Reference on EC 4.2.1.2 - fumarate hydratase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hill, R.L.; Teipel, J.W.
Fumarase and crotonase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
5
539-571
1971
Sus scrofa
-
Alberty, R.A.
Fumarase
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
5
531-544
1961
Azotobacter vinelandii, Saccharomyces cerevisiae, Sus scrofa
-
Yumoto, N.; Tokushige, M.
Characterization of multiple fumarase proteins in Escherichia coli
Biochem. Biophys. Res. Commun.
153
1236-1243
1988
Escherichia coli
Woods, S.A.; Schwartzbach, S.D.; Guest, J.R.
Two biochemically distinct classes of fumarase in Escherichia coli
Biochim. Biophys. Acta
954
14-26
1988
Escherichia coli
Wu, M.; Tzagoloff, A.
Mitochondrial and cytoplasmic fumarases in Saccharomyces cerevisiae are encoded by a single nuclear gene FUM1
J. Biol. Chem.
262
12275-12282
1987
Saccharomyces cerevisiae
Sacchettini, J.C.; Meininger, T.; Roderick, S.; Banaszak, L.J.
Purification, crystallization, and preliminary X-ray data for porcine fumarase
J. Biol. Chem.
261
15183-15185
1986
Sus scrofa
Shibata, H.; Gardiner, W.E.; Schwartzbach, S.D.
Purification, characterization, and immunological properties of fumarase from Euglena gracilis var. bacillaris
J. Bacteriol.
164
762-768
1985
Euglena gracilis
Hirota, K.; Shimamura, M.
Sepharose derivatives containing citric acid as affinity ligand. Purification of fumarase
J. Chromatogr.
319
173-185
1985
Sus scrofa
O'Hare, M.C.; Doonan, S.
Purification and structural comparisons of the cytosolic and mitochondrial isoenzymes of fumarase from pig liver
Biochim. Biophys. Acta
827
127-134
1985
Sus scrofa
Kobayashi, K.; Yamanishi, T.; Tuboi, S.
Physicochemical, catalytic, and immunochemical properties of fumarases crystallized separately from mitochondrial and cytosolic fractions of rat liver
J. Biochem.
89
1923-1931
1981
Rattus norvegicus
Beeckmans, S.; Kanarek, L.
A new purification procedure for fumarase based of affinity chromatography. Isolation and characterization of pig-liver fumarase
Eur. J. Biochem.
78
437-444
1977
Sus scrofa
Cook, W.R.; Ramaley, R.F.
Purification and catalytic properties of "thermostable" fumarase from Bacillus stearothermophilus NU-10 and Thermus X-1
Experientia
26
207-222
1976
Geobacillus stearothermophilus, Thermus sp., Thermus sp. X-1, Geobacillus stearothermophilus NU-10
Tuboi, S.; Sato, M.; Ono, H.; Kobayashi, K.; Hiraga, K.
Mechanism of synthesis and localization of mitochondrial and cytosolic fumarases in rat liver
Adv. Enzyme Regul.
25
461-484
1986
Rattus norvegicus
O'Hare, M.C.; Doonan, S.
Cytosolic and mitochondrial fumarases
Biochem. Soc. Trans.
12
443-444
1984
Sus scrofa
-
Yamato, S.; Murachi, T.
Dissociation and association of fumarase subunits with special reference to the formation of a functional tetramer
Eur. J. Biochem.
93
189-195
1979
Sus scrofa
Kanarek, L.; Marler, E.; Bradshaw, R.A.; Fellows, R.E.; Hill, R.L.
The subunits of fumarase
J. Biol. Chem.
239
4207-4211
1964
Sus scrofa
Kanarek, L.; Hill, R.L.
The preparation and characterization of fumarase from swine heart muscle
J. Biol. Chem.
239
4202-4206
1964
Sus scrofa
Van Kuijk, B.L.M.; van Loo, N.D.; Arendsen, A.F.; Hagen, W.R.; Stams, A.J.M.
