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GTP + H2O
GDP + phosphate
guanosine 5'-O-(3-thio)triphosphate + H2O
guanosine 5'-diphosphate + thiophosphate
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-
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?
guanosine 5'-O-(3-thiotriphosphate) + H2O
guanosine 5'-O-diphosphate + thiophosphate
MEK kinase 1 + H2O
?
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RhoA binds and activates MEK kinase 1
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?
p21-activated kinase 1 + H2O
activated p21-activated kinase 1 + ?
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Gamide signals Rac/Cdc42 to activate p21-activated kinase 1
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?
Rho-activated kinase + H2O
activated Rho-activated kinase + ?
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Ggly signals Rac/Cdc42 