Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',3,3',4',5'-pentachlorobiphenyl | strong inhibition of PDI 3,3',5-triiodo-L-thyronine-binding activity | Rattus norvegicus | |
2',3,3',5,5',6'-hexachlorobiphenyl | strong inhibition of PDI 3,3',5-triiodo-L-thyronine-binding activity | Rattus norvegicus | |
bisphenol A | halogenated derivatives of bisphenol A as well as bisphenol A itself bind to PDI and thereby suppress the oxidative refolding of reduced RNaseA by PDI | Rattus norvegicus | |
additional information | no effects of nonhydroxylated biphenyls on 3,3',5-triiodo-L-thyronine binding | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | PDI is a catalyst of isomerization of substrate protein intra- and extramolecular disulfide bridges and also has 3,3',5-triiodo-L-thyronine-binding activity and molecular chaperone-like activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GH3 cell | a pituitary tumor cell line | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PDI is a catalyst of isomerization of substrate protein intra- and extramolecular disulfide bridges and also has 3,3',5-triiodo-L-thyronine-binding activity and molecular chaperone-like activity | Rattus norvegicus | ? | - |
? | |
additional information | oxidative refolding of redRNaseA by disulfide isomerization activity, suppression of the thermal aggregation of alcohol dehydrogenase by chaperone activity, binding activity of 3,3',5-triiodo-L-thyronine in GH3 cells | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDI | - |
Rattus norvegicus |
protein disulfide isomerase | - |
Rattus norvegicus |