4.2.1.2: fumarate hydratase

This is an abbreviated version!
For detailed information about fumarate hydratase, go to the full flat file.

Word Map on EC 4.2.1.2

4.2.1.2

succinate

leiomyomatosis

hereditary

tricarboxylic

uterine

leiomyoma

hlrcc

germline

isocitrate

citrate

tca

papillary

krebs

aconitase

carboxylase

citric

predisposition

fibroids

phosphoenolpyruvate

succinyl-coa

nucleoli

l-malic

halo

alpha-ketoglutarate

leiomyosarcoma

oncometabolite

paragangliomas

aspartase

pseudohypoxic

reed

oxalacetate

perinucleolar

hippel-lindau

hysterectomy

chromophobe

1.1.1.37

analysis

2-hydroxyglutarate

synthesis

papules

oncocytomas

medicine

industry

Reaction

Synonyms

At2g47510, At5g50950, Bxe_A1038, Bxe_A3136, class II fumarase, Fum, FUM C, FUM1, FUM2, FumA, fumarase, fumarase A, fumarase C, fumarase/mesaconase, fumarate hydratase, FumB, FumC, FumD, FumF, FUMR, hydratase, fumarate, L-malate hydro-lyase, LmFH-1, LmFH-2, LmjF24.0320, LmjF29.1960, mesaconase/fumarase, MmcBC, PF1754, PF1755, rv1098c, scFUMC, slFumC, stFUMC, Tneu_1334, Tneu_1335

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.2 fumarate hydratase

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Results	in table
15	Activating Compound
58052	AA Sequence
23	Application
1	CAS Registry Number
35	Cloned(Commentary)
1	Cofactor
12	Crystallization (Commentary)
2255	Disease/ Diagnostics
12	Expression
29	General Information
11	General Stability
1	IC50 Value
84	Inhibitors
86	kcat/KM [mM/s]
6	Ki Value [mM]
159	KM Value [mM]
60	Localization
23	Metals/Ions
61	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
11	Organic Solvent Stability
154	Organism
3	Oxidation Stability
28	Pathway
173	PDB ID
37	pH Optimum
6	pH Range
5	pH Stability
2	pI Value
1	Posttranslational Modification
112	Protein Variants
30	Purification (Commentary)
4	Reaction
3	Reaction Type
134	Reference
57	Source Tissue
27	Specific Activity [micromol/min/mg]
6	Storage Stability
178	Substrates and Products (Substrate)
36	Subunits
115	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
4	Temperature Range [°C]
28	Temperature Stability [°C]
50	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 4.2.1.2 - fumarate hydratase

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114000

gel filtration

120000

135000

gel filtration, mutants H318Y and A308T

748801

160000

Saccharolobus solfataricus

sucrose density gradient centrifugation

33767

170000

Saccharolobus solfataricus

gel filtration

175000

gel filtration

180000

190000

gel filtration

194000

equilibrium sedimentation

33728, 33760, 33761

195000

198000

gel filtration

200000

210000

gel filtration, wild-type

216000

gel filtration

440000

oligomer 1, gel filtration

45000

46000

4 * 46000, SDS-PAGE

47900

Saccharolobus solfataricus

P39461

calculated from amino acid sequence

679811

48000

2 entries

48500

Sus scrofa

4 * 48500, equilibrium sedimentation in 6 M guanidine HCl, pH 4.25

49000

50000

50502

x * 50502, calculation from nucleotide sequence

653771

50900

Helicobacter pylori

x * 50900, about, sequence calculation, x * 43000-45000, recombinant enzyme, SDS-PAGE

51000

x * 51000, SDS-PAGE

54000

mitochondrial fumarate hydratase is translated as an approximately 54000 Da precursor, which is processed upon mitochondrial transport by cleavage of the N-terminal targeting signal, resulting in a mature form of 48000 Da

696399

60000

7 entries

600000

Helicobacter pylori

oligomer 2, gel filtration

714402

60105

2 entries

61000

Escherichia coli

2 * 61000, enzyme form FUMA, SDS-PAGE

61100

calculated from cDNA

62600

calculated from cDNA

64200

Pelotomaculum thermopropionicum

gel filtration

679910