activity with isoenzyme B2 and C2
-
-
r
furfural + NADH
furfuryl alcohol + NADH
show the reaction diagram
-
activity with enzyme form ADH I, no activity with enzyme form ADH II
-
r
furfural + NADH + H+
furfuryl alcohol + NADH
show the reaction diagram
P00330
mutant enzyme S109P/L116S/Y294C
-
-
?
furfuryl alcohol + NAD+
furfural + NADH
show the reaction diagram
-
-
-
-
?
furfuryl alcohol + NAD+
furfural + NADH
show the reaction diagram
-
activity with ADH I, no activity with ADH II
-
r
glutaraldehyde + NADH + H+
?
show the reaction diagram
-
70.8fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
glycerol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 45% of the activity with ethanol
-
-
r
glycerol + NAD+
dihydroxyacetone + NADH
show the reaction diagram
-
-
-
-
?
glycerol + NAD+
dihydroxyacetone + NADH
show the reaction diagram
-
-
-
-
?
glycerol + NAD+
dihydroxyacetone + NADH + H+
show the reaction diagram
-
-
-
-
?
heptaldehyde + NADH + H+
? + NAD+
show the reaction diagram
-, Q76HN6
33% activity compared to benzyl alcohol
-
-
?
heptan-2-ol + NAD+
heptan-2-one + NADH
show the reaction diagram
-
-
-
-
?
heptan-4-ol + NAD+
heptan-4-one + NADH
show the reaction diagram
-
-
-
-
?
hexadecanol + NAD+
hexadecanal + NADH
show the reaction diagram
-
very low activity
-
-
?
hexadecanol + NAD+
hexadecanal + NADH + H+
show the reaction diagram
-
immobilized HLAD shows about 60% reaction rate and free HLAD shows about 15% reaction rate with hexadecanol compared to ethanol at pH 8.8 and 30C
-
-
?
hexaldehyde + NADH + H+
1-heptanol + NAD+
show the reaction diagram
-, Q76HN6
7% activity compared to benzyl alcohol
-
-
?
hexan-1-ol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexan-1-ol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexan-1-ol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexan-1-ol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexan-1-ol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexan-1-ol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexan-2-ol + NAD+
2-hexanone + NADH
show the reaction diagram
-
-
-
-
?
hexanal + NADH + H+
1-hexanone + NAD+
show the reaction diagram
-
49% of the activity with acetaldehyde
-
-
?
hexanal + NADH + H+
n-hexanol + NAD+
show the reaction diagram
-
22.3fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
hexanal + NADPH + H+
1-hexanone + NADP+
show the reaction diagram
-
24% of the activity with NADH
-
-
?
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
-
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
-
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
?
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
-
-
-
?
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
?
hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
activity with ADH I, no activity with ADH II
-
-
-
hexanol + NAD+
hexaldehyde + NADH
show the reaction diagram
-
-
-
-
?
hexanol + NAD+
hexanal + NADH
show the reaction diagram
-
-
-
-
?
hydrocinnamaldehyde + NADH + H+
hydrocinnamyl alcohol + NAD+
show the reaction diagram
-, Q76HN6
12% activity compared to benzyl alcohol
-
-
r
hydrocinnamyl alcohol + NAD+
hydrocinnamaldehyde + NADH + H+
show the reaction diagram
-, Q76HN6
31% activity compared to benzyl alcohol
-
-
r
hydroxyacetone + NADH + H+
propane-1,2-diol + NAD+
show the reaction diagram
-
27% of the activity with N-benzyl-3-pyrrolidinone
-
-
?
isatin + NADH
?
show the reaction diagram
Q4J702
-
-
-
?
iso-propanol + NAD+
isopropanal + NADH + H+
show the reaction diagram
Q9UXF1, -
-
-
-
?
iso-propanol + NAD+
isopropanal + NADH + H+
show the reaction diagram
Q9UXF1, -
-
-
-
?
isoamylalcohol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 5% of the activity with 1-octanol
-
-
r
isoborneol + NAD+
?
show the reaction diagram
Q4J9F2, -
isoborneol is the best substrate in the oxidation reaction
-
-
?
isobutyl alcohol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
isobutyraldehyde + NADH + H+
isobutanol + NAD+
show the reaction diagram
-
-
-
-
r
isobutyramide + NAD+
?
show the reaction diagram
-
-
-
-
r
isopentanol + NAD+
? + NADH + H+
show the reaction diagram
B8QU18
low affinity
-
-
?
isopentenyl alcohol + NAD+
isopentanone + NADH
show the reaction diagram
-
-
-
-
?
isopropanol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 10% of the activity with 1-octanol
-
-
r
isopropanol + 2 NAD+ + H2O
? + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 15% of the activity with 1-octanol
-
-
r
isopropanol + NAD+
acetone + NADH + H+
show the reaction diagram
-
-
-
-
?
isopropanol + NAD+
acetone + NADH + H+
show the reaction diagram
B8QU18
low affinity
-
-
?
isopropanol + NAD+
2-propanone + NADH + H+
show the reaction diagram
B2ZRE3
-
-
-
r
levulinic acid + NADH + H+
?
show the reaction diagram
-
11% of activity with N-benzyl-3-pyrrolidinone
-
-
?
m-chlorophenacyl chloride + NADH + H+
2-chloro-1-(3-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
4.6fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
m-nitrobenzaldehyde + NAD+
m-nitrobenzyl alcohol + NADH
show the reaction diagram
-
-
-
-
m-nitrobenzaldehyde + NAD+
m-nitrobenzyl alcohol + NADH + H+
show the reaction diagram
-
substrate of class IV ADH
-
-
?
m-nitrobenzaldehyde + NADH + H+
m-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
substrate of class IV ADH isozyme
-
-
r
methanol + 2 NAD+ + H2o
formic acid + 2 NADH + 2 H+
show the reaction diagram
A4IP64, A4ISB9
about 25% of the activity with 1-octanol
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
ir
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-, Q6L0S1
-
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
no activity
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
no activity
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
no activity
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
no activity
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
no activity
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
Sporotrichum pulverulentum
-
no activity
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
low activity
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
Candida sp.
