5.3.4.1: protein disulfide-isomerase
This is an abbreviated version!
For detailed information about protein disulfide-isomerase, go to the full flat file.
Word Map on EC 5.3.4.1
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5.3.4.1
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collagen
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laminin
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integrins
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endothelial
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actin
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fibrosis
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adhesive
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basement
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mesenchymal
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vessel
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fiber
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metastasis
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proteoglycans
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vitronectin
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fibrinogen
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matrices
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nephropathy
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albumin
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gelatin
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interstitial
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mesangial
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platelet
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monolayer
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cytoskeleton
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glomerular
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rgd
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vimentin
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e-cadherin
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cell-cell
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adhesions
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zeta
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myofibroblasts
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willebrand
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epithelial-mesenchymal
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factor-beta
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fak
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fibrin
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metalloproteinases
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preterm
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dish
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biomaterials
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procollagens
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heparan
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alpha-smooth
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dermal
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tgf-beta
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plasminogen
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fibrillar
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drug development
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heparin-binding
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synthesis
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thrombospondin
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medicine
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industry
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diagnostics
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pharmacology
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biotechnology
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analysis
- 5.3.4.1
- collagen
- laminin
- integrins
- endothelial
- actin
- fibrosis
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adhesive
-
basement
- mesenchymal
- vessel
- fiber
- metastasis
- proteoglycans
- vitronectin
- fibrinogen
- matrices
- nephropathy
- albumin
- gelatin
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interstitial
-
mesangial
- platelet
- monolayer
- cytoskeleton
- glomerular
- rgd
- vimentin
- e-cadherin
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cell-cell
- adhesions
- zeta
- myofibroblasts
- willebrand
-
epithelial-mesenchymal
- factor-beta
- fak
- fibrin
- metalloproteinases
-
preterm
-
dish
-
biomaterials
- procollagens
- heparan
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alpha-smooth
- dermal
- tgf-beta
- plasminogen
-
fibrillar
- drug development
-
heparin-binding
- synthesis
- thrombospondin
- medicine
- industry
- diagnostics
- pharmacology
- biotechnology
- analysis
Reaction
catalyses the rearrangement of -S-S- bonds in proteins =
Synonyms
