6.3.5.5: carbamoyl-phosphate synthase (glutamine-hydrolysing)
This is an abbreviated version!
For detailed information about carbamoyl-phosphate synthase (glutamine-hydrolysing), go to the full flat file.
Word Map on EC 6.3.5.5
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6.3.5.5
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pyrimidine
-
dihydroorotase
-
cpsases
-
transcarbamoylase
-
2.1.3.2
-
ornithine-urea
-
2.7.2.9
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3.5.2.3
-
acivicin
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caspase-activated
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dhoase
-
ureotelic
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atcase
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lungfish
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ammonia-dependent
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carab
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5-phosphoribosyl
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1-pyrophosphate
-
protopterus
-
n-acetyl-l-glutamate
-
drug development
-
medicine
- 6.3.5.5
- pyrimidine
- dihydroorotase
- cpsases
-
transcarbamoylase
-
2.1.3.2
-
ornithine-urea
-
2.7.2.9
-
3.5.2.3
- acivicin
-
caspase-activated
- dhoase
-
ureotelic
- atcase
- lungfish
-
ammonia-dependent
-
carab
-
5-phosphoribosyl
- 1-pyrophosphate
- protopterus
- n-acetyl-l-glutamate
- drug development
- medicine
Reaction
2 ATP
+
Synonyms
CAD, CAD carbamoyl-phosphate synthetase, CAD protein, Carbamoyl phosphate synthase (glutamine), carbamoyl phosphate synthetase, Carbamoyl phosphate synthetase (glutamine-hydrolyzing), carbamoyl phosphate synthetase 1, carbamoyl phosphate synthetase II, carbamoyl phosphate synthetase III, carbamoyl-phosphate synthetase, Carbamoyl-phosphate synthetase (glutamine-hydrolysing), carbamoyl-phosphate synthetase 2, Carbamoylphosphate synthase, Carbamoylphosphate synthetase, Carbamoylphosphate synthetase II, Carbamyl phosphate synthetase (glutamine), Carbamyl phosphate sythetase II, carbamylphosphate synthetase - aspartate transcarbamylase, CPA2, CPS, CPS II (glutamine-dependent), CPS III, CPS III (glutamine- and N-acetyl-L-glutamine-dependent), CPS1, CPSase, CPSase type II, CPSase-A, CPSase-P, CPSII, EC 2.7.2.9, Glutamine-dependent carbamyl phosphate synthetase, glutamine-hydrolyzing CPSase, MGG_04503, More, MtCPSs1, MtCPSs2, Synthase, carbamoylphosphate (glutamine), Synthetase, carbamoylphosphate (glutamine-hydrolyzing)
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6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 6.3.5.5 - carbamoyl-phosphate synthase (glutamine-hydrolysing)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 ATP + L-Gln + HCO3- + H+ + H2O
2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
the product carbamoyl phosphate is utilized in the pyrimidine and arginine biosynthetic pathways
-
?
2 ATP + L-glutamine + HCO3- + H2O + H+
2 ADP + phosphate + L-glutamate + carbamoyl phosphate
ATP + L-glutamine + HCO3- + H2O
2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
there is no preferential partitioning of carbamoyl phosphate between the arginine and pyrimidine biosynthetic pathways. Channeling must occur during the dynamic association of coupled enzymes pairs. The interaction of carbamoyl-phosphate synthetase/aspartate transcarbamoylase is demonstrated by the unexpectedly weak inhibition of the coupled reaction by the bisubstrate analog, N-(phosphonacetyl)-L-aspartate. In the coupled reaction, the effective concentration of carbamoyl phosphate in the vicinity of the aspartate transcarbamoylase active site is 96fold higher than the concentration in the bulk phase. Channeling probably plays an essential role in protecting this very unstable intermediate of metabolic pathways performing at extreme temperatures
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate is the initial intermediate in the biosynthesis of both pyrimidine and arginine
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
enzyme is a key enzyme in the pyrimidine nucleotide and arginine biosynthetic pathways
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
ir
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
enzyme is a key enzyme in the pyrimidine nucleotide and arginine biosynthetic pathways
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
enzyme is a key enzyme in the pyrimidine nucleotide and arginine biosynthetic pathways
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
enzyme is a key enzyme in the pyrimidine nucleotide and arginine biosynthetic pathways
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the enzyme catalyses the entry and rate-limiting step of the urea cycle
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the enzyme catalyses the first step in the synthesis of arginine and pyrimidine
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate is utilized for the arginine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate is utilized for the arginine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate plays a critical role in both arginine and pyrimidine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate plays a critical role in both arginine and pyrimidine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoylphosphate is utilized in the synthesis of arginine and pyrimidine nucleotides and in the urea cycle
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
enzyme is a key enzyme in the pyrimidine nucleotide and arginine biosynthetic pathways
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
the enzyme catalyses the first step in the arginine and pyrimidine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
enzyme is a key enzyme in the pyrimidine nucleotide and arginine biosynthetic pathways, possible role in the pathway for the synthesis of exopolysaccharides
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
enzyme catalyses the first step of urea cycle in fish
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate is utilized for the arginine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
the product carbamoyl phosphate is utilized for the arginine biosynthesis
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
-
-
?