-
reaction is extremly weak
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
anodic enzyme form shows no activity
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
no activity at pH 7.5, slight activity at pH 10.8
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
weak activity with isoenzyme A2, no activity with isoenzyme B2 and C2
-
-
?, r
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
oxidized with ADH-3, no activity with ADH-1 and ADH-2
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
class I isoenzymes
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
no activity with isoenzyme beta3,beta3
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
reaction is catalyzed by the pyrazole-sensitive enzyme, no activity with the pyrazole-insensitive enzyme
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
reaction is catalyzed by the cathodic pyrazole-sensitive enzyme, no activity by the cathodic pyrazole-insensitive enzyme and by the anodic pyrazole-insensitive enzyme
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
activity detected with class II isoenzyme pi-ADH
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
oxidized by isoenzyme beta1,beta1
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
class III isoenzyme chi-ADH shows no activity
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
-
no activity with class III enzyme
-
-
-
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
Q9HIM3, -
49.9% activity compared to ethanol
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
Candida sp. N-16
-
reaction is extremly weak
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
show the reaction diagram
Meyerozyma guilliermondii B10-05
-
no activity
-
-
-
methyl 3-oxobutanoate + NADH + H+
methyl 3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
130% of the activity with phenyl trifluoromethyl ketone
-
-
?
methyl 4-bromo-3-oxobutanoate + NADH + H+
methyl 4-bromo-3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
164% of the activity with phenyl trifluoromethyl ketone
-
-
?
methyl acetoacetate + NADH + H+
methyl 3-hydroxybutanoate + NAD+
show the reaction diagram
-
-
-
-
r
methyl benzoylformate + NADH
?
show the reaction diagram
Q4J702
about 35% of the activity compared to isatin
-
-
?
methyl benzoylformate + NADH + H+
methyl (R)-(-)-mandelate + NAD+
show the reaction diagram
-
92% enantiomeric excess
-
-
?
methyl glyoxal + NADH + H+
?
show the reaction diagram
-
3.5fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
methyl o-chlorobenzoylformate + NADH
?
show the reaction diagram
Q4J702
about 55% of the activity compared to isatin
-
-
?
methyl pyruvate + NADH + H+
methyl 2-hydroxypropanoate + NAD+
show the reaction diagram
-
18.9fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
methyl pyruvate + NADH + H+
methyl lactate + NAD+
show the reaction diagram
-
-
-
-
r
methyl-3-oxo-3-phenylpropanol + NADH
methyl-3-hydroxy-3-phenylpropanol + NAD+
show the reaction diagram
-
-
-
-
?
methylbenzoylformate + NADH + H+
?
show the reaction diagram
-
13% of the activity with 2,2,2-trifluoroacetophenone
-
-
?
methylcrotonyl alcohol + NAD+
methylcrotonaldehyde + NADH
show the reaction diagram
-
-
-
-
?
N-benzyl-3-piperidone + NADH + H+
N-benzylpiperidin-3-ol + NAD+
show the reaction diagram
-
2.3fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
N-benzyl-3-pyrrolidinol + NAD+
1-benzylpyrrolidin-3-one + NADH + H+
show the reaction diagram
-
33% of the activity with (S)-N-benzyl-3-pyrrolidinol
-
-
?
N-benzyl-3-pyrrolidinone + NADH + H+
(R)-N-benzyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
(R)-stereoselectivity of the reduction carried out with the heat-treated cells
-
-
r
N-benzyl-3-pyrrolidinone + NADH + H+
(S)-N-benzyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
-
-
-
r
N-benzyl-3-pyrrolidinone + NADH + H+
(S)-N-benzyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
(S)-N-benzyl-3-pyrrolidinol is produced at an enantiomeric excess of more than 99.9%
-
-
r
N-benzyl-4-piperidone + NADH + H+
N-benzylpiperidin-4-ol + NAD+
show the reaction diagram
-
10.7fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
n-butanal + NADH + H+
n-butanol + NAD+
show the reaction diagram
-
-
-
-
?
n-butanol + NAD+
n-butanal + NADH
show the reaction diagram
-
-
-
-
?
n-butanol + NAD+
n-butanal + NADH
show the reaction diagram
-
-
-
-
r
n-butanol + NAD+
butanal + NADH
show the reaction diagram
-
low activity
-
-
?
n-butanol + NAD+
butyraldehyde + NADH
show the reaction diagram
-
-
-
-
?
n-butanol + NAD+
butylaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
?
n-butanol + NAD+
butylaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
n-butanol + NAD+
butyraldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
n-butanol + NAD+
n-butanal + NADH + H+
show the reaction diagram
-
-
-
-
?
