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Literature summary for 5.3.4.1 extracted from

  • Pescatore, L.A.; Bonatto, D.; Forti, F.L.; Sadok, A.; Kovacic, H.; Laurindo, F.R.
    Protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and RhoGTPase activation (2012), J. Biol. Chem., 287, 29290-29300.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Insulin-(SS) + GSH Oryctolagus cuniculus
-
Insulin-(SH)2 + GSSG
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Insulin-(SS) + GSH
-
Oryctolagus cuniculus Insulin-(SH)2 + GSSG
-
?

Synonyms

Synonyms Comment Organism
PDI
-
Oryctolagus cuniculus
protein disulfide isomerase
-
Oryctolagus cuniculus

General Information

General Information Comment Organism
malfunction enzyme silencing decreases Nox1 expression and reactive oxygen species production as well as platelet-derived growth factor-induced Rac1 and RhoA activities Oryctolagus cuniculus
physiological function protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and Rho-GTPase activation Oryctolagus cuniculus