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Literature summary for 5.3.4.1 extracted from

  • Schultz-Norton, J.R.; McDonald, W.H.; Yates, J.R.; Nardulli, A.M.
    Protein disulfide isomerase serves as a molecular chaperone to maintain estrogen receptor alpha structure and function (2006), Mol. Endocrinol., 20, 1982-1995.
    View publication on PubMed
Search for more literature for 5.3.4.1

Protein Variants

Protein Variants Comment Organism
additional information eliminating the isomerase activity of PDI does not affect ERalpha-ERE complex formation, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrogen receptor alpha Homo sapiens i.e. ERalpha, PDI plays a critical role in estrogen responsiveness by functioning as a molecular chaperone and assisting the receptor in differentially regulating target gene expression, PDI alters estrogen-mediated transactivation, overview, PDI enhances ERalpha-DNA interactions in presence of an oxidizing agent ?
-
 ?
additional information Homo sapiens PDI has two distinct functions: acting as a molecular chaperone to maintain properly folded proteins and regulating the redox state of proteins by catalyzing the thiol-disulfide exchange reaction through two thioredoxin-like domains ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrogen receptor alpha i.e. ERalpha, PDI plays a critical role in estrogen responsiveness by functioning as a molecular chaperone and assisting the receptor in differentially regulating target gene expression, PDI alters estrogen-mediated transactivation, overview, PDI enhances ERalpha-DNA interactions in presence of an oxidizing agent Homo sapiens ?
-
 ?
estrogen receptor alpha i.e. ERalpha, PDI colocalizes with ERalpha in MCF-7 nuclei, alters ERalpha conformation, enhances the ERalpha-estrogen response element interaction in the absence and presence of an oxidizing agent, influences the ability of ERalpha to mediate changes in gene expression, and associates with promoter regions of two endogenous estrogen-responsive genes, overview Homo sapiens ?
-
 ?
additional information PDI has two distinct functions: acting as a molecular chaperone to maintain properly folded proteins and regulating the redox state of proteins by catalyzing the thiol-disulfide exchange reaction through two thioredoxin-like domains Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PDI
-
 Homo sapiens
protein disulfide isomerase
-
 Homo sapiens