Purification and characterization of fumarase from the syntrophic propionate-oxidizing bacterium strain MPOB
Arch. Microbiol.
165
126-131
1996
Bacteria
Nast, G.; Muller-Rber, B.
Molecular characterization of potato fumarate hydratase and functional expression in Escherichia coli
Plant Physiol.
112
1219-1227
1996
Solanum tuberosum
Weaver, T.; Lees, M.; Zaitsev, V.; Zaitseva, I.; Duke, E.; Lindley, P.; McSweeny, S.; Svensson, A.; Keruchenko, J.; Keruchenko, I.; Gladilin, K.; Banaszak, L.
Crystal structures of native and recombinant yeast fumarase
J. Mol. Biol.
280
431-442
1998
Saccharomyces cerevisiae (P08417), Saccharomyces cerevisiae
Weaver, T.M.; Levitt, D.G.; Banaszak, L.J.
Purification and crystallization of fumarase C from Escherichia coli
J. Mol. Biol.
231
141-144
1993
Escherichia coli
Hassett, D.J.; Howell, M.L.; Sokol, P.A.; Vasil, M.L.; Dean, G.E.
Fumarase C activity is elevated in response to iron deprivation and in mucoid, alginate-producing Pseudomonas aeruginosa: cloning and characterization of fumC and purification of native fumC
J. Bacteriol.
179
1442-1451
1997
Pseudomonas aeruginosa
Puchegger, S.; Redl, B.; Stpfler, G.
Purification and properties of a thermostable fumarate hydratase from the archaeobacterium Sulfolobus solfataricus
J. Gen. Microbiol.
136
1537-1541
1990
Saccharolobus solfataricus, Saccharolobus solfataricus DSM 1616
Ueda, Y.; Yumoto, N.; Tokushige, M.; Fukui, K.; Ohya-Nishiguchi, H.
Purification and characterization of two types of fumarase from Escherichia coli
J. Biochem.
109
728-733
1991
Escherichia coli
Keruchenko, J.S.; Keruchenko, I.D.; Gladilin, K.L.; Zaitsev, V.; Chiragadze, N.Y.
Purification, characterization and preliminary X-ray study of fumarase from Saccharomyces cerevisiae
Biochim. Biophys. Acta
1122
85-92
1992
Saccharomyces cerevisiae
Flint, D.H.; Emptage, M.H.; Guest, J.R.
Fumarase a from Escherichia coli: purification and characterization as an iron-sulfur cluster containing enzyme
Biochemistry
31
10331-10337
1992
Escherichia coli
Flint, D.H.
Initial kinetic and mechanistic characterization of Escherichia coli fumarase A
Arch. Biochem. Biophys.
311
509-516
1994
Escherichia coli
Mizobata, T.; Fujioka, T.; Yamasaki, F.; Hidaka, M.; Nagai, J.; Kawata, Y.
Purification and characterization of a thermostable class II fumarase from Thermus thermophilus
Arch. Biochem. Biophys.
355
49-55
1998
Saccharomyces cerevisiae, Thermus thermophilus
Behal, R.H.; Oliver, D.J.
Biochemical and molecular characterization of fumarase from plants: purification and characterization of the enzyme--cloning, sequencing, and expression of the gene
Arch. Biochem. Biophys.
348
65-74
1997
Pisum sativum, Arabidopsis thaliana (P93033), Arabidopsis thaliana
Leuchtenberger, W.; Karrenbauer, M.; Plcker, U.
Scale-up of an enzyme membrane reactor process for the manufacture of L-enantiomeric compounds
Ann. N. Y. Acad. Sci.
434
78-86
1984
Corynebacterium ammoniagenes
-
Shyadehi, A.Z.; Harding, J.J.
Protective effects of ibuprofen and its major metabolites against in vitro inactivation of catalase and fumarase: relevance to cataract
Biochim. Biophys. Acta
1587
31-35
2002
Sus scrofa
Smith, M.A.; Mendz, G.L.; Jorgensen, M.A.; Hazell, S.L.