5'-MD, 58 kDa glucose regulated protein, 58 kDa microsomal protein, AGR2, anterior gradient homolog 2, BPA-binding protein, CaBP1, CaBP2, Cellular thyroid hormone binding protein, cotyledon-specific chloroplast biogenesis factor CYO1, CYO1, DbsG, disulfide bond isomerase, disulfide bond-forming enzyme, Disulfide interchange enzyme, disulfide isomerase, Disulfide isomerase ER-60, disulfide-bond isomerase, dithiol-disulfide isomerase, Dsb, DsbA, DsbB, DsbC, DsbD, DsbG, ECaSt/PDI, endoplasmic reticulum protein EUG1, Eps1p, ER protein 57, ER58, ER60, ERcalcistorin/protein-disulfide isomerase, ERdj5, Ero1, Erp, ERP-57, ERp-72 homolog, ERp18, ERp27, ERp28, ERp44, Erp46, ERp5, ERp57, ERP59, ERP60, ERp72, Eug1p, fibronectin, gPDI-1, gPDI-2, gPDI-3, HIP-70, HlPDI-1, HlPDI-2, HlPDI-3, Iodothyronine 5'-monodeiodinase, More, Mpd1p, Mpd2p, multifunctional protein disulfide isomerase, ncgl2478, P5, P55, P58, pancreas-specific protein disulfide isomerase, PDI, PDI A4, PDI I, PDI II, pdi-15, PDI-1a, pdi-40, pdi-47, pdi-52, PDI-A, PDI-M, PDI-P5, PDI-related protein, PDI1, PDI11, PDI2, PDI7, PDI8, PDIA1, PDIA2, PDIA3, PDIA4, PDIA6, PDIL-1, PDIL-2, PDIL1-1, PDIL1;1, PDIL1Aalpha, PDIL1B, PDIL2, PDIL2-3, PDIL3A, PDIL4D, PDIL5A, PDILT, PDIp, PDIr, protein disulfide isomerase, protein disulfide isomerase 1, protein disulfide isomerase 2, protein disulfide isomerase 3, protein disulfide isomerase A1, protein disulfide isomerase A3, protein disulfide isomerase A5, protein disulfide isomerase A6, protein disulfide isomerase associated 3, Protein disulfide isomerase P5, protein disulfide isomerase-1, protein disulfide isomerase-11, protein disulfide isomerase-2, protein disulfide isomerase-3, protein disulfide isomerase-8, protein disulfide isomerase-like protein of the testis, protein disulfide isomerase-P5, protein disulfide isomerase-related chaperone Wind, Protein disulfide isomerase-related protein, protein disulfide oxidoreductase, protein disulfide reductase/isomerase, protein disulfide-isomerase A4, Protein disulphide isomerase, Protein ERp-72, protein-disulfide isomerase, R-cognin, RB60, Rearrangease, Reduced ribonuclease reactivating enzyme, Retina cognin, S-S rearrangase, SSO0192, SsPDO, thiol-disulfide oxidoreductase, thiol-protein oxidoreductase, thioredoxin domain-containing protein 5, Thyroid hormone-binding protein, Thyroxine deiodinase, TXNDC5, yPDI
ECTree
5.3.4.1 protein disulfide-isomeraseAdvanced search results
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results (Source Tissue
Source Tissue on EC 5.3.4.1 - protein disulfide-isomerase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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time-dependent decrease in in PDI expression in thrombi following injury. Infusion of monoclonal antibodies against PDI into the circulation of mice lacking the G protein-coupled platelet receptor Par4 prior to vessel wall injury inhibits fibrin generation
TXNDC5 is highly expressed in patient-derived lung cancer specimens, immunohistochemic analysis
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activities in adult tissues are only 10-40% of those found in newborn
female tick, high expression of HlPDI-1
epididymal caput, corpus, and cauda sperm, isozymes PDIA3 and PDI-P5. PDI-P5 is downregulated from the epididymal corpus to cauda sperm, while PDIA3 is constitutively expressed
additional information
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the thiol-containing form of PDI increases in the platelet surface with platelet activition
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activities in adult tissues are only 10-40% of those found in newborn
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distribution to the endoplasmic reticulum and protein storage vacuoles, PDIS-1 levels, but not PDIS-2 levels, are increased in cotyledons
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expression of GmPDIL-3a and GmPDIL-3b in soybean cotyledons during maturation, overview
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transcription is more than 7fold enriched in L1 state compared to eggs
female tick, highest expression level of HlPDI-1
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activities in adult tissues are only 10-40% of those found in newborn
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transiently transfected with human wild-type US2, wild-type US11, or different cysteine mutants of US2 and US11
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activities in adult tissues are only 10-40% of those found in newborn
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3042, 3046, 3048, 3051, 3052, 3061, 3069, 3077, 3089, 3093, 661029, 661292, 678408, 692913, 695185, 706820, 713901, 714977, 715615
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activities in adult tissues are only 10-40% of those found in newborn
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enzyme activity increases in response to polyclonal activation by bacterial lipopolysaccharide. Induction of the enzyme is closely coupled to the final stages of differentiation to plasma cells
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pancreas-specific protein disulfide isomerase, PDIp, specific expression in pancreatic acinar cells, high expression level of PDIp
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on the extracellular surface of both nonactivated and thrombin-activated platelets. Enzyme is released by vesiculation from activated platelets
female tick, high expression of HlPDI-1
female tick, high expression of HlPDI-2
female tick, high expression of HlPDI-3
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changes in the levels of PDIS-1 and PDIS-2 during seed development, overview
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activities in adult tissues are only 10-40% of those found in newborn
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specific expression of PDIp in gastric chief cells, high expression level of PDIp
