Activating Compound | Comment | Organism | Structure |
---|---|---|---|
DTT | the disulfide reduction activity of PDI-DTT is reduced | Bos taurus | |
additional information | thioredoxin reductase activates PDI at pH 7.4, 37°C involving glutathione reduction and NADPH, the disulfide reduction activity of PDI-thioredoxin reductase is reduced | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Bos taurus | 5783 | - |
membrane | - |
Bos taurus | 16020 | - |
microsome | - |
Bos taurus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | liver enzyme | Bos taurus | - |
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GSSG | disulfide reduction of GSSG, the disulfide reduction activity of both PDI-thioredoxin reductase and PDI-DTT is reduced | Bos taurus | GSH | - |
? | |
additional information | PDI is a better thiol oxidant than a disulfide protein reductant | Bos taurus | ? | - |
? | |
ricin | reductive activation of ricin and ricin A-chain immunotoxins, assay system involving thioredoxin reductase and NADPH, overview | Bos taurus | ? | - |
? | |
ricin A-chain immunotoxins | reductive activation of ricin and ricin A-chain immunotoxins, assay system involving thioredoxin reductase and NADPH, overview | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDI | - |
Bos taurus |
protein disulfide isomerase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Bos taurus |