Reference on EC 6.3.5.5 - carbamoyl-phosphate synthase (glutamine-hydrolysing)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Meister, A.
Mechanism and regulation of the glutamine-dependent carbamyl phosphate synthetase of Escherichia coli
Adv. Enzymol. Relat. Areas Mol. Biol.
62
315-374
1989
Agaricus bisporus, Escherichia coli, Elasmobranchii, Fresh-water teleost, Mammalia, Squalus acanthias
Aoki, T.; Oya, H.
Kinetic properties of carbamoyl-phosphate synthetase II (glutamine-hydrolyzing) in the parasitic protozoan Crithidia fasciculata and separation of the enzyme from aspartate carbamoyltransferase
Comp. Biochem. Physiol. B
87
143-150
1987
Crithidia fasciculata
Aoki, T.; Oya, H.
Inactivation of Crithidia fasciculata carbamoyl phosphate synthetase II by the antitumor drug acivicin
Mol. Biochem. Parasitol.
23
173-181
1987
Crithidia fasciculata
Meek, T.D.; Karsten, W.E.; DeBrosse, C.W.
Carbamoyl-phosphate synthetase II of the mammalian CAD protein: kinetic mechanism and elucidation of reaction intermediates by positional isotope exchange
Biochemistry
26
2584-2593
1987
Mesocricetus auratus
Anderson, P.M.
Carbamoyl-phosphate synthetase: an example of effects on enzyme properties of shifting an equilibrium between active monomer and active oligomer
Biochemistry
25
5576-5582
1986
Escherichia coli
Wandinger-Ness, A.U.; Ness, S.A.; Weiss, R.L.
Simultaneous purification of three mitochondrial enzymes. Acetylglutamate kinase, acetylglutamyl-phosphate reductase and carbamoyl-phosphate synthetase from Neurospora crassa
J. Biol. Chem.
261
4820-4827
1986
Neurospora crassa
Kaseman, D.S.; Meister, A.
carbamyl phosphate synthetase (glutamine-utilizing) from Escherichia coli
Methods Enzymol.
113
305-326
1985
Escherichia coli, Escherichia coli B / ATCC 11303
Lyons, S.D.; Christopherson, R.I.
Regulation of hamster carbamoyl-phosphate synthase II by 5-phospho-alpha-D-ribosyl 1-phosphate and uridine 5'-triphosphate
Eur. J. Biochem.
147
587-592
1985
Mesocricetus auratus
Abdelal, A.T.; Bussey, L.; Vickers, L.
Carbamoylphosphate synthetase from Pseudomonas aeruginosa. Subunit composition, kinetic analysis and regulation
Eur. J. Biochem.
129
697-702
1983
Pseudomonas aeruginosa
Coleman, P.F.; Suttle, D.P.; Stark, G.R.
Purification of a multifunctional protein bearing carbamyl-phosphate synthase, aspartate transcarbamylase, and dihydroorotase enzyme activities from mutant hamster cells
Methods Enzymol.
51
121-134
1978
Mesocricetus auratus
Mori, M.; Tatibana, M.
A multienzyme complex of carbamoyl-phosphate synthase (glutamine):aspartate carbamoyltransferase:dihydroorotase (rat ascites hepatoma cells and rat liver)
Methods Enzymol.
51
111-121
1978
Rattus norvegicus
Ingraham, J.L.; Abdelal, A.T.H.
Carbamoyl-phosphate synthetase (glutamine): Salmonella
Methods Enzymol.
51
29-35
1978
Salmonella enterica subsp. enterica serovar Typhimurium
Ishida, H.; Mori, M.; Tatibana, M.
Effects of dimethyl sulfoxide and glycerol on catalytic and regulatory properties of glutamine-dependent carbamoyl phosphate synthase from rat liver and dual effects of uridine triphosphate
Arch. Biochem. Biophys.
182
258-265
1977
Rattus norvegicus
Powers, S.G.; Griffith, O.W.; Meister, A.
Inhibition of carbamyl phosphate synthetase by P1,P5-di(adenosine 5')-pentaphosphate
J. Biol. Chem.
252
3558-3560
1977
Escherichia coli
Mori, M.; Tatibana, M.
