Literature summary for 1.1.1.1 extracted from

Borzecka, W.; Lavandera, I.; Gotor, V.
Synthesis of enantiopure fluorohydrins using alcohol dehydrogenases at high substrate concentrations (2013), J. Org. Chem., 78, 7312-7317.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Rhodococcus ruber

Organic Solvent Stability

Organic Solvent	Comment	Organism
propan-2-ol	10% v/v, enzyme catalyzes reduction of fluorinated ketones without addition of NADH	Rhodococcus ruber

Organism

Organism	UniProt	Comment	Textmining
Rhodococcus ruber	Q8KLT9	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2,2,2-trifluoro-1-phenylethanone + propan-2-ol	in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH	Rhodococcus ruber	(1R)-2,2,2-trifluoro-1-phenylethanol + acetone	99% conversion, 99% enantiomeric excess	?
2,2-difluoro-1-phenylethanone + propan-2-ol	in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH	Rhodococcus ruber	(1R)-2,2-difluoro-1-phenylethanol + acetone	99% conversion, 94% enantiomeric excess	?
2-fluoro-1-(4-chlorophenyl)ethanone + propan-2-ol	in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH	Rhodococcus ruber	(1R)-2-fluoro-1-(4-chlorophenyl)ethanol + acetone	99% conversion, 98% enantiomeric excess	?
2-fluoro-1-(4-fluorophenyl)ethanone + propan-2-ol	in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH	Rhodococcus ruber	(1R)-2-fluoro-1-(4-fluorophenyl)ethanol + acetone	99% conversion, 97% enantiomeric excess	?
2-fluoro-1-(4-iodophenyl)ethanone + propan-2-ol	in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH	Rhodococcus ruber	(1R)-2-fluoro-1-(4-iodophenyl)ethanol + acetone	99% conversion, 99% enantiomeric excess	?
2-fluoro-1-phenylethanone + propan-2-ol	in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH	Rhodococcus ruber	(1R)-2-fluoro-1-phenylethanol + acetone	99% conversion, 99% enantiomeric excess	?

Synonyms

Synonyms	Comment	Organism
ADH-A	-	Rhodococcus ruber
SADH	-	Rhodococcus ruber

Cofactor

Cofactor	Comment	Organism	Structure
additional information	in presence of propan-2-ol at 10% v/v, reduction of fluorinated ketones is catalyzed without addition of NADH	Rhodococcus ruber

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Release 2023.1 (January 2023)