n-butylaldehyde + NADH + H+
butanal + NAD+
show the reaction diagram
-
activity is 1.8fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
n-butyraldehyde + NADH + H+
n-butanol + NAD+
show the reaction diagram
-
7.3fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
n-decanol + NAD+
n-decanal + NADH
show the reaction diagram
-
-
-
-
r
n-hexanol + NAD+
n-hexanal + NADH
show the reaction diagram
-
-
-
-
r
n-hexylaldehyde + NADH + H+
hexanal + NAD+
show the reaction diagram
-
activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
n-octylaldehyde + NADH + H+
n-octanol + NAD+
show the reaction diagram
-
activity is 1.7fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
n-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
-
-
-
-
?
n-pentylaldehyde + NAD+
n-pentanol + NADH
show the reaction diagram
-
-
-
-
r
n-propanol + NAD+
n-propanal + NADH
show the reaction diagram
-
-
-
-
r
n-propanol + NAD+
propanal + NADH
show the reaction diagram
-
-
-
-
?
n-propanol + NAD+
propanal + NADH
show the reaction diagram
P00327
-
-
-
?
n-propanol + NAD+
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
n-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
Q9UXF1, -
-
-
-
?
n-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
-
-
-
-
r
n-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
Q9UXF1, -
-
-
-
?
N-tert-butoxycarbonyl-3-pyrrolidinone + NADH + H+
(S)-N-tert-butoxycarbonyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
production of (S)-N-tert-butoxycarbonyl-3-pyrrolidinol with 99.6% enantiomeric excess
-
-
?
n-valeraldehyde + NADH + H+
n-pentanol + NAD+
show the reaction diagram
-
activity is 2.8fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
nonyl aldehyde + NADH + H+
1-nonanol + NAD+
show the reaction diagram
-, Q76HN6
25% activity compared to benzyl alcohol
-
-
?
nonylphenol polyethoxylate 9 + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
7% activity compared to benzyl alcohol
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
-
-
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
-
-
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
-
-
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
-
-
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
-
-
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
-
-
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
-
-
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
-
-
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
weak activity
-
-
?
octan-1-ol + NAD+
n-octanal + NADH
show the reaction diagram
-
activity with ADH I, no activity with ADH II
-
-
?
octan-2-ol + NAD+
octan-2-one + NADH
show the reaction diagram
-
-
-
-
?
octan-2-ol + NAD+
octan-2-one + NADH
show the reaction diagram
-
-
-
-
?
octan-2-ol + NAD+
octan-2-one + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
weak activity
-
-
?
octan-2-ol + NAD+
octan-2-one + NADH
show the reaction diagram
-
(R)-2-octanol and (S)-2-octanol
-
-
?
octanal + NAD+ + H2O
octanoic acid + NADH + H+
show the reaction diagram
A4IP64, A4ISB9
about 25% of the activity with 1-octanol
-
-
r
octanal + NAD+ + H2O
octanoic acid + NADH + H+
show the reaction diagram
A4IP64, A4ISB9, -
about 25% of the activity with 1-octanol
-
-
r
octanal + NADH + H+
octanol + NAD+
show the reaction diagram
-
-
-
-
?
octanal + NADH + H+
octanol + NAD+
show the reaction diagram
-
-
-
-
?
octanal + NADH + H+
octanol + NAD+
show the reaction diagram
-
-
-
-
?
octanoic acid + 2 NADH + 2 H+
1-octanol + 2 NAD+ + H2o
show the reaction diagram
A4IP64, A4ISB9
-
-
-
r
octanol + NAD+
octanal + NADH
show the reaction diagram
Q9QYY9
-
-
-
?
octanol + NAD+
octanal + NADH
show the reaction diagram
-
-
-
-
?
octanol + NAD+
octanal + NADH
show the reaction diagram
-
-
-
-
?
octanol + NAD+
heptaldehyde + NADH + H+
show the reaction diagram
B2ZRE3
-
178% activity compared to cyclohexanone
-
r
octanol + NAD+
octanal + NADH + H+
show the reaction diagram
-
-
-
-
?
octanol + NAD+
octanal + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
?
octanol + NAD+
octanal + NADH + H+
show the reaction diagram
P86883
-
-
-
?
octanol + NAD+
octanal + NADH + H+
show the reaction diagram
-
immobilized and free HLAD show 100% reaction rate with octanol compared to ethanol at pH 8.8 and 30C
-
-
?
octyl aldehyde + NADH + H+
1-octanol + NAD+
show the reaction diagram
-, Q76HN6
29% activity compared to benzyl alcohol
-
-
?
octylphenol polyethoxylate 2 + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
59% activity compared to benzyl alcohol
-
-
?
octylphenol polyethoxylate 8 + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
7% activity compared to benzyl alcohol
-
-
?
oxalacetic acid + NADH + H+
?
show the reaction diagram
-
14% of activity with N-benzyl-3-pyrrolidinone
-
-
?
oxaloacetate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
p-chlorobenzaldehyde + NADH + H+
p-chlorobenzyl alcohol + NAD+
show the reaction diagram
-
1.2fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
p-methoxybenzyl alcohol + NAD+
p-methoxybenzaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
p-methoxybenzyl alcohol + NAD+
p-methoxybenzaldehyde + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
r
p-nitrobenzaldehyde + NADH
p-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
p-nitrobenzaldehyde + NADH + H+
p-nitrobenzyl alcohol + NAD+
show the reaction diagram
-
substrate of isozyme ADH4
-
-
r
p-nitrobenzyloxycarbonyl-3-pyrrolidinone + NADH + H+
(S)-N-p-nitrobenzyloxycarbonyl-3-pyrrolidinol + NAD+
show the reaction diagram
-
production with 90.7% enantiomeric excess
-
-
?