Glutamine-dependent carbamoyl phosphate synthetase: polyamines inhibit the activity and modify the activating effect of 5-phosphoribosyl 1-pyrophosphate
Biochem. Biophys. Res. Commun.
67
287-293
1975
Mammalia, Mus musculus, Rattus norvegicus
Guy, H.I.; Evans, D.R.
Cloning and expression of the mammalian multifunctional protein CAD in Escherichia coli. Characterization of the recombinant multifunctional protein CAD in Escherichia coli. Characterization of the recombinant protein and a deletion mutant lacking the major interdomain linker
J. Biol. Chem.
269
23808-23816
1994
Mammalia
Trotta, P.P; Estis, L.F.; Meister, A.; Haschemeyer, R.H.
Self-association and allosteric properties of glutamine-dependent carbamyl phosphate synthetase
J. Biol. Chem.
249
482-491
1974
Escherichia coli
Anderson, P.M.; Carlson, J.D.; Rosenthal, G.A.; Meister, A.
Effect of potassium cyanate on the catalytic activities of carbamyl phosphate synthetase
Biochem. Biophys. Res. Commun.
55
246-252
1973
Escherichia coli
Yip, M.C.M.; Knox, W.E.
Glutamine-dependent carbamyl phosphate synthetase. Properties and distribution in normal and neoplastic rat tissues
J. Biol. Chem.
245
2199-2204
1970
Rattus norvegicus
Anderson, P.M.; Meister, A.
Evidence for an activated form of carbon dioxide in the reaction catalyzed by Escherichia coli carbamyl phosphate synthetase
Biochemistry
4
2803-2808
1965
Escherichia coli, Escherichia coli B / ATCC 11303
Weber, G.; Reardon, M.
Regulation of carbamoyl-phosphate synthase II
Adv. Enzyme Regul.
25
65-83
1986
Rattus norvegicus
Rubio, V.; Llorente, P.
Activation of carbamoyl phosphate synthetase from Escherichia coli by glycerol
Biochem. Biophys. Res. Commun.
107
1400-1405
1982
Escherichia coli
Mori, M.; Tatibana, M.
Glutaminase activity of glutamine-dependent carbamoylphosphate synthase from rat ascites hepatoma. Regulation by adenosine triphosphate-magnesium and magnesium ion
Biochim. Biophys. Acta
483
90-99
1977
Rattus norvegicus
Avid-Majd, F.; Stapleton, M.A.; Harmon, M.F.; Hanks, B.A.; Mullins, L.S.; Raushel, F.M.
Comparison of the functional differences for the homologous residues within the carboxy phosphate and carbamate domains of carbamoyl phosphate synthetase
Biochemistry
35
14362-14369
1996
Escherichia coli
Stapleton, M.A.; Javid-Majd, F.; Harmon, M.F.; Hanks, B.A.; Grahmann, J.L.; Mullins, L.S.; Raushel, F.M.
Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase
Biochemistry
35
14352-14361
1996
Escherichia coli
Czerwinski, R.M.; Mareya, S.M.; Raushel, F.M.
Regulatory changes in the control of carbamoyl phosphate synthetase induced by truncation and mutagenesis of the allosteric binding domain
Biochemistry
34
13920-13927
1995
Escherichia coli
Herve, G.; Nagy, M.; Le Gouar, M.; Penverne, B.; Ladjimi, M.
The carbamoyl phosphate synthetase-aspartate transcarbamoylase complex of Saccharomyces cerevisiae: molecular and cellular aspects
Biochem. Soc. Trans.
21
195-198
1993
Saccharomyces cerevisiae, Escherichia coli, eukaryota, Mesocricetus auratus
Guy, H.I.; Evans, D.R.
Function of the major synthetase subdomains of carbamylphosphate synthetase
J. Biol. Chem.
271
13762-13769
1996
Mammalia
Yang, H.; Park, S.M.; Nolan, W.G.; Lu, C.D.; Abdelal, A.T.
Cloning and characterization of the arginine-specific carbamoyl-phosphate synthetase from Bacillus stearothermophilus
Eur. J. Biochem.
