4.2.1.2: fumarate hydratase

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For detailed information about fumarate hydratase, go to the full flat file.

Word Map on EC 4.2.1.2

4.2.1.2

succinate

leiomyomatosis

hereditary

tricarboxylic

uterine

leiomyoma

hlrcc

germline

isocitrate

citrate

tca

papillary

krebs

aconitase

carboxylase

citric

predisposition

fibroids

phosphoenolpyruvate

succinyl-coa

nucleoli

l-malic

halo

alpha-ketoglutarate

leiomyosarcoma

oncometabolite

paragangliomas

aspartase

pseudohypoxic

reed

oxalacetate

perinucleolar

hippel-lindau

hysterectomy

chromophobe

1.1.1.37

analysis

2-hydroxyglutarate

synthesis

papules

oncocytomas

medicine

industry

Reaction

Synonyms

At2g47510, At5g50950, Bxe_A1038, Bxe_A3136, class II fumarase, Fum, FUM C, FUM1, FUM2, FumA, fumarase, fumarase A, fumarase C, fumarase/mesaconase, fumarate hydratase, FumB, FumC, FumD, FumF, FUMR, hydratase, fumarate, L-malate hydro-lyase, LmFH-1, LmFH-2, LmjF24.0320, LmjF29.1960, mesaconase/fumarase, MmcBC, PF1754, PF1755, rv1098c, scFUMC, slFumC, stFUMC, Tneu_1334, Tneu_1335

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.2 fumarate hydratase

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Results	in table
15	Activating Compound
58052	AA Sequence
23	Application
1	CAS Registry Number
35	Cloned(Commentary)
1	Cofactor
12	Crystallization (Commentary)
2255	Disease/ Diagnostics
12	Expression
29	General Information
11	General Stability
1	IC50 Value
84	Inhibitors
86	kcat/KM [mM/s]
6	Ki Value [mM]
159	KM Value [mM]
60	Localization
23	Metals/Ions
61	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
11	Organic Solvent Stability
154	Organism
3	Oxidation Stability
28	Pathway
173	PDB ID
37	pH Optimum
6	pH Range
5	pH Stability
2	pI Value
1	Posttranslational Modification
112	Protein Variants
30	Purification (Commentary)
4	Reaction
3	Reaction Type
134	Reference
57	Source Tissue
27	Specific Activity [micromol/min/mg]
6	Storage Stability
178	Substrates and Products (Substrate)
36	Subunits
115	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
4	Temperature Range [°C]
28	Temperature Stability [°C]
50	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 4.2.1.2 - fumarate hydratase

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6.5

6.7

6.8 - 7.5

6.9

7.2

7.5

7.5 - 8.5

7.6

assay at

7.7

fumarate hydratase reaction

8.2

malate dehydratase reaction

747749

8.3

Corynebacterium glutamicum

Q8NRN8

phosphate buffer, substrate: malate

8.4

8.5

8.7

additional information

Sus scrofa

at low concentrations, phosphate, sulfate, borate, selenate, arsenate and citrate activate fumarase and shift somewhat the pH optimum to a more alkaline pH

33728