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Literature summary for 6.3.5.5 extracted from

  • Mori, M.; Tatibana, M.
    Glutaminase activity of glutamine-dependent carbamoylphosphate synthase from rat ascites hepatoma. Regulation by adenosine triphosphate-magnesium and magnesium ion (1977), Biochim. Biophys. Acta, 483, 90-99.
    View publication on PubMed
Search for more literature for 6.3.5.5

Inhibitors

Inhibitors Comment Organism Structure
Ala inhibits glutamine hydrolysis and Gln-dependent carbamoyl phosphate synthesis Rattus norvegicus
Gly 10 mM, inhibition of glutaminase activity Rattus norvegicus
L-Glu inhibits glutaminase activity moderately Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ MgATP2- or Mg2+ enhances glutaminase activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-Gln + HCO3- Rattus norvegicus catalyzes the first step of de novo pyrimidine biosynthesis ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
hepatoma ascites cell AH13 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
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 Rattus norvegicus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
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 ?
ATP + L-Gln + HCO3- catalyzes the first step of de novo pyrimidine biosynthesis Rattus norvegicus ?
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 ?
additional information hydrolysis of L-Gln in absence of the other substrates, at 5.9% the rate of glutamine hydrolysis in the complete system Rattus norvegicus ?
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 ?