p-nitrophenyl octanoate + H2O
p-nitrophenol + octanoate
show the reaction diagram
-
acid-assisted nucleophilic catalysis involving the ammonium ion of Lys and the thiolate of Cys in the acyl-oxygen cleavage
-
?
pentan-2-ol + NAD+
2-pentanone + NADH
show the reaction diagram
-
-
-
-
?
pentan-2-ol + NAD+
2-pentanone + NADH
show the reaction diagram
-
-
-
-
?
pentan-2-ol + NAD+
2-pentanone + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
-
-
-
?
pentan-2-ol + NAD+
2-pentanone + NADH
show the reaction diagram
-
-
-
-
?
pentan-2-ol + NAD+
2-pentanone + NADH
show the reaction diagram
-
(R)-2-pentanol and (S)-2-pentanol
-
r
pentan-3-ol + NAD+
3-pentanone + NADH
show the reaction diagram
-
-
-
r
pentan-3-ol + NAD+
3-pentanone + NADH
show the reaction diagram
-
-
-
-
?
pentan-3-ol + NAD+
3-pentanone + NADH + H+
show the reaction diagram
-
-
-
-
r
pentanal + NADH
1-pentanol + NAD+ + H+
show the reaction diagram
Leifsonia sp.
-
132% of the activity with phenyl trifluoromethyl ketone, in the reverse reaction 5% of the activity with 2-propanol
-
-
?
pentanol + NAD+
pentanone + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
pentanone + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
pentanone + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
pentanone + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
-
-
-
?
pentanol + NAD+
pentanone + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
pentanone + NADH
show the reaction diagram
-
oxidized by isoenzyme A2 and B2, no activity with isoenzyme C2
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
n-pentanal + NADH
show the reaction diagram
-
activity with ADH I, no activity with ADH II
-
-
?
pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
-
-
-
-
?
pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
B6UQD0
-
-
-
?
pentanol + NAD+
valeraldehyde + NADH + H+
show the reaction diagram
B2ZRE3
-
240% activity compared to cyclohexanone
-
r
phenyl trifluoromethyl ketone + NADH + H+
(S)-1-phenyltrifluoroethanol + NAD+
show the reaction diagram
Leifsonia sp.
-
-
more than 99% enantiomeric excess
-
?
phenylacetaldehyde + NADH
phenylethanol + NAD+
show the reaction diagram
Rhodococcus ruber, Rhodococcus ruber 219
-
-
-
-
r
phenylalaninol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
phenylethanol + NAD+
phenylacetaldehyde + NADH
show the reaction diagram
-
R-(+)-phenylethanol and S-(-)-phenylethanol
-
-
?
phenylethanol + NAD+
phenylacetaldehyde + NADH + H+
show the reaction diagram
-
15% of activity with N-benzyl-3-pyrrolidinol
-
-
?
phenylglyoxylic acid + NADH + H+
hydroxy(phenyl)acetic acid + NAD+
show the reaction diagram
-
enzyme covalently immobilized to magnetic Fe3O4 nanoparticles via glutaraldehyde retains 48.77% activity of its original activity
-
-
?
phytol + NAD+
phytenal + NADH + H+
show the reaction diagram
-
-
-
-
?
polyoxyethylene 8 decyl ether + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
12% activity compared to benzyl alcohol
-
-
?
primary or secondary alcohol + NAD+
aldehyde or ketone + NADH
show the reaction diagram
Pseudomonas aeruginosa, Pseudomonas aeruginosa PaADH
-
-
-
-
r
prop-2-en-1-ol + NAD+
? + NADH
show the reaction diagram
-
140.6% of the activity with ethanol
-
-
?
propan-1,2-diol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
propan-1,2-diol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
-
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
no activity
-
-
-
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
very low activity
-
-
-
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
-
3% of the activity with ethanol
-
-
-
propan-2-ol + NAD+
acetone + NADH
show the reaction diagram
Meyerozyma guilliermondii B10-05
-
-
-
-
?
propan-2-ol + NAD+
acetone + NADH + H+
show the reaction diagram
B2ZRE3
-
6% activity compared to cyclohexanone
-
r
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
-
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
Sporotrichum pulverulentum
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
-
-
-
-
?
propanol + NADH
propionaldehyde + NADH
show the reaction diagram
Meyerozyma guilliermondii B10-05
-
-
-
-
?
propionaldehyde + NADH
propanol + NAD+
show the reaction diagram
-
-
-
-
?
propionaldehyde + NADH
propanol + NAD+
show the reaction diagram
-
-
-
-
?
propionaldehyde + NADH
propanol + NAD+
show the reaction diagram
-
-
-
-
?
propionaldehyde + NADH
propanol + NAD+
show the reaction diagram
-
94% of the activity with acetaldehyde
-
-
?
propionaldehyde + NADH + H+
?
show the reaction diagram
-
activity is 1.1fold higher than with N-benzyl-3-pyrrolidinone
-
-
?
propionaldehyde + NADH + H+
1-propanol + NAD+
show the reaction diagram
-
-
-
-
r
propiophenone + NADH + H+
1-phenylpropan-1-ol + NAD+
show the reaction diagram
-
27% of activity with N-benzyl-3-pyrrolidinone
-
-
?
pyridine 2-aldehyde + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
pyridine 3-aldehyde + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
pyridine 4-aldehyde + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
pyridine-3-aldehyde + NADH + H+
pyridin-3-yl ethanol + NAD+
show the reaction diagram
-
82% of activity with N-benzyl-3-pyrrolidinone
-
-
?
pyridine-4-aldehyde + NADH + H+
pyridin-4-yl methanol + NAD+
show the reaction diagram
-
4.4fold higher activity compared to activity with N-benzyl-3-pyrrolidinone
-
-
?