2 ATP + L-glutamine + HCO3- + H2O
2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
-
-
-
?
2 ATP + L-glutamine + HCO3- + H2O
2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
-
carbamoyl phosphate is utilized in the biosynthesis of arginine and pyrimidine nucleotides
-
?
2 ATP + L-glutamine + HCO3- + H2O
2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
-
-
?
2 ATP + L-glutamine + HCO3- + H2O + H+
2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
a single carbamoyl phosphate synthetase supplies both the pyrimidine and arginine pathways of this organism
-
-
?
2 ATP + L-glutamine + HCO3- + H2O + H+
2 ADP + phosphate + L-glutamate + carbamoyl phosphate
Sulfolobus acidocaldarius DG6 / ATCC 49426
-
a single carbamoyl phosphate synthetase supplies both the pyrimidine and arginine pathways of this organism
-
-
?
ATP + L-Gln + HCO3-
?
-
catalyzes the first step of de novo pyrimidine biosynthesis
-
-
?
ATP + L-Gln + HCO3-
?
-
functions in the synthesis of urea used in osmoregulation
-
-
?
ATP + L-Gln + HCO3-
?
-
catalyzes the first step of de novo pyrimidine biosynthesis
-
-
?
ATP + L-Gln + HCO3-
?
-
important role of insulin in regulation of liver carbamoyl-phosphate synthase II and lack of responsiveness of the hepatoma enzyme to insulin concentration
-
-
?
ATP + L-Gln + HCO3-
?
-
catalyzes the first step of de novo pyrimidine biosynthesis
-
-
?
ATP + L-Gln + HCO3-
?
-
catalyzes the synthesis of all carbamoyl phosphate which serves two metabolic functions: it is an intermediate in synthesis of arginine and in the synthesis of pyrimidines
-
-
?
ATP + L-glutamine + HCO3- + H2O
ADP + phosphate + L-glutamate + carbamoyl phosphate
-
-
-
-
?
ATP + L-glutamine + HCO3- + H2O
ADP + phosphate + L-glutamate + carbamoyl phosphate
-
-
-
-
?
ATP + L-glutamine + HCO3- + H2O
ADP + phosphate + L-glutamate + carbamoyl phosphate
-
-
-
-
?
ATP + L-glutamine + HCO3- + H2O
ADP + phosphate + L-glutamate + carbamoyl phosphate
-
-
-
-
?
ATP + L-glutamine + HCO3- + H2O
ADP + phosphate + L-glutamate + carbamoyl phosphate
-
-
-
-
?
ATP + L-glutamine + HCO3- + H2O
ADP + phosphate + L-glutamate + carbamoyl phosphate
-
CPS1 plays a critical role in the biosynthesis of pyrimidine nucleotides and the detoxification of ammonia
-
-
?
ATP + L-glutamine + HCO3- + H2O
ADP + phosphate + L-glutamate + carbamoyl phosphate
-
allosteric regulation and CPSII regulatory domains, overview
-
-
?
additional information
?
-
-
CPS uses the hydrolysis of glutamine as a localized source of ammonia for biosynthetic transformations
-
-
?
additional information
?
-
-
the enzyme is organized as CAD, i.e. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, a tripartite enzyme that catalyzes the first three steps of pyrimidine biosynthesis
-
-
?
additional information
?
-
-
the gene for carbamoylphosphate synthetase (carAB) is induced by FlhD and FlhC
-
-
?