Fumarate metabolism and the microaerophily of Campylobacter species
Int. J. Biochem. Cell Biol.
31
961-975
1999
Campylobacter jejuni, Campylobacter coli, Campylobacter fetus
Tejera, N.A.; Ortega, E.; Gonzalez-Lopez, J.; Lluch, C.
Effect of some abiotic factors on the biological activity of Gluconacetobacter diazotrophicus
J. Appl. Microbiol.
95
528-535
2003
Gluconacetobacter diazotrophicus
Tseng, C.P.; Yu, C.C.; Lin, H.H.; Chang, C.Y.; Kuo, J.T.
Oxygen- and growth rate-dependent regulation of Escherichia coli fumarase (FumA, FumB, and FumC) activity
J. Bacteriol.
183
461-467
2001
Escherichia coli
Sass, E.; Blachinsky, E.; Karniely, S.; Pines, O.
Mitochondrial and cytosolic isoforms of yeast fumarase are derivatives of a single translation product and have identical amino termini
J. Biol. Chem.
276
46111-46117
2001
Saccharomyces cerevisiae
Sass, E.; Karniely, S.; Pines, O.
Folding of fumarase during mitochondrial import determines its dual targeting in yeast
J. Biol. Chem.
278
45109-45116
2003
Saccharomyces cerevisiae
Miszalski, Z.; Niewiadomska, E.; Slesak, I.; Luttge, U.; Kluge, M.; Ratajczak, R.
The effect of irradiance on carboxylating/decarboxylating enzymes and fumarase activities in Mesembryanthemum crystallinum L. exposed to salinity stress
Plant Biol.
3
17-23
2001
Mesembryanthemum crystallinum, Mesembryanthemum crystallinum L.
-
Rose, I.A.; Weaver, T.M.
The role of the allosteric B site in the fumarase reaction
Proc. Natl. Acad. Sci. USA
101
3393-3397
2004
Escherichia coli, Escherichia coli FumC
Kulkarni, G.; Sabnis, N.A.; Harris, B.G.
Cloning, expression, and purification of fumarase from the parasitic nematode Ascaris suum
Protein Expr. Purif.
33
209-213
2004
Ascaris suum (Q7Z1D9), Ascaris suum
Estevez, M.; Skarda, J.; Spencer, J.; Banaszak, L.; Weaver, T.M.
X-ray crystallographic and kinetic correlation of a clinically observed human fumarase mutation
Protein Sci.
11
1552-1557
2002
Homo sapiens, Escherichia coli (P05042), Escherichia coli
Tosa, T.; Shibatani, T.
Industrial applications of immobilized biocatalysts in Japan
Ann. N. Y. Acad. Sci.
750
364-375
1995
[Brevibacterium] flavum
Daneel, H.J.; Busse, M.; Faurie, R.
Pharmaceutical grade L-malic acid from fumaric acid - development of an integrated biotransformation and product purification process
Med. Fac. Landbouww. Univ. Gent
61/4a
1333-1340
1996
Corynebacterium glutamicum
-
Weaver, T.
Structure of free fumarase C from Escherichia coli
Acta Crystallogr. Sect. D
61
1395-1401
2005
Escherichia coli (P05042), Escherichia coli
Lehtonen, R.; Kiuru, M.; Vanharanta, S.; Sjoeberg, J.; Aaltonen, L.M.; Aittomaeki, K.; Arola, J.; Butzow, R.; Eng, C.; Husgafvel-Pursiainen, K.; Isola, J.; Jaervinen, H.; Koivisto, P.; Mecklin, J.P.; Peltomaeki, P.; Salovaara, R.; Wasenius, V.M.; Karhu, A.; Launonen, V.; Nupponen, N.N.; Aaltonen, L.A.
Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors
Am. J. Pathol.