R-(+)-1-phenylethanol + NAD+
1-phenylethanone + NADH
show the reaction diagram
-
-
-
-
-
R-(+)-cis-verbenol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
R-(+)-trans-bicyclo(2.2.1)-heptanol + NAD+
R-(+)-trans-bicyclo(2.2.1)-heptanal + NADH
show the reaction diagram
-
R-(+)-trans-bicyclo(2.2.1)-heptanol and S-(-)-trans-bicyclo(2.2.1)-heptanol
-
-
?
rac-3-methylcyclohexanone + NADH + H+
(1S,3S)-3-methylcyclohexanol + NAD+
show the reaction diagram
-
-
-
-
?
retinal + NADH + H+
retinol + NAD+
show the reaction diagram
-
substrate of isozyme ADH4
-
-
r
retinol + NAD+
retinal + NADH
show the reaction diagram
-
-
-
-
?
S-(-)-1-phenylethanol + NAD+
1-phenylethanone + NADH
show the reaction diagram
-
-
-
-
-
S-(-)-cis-bicyclo(2.2.1)-heptanol + NAD+
S-(-)-cis-bicyclo(2.2.1)-heptanal + NADH
show the reaction diagram
-
-
-
-
?
secondary alcohol + NAD+
aldehyde + NADH
show the reaction diagram
-
-
-
-
?
tert-butyl 3-oxobutanoate + NADH + H+
tert butyl 3-hydroxybutanoate + NAD+
show the reaction diagram
Leifsonia sp.
-
568% of the activity with phenyl trifluoromethyl ketone
-
-
?
tetracosanol + NAD+
? + NADH + H+
show the reaction diagram
-
immobilized HLAD shows about 55% reaction rate and free HLAD shows about 15% reaction rate with tetracosanol compared to ethanol at pH 8.8 and 30C
-
-
?
tetrahydro-4H-pyran-4-one + NADH + H+
? + NAD+
show the reaction diagram
B2ZRE3
10% activity compared to cyclohexanone
-
-
?
trans-4-(N,N-dimethylamino)-cinnamaldehyde + NADH
trans-4-(N,N-dimethylamino)-cinnamyl alcohol + NAD+
show the reaction diagram
-
-
-
-
?
trans-4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH
show the reaction diagram
-
-
-
-
?
trans-cinnamaldehyde + NADH + H+
cinnamyl alcohol + NAD+
show the reaction diagram
-
-
-
-
r
trans-cinnamaldehyde + NADH + H+
cinnamyl alcohol + NAD+
show the reaction diagram
Leifsonia sp.
-
% of the activity with phenyl trifluoromethyl ketone
-
-
?
trans-cinnamyl alcohol + NAD+
(2E)-3-phenylprop-2-enal + NADH + H+
show the reaction diagram
-
activity is 3.9fold higher than with (S)-(-)-1-phenylethanol
-
-
?
Tris + NAD+
? + NADH
show the reaction diagram
-
-
-
-
r
Triton X-100 + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
7% activity compared to benzyl alcohol
-
-
?
Triton X-114 + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
3% activity compared to benzyl alcohol
-
-
?
Triton X-165 + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
24% activity compared to benzyl alcohol
-
-
?
Triton X-35 + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
43% activity compared to benzyl alcohol
-
-
?
Triton X-405 + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
19% activity compared to benzyl alcohol
-
-
?
Triton X-45 + NAD+
? + NADH
show the reaction diagram
-, Q76HN6
7% activity compared to benzyl alcohol
-
-
?
tryptophol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
valeraldehyde + NADH
1-pentanol + NAD+
show the reaction diagram
Rhodococcus ruber, Rhodococcus ruber 219
-
-
-
-
r
vanillyl alcohol + NAD+
vanillin + NADH
show the reaction diagram
-
-
-
-
?
methylglyoxal + NADH
? + NADH
show the reaction diagram
-
11.9% of the activity with acetaldehyde
-
-
?
additional information
?
-
-
broad substrate specificity
-
-
-
additional information
?
-
-
constitutive enzyme
-
-
-
additional information
?
-
-
key enzyme in ethanol production
-
-
-
additional information
?
-
Candida sp.
-
one constitutive enzyme, ADH-MI and one inducible enzyme, ADH-MII
-
-
-
additional information
?
-
-
enzyme may be involved in the metabolism of dietary wax esters in salmonid fish
-
-
-
additional information
?
-
-
the enzyme oxidizes alcohols to aldehydes or ketones both for detoxification and metabolic purposes
-
-
-
additional information
?
-
-
involvement in the development of male hamster reproductive system
-
-
-
additional information
?
-
-
enzyme shows high substrate specificity towards primary aliphatic alcohols, no activity with 2-butanol, tert-butanol, isoamyl alcohol, isobutyl alcohol, 1,6-hexadiol, and mono-, di-, and triethanolamine
-
-
-
additional information
?