249
443-449
1997
Geobacillus stearothermophilus
Guy, H.I.; Bouvier, A.; Evans, D.R.
The smallest carbamoyl-phosphate synthetase. A single catalytic subdomain catalyzes all three partial reactions
J. Biol. Chem.
14; 272
29255-29262
1997
Escherichia coli
Guy, H.I.; Rotgeri, A.; Evans, D.R.
Activation by fusion of the glutaminase and synthetase subunits of Escherichia coli carbamyl-phosphate synthetase
J. Biol. Chem.
272
19913-19918
1997
Escherichia coli
Guy, H.I.; Evans, D.R.
Trapping an activated conformation of mammalian carbamylphosphate synthetase
J. Biol. Chem.
272
19906-19912
1997
Mammalia
Guy, H.I.; Evans, D.R.
Substructure of the amidotransferase domain of mammalian carbamyl phosphate synthetase
J. Biol. Chem.
270
2190-2197
1995
Mammalia
Pierrat, O.A.; Javid-Majd, F.; Raushel, F.M.
Dissection of the conduit for allosteric control of carbamoyl phosphate synthetase by ornithine
Arch. Biochem. Biophys.
400
26-33
2002
Escherichia coli
Thoden, J.B.; Miran, S.G.; Phillips, J.C.; Howard, A.J.; Raushel, F.M.; Holden, H.M.
Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis
Biochemistry
37
8825-8831
1998
Escherichia coli
Braxton, B.L.; Mullins, L.S.; Raushel, F.M.; Reinhart, G.D.
Allosteric dominance in carbamoyl phosphate synthetase
Biochemistry
38
1394-1401
1999
Escherichia coli
Thoden, J.B.; Huang, X.; Raushel, F.M.; Holden, H.M.
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway
Biochemistry
38
16158-16166
1999
Escherichia coli
Thoden, J.B.; Wesenberg, G.; Raushel, F.M.; Holden, H.M.
Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding
Biochemistry
38
2347-2357
1999
Escherichia coli
Bueso, J.; Cervera, J.; Fresquet, V.; Marina, A.; Lusty, C.J.; Rubio, V.
Photoaffinity labeling with the activator IMP and Site-Directed mutagenesis of histidine 995 of carbamoyl phosphate synthetase from Escherichia coli demonstrate that the binding site for IMP overlaps with that for the inhibitor UMP
Biochemistry
38
3910-3917
1999
Escherichia coli
Huang, X.; Raushel, F.M.
An engineered blockage within the ammonia tunnel of carbamoyl phosphate synthetase prevents the use of glutamine as a substrate but not ammonia
Biochemistry
39
3240-3247
2000
Escherichia coli
Miles, B.W.; Raushel, F.M.
Synchronization of the three reaction centers within carbamoyl Phosphate synthetase
Biochemistry
39
5051-5056
2000
Escherichia coli
Rishavy, M.A.; Cleland, W.W.; Lusty, C.J.
15N isotope effects in glutamine hydrolysis catalyzed by carbamyl phosphate synthetase: evidence for a tetrahedral intermediate in the mechanism
Biochemistry
39
7309-7315
2000
Escherichia coli
Kim, J.; Raushel, F.M.
Allosteric control of the oligomerization of carbamoyl phosphate synthetase from Escherichia coli
Biochemistry
40
11030-11036
2001
Escherichia coli
Kim, J.; Howell, S.; Huang, X.; Raushel, F.M.
Structural defects within the carbamate tunnel of carbamoyl phosphate synthetase
Biochemistry
41
12575-12581
2002
Escherichia coli
Nara, T.; Gao, G.; Yamasaki, H.; Nakajima-Shimada, J.; Aoki, T.
Carbamoyl-phosphate synthetase II in kinetoplastids
Biochim. Biophys. Acta
1387
462-468
1998
Saccharomyces cerevisiae, Dictyostelium discoideum, Drosophila melanogaster, Escherichia coli, Mesocricetus auratus, Leishmania mexicana (O15829), Trypanosoma cruzi (O15830)
Gibson, G.E.; Mullins, L.S.; Raushel, F.M.
