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Literature summary for 5.3.4.1 extracted from

  • Fu, X.; Wang, P.; Zhu, B.
    Characterization of the estradiol-binding site structure of human pancreas-specific protein disulfide isomerase: Indispensable role of the hydrogen bond between His278 and the estradiol 3-hydroxyl group (2011), Biochemistry, 50, 106-115.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.4.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
H278L the mutant protein does not have an appreciable E2-binding activity Homo sapiens
Q265L the mutant displays similar E2-binding activity as the corresponding wild type proteins Homo sapiens
Q265L/H278L the mutant protein does not have any E2-binding activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme has a single E2-binding site ?
-
 ?
additional information Homo sapiens ATCC 6706839 the enzyme has a single E2-binding site ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens ATCC 6706839
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
pancreas highly expressed in pancreatic acinar cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme has a single E2-binding site Homo sapiens ?
-
 ?
additional information the enzyme has a single E2-binding site Homo sapiens ATCC 6706839 ?
-
 ?

Synonyms

Synonyms Comment Organism
pancreas-specific protein disulfide isomerase
-
 Homo sapiens
PDIp
-
 Homo sapiens