Literature summary for 5.3.4.1 extracted from

Lovat, P.E.; Corazzari, M.; Armstrong, J.L.; Martin, S.; Pagliarini, V.; Hill, D.; Brown, A.M.; Piacentini, M.; Birch-Machin, M.A.; Redfern, C.P.
Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress (2008), Cancer Res., 68, 5363-5369.

Search for more literature for 5.3.4.1

Application

Application	Comment	Organism
medicine	inhibition of isoform procollagen-proline, 2-oxoglutarate-4-dioxygenase beta subunit activity increases apoptosis in response to agents which induce ER-stress such as fenretinide and velcade	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of isoform procollagen-proline, 2-oxoglutarate-4-dioxygenase beta subunit results in increased protein disulfide isomerase activity and abrogates the apoptosis-enhancing effect of inhibitor bacitracin. Overexpression of a mutant lacking protein disulfide isomerase activity does not increase cellular enzymic activity or block the effects of bacitracin	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
bacitracin	inhibition of protein disulfide isomerase results in enhanced stress response and apoptosis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform procollagen-proline, 2-oxoglutarate-4-dioxygenase beta subunit	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-375 cell	-	Homo sapiens	-
CHL-1 cell	-	Homo sapiens	-
melanocyte	-	Homo sapiens	-
WM-266-4 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)