4.2.1.2: fumarate hydratase
This is an abbreviated version!
For detailed information about fumarate hydratase, go to the full flat file.
Word Map on EC 4.2.1.2
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4.2.1.2
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succinate
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leiomyomatosis
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hereditary
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tricarboxylic
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uterine
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leiomyoma
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hlrcc
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germline
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isocitrate
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citrate
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tca
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papillary
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krebs
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aconitase
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carboxylase
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citric
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predisposition
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fibroids
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phosphoenolpyruvate
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succinyl-coa
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nucleoli
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l-malic
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halo
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alpha-ketoglutarate
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leiomyosarcoma
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oncometabolite
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paragangliomas
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aspartase
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pseudohypoxic
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reed
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oxalacetate
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perinucleolar
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hippel-lindau
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hysterectomy
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chromophobe
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1.1.1.37
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analysis
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2-hydroxyglutarate
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synthesis
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papules
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oncocytomas
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medicine
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industry
- 4.2.1.2
- succinate
- leiomyomatosis
- hereditary
-
tricarboxylic
- uterine
- leiomyoma
-
hlrcc
-
germline
- isocitrate
- citrate
- tca
-
papillary
-
krebs
- aconitase
- carboxylase
-
citric
-
predisposition
- fibroids
- phosphoenolpyruvate
- succinyl-coa
- nucleoli
-
l-malic
-
halo
- alpha-ketoglutarate
- leiomyosarcoma
-
oncometabolite
- paragangliomas
- aspartase
-
pseudohypoxic
-
reed
- oxalacetate
-
perinucleolar
-
hippel-lindau
-
hysterectomy
-
chromophobe
-
1.1.1.37
- analysis
- 2-hydroxyglutarate
- synthesis
-
papules
- oncocytomas
- medicine
- industry
Reaction
Synonyms
At2g47510, At5g50950, Bxe_A1038, Bxe_A3136, class II fumarase, Fum, FUM C, FUM1, FUM2, FumA, fumarase, fumarase A, fumarase C, fumarase/mesaconase, fumarate hydratase, FumB, FumC, FumD, FumF, FUMR, hydratase, fumarate, L-malate hydro-lyase, LmFH-1, LmFH-2, LmjF24.0320, LmjF29.1960, mesaconase/fumarase, MmcBC, PF1754, PF1755, rv1098c, scFUMC, slFumC, stFUMC, Tneu_1334, Tneu_1335
ECTree
4.2.1.2 fumarate hydrataseAdvanced search results
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results (Localization
Localization on EC 4.2.1.2 - fumarate hydratase
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LOCALIZATION 
ORGANISM
UNIPROT
COMMENTARY 
GeneOntology No.
LITERATURE
SOURCE
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in thin sections from kidney, liver, heart, adrenal gland and anterior pituitary, strong and specific labeling due to fumarase antibody is only detected in mitochondria. In pancreatic acinar cells, in addition to mitochondria, highly significant labeling is also observed in the zymogen granules and endoplasmic reticulum
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in thin sections from kidney, liver, heart, adrenal gland and anterior pituitary, strong and specific labeling due to fumarase antibody is only detected in mitochondria. In pancreatic acinar cells, in addition to mitochondria, highly significant labeling is also observed in the zymogen granules and endoplasmic reticulum
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mitochondrial and cytosolic isoforms are derivatives of a single translation product and have identical amino termini
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translation product of the FUM1 gene, distribution can be affected by hsp70 molecular chaperones
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the cytosolic isoenzyme and the mitochondrial isoenzyme are identical over nearly all of their amino acid sequences but differ at their N-termini
Cos-1 cells transfected with fumarase constructs, human fumarase with either the native or cytochrome c oxidase subunit VIII mitochondrial targeting sequence is detected exclusively in mitochondria in more than 98% of the cells, while the remainder 1-2% of the cells shows varying amounts of nuclear labeling. When human fumarase is fused to the yeast mitochondrial targeting sequence, more than 50% of the cells show nuclear labeling
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cytosolic fumarase and mitochondrial fumarase are identical products of the same nuclear gene
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in thin sections from kidney, liver, heart, adrenal gland and anterior pituitary, strong and specific labeling due to fumarase antibody is only detected in mitochondria. In pancreatic acinar cells, in addition to mitochondria, highly significant labeling is also observed in the zymogen granules and endoplasmic reticulum
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mitochondrial and cytosolic isoforms are derivatives of a single translation product and have identical amino termini
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translation product of the FUM1 gene, distribution can be affected by hsp70 molecular chaperones
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the presequence of fumarase is exposed to the cytosol during import into mitochondria
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the cytosolic isoenzyme and the mitochondrial isoenzyme are identical over nearly all of their amino acid sequences but differ at their N-termini
Cos-1 cells transfected with fumarase constructs, human fumarase with either the native or cytochrome c oxidase subunit VIII mitochondrial targeting sequence is detected exclusively in mitochondria in more than 98% of the cells, while the remainder 1-2% of the cells shows varying amounts of nuclear labeling. When human fumarase is fused to the yeast mitochondrial targeting sequence, more than 50% of the cells show nuclear labeling
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after both hydroxyurea or ionizing radiation treatments, is localized in the nucleus after DNA damage
