4.2.1.2: fumarate hydratase
This is an abbreviated version!
For detailed information about fumarate hydratase, go to the full flat file.
Word Map on EC 4.2.1.2
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4.2.1.2
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succinate
-
leiomyomatosis
-
hereditary
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tricarboxylic
-
uterine
-
leiomyoma
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hlrcc
-
germline
-
isocitrate
-
citrate
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tca
-
papillary
-
krebs
-
aconitase
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carboxylase
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citric
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predisposition
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fibroids
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phosphoenolpyruvate
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succinyl-coa
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nucleoli
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l-malic
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halo
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alpha-ketoglutarate
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leiomyosarcoma
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oncometabolite
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paragangliomas
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aspartase
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pseudohypoxic
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reed
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oxalacetate
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perinucleolar
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hippel-lindau
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hysterectomy
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chromophobe
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1.1.1.37
-
analysis
-
2-hydroxyglutarate
-
synthesis
-
papules
-
oncocytomas
-
medicine
-
industry
- 4.2.1.2
- succinate
- leiomyomatosis
- hereditary
-
tricarboxylic
- uterine
- leiomyoma
-
hlrcc
-
germline
- isocitrate
- citrate
- tca
-
papillary
-
krebs
- aconitase
- carboxylase
-
citric
-
predisposition
- fibroids
- phosphoenolpyruvate
- succinyl-coa
- nucleoli
-
l-malic
-
halo
- alpha-ketoglutarate
- leiomyosarcoma
-
oncometabolite
- paragangliomas
- aspartase
-
pseudohypoxic
-
reed
- oxalacetate
-
perinucleolar
-
hippel-lindau
-
hysterectomy
-
chromophobe
-
1.1.1.37
- analysis
- 2-hydroxyglutarate
- synthesis
-
papules
- oncocytomas
- medicine
- industry
Reaction
Synonyms
At2g47510, At5g50950, Bxe_A1038, Bxe_A3136, class II fumarase, Fum, FUM C, FUM1, FUM2, FumA, fumarase, fumarase A, fumarase C, fumarase/mesaconase, fumarate hydratase, FumB, FumC, FumD, FumF, FUMR, hydratase, fumarate, L-malate hydro-lyase, LmFH-1, LmFH-2, LmjF24.0320, LmjF29.1960, mesaconase/fumarase, MmcBC, PF1754, PF1755, rv1098c, scFUMC, slFumC, stFUMC, Tneu_1334, Tneu_1335
ECTree
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Metals Ions
Metals Ions on EC 4.2.1.2 - fumarate hydratase
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Fe2+
Iron
Mg2+
Mn2+
additional information
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aerobic purification results in inactive protein, which can only partly be reactivated with Fe2+ and thiol
Fe2+
storage of the protein for 6 months leads to almost complete loss of its activity, which can be fully restored by the reactivation with Fe2+ and thiol
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one Fe-S-dependent enzyme form and one Fe-S-independent enzyme form
Iron
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in cells grown without aeration the Fe-S-independent enzyme form occupies over 80% of the overall fumarase. In aerobically grown cells the Fe-S-dependent fumarase occupies 80% of the overall activity
Mg2+
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cytosolic form gets strongly activated, mitochondrial form only moderately activated
Mn2+
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cytosolic form gets strongly activated, mitochondrial form only less effectively activated
activity does not increase upon incubation with Fe2+
additional information
activity does not increase upon incubation with Fe2+
additional information
activity does not increase upon incubation with Fe2+
additional information
activity does not increase upon incubation with Fe2+
additional information
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activity does not increase upon incubation with Fe2+
additional information
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aluminium and gallium do not perturb the activity of fumarase C
additional information
no effects of Zn2+, Fe2+, or EDTA on enzyme activity
additional information
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class II fumarase activity is frequently influenced by divalent metal ions and non-ionic surfactants. No effect by Ca2+