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activities in adult tissues are only 10-40% of those found in newborn
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localized in the hypodermis and uterus wall of female adults
additional information
the PDI expression levels in salivary gland is uniform in unfed ticks and ticks fed for different time intervals, no differences in enzyme expression between female and male ticks, PDI tissue distribution analysis, overview
additional information
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the PDI expression levels in salivary gland is uniform in unfed ticks and ticks fed for different time intervals, no differences in enzyme expression between female and male ticks, PDI tissue distribution analysis, overview
additional information
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no detection of protein of the 52 kDa isoform in root
additional information
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PDI-2 is required for normal post-embryonic development
additional information
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transcription is more than 7fold enriched in L1 state compared to eggs, and displays a dramatic decrease in L3. Following an increase in the L5 stage, there is again a decrease in the adult worm
additional information
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GmPDIL-3a and GmPDIL-3b are ubiquitously expressed in the plant body
additional information
the isozymes are present in all the developmental stages of the tick, immunihistochemic and quantitative expression analysis, overview
additional information
the isozymes are present in all the developmental stages of the tick, immunihistochemic and quantitative expression analysis, overview
additional information
the isozymes are present in all the developmental stages of the tick, immunihistochemic and quantitative expression analysis, overview
additional information
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the isozymes are present in all the developmental stages of the tick, immunihistochemic and quantitative expression analysis, overview
additional information
the isozymes are present in all the developmental stages of the tick, immunohistochemic and quantitative expression analysis, overview
additional information
the isozymes are present in all the developmental stages of the tick, immunohistochemic and quantitative expression analysis, overview
additional information
the isozymes are present in all the developmental stages of the tick, immunohistochemic and quantitative expression analysis, overview
additional information
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the isozymes are present in all the developmental stages of the tick, immunohistochemic and quantitative expression analysis, overview
additional information
TXNDC5 cannot be detected in human normal organs, including bone marrow, prostate, cardiac muscle, and cervix. In contrast, strong positive TXNDC5 staining is consistently observed in tissues from human normal cerebral gray matter, small intestine, colon, stomach, kidney, and salivary gland. No significant numbers of TXNDC5 are positively stained cells in normal lung tissue while strongly positive staining of TXNDC5 is found in lung tumor cells, as evidenced by the dark brown color in examples of lung squamous cell carcinoma, bronchioloalveolar carcinoma, adenocarcinoma, and small cell carcinoma. Differential expression pattern of TXNDC5 in human lung normal and cancer specimens
additional information
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TXNDC5 cannot be detected in human normal organs, including bone marrow, prostate, cardiac muscle, and cervix. In contrast, strong positive TXNDC5 staining is consistently observed in tissues from human normal cerebral gray matter, small intestine, colon, stomach, kidney, and salivary gland. No significant numbers of TXNDC5 are positively stained cells in normal lung tissue while strongly positive staining of TXNDC5 is found in lung tumor cells, as evidenced by the dark brown color in examples of lung squamous cell carcinoma, bronchioloalveolar carcinoma, adenocarcinoma, and small cell carcinoma. Differential expression pattern of TXNDC5 in human lung normal and cancer specimens
additional information
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no or poor expression of PDIp in colon, cecum, and duodenum. PDIp shows a cell-type specific expression in various mouse tissues, in the digestive organs, such as the stomach and pancreas, very high levels of PDIp are selectively expressed in the digestive enzyme-secreting cells
additional information
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PDI expression during parasite development, overview
additional information
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stage-specific expression and cellular localization of isozymes, overview, isozyme PDI-8 is expressed during all stages of parasite life cycle
additional information
differential expression of PDIA3 mRNA in salmon tissues
additional information
developmentally regulated expression of both PDI enzyme forms, the enzymes are not essential for growth of trypanosomes
additional information
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developmentally regulated expression of both PDI enzyme forms, the enzymes are not essential for growth of trypanosomes