Carbamoyl phosphate synthetase from Escherichia coli does not catalyze the dehydration of bicarbonate to carbon dioxide
Bioorg. Chem.
26
255-268
1998
Escherichia coli
-
Holden, H.M.; Thoden, J.B.; Raushel, F.M.
Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product
Cell. Mol. Life Sci.
56
507-522
1999
Escherichia coli
Terjesen, B.F.; Ronnestad, I.; Norberg, B.; Anderson, P.M.
Detection and basic properties of carbamoyl phosphate synthetase III during teleost ontogeny: a case study in the Atlantic halibut (Hippoglossus hippoglossus L.)
Comp. Biochem. Physiol. B
126
521-535
2000
Hippoglossus hippoglossus, Galeus melastomus
Raushel, F.M.; Thoden, J.B.; Reinhart, G.D.; Holden, H.M.
Carbamoyl phosphate synthetase: a crooked path from substrates to products
Curr. Opin. Chem. Biol.
2
624-632
1998
Escherichia coli
Holden, H.M.; Thoden, J.B.; Raushel, F.M.
Carbamoyl phosphate synthetase: a tunnel runs through it
Curr. Opin. Struct. Biol.
8
679-685
1998
Escherichia coli
Llamas, I.; Suarez, A.; Quesada, E.; Bejar, V.; del Moral, A.
Identification and characterization of the carAB genes responsible for encoding carbamoylphosphate synthetase in Halomonas eurihalina
Extremophiles
7
205-211
2003
Halomonas eurihalina (Q8RSS4 and Q8RSS3)
Mora, P.; Rubio, V.; Cervera, J.
Mechanism of oligomerization of Escherichia coli carbamoyl phosphate synthetase and modulation by the allosteric effectors. A site-directed mutagenesis study
FEBS Lett.
511
6-10
2002
Escherichia coli
Vlaskova, H.; Krasny, L.; Fucik, V.; Jonak, J.
The pyrAb gene coding for the large subunit of carbamoylphosphate synthetase from Bacillus stearothermophilus: molecular cloning and functional characterization
Folia Biol. (Praha)
44
163-172
1998
Geobacillus stearothermophilus (O50302)
Vaishnav, P.; Randev, S.; Jatiani, S.; Aggarwal, S.; Keharia, H.; Vyas, P.R.; Nareshkumar, G.; Archana, G.
Characterization of carbamoyl phosphate synthetase of Streptomyces spp
Indian J. Exp. Biol.
38
931-935
2000
Escherichia coli, Streptomyces coelicolor, Streptomyces lividans, Streptomyces lividans MTCC1
Fox, B.A.; Bzik, D.J.
Organisation and sequence determination of glutamine-dependent carbamoyl phosphate synthetase II in Toxoplasma gondii
Int. J. Parasitol.
33
89-96
2003
Toxoplasma gondii
Guy, H.I.; Schmidt, B.; Herve, G.; Evans, D.R.
Pressure-induced dissociation of carbamoyl-phosphate synthetase domains. The catalytically active form is dimeric
J. Biol. Chem.
273
14172-14178
1998
Escherichia coli
Sahay, N.; Guy, H.I.; Liu, X.; Evans, D.R.
Regulation of an Escherichia coli/mammalian chimeric carbamoyl-phosphate synthetase
J. Biol. Chem.
273
31195-31202
1998
Escherichia coli, Mammalia
Thoden, J.B.; Raushel, F.M.; Wesenberg, G.; Holden, H.M.
The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase
J. Biol. Chem.
274
22502-22507
1999
Escherichia coli
Hewagama, A.; Guy, H.I.; Vickrey, J.F.; Evans, D.R.
Functional linkage between the glutaminase and synthetase domains of carbamoyl-phosphate synthetase. Role of serine 44 in carbamoyl-phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD)
J. Biol. Chem.
274
28240-28245
1999
Escherichia coli, Mammalia
Huang, X.; Raushel, F.M.
Restricted passage of reaction intermediates through the ammonia tunnel of carbamoyl phosphate synthetase
J. Biol. Chem.
275
26233-26240
2000
Escherichia coli
Ahuja, A.; Purcarea, C.; Guy, H.I.; Evans, D.R.
