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Literature summary for 5.3.4.1 extracted from

  • Okada, K.; Hashimoto, S.; Funae, Y.; Imaoka, S.
    Hydroxylated polychlorinated biphenyls (PCBs) interact with protein disulfide isomerase and inhibit its activity (2009), Chem. Res. Toxicol., 22, 899-904.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2',3,3',4',5'-pentachlorobiphenyl strong inhibition of PDI 3,3',5-triiodo-L-thyronine-binding activity Rattus norvegicus
2',3,3',5,5',6'-hexachlorobiphenyl strong inhibition of PDI 3,3',5-triiodo-L-thyronine-binding activity Rattus norvegicus
bisphenol A halogenated derivatives of bisphenol A as well as bisphenol A itself bind to PDI and thereby suppress the oxidative refolding of reduced RNaseA by PDI Rattus norvegicus
additional information no effects of nonhydroxylated biphenyls on 3,3',5-triiodo-L-thyronine binding Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PDI is a catalyst of isomerization of substrate protein intra- and extramolecular disulfide bridges and also has 3,3',5-triiodo-L-thyronine-binding activity and molecular chaperone-like activity ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
GH3 cell a pituitary tumor cell line Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PDI is a catalyst of isomerization of substrate protein intra- and extramolecular disulfide bridges and also has 3,3',5-triiodo-L-thyronine-binding activity and molecular chaperone-like activity Rattus norvegicus ?
-
?
additional information oxidative refolding of redRNaseA by disulfide isomerization activity, suppression of the thermal aggregation of alcohol dehydrogenase by chaperone activity, binding activity of 3,3',5-triiodo-L-thyronine in GH3 cells Rattus norvegicus ?
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?

Synonyms

Synonyms Comment Organism
PDI
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Rattus norvegicus
protein disulfide isomerase
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Rattus norvegicus