164
17-22
2004
Homo sapiens
Bagdasaryan, Z.N.; Aleksanyan, G.A.; Mirzoyan, A.M.; Roseiro, J.C.; Bagdasaryan, S.N.
Stimulation of Erwinia sp. fumarase and aspartase synthesis by changing medium components
Appl. Biochem. Biotechnol.
125
113-126
2005
Erwinia sp.
Hong, S.H.; Lee, S.Y.
Enhanced production of succinic acid by metabolically engineered Escherichia coli with amplified activities of malic enzyme and fumarase
Biotechnol. Bioprocess Eng.
9
252-255
2004
Escherichia coli
-
Gross, K.L.; Panhuysen, C.I.; Kleinman, M.S.; Goldhammer, H.; Jones, E.S.; Nassery, N.; Stewart, E.A.; Morton, C.C.
Involvement of fumarate hydratase in nonsyndromic uterine leiomyomas: genetic linkage analysis and FISH studies
Genes Chromosomes Cancer
41
183-190
2004
Homo sapiens
Alam, N.A.; Olpin, S.; Rowan, A.; Kelsell, D.; Leigh, I.M.; Tomlinson, I.P.; Weaver, T.
Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer
J. Mol. Diagn.
7
437-443
2005
Homo sapiens
Remes, A.M.; Filppula, S.A.; Rantala, H.; Leisti, J.; Ruokonen, A.; Sharma, S.; Juffer, A.H.; Hiltunen, J.K.
A novel mutation of the fumarase gene in a family with autosomal recessive fumarase deficiency
J. Mol. Med.
82
550-554
2004
Homo sapiens
Lin, W.; Chan, M.; Goh, L.L.; Sim, T.S.
Molecular basis for thermal properties of Streptomyces thermovulgaris fumarase C hinge at hydrophilic amino acids R163, E170 and S347
Appl. Microbiol. Biotechnol.
75
329-335
2007
Streptomyces coelicolor, Streptomyces thermovulgaris (A5Y6J1), Streptomyces thermovulgaris
Singh, B.; Gupta, R.S.
Mitochondrial import of human and yeast fumarase in live mammalian cells: retrograde translocation of the yeast enzyme is mainly caused by its poor targeting sequence
Biochem. Biophys. Res. Commun.
346
911-918
2006
Homo sapiens (P07954), Homo sapiens, Saccharomyces cerevisiae (P08417), Saccharomyces cerevisiae
Barteri, M.; Coluzza, C.; Rotella, S.
Fractal aggregation of porcine fumarase induced by free radicals
Biochim. Biophys. Acta
1774
192-199
2007
Sus scrofa
Genda, T.; Watabe, S.; Ozaki, H.
Purification and characterization of fumarase from Corynebacterium glutamicum
Biosci. Biotechnol. Biochem.
70
1102-1109
2006
Corynebacterium glutamicum (Q8NRN8), Corynebacterium glutamicum
Colombo, S.; Grisa, M.; Tortora, P.; Vanoni, M.
Molecular cloning, nucleotide sequence and expression of a Sulfolobus solfataricus gene encoding a class II fumarase
FEBS Lett.
337
93-98
1994
Saccharolobus solfataricus (P39461), Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833 (P39461)
Shimoyama, T.; Rajashekhara, E.; Ohmori, D.; Kosaka, T.; Watanabe, K.
MmcBC in Pelotomaculum thermopropionicum represents a novel group of prokaryotic fumarases
FEMS Microbiol. Lett.
270
207-213
2007
Pelotomaculum thermopropionicum
Bowes, T.; Singh, B.; Gupta, R.S.
Subcellular localization of fumarase in mammalian cells and tissues
Histochem. Cell Biol.
127
335-346
2007
Rattus norvegicus
Lehtonen, H.J.; Blanco, I.; Piulats, J.M.; Herva, R.; Launonen, V.; Aaltonen, L.A.
Conventional renal cancer in a patient with fumarate hydratase mutation
Hum. Pathol.