A novel carbamoyl-phosphate synthetase from Aquifex aeolicus
J. Biol. Chem.
276
45694-45703
2001
Aquifex aeolicus, Bacillus subtilis, Cricetinae, Escherichia coli, Methanocaldococcus jannaschii, Pseudomonas aeruginosa
Eroglu, B.; Powers-Lee, S.G.
Unmasking a functional allosteric domain in an allosterically nonresponsive carbamoyl-phosphate synthetase
J. Biol. Chem.
277
45466-45472
2002
Saccharomyces cerevisiae, Escherichia coli
Saeed-Kothe, A.; Powers-Lee, S.G.
Specificity determining residues in ammonia- and glutamine-dependent carbamoyl phosphate synthetases
J. Biol. Chem.
277
7231-7238
2002
Escherichia coli
Saeed-Kothe, A.; Powers-Lee, S.G.
Gain of glutaminase function in mutants of the ammonia-specific frog carbamoyl phosphate synthetase
J. Biol. Chem.
278
26722-26726
2003
Escherichia coli
Saha, N.; Das, L.; Dutta, S.
Types of carbamyl phosphate synthetases and subcellular localization of urea cycle and related enzymes in air-breathing walking catfish, Clarias batrachus
J. Exp. Zool.
283
121-130
1999
Clarias batrachus
-
Delannay, S.; Charlier, D.; Tricot, C.; Villeret, V.; Pierard, A.; Stalon, V.
Serine 948 and threonine 1042 are crucial residues for allosteric regulation of Escherichia coli carbamoylphosphate synthetase and illustrate coupling effects of activation and inhibition pathways
J. Mol. Biol.
286
1217-1228
1999
Escherichia coli
Simmons, A.J.; Rawls, J.M.; Piskur, J.; Davidson, J.N.
A mutation that uncouples allosteric regulation of carbamyl phosphate synthetase in Drosophila
J. Mol. Biol.
287
277-285
1999
Drosophila melanogaster (P05990)
Fresquet, V.; Mora, P.; Rochera, L.; Ramon-Maiques, S.; Rubio, V.; Cervera, J.
Site-directed mutagenesis of the regulatory domain of Escherichia coli carbamoyl phosphate synthetase identifies crucial residues for allosteric regulation and for transduction of the regulatory signals
J. Mol. Biol.
299
979-991
2000
Escherichia coli, Escherichia coli L814
Kim, J.; Raushel, F.M.
Access to the carbamate tunnel of carbamoyl phosphate synthetase
Arch. Biochem. Biophys.
425
33-41
2004
Escherichia coli
Simmons, C.Q.; Simmons, A.J.; Haubner, A.; Ream, A.; Davidson, J.N.
Substitutions in hamster CAD carbamoyl-phosphate synthetase alter allosteric response to 5-phosphoribosyl-alpha-pyrophosphate (PRPP) and UTP
Biochem. J.
378
991-998
2004
Cricetulus griseus
Kim, J.; Raushel, F.M.
Perforation of the tunnel wall in carbamoyl phosphate synthetase derails the passage of ammonia between sequential active sites
Biochemistry
43
5334-5340
2004
Escherichia coli
Serre, V.; Penverne, B.; Souciet, J.L.; Potier, S.; Guy, H.; Evans, D.; Vicart, P.; Herve, G.
Integrated allosteric regulation in the S. cerevisiae carbamylphosphate synthetase - aspartate transcarbamylase multifunctional protein
BMC Biochem.
5
6
2004
Saccharomyces cerevisiae (P07259), Saccharomyces cerevisiae
Yefimenko, I.; Fresquet, V.; Marco-Marin, C.; Rubio, V.; Cervera, J.
Understanding carbamoyl phosphate synthetase deficiency: impact of clinical mutations on enzyme functionality
J. Mol. Biol.
349
127-141
2005
Escherichia coli
Kapatral, V.; Campbell, J.W.; Minnich, S.A.; Thomson, N.R.; Matsumura, P.; Pruss, B.M.
