Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 (DE3) pLysS cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni Sepharose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PDI | - |
Homo sapiens |
protein disulfide isomerase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | protein disulfide isomerase interacts with tau protein and physiologically inhibits its fibrillization mainly through ist thioredoxin-like catalytic domain a, forming a 1:1 complex and preventing Tau misfolding. Protein disulfide isomerase is both an enzyme and a chaperone, and implicated in neuroprotection against Alzheimer disease | Homo sapiens |