38
793-796
2007
Homo sapiens
Ylisaukko-oja, S.K.; Kiuru, M.; Lehtonen, H.J.; Lehtonen, R.; Pukkala, E.; Arola, J.; Launonen, V.; Aaltonen, L.A.
Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients
Int. J. Cancer
119
283-287
2006
Homo sapiens
Yogev, O.; Karniely, S.; Pines, O.
Translation-coupled translocation of yeast fumarase into mitochondria in vivo
J. Biol. Chem.
282
29222-29229
2007
Saccharomyces cerevisiae
Carvajal-Carmona, L.G.; Alam, N.A.; Pollard, P.J.; Jones, A.M.; Barclay, E.; Wortham, N.; Pignatelli, M.; Freeman, A.; Pomplun, S.; Ellis, I.; Poulsom, R.; El-Bahrawy, M.A.; Berney, D.M.; Tomlinson, I.P.
Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations
J. Clin. Endocrinol. Metab.
91
3071-3075
2006
Homo sapiens
Pithukpakorn, M.; Wei, M.H.; Toure, O.; Steinbach, P.J.; Glenn, G.M.; Zbar, B.; Linehan, W.M.; Toro, J.R.
Fumarate hydratase enzyme activity in lymphoblastoid cells and fibroblasts of individuals in families with hereditary leiomyomatosis and renal cell cancer
J. Med. Genet.
43
755-762
2006
Homo sapiens
Karniely, S.; Regev-Rudzki, N.; Pines, O.
The presequence of fumarase is exposed to the cytosol during import into mitochondria
J. Mol. Biol.
358
396-405
2006
Saccharomyces cerevisiae
King, A.; Selak, M.A.; Gottlieb, E.
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer
Oncogene
25
4675-4682
2006
Homo sapiens
Chenier, D.; Beriault, R.; Mailloux, R.; Baquie, M.; Abramia, G.; Lemire, J.; Appanna, V.
Involvement of fumarase C and NADH oxidase in metabolic adaptation of Pseudomonas fluorescens cells evoked by aluminum and gallium toxicity
Appl. Environ. Microbiol.
74
3977-3984
2008
Pseudomonas fluorescens, Pseudomonas fluorescens 13525
Raimundo, N.; Ahtinen, J.; Fumic, K.; Baric, I.; Remes, A.M.; Renkonen, R.; Lapatto, R.; Suomalainen, A.
Differential metabolic consequences of fumarate hydratase and respiratory chain defects
Biochim. Biophys. Acta
1782
287-294
2008
Homo sapiens
Bayley, J.; Launonen, V.; Tomlinson, I.P.
The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency
BMC Med. Genet.
9
20
2008
Homo sapiens
Ahvenainen, T.; Lehtonen, H.J.; Lehtonen, R.; Vahteristo, P.; Aittomaeki, K.; Baynam, G.; Dommering, C.; Eng, C.; Gruber, S.B.; Groenberg, H.; Harvima, R.; Herva, R.; Hietala, M.; Kujala, M.; Kaeaeriaeinen, H.; Sunde, L.; Vierimaa, O.; Pollard, P.J.; Tomlinson, I.P.; Bjoerck, E.; Aaltonen, L.A.; Launonen, V.
Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer
Cancer genet. Cytogenet.
183
83-88
2008
Homo sapiens
Lorenzato, A.; Olivero, M.; Perro, M.; Briere, J.J.; Rustin, P.; Di Renzo, M.F.
A cancer-predisposing "hot spot" mutation of the fumarase gene creates a dominant negative protein
Int. J. Cancer
122
947-951
2008
Homo sapiens
Regev-Rudzki, N.; Yogev, O.; Pines, O.
The mitochondrial targeting sequence tilts the balance between mitochondrial and cytosolic dual localization
J. Cell Sci.
121
2423-2431
2008
Saccharomyces cerevisiae
Badeloe, S.; Bladergroen, R.S.; Jonkman, M.F.; Burrows, N.P.; Steijlen, P.M.; Poblete-Gutierrez, P.; van Steensel, M.A.; van Geel, M.; Frank, J.