Gene array analysis of Yersinia enterocolitica FlhD and FlhC: regulation of enzymes affecting synthesis and degradation of carbamoylphosphate
Microbiology
150
2289-2300
2004
Yersinia enterocolitica
Lindsey-Boltz, L.A.; Wauson, E.M.; Graves, L.M.; Sancar, A.
The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD
Nucleic Acids Res.
32
4524-4530
2004
Homo sapiens
Thoden, J.B.; Huang, X.; Kim, J.; Raushel, F.M.; Holden, H.M.
Long-range allosteric transitions in carbamoyl phosphate synthetase
Protein Sci.
13
2398-2405
2004
Escherichia coli
Kothe, M.; Powers-Lee, S.G.
Nucleotide recognition in the ATP-grasp protein carbamoyl phosphate synthetase
Protein Sci.
13
466-475
2004
Escherichia coli
Kothe, M.; Purcarea, C.; Guy, H.I.; Evans, D.R.; Powers-Lee, S.G.
Direct demonstration of carbamoyl phosphate formation on the C-terminal domain of carbamoyl phosphate synthetase
Protein Sci.
14
37-44
2005
Methanocaldococcus jannaschii
Johnson, J.L.; West, J.K.; Nelson, A.D.; Reinhart, G.D.
Resolving the fluorescence response of Escherichia coli carbamoyl phosphate synthetase: mapping intra- and intersubunit conformational changes
Biochemistry
46
387-397
2007
Escherichia coli
Devroede, N.; Huysveld, N.; Charlier, D.
Mutational analysis of intervening sequences connecting the binding sites for integration host factor, PepA, PurR, and RNA polymerase in the control region of the Escherichia coli carAB operon, encoding carbamoylphosphate synthase
J. Bacteriol.
188
3236-3245
2006
Escherichia coli
Lindley, T.E.; Laberge, T.; Hall, A.; Hewett-Emmett, D.; Walsh, P.J.; Anderson, P.M.
Sequence, expression and evolutionary relationships of carbamoyl phosphate synthetase I in the toad Xenopus laevis
J. Exp. Zool. A
307
163-175
2007
Homo sapiens
McPhail, D.; Cheung, M.K.; Brown, J.; Shepherdson, M.
Factors accelerating pyrimidine production in Deinococcus radiophilus
Arch. Microbiol.
191
73-82
2009
Deinococcus radiophilus, Deinococcus radiophilus NCIMB 10648
Fan, Y.; Lund, L.; Yang, L.; Raushel, F.M.; Gao, Y.Q.
Mechanism for the transport of ammonia within carbamoyl phosphate synthetase determined by molecular dynamics simulations
Biochemistry
47
2935-2944
2008
Escherichia coli
Fox, B.A.; Ristuccia, J.G.; Bzik, D.J.
Genetic identification of essential indels and domains in carbamoyl phosphate synthetase II of Toxoplasma gondii
Int. J. Parasitol.
39
533-539
2008
Toxoplasma gondii
Hart, E.J.; Powers-Lee, S.G.
Role of Cys1327 and Cys1337 in redox sensitivity and allosteric monitoring in human carbamoyl phosphate synthetase
J. Biol. Chem.
284
5977-5985
2008
Escherichia coli
Hart, E.J.; Powers-Lee, S.G.
Mutation analysis of carbamoyl phosphate synthetase: does the structurally conserved glutamine amidotransferase triad act as a functional dyad?
Protein Sci.
17
1120-1128
2008
Escherichia coli
Potel, F.; Valadier, M.H.; Ferrario-Mery, S.; Grandjean, O.; Morin, H.; Gaufichon, L.; Boutet-Mercey, S.; Lothier, J.; Rothstein, S.J.; Hirose, N.; Suzuki, A.
Assimilation of excess ammonium into amino acids and nitrogen translocation in Arabidopsis thaliana - roles of glutamate synthases and carbamoylphosphate synthetase in leaves
FEBS J.
276
4061-4076
2009
Arabidopsis thaliana
Fan, Y.; Lund, L.; Shao, Q.; Gao, Y.Q.; Raushel, F.M.
A combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase
J. Am. Chem. Soc.
131
10211-10219
2009
Escherichia coli
Arioli, S.; Monnet, C.; Guglielmetti, S.; Mora, D.
Carbamoylphosphate synthetase activity is essential for the optimal growth of Streptococcus thermophilus in milk
J. Appl. Microbiol.
107
348-354
2009
Streptococcus thermophilus (B2G3Q3)
Borawski, J.; Troke, P.; Puyang, X.; Gibaja, V.; Zhao, S.; Mickanin, C.; Leighton-Davies, J.; Wilson, C.J.; Myer, V.; Cornellataracido, I.; Baryza, J.; Tallarico, J.; Joberty, G.; Bantscheff, M.; Schirle, M.; Bouwmeester, T.; Mathy, J.E.; Lin, K.; Compton, T.; Labow, M.; Wiedmann, B.; Gaither, L.A.
Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication
J. Virol.
83
10058-10074
2009
Hepacivirus C
Brady, B.S.; Hyman, B.C.; Lovatt, C.J.
Regulation of CPSase, ACTase, and OCTase genes in Medicago truncatula: Implications for carbamoylphosphate synthesis and allocation to pyrimidine and arginine de novo biosynthesis
Gene
462
18-25
2010
Medicago truncatula, Medicago truncatula (B9V284)
Lund, L.; Fan, Y.; Shao, Q.; Gao, Y.; Raushel, F.
Carbamate transport in carbamoyl phosphate synthetase: A theoretical and experimental investigation
J. Am. Chem. Soc.
132
3870-3878
2010
Escherichia coli, Escherichia coli (P00968)
Purcarea, C.; Evans, D.R.; Herve, G.
Channeling of carbamoyl phosphate to the pyrimidine and arginine biosynthetic pathways in the deep sea hyperthermophilic archaeon Pyrococcus abyssi
J. Biol. Chem.
274
6122-6129
1999
Pyrococcus abyssi
Grogan, D.W.; Gunsalus, R.P.
Sulfolobus acidocaldarius synthesizes UMP via a standard de novo pathway: results of biochemical-genetic study
J. Bacteriol.
175
1500-1507
1993
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DG6 / ATCC 49426
Fang, H.; Liu, H.; Chen, N.; Zhang, C.; Xie, X.; Xu, Q.
Site-directed mutagenesis studies on the uridine monophosphate binding sites of feedback inhibition in carbamoyl phosphate synthetase and effects on cytidine production by Bacillus amyloliquefaciens
Can. J. Microbiol.
59
374-379
2013
Bacillus amyloliquefaciens, Bacillus amyloliquefaciens CYT1
Weerasinghe, S.V.; Jang, Y.J.; Fontana, R.J.; Omary, M.B.
Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury
Am. J. Physiol. Gastrointest. Liver Physiol.
307
G355-G364
2014
Homo sapiens, Mus musculus
Coxam, B.; Neyt, C.; Grassini, D.R.; Le Guen, L.; Smith, K.A.; Schulte-Merker, S.; Hogan, B.M.
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish
Dev. Dyn.
244
1-9
2015
Danio rerio (Q5EI67), Danio rerio
Liu, X.; Cai, Y.; Zhang, X.; Zhang, H.; Zheng, X.; Zhang, Z.
Carbamoyl phosphate synthetase subunit MoCpa2 affects development and pathogenicity by modulating arginine biosynthesis in Magnaporthe oryzae
Front. Microbiol.
7
2023
2016
Pyricularia oryzae (G4MS82), Pyricularia oryzae ATCC MYA-4617 (G4MS82)
Cox, J.; LaMora, A.; Johnson, S.; Voigt, M.
Novel role for carbamoyl phosphate synthetase 2 in cranial sensory circuit formation
Int. J. Dev. Neurosci.
33
41-48
2014
Danio rerio (Q5EI67)
Sato, T.; Akasu, H.; Shimono, W.; Matsu, C.; Fujiwara, Y.; Shibagaki, Y.; Heard, J.J.; Tamanoi, F.; Hattori, S.
Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity
J. Biol. Chem.
290
1096-1105
2015
Homo sapiens (P27708)
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