Protein Variants | Comment | Organism |
---|---|---|
additional information | transfection of HUVECs with PDI siRNA using electroporation by nucleofector | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
male C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
arteriole | - |
Homo sapiens | - |
endothelial cell | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
left ventricle | - |
Mus musculus | - |
myocardium | - |
Mus musculus | - |
umbilical vein endothelial cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PDI | - |
Mus musculus |
PDI | - |
Homo sapiens |
protein disulfide isomerase | - |
Mus musculus |
protein disulfide isomerase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | protein disulfide isomerase is highly upregulated in hypoxic myocardial capillary endothelial cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | PDI inhibition or silencing increases apoptosis and inhibits migration and adhesion of endothelial cells, overview | Homo sapiens |
physiological function | the enzyme is involved in myocardial angiogenesis, overview | Homo sapiens |
physiological function | the enzyme is involved in myocardial angiogenesis. Protein disulfide isomerase is highly upregulated in hypoxic myocardial capillary endothelial cells, chronic hypoxia increases the survival rate and reduces the infarct size in myocardial ischemia, overview | Mus musculus |