Hereditary multiple cutaneous leiomyoma resulting from novel mutations in the fumarate hydratase gene
J. Dermatol. Sci.
51
139-143
2008
Homo sapiens
van der Merwe, M.J.; Osorio, S.; Moritz, T.; Nunes-Nesi, A.; Fernie, A.R.
Decreased mitochondrial activities of malate dehydrogenase and fumarase in tomato lead to altered root growth and architecture via diverse mechanisms
Plant Physiol.
149
653-669
2009
Solanum lycopersicum
Vrsalovic Presecki, A.; Zelic, B.; Vasic-Racki, D.
Modelling of continuous L-malic acid production by porcine heart fumarase and fumarase in yeast cells
Chem. Biochem. Eng. Q.
23
519-525
2009
Saccharomyces bayanus, Saccharomyces sp., Sus scrofa
-
Tian, Z.; Liu, Y.; Usa, K.; Mladinov, D.; Fang, Y.; Ding, X.; Greene, A.S.; Cowley, A.W.; Liang, M.
Novel role of fumarate metabolism in dahl-salt sensitive hypertension
Hypertension
54
255-260
2009
Rattus norvegicus
Regev-Rudzki, N.; Battat, E.; Goldberg, I.; Pines, O.
Dual localization of fumarase is dependent on the integrity of the glyoxylate shunt
Mol. Microbiol.
72
297-306
2009
Saccharomyces cerevisiae
Pracharoenwattana, I.; Zhou, W.; Keech, O.; Francisco, P.B.; Udomchalothorn, T.; Tschoep, H.; Stitt, M.; Gibon, Y.; Smith, S.M.
Arabidopsis has a cytosolic fumarase required for the massive allocation of photosynthate into fumaric acid and for rapid plant growth on high nitrogen
Plant J.
62
785-795
2010
Arabidopsis thaliana (P93033), Arabidopsis thaliana (Q9FI53)
Yogev, O.; Yogev, O.; Singer, E.; Shaulian, E.; Goldberg, M.; Fox, T.D.; Pines, O.
Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response
PLoS Biol.
8
e1000328
2010
Homo sapiens, Saccharomyces cerevisiae
Chen, Z.; Zhou, Q.; Ge, R.
Inhibition of fumarase by bismuth(III): implications for the tricarboxylic acid cycle as a potential target of bismuth drugs in Helicobacter pylori
Biometals
25
95-102
2012
Helicobacter pylori
Song, P.; Li, S.; Ding, Y.; Xu, Q.; Huang, H.
Expression and characterization of fumarase (FUMR) from Rhizopus oryzae
Fungal Biol.
115
49-53
2011
Rhizopus arrhizus (P55250)
Mescam, M.; Vinnakota, K.; Beard, D.
Identification of the catalytic mechanism and estimation of kinetic parameters for fumarase
J. Biol. Chem.
286
21100-21109
2011
Sus scrofa
Jiang, C.; Wu, L.L.; Zhao, G.C.; Shen, P.H.; Jin, K.; Hao, Z.Y.; Li, S.X.; Ma, G.F.; Luo, F.F.; Hu, G.Q.; Kang, W.L.; Qin, X.M.; Bi, Y.L.; Tang, X.L.; Wu, B.
Identification and characterization of a novel fumarase gene by metagenome expression cloning from marine microorganisms
Microb. Cell Fact.
9
91
2010
uncultured marine microorganism
Ramos-Vera, W.H.; Labonte, V.; Weiss, M.; Pauly, J.; Fuchs, G.
