Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is stress-inducible | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
sequence comparison | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is involved in correct disulfide bond formation in secretory proteins as a key step in endoplasmic reticulum quality control, ERp57 works in conjunction with the endoplasmic reticulum lectin-like chaperones calnexin and calreticulin via the noncatalytic b' domain of the enzyme, the b' domains of ERp57 and PDI are very different, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07237 | PDIA1 | - |
Homo sapiens | P13667 | ERp72 or PDIA4, respecitvely | - |
Homo sapiens | P30101 | ERp57 | - |
Homo sapiens | Q13087 | PDIA2 precursor | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | inducible | Homo sapiens | - |
additional information | ubiquitous tissue expression | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in correct disulfide bond formation in secretory proteins as a key step in endoplasmic reticulum quality control, ERp57 works in conjunction with the endoplasmic reticulum lectin-like chaperones calnexin and calreticulin via the noncatalytic b' domain of the enzyme, the b' domains of ERp57 and PDI are very different, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme catalyzes the oxidation, reduction, and isomerization of secretory proteins and plasma membrane proteins, substrate specificity, the enzyme contains a WCGHC active site, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | domain structure of isozymes, comparison, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ERp57 | - |
Homo sapiens |
ERp72 | - |
Homo sapiens |
More | the enzyme belongs to the protein disulfide isomerase family | Homo sapiens |
multifunctional protein disulfide isomerase | - |
Homo sapiens |
PDIA1 | - |
Homo sapiens |
PDIA2 | - |
Homo sapiens |
PDIA4 | - |
Homo sapiens |