4.2.1.2: fumarate hydratase
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For detailed information about fumarate hydratase, go to the full flat file.
Word Map on EC 4.2.1.2
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4.2.1.2
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succinate
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leiomyomatosis
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hereditary
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tricarboxylic
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uterine
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leiomyoma
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hlrcc
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germline
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isocitrate
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citrate
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tca
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papillary
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krebs
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aconitase
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carboxylase
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citric
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predisposition
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fibroids
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phosphoenolpyruvate
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succinyl-coa
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nucleoli
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l-malic
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halo
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alpha-ketoglutarate
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leiomyosarcoma
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oncometabolite
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paragangliomas
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aspartase
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pseudohypoxic
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reed
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oxalacetate
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perinucleolar
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hippel-lindau
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hysterectomy
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chromophobe
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1.1.1.37
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analysis
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2-hydroxyglutarate
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synthesis
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papules
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oncocytomas
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medicine
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industry
- 4.2.1.2
- succinate
- leiomyomatosis
- hereditary
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tricarboxylic
- uterine
- leiomyoma
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hlrcc
-
germline
- isocitrate
- citrate
- tca
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papillary
-
krebs
- aconitase
- carboxylase
-
citric
-
predisposition
- fibroids
- phosphoenolpyruvate
- succinyl-coa
- nucleoli
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l-malic
-
halo
- alpha-ketoglutarate
- leiomyosarcoma
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oncometabolite
- paragangliomas
- aspartase
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pseudohypoxic
-
reed
- oxalacetate
-
perinucleolar
-
hippel-lindau
-
hysterectomy
-
chromophobe
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1.1.1.37
- analysis
- 2-hydroxyglutarate
- synthesis
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papules
- oncocytomas
- medicine
- industry
Reaction
Synonyms
At2g47510, At5g50950, Bxe_A1038, Bxe_A3136, class II fumarase, Fum, FUM C, FUM1, FUM2, FumA, fumarase, fumarase A, fumarase C, fumarase/mesaconase, fumarate hydratase, FumB, FumC, FumD, FumF, FUMR, hydratase, fumarate, L-malate hydro-lyase, LmFH-1, LmFH-2, LmjF24.0320, LmjF29.1960, mesaconase/fumarase, MmcBC, PF1754, PF1755, rv1098c, scFUMC, slFumC, stFUMC, Tneu_1334, Tneu_1335
ECTree
4.2.1.2 fumarate hydrataseAdvanced search results
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
analysis
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fumarate hydratase activity can be useful in the diagnosis of hereditary leiomyomatosis and renal cell cancer in cases with atypical presentation and undetectable fumarate hydratase mutations. Furthermore, fumarate hydratase activity testing is of value in laboratory investigations to elucidate the mechanism of hereditary leiomyomatosis and renal cell cancer
industry
medicine
synthesis
industry
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use of purified enzyme in L-malic acid production is uneconomical because whole cells are cheaper. Use of one mg of purified fumarase in continuous production of L-malic acids, corresponds to the use of enzyme in 68 g (wet weight) cells of Saccharomyces bayanus or in 120 g (wet weight) cells of baker's yeast
industry
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use of purified enzyme in L-malic acid production is uneconomical because whole cells are cheaper. Use of one mg of purified fumarase in continuous production of L-malic acids, corresponds to the use of enzyme in 68 g (wet weight) cells of Saccharomyces bayanus or in 120 g (wet weight) cells of baker's yeast
industry
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use of purified enzyme in L-malic acid production is uneconomical because whole cells are cheaper. Use of one mg of purified fumarase in continuous production of L-malic acids, corresponds to the use of enzyme in 68 g (wet weight) cells of Saccharomyces bayanus or in 120 g (wet weight) cells of baker's yeast
medicine
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metabolites of ibuprofen may play a role in its anti-cataract effect by protecting lenticular enzymes
medicine
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fumarate hydratase activity can be useful in the diagnosis of hereditary leiomyomatosis and renal cell cancer in cases with atypical presentation and undetectable fumarate hydratase mutations. Furthermore, fumarate hydratase activity testing is of value in laboratory investigations to elucidate the mechanism of hereditary leiomyomatosis and renal cell cancer
medicine
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fumarate immunohistochemistry may serve as a useful low-cost screening method to identify hereditary leiomyomatosis and renal cancer
medicine
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whole-gene fumarate hydratase deletions are not a frequent cause of hereditary leiomyomatosis and renal cell cancer syndrome
medicine
elevation of total fumarase activity may attenuate the development of hypertension
medicine
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the degradation of cell membranes in connection with necrosis leads to elevated fumarase activity in plasma and urine and hyperpolarized [1,4-13C2]malate production 24 h after reperfusion correlates with renal necrosis in a 40-min unilateral ischemic rat model. Fumarase activity screening on bio-fluids can detect injury severity. After verification of renal injury by bio-fluid analysis the precise injury location can be monitored by in vivo measurements of the fumarase activity non-invasively by hyperpolarized [1,4-13C]fumarate magnetic resonance imaging
synthesis
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highly stable enzyme would be ideal for use in various industrial processes, especially since the specific activity is also very high
synthesis
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economic production of L-malate in an enzyme membrane reactor
synthesis
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production of (S)-malic acid, which is used as an acidurant in fruit and vegetable juices, carbonated soft drinks, jams and candies, in amino acid infusions and for the treatment of hepatic malfunctioning
synthesis
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a pfl ldhA double mutant Escherichia coli strain NZN11 is used to produce succinic acid by overexpressing the Escherichia coli malic enzyme gene sfcA. This strain, however, produces a large amount of malic acid as well as succinic acid. The fumB gene encoding the anaerobic fumarase of Escherichia coli is co-amplified to solve the problem of malic acid accumulation, and subsequently improve the succinic acid production
synthesis
stFUMC is a highly efficient, thermostable fumarase C with industrial potential
synthesis
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fumarase is used for the industrial production of L-malate from the substrate fumarate
synthesis
overexpression of mutant P160A in Torulopsis glabrata leads to production 5.2 g/l fumarate. Additional deletion of adenylosuccinate synthase, a component of the purine nucleotide cycle, results in production of 9.2 g/l fumarate
synthesis
synthesis of fumarate in 50% ethylene glycol to shift the reaction equilibrium to fumaric acid. 54.7% conversion is observed using fumarase for transforming 1 mmol L-malic acid. 27% total yield is obtained with 99% purity
synthesis
use of tryptophan synthase in the generation of L-dihalotryptophans and L-alkynyltryptophans
synthesis
use of tryptophan synthase in the generation of L-dihalotryptophans and L-alkynyltryptophans
synthesis
Paraburkholderia xenovorans DSMZ 17367 / LB400
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use of tryptophan synthase in the generation of L-dihalotryptophans and L-alkynyltryptophans
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synthesis
Rhizopus arrhizus ATCC 10260
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overexpression of mutant P160A in Torulopsis glabrata leads to production 5.2 g/l fumarate. Additional deletion of adenylosuccinate synthase, a component of the purine nucleotide cycle, results in production of 9.2 g/l fumarate
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synthesis
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use of tryptophan synthase in the generation of L-dihalotryptophans and L-alkynyltryptophans
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