Regulation of autotrophic CO2 fixation in the archaeon Thermoproteus neutrophilus
J. Bacteriol.
192
5329-5340
2010
Pyrobaculum neutrophilum (B1Y931 and B1Y932), Pyrobaculum neutrophilum, Pyrobaculum neutrophilum DSM 2338 (B1Y931 and B1Y932)
Phan, I.; Subramanian, S.; Olsen, C.; Edwards, T.E.; Guo, W.; Zhang, Y.; Van Voorhis, W.C.; Stewart, L.J.; Myler, P.J.
Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria
Acta Crystallogr. Sect. F
67
1123-1128
2011
Rickettsia prowazekii (Q9ZCQ4), Rickettsia prowazekii
Adam, J.; Yang, M.; Bauerschmidt, C.; Kitagawa, M.; OFlaherty, L.; Maheswaran, P.; Oezkan, G.; Sahgal, N.; Baban, D.; Kato, K.; Saito, K.; Iino, K.; Igarashi, K.; Stratford, M.; Pugh, C.; Tennant, D.A.; Ludwig, C.; Davies, B.; Ratcliffe, P.J.; El-Bahrawy, M.; Ashrafian, H.; Soga, T.; Pollard, P.J.
A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia
Cell Rep.
3
1440-1448
2013
Homo sapiens
Mechaly, A.E.; Haouz, A.; Miras, I.; Barilone, N.; Weber, P.; Shepard, W.; Alzari, P.M.; Bellinzoni, M.
Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis
FEBS Lett.
586
1606-1611
2012
Mycobacterium tuberculosis (P9WN93), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WN93)
Feliciano, P.R.; Gupta, S.; Dyszy, F.; Dias-Baruffi, M.; Costa-Filho, A.J.; Michels, P.A.; Nonato, M.C.
Fumarate hydratase isoforms of Leishmania major: subcellular localization, structural and kinetic properties
Int. J. Biol. Macromol.
51
25-31
2012
Leishmania major
Su, R.R.; Wang, A.; Hou, S.T.; Gao, P.; Zhu, G.P.; Wang, W.
Identification of a novel fumarase C from Streptomyces lividans TK54 as a good candidate for L-malate production
Mol. Biol. Rep.
41
497-504
2014
Streptomyces lividans
Eprintsev, A.; Fedorin, D.; Starinina, E.; Igamberdiev, A.
Expression and properties of the mitochondrial and cytosolic forms of fumarase in germinating maize seeds
Physiol. Plant.
152
231-240
2014
Zea mays
van Vugt-Lussenburg, B.M.; van der Weel, L.; Hagen, W.R.; Hagedoorn, P.L.
Biochemical similarities and differences between the catalytic [4Fe-4S] cluster containing fumarases FumA and FumB from Escherichia coli
PLoS ONE
8
e55549
2013
Escherichia coli
van Vugt-Lussenburg, B.; van der Weel, L.; Hagen, W.; Hagedoorn, P.
Identification of two [4Fe-4S]-cluster-containing hydro-lyases from Pyrococcus furiosus
Microbiology
155
3015-3020
2009
Pyrococcus furiosus (Q8U062 and Q8U063), Pyrococcus furiosus
Pereira De Padua, R.; Nonato, M.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase
Acta Crystallogr. Sect. F
70
120-122
2014
Homo sapiens (P07954), Homo sapiens
Liu, Y.; Song, J.; Tan, T.; Liu, L.
Production of fumaric acid from L-malic acid by solvent engineering using a recombinant thermostable fumarase from Thermus thermophilus HB8
Appl. Biochem. Biotechnol.
175
2823-2831
2015
Thermus thermophilus (Q5SKT5), Thermus thermophilus
Kronen, M.; Sasikaran, J.; Berg, I.A.
Mesaconase activity of class I fumarase contributes to mesaconate utilization by Burkholderia xenovorans
Appl. Environ. Microbiol.
81
5632-5638
2015
Paraburkholderia xenovorans (Q13VI0), Paraburkholderia xenovorans (Q141Z6), Paraburkholderia xenovorans, Paraburkholderia xenovorans DSMZ 17367 / LB400 (Q13VI0), Paraburkholderia xenovorans DSMZ 17367 / LB400 (Q141Z6)
Singer, E.; Silas, Y.; Ben-Yehuda, S.; Pines, O.
Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response
eLife
6
e30927
2017
Bacillus subtilis
Lin, L.; Wang, Y.; Wu, M.; Zhu, L.; Yang, L.; Lin, J.
Enhancing the thermostability of fumarase C from Corynebacterium glutamicum via molecular modification
Enzyme Microb. Technol.
115
45-51
2018
Corynebacterium glutamicum (Q8NRN8), Corynebacterium glutamicum, Corynebacterium glutamicum DSM 20300 (Q8NRN8)
Zubimendi, J.P.; Martinatto, A.; Valacco, M.P.; Moreno, S.; Andreo, C.S.; Drincovich, M.F.; Tronconi, M.A.
The complex allosteric and redox regulation of the fumarate hydratase and malate dehydratase reactions of Arabidopsis thaliana fumarase 1 and 2 gives clues for understanding the massive accumulation of fumarate
FEBS J.
285
2205-2224
2018
Arabidopsis thaliana (P93033), Arabidopsis thaliana (Q9FI53), Arabidopsis thaliana
Bulku, A.; Weaver, T.M.; Berkmen, M.B.
Biochemical characterization of two clinically-relevant human fumarase variants defective for oligomerization
Open Biochem. J.
12
1-15
2018
Homo sapiens (P07954), Homo sapiens
Usa, K.; Liu, Y.; Geurts, A.M.; Cheng, Y.; Lazar, J.; Baker, M.A.; Grzybowski, M.; He, Y.; Tian, Z.; Liang, M.
Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain
Physiol. Genomics
49
496-504
2017
Rattus norvegicus (P14408)
Dyson, B.C.; Miller, M.A.; Feil, R.; Rattray, N.; Bowsher, C.G.; Goodacre, R.; Lunn, J.E.; Johnson, G.N.
FUM2, a cytosolic fumarase, is essential for acclimation to low temperature in Arabidopsis thaliana
Plant Physiol.
172
118-127
2016
Arabidopsis thaliana (Q9FI53), Arabidopsis thaliana
Eprintsev, A.T.; Fedorin, D.N.; Sazonova, O.V.; Igamberdiev, A.U.
Light inhibition of fumarase in Arabidopsis leaves is phytochrome A-dependent and mediated by calcium
Plant Physiol. Biochem.
102
161-166
2016
Arabidopsis thaliana (P93033), Arabidopsis thaliana (Q9FI53)
Eprintsev, A.T.; Fedorin, D.N.; Sazonova, O.V.; Igamberdiev, A.U.
Expression and properties of the mitochondrial and cytosolic forms of fumarase in sunflower cotyledons
Plant Physiol. Biochem.
129
305-309
2018
Helianthus annuus (A0A251UH44), Helianthus annuus (A0A251UZF1)
Kronen, M.; Berg, I.A.
Mesaconase/Fumarase FumD in Escherichia coli O157 H7 and promiscuity of Escherichia coli class I fumarases FumA and FumB
PLoS ONE
10
e0145098
2015
Escherichia coli O157:H7, Escherichia coli (P05042), Escherichia coli (P0AC33), Escherichia coli (P14407), Escherichia coli (Q8X999), Escherichia coli, Escherichia coli K-12 (P14407), Escherichia coli K-12 W3110 / K-12 (P14407), Escherichia coli W3110 / K-12 (P05042), Escherichia coli W3110 / K-12 (P0AC33), Escherichia coli O157:H7 ATCC 700728
Chen, X.; Song, W.; Gao, C.; Qin, W.; Luo, Q.; Liu, J.; Liu, L.
Fumarate production by Torulopsis glabrata engineering heterologous fumarase expression and improving acid tolerance
PLoS ONE
11
e0164141
2016
Rhizopus arrhizus (P55250), Rhizopus arrhizus ATCC 10260 (P55250)
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