-
-
no activity with methanol, 2-propanol, and isoamyl alcohol
-
-
-
additional information
?
-
-
substrate specificity and stereospecificity, substrate binding pocket structure of the 3 isozymes, involving Met294, Trp57, and Trp93
-
-
-
additional information
?
-
-
substrate specificity of the 2 isozmyes with various substrates, overview, isozymes are highly specific for the (R)-stereoisomers and enantioselctive for the R(-)isomers
-
-
-
additional information
?
-
P39462
the enzyme undergoes a substantial conformational change in the apo-holo transition, accompanied by loop movements at the domain interface
-
-
-
additional information
?
-
-
alcohol dehydrogenase activity may not limit alcohol supply for ester production during ripening
-
-
-
additional information
?
-
-
Cm-ADH2 cannot reduce branched aldehydes
-
-
-
additional information
?
-
-
effects of pressure on deuterium isotope effects of yeast alcohol dehydrogenase using alternative substrates
-
-
-
additional information
?
-
-, Q8L3C9
no activity with methanol
-
-
-
additional information
?
-
Leifsonia sp.
-
the enzyme does not act on short-chain normal alkyl alcohols, including methanol and ethanol
-
-
-
additional information
?
-
-, Q76HN6
no activity towards methanol, ethanol, 1-propanol, triethylene glycol, polyethylene glycol 400, polyethylene glycol 1000, D-sorbitol, D-sorbose, formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde, and valeraldehyde
-
-
-
additional information
?
-
-, Q9P6C8
ADH1 preferrs primary alcohols containing C3-C8 carbons to secondary alcohols such as 2-propanol and 2-butanol. ADH1 possesses specific carboxylate ester-forming activity
-
-
-
additional information
?
-
-
no activity detected with: N-benzyl-2-pyrrolidinone, 2-pyrrolidinone, 3-hexanone, 4-hydroxy-2-butanone, (R)-N-benzyl-3-pyrrolidinol, ethanol, 1,3-propanediol, 1-butanol, 1,4-butanediol, 1,2,3-butanetriol, 1,2,4-butanetriol, acetol, 2-phenyl-1-propanol, 3-phenyl-1-propanol, benzyl alcohol and glycerol. No activity with NADP+ or NADPH
-
-
-
additional information
?
-
-
preference for reduction of aromatic ketones and alpha-keto esters, and poor activity on aromatic alcohols and aldehydes
-
-
-
additional information
?
-
-
when NADH is replaced with NADPH, the reaction rate is reduced by 0.6%
-
-
-
additional information
?
-
-
activity is severely reduced towards aliphatic alcohols of more than 8 carbon atoms for the free enzyme, but not so with immobilized HLAD, exhibiting an activity towards C22 and C24 aliphatic alcohols higher than 50% of the highest value, obtained with C8
-
-
-
additional information
?
-
-
differences in the activities of total ADH and class I ADH isoenzyme between cancer liver tissues and healthy hepatocytes may be a factor in ethanol metabolism disorders, which can intensify carcinogenesis
-
-
-
additional information
?
-
B2ZRE3
TADH is a NAD(H)-dependent enzyme and shows a very broad substrate spectrum producing exclusively the (S)-enantiomer in high enantiomeric excess (more than 99%) during asymmetric reduction of ketones
-
-
-
additional information
?
-
P00326, P08319
1-octanal is no substrate for isozyme ADH1C
-
-
-
additional information
?
-
P00326, P08319
1-octanal is no substrate for isozyme ADH2
-
-
-
additional information
?
-
P00326, P08319
1-octanal is no substrate for isozyme ADH4
-
-
-
additional information
?
-
B2ZRE3
ADH exhibits a clear preference for primary alcohols and corresponding aldehydes for aliphatic substrates, in the oxidative direction activity steeply increases with chain length until 1-propanol and then decreases slightly again with growing chain length, alpha,beta-unsaturated ketones like 3-penten-2-one and cyclohexenone are not converted by ADH, almost no conversion of methanol (0.2%) and (+)-carvone (0.4%) is detected
-
-
-
additional information
?
-
B8QU18
no activity is detected using 1 mM NADP+
-
-
-
additional information
?
-
-, Q6RS93
no activity towards methanol
-
-
-
additional information
?
-
A4IP64, A4ISB9
substrates are a broad range of alkyl alcohols from ethanol to 1-triacontanol
-
-
-
additional information
?
-
Q4J702
the physiological direction of the catalytic reaction is reduction rather than oxidation
-
-
-
additional information
?
-
Q4J9F2, -
the enzyme displays a preference for the reduction of alicyclic, bicyclic and aromatic ketones and alpha-ketoesters, but is poorly active on aliphatic, cyclic and aromatic alcohols, showing no activity on aldehydes
-
-
-
additional information
?
-
Q4J702
the enzyme shows no activity on aliphatic linear and branched alcohols, except for a poor activity on 2-propyn-1-ol, 3-methyl-1-butanol and 2-pentanol; however, it shows a discrete activity on aliphatic cyclic and bicyclic alcohols. Benzyl alcohol and 4-bromobenzyl alcohol are not found to be substrates. The S and R enantiomers of a-(trifluoromethyl)benzyl alcohol and methyl and ethyl mandelates show no apparent activity with SaADH. The enzyme shows poor activity on (+/-)-1-phenyl-1-propanol, 1-(1-naphthyl)ethanol and the two enantiomers of 1-(2-naphthyl)ethanol. The enzyme is not active on aliphatic and aromatic aldehydes, and on aliphatic linear, branched and cyclic ketones except for 3-methylcyclohexanone. Catalytic inactivity is observed with acetophenone and (S)-a-(trifluoromethyl)benzyl
-
-
-
additional information
?
-
H9ZGN0
methanol, formaldehyde, and acetone are no substrates for HpADH3
-
-
-
additional information
?
-
-
no activity with methanol, 1-butanol, glycerol or 2-propanol
-
-
-
additional information
?
-
-
substrate specificity and enantiospecificity, overview. The (R)-specific alcohol dehydrogenase requires NADH and reduces various kinds of carbonyl compounds, including ketones and aldehydes. AFPDH reduces acetylpyridine derivatives, beta-keto esters, and some ketones compounds with high enantiospecificity, overview. No activity with 2-chlorobenzaldehyde and 2-tetralone, poor activity with 1-tetralone, pyruvate, 2-oxobutyrate, oxalacetate, cyclopentanone, cyclohexanone, cycloheptanone, and dipropylketone. No activity with 1,2-propanediol, 3-chloro-1,2-propanediol, 3-bromo-1,2-propanediol, glycerol, 1-pentanol, poor activity with 1-butanol, 1-propanol, ethanol, and methanol
-
-
-
additional information
?
-
-
the enzyme exhibits broad substrate specificity towards aliphatic ketones, cycloalkanones, aromatic ketones, and ketoesters
-
-
-
additional information
?
-
Q4J702
the physiological direction of the catalytic reaction is reduction rather than oxidation, the enzyme shows no activity on aliphatic linear and branched alcohols, except for a poor activity on 2-propyn-1-ol, 3-methyl-1-butanol and 2-pentanol; however, it shows a discrete activity on aliphatic cyclic and bicyclic alcohols. Benzyl alcohol and 4-bromobenzyl alcohol are not found to be substrates. The S and R enantiomers of a-(trifluoromethyl)benzyl alcohol and methyl and ethyl mandelates show no apparent activity with SaADH. The enzyme shows poor activity on (+/-)-1-phenyl-1-propanol, 1-(1-naphthyl)ethanol and the two enantiomers of 1-(2-naphthyl)ethanol. The enzyme is not active on aliphatic and aromatic aldehydes, and on aliphatic linear, branched and cyclic ketones except for 3-methylcyclohexanone. Catalytic inactivity is observed with acetophenone and (S)-a-(trifluoromethyl)benzyl
-
-
-
additional information
?
-
Q4J9F2
the enzyme displays a preference for the reduction of alicyclic, bicyclic and aromatic ketones and alpha-ketoesters, but is poorly active on aliphatic, cyclic and aromatic alcohols, showing no activity on aldehydes
-
-
-
additional information
?
-
B2ZRE3
TADH is a NAD(H)-dependent enzyme and shows a very broad substrate spectrum producing exclusively the (S)-enantiomer in high enantiomeric excess (more than 99%) during asymmetric reduction of ketones, ADH exhibits a clear preference for primary alcohols and corresponding aldehydes for aliphatic substrates, in the oxidative direction activity steeply increases with chain length until 1-propanol and then decreases slightly again with growing chain length, alpha,beta-unsaturated ketones like 3-penten-2-one and cyclohexenone are not converted by ADH, almost no conversion of methanol (0.2%) and (+)-carvone (0.4%) is detected
-
-
-
additional information
?
-
-
the enzyme exhibits broad substrate specificity towards aliphatic ketones, cycloalkanones, aromatic ketones, and ketoesters
-
-
-
additional information
?
-
Oenococcus oeni DSM20252
-
no activity with methanol, 1-butanol, glycerol or 2-propanol
-
-
-
additional information
?
-
Flavobacterium frigidimaris KUC-1
Q8L3C9
no activity with methanol
-
-
-
additional information
?
-
Devosia riboflavina KNK10702
-
when NADH is replaced with NADPH, the reaction rate is reduced by 0.6%
-
-
-
additional information
?
-
Candida sp. N-16
-
one constitutive enzyme, ADH-MI and one inducible enzyme, ADH-MII
-
-
-
additional information
?
-
Candida maris IFO10003
-
substrate specificity and enantiospecificity, overview. The (R)-specific alcohol dehydrogenase requires NADH and reduces various kinds of carbonyl compounds, including ketones and aldehydes. AFPDH reduces acetylpyridine derivatives, beta-keto esters, and some ketones compounds with high enantiospecificity, overview. No activity with 2-chlorobenzaldehyde and 2-tetralone, poor activity with 1-tetralone, pyruvate, 2-oxobutyrate, oxalacetate, cyclopentanone, cyclohexanone, cycloheptanone, and dipropylketone. No activity with 1,2-propanediol, 3-chloro-1,2-propanediol, 3-bromo-1,2-propanediol, glycerol, 1-pentanol, poor activity with 1-butanol, 1-propanol, ethanol, and methanol
-
-
-
additional information
?
-
Geobacillus thermoglucosidasius M10EXG
Q6RS93
no activity towards methanol
-
-
-
additional information
?
-
Ogataea angusta DL-1, ATCC 26012
H9ZGN0
methanol, formaldehyde, and acetone are no substrates for HpADH3
-
-
-
additional information
?
-
Acetobacter pasteurianus SKU1108
-
substrate specificity of the 2 isozmyes with various substrates, overview, isozymes are highly specific for the (R)-stereoisomers and enantioselctive for the R(-)isomers
-
-
-
additional information
?
-
-
the enzyme does not act on short-chain normal alkyl alcohols, including methanol and ethanol
-
-
-
additional information
?
-
Neurospora crassa FGSC2489
-, Q9P6C8
ADH1 preferrs primary alcohols containing C3-C8 carbons to secondary alcohols such as 2-propanol and 2-butanol. ADH1 possesses specific carboxylate ester-forming activity
-
-
-
additional information
?
-
A4IP64, A4ISB9, -
substrates are a broad range of alkyl alcohols from ethanol to 1-triacontanol
-
-
-
additional information
?
-
Pseudomonas putida S-5
Q76HN6
no activity towards methanol, ethanol, 1-propanol, triethylene glycol, polyethylene glycol 400, polyethylene glycol 1000, D-sorbitol, D-sorbose, formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde, and valeraldehyde
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
-
-
-
-
?
a primary alcohol + NAD+
an aldehyde + NADH + H+
show the reaction diagram
-
ADH3 is involved in multiple cellular pathways, as diverse as formaldehyde detoxification, retinoid metabolism and NO homeostasis, ADH3 is considered to play only a minor role in hepatic alcohol metabolism because ethanol concentrations rarely exceed 50 mM
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
H9ZGN0
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
cells with an extra copy of ADH1 display chronological life-span extension. Antioxidant enzymes are induced in 2xADH1 cells. Strains carrying an extra ADH1 copy show extended replicative life span and increased Sir2p activity
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
Ogataea angusta DL-1, ATCC 26012
H9ZGN0
-
-
-
r
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
-
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
-
ADH4 might be involved in biosynthesis of retinoic acid
-
-
r
allyl alcohol + NAD+
acrolein + NADH
show the reaction diagram
-
-
product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol
-
?
crotyl alcohol + NAD+
crotonaldehyde + NADH
show the reaction diagram
-
-
product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol
-
?
crotyl alcohol + NAD+
crotonaldehyde + NADH
show the reaction diagram
-
product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
role of the major liver isoenzyme A2 in ethanol metabolism
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
plays an important role in the metabolism of ethanol
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
chi-ADH plays an important role in the metabolism of long chain alcohols and aldehydes
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
the anodic enzyme form may contribute significantly to alcohol elimination in man, particularly at high concentrations when the other enzyme species are saturated
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
the enzyme plays a significant role in first-pass metabolism of ethanol in human
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
enzyme is responsible for the major ethanol oxidation capacity in the body. The products acetaldehyde and NADH are responsible for the most of the toxic effects and metabolic disturbances produced by ethanol ingestion
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
rate-limiting step of the alcoholic fermentation
-
-
?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
-
DH3 plays an important role in systemic ethanol metabolism at higher levels of blood ethanol through activation by cytoplasmic solution hydrophobicity
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-, Q9ZT38
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Q1G151
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
H9ZGN0
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
Glycine max Enrei
Q9ZT38
-
-
-
r
octanol + NAD+
octanal + NADH
show the reaction diagram
-
-
-
-
?
isobutyramide + NAD+
?
show the reaction diagram
-
-
-
-
r
additional information
?
-
-
constitutive enzyme
-
-
-
additional information
?
-
-
key enzyme in ethanol production
-
-
-
additional information
?
-
Candida sp.
-
one constitutive enzyme, ADH-MI and one inducible enzyme, ADH-MII
-
-
-
additional information
?
-
-
enzyme may be involved in the metabolism of dietary wax esters in salmonid fish
-
-
-
additional information
?
-
-
the enzyme oxidizes alcohols to aldehydes or ketones both for detoxification and metabolic purposes
-
-
-
additional information
?
-
-
involvement in the development of male hamster reproductive system
-
-
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additional information
?
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alcohol dehydrogenase activity may not limit alcohol supply for ester production during ripening
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-
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additional information
?
-
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activity is severely reduced towards aliphatic alcohols of more than 8 carbon atoms for the free enzyme, but not so with immobilized HLAD, exhibiting an activity towards C22 and C24 aliphatic alcohols higher than 50% of the highest value, obtained with C8
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additional information
?
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differences in the activities of total ADH and class I ADH isoenzyme between cancer liver tissues and healthy hepatocytes may be a factor in ethanol metabolism disorders, which can intensify carcinogenesis
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additional information
?
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B2ZRE3
TADH is a NAD(H)-dependent enzyme and shows a very broad substrate spectrum producing exclusively the (S)-enantiomer in high enantiomeric excess (more than 99%) during asymmetric reduction of ketones
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-
-
additional information
?
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Q4J702
the physiological direction of the catalytic reaction is reduction rather than oxidation
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additional information
?
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B2ZRE3
TADH is a NAD(H)-dependent enzyme and shows a very broad substrate spectrum producing exclusively the (S)-enantiomer in high enantiomeric excess (more than 99%) during asymmetric reduction of ketones
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-
-
additional information
?
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Candida sp. N-16
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one constitutive enzyme, ADH-MI and one inducible enzyme, ADH-MII
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COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
NAD+
-
kinetics of coenzyme binding in the pH-range 10-12
NAD+
-
NAD+ acts as an activator which induces an active form of the enzyme
NAD+
-
preferred substrate
NAD+
-
NAD+-plus-acetone-induced conversion
NAD+
Candida sp.
-
-
NAD+
Sporotrichum pulverulentum
-
-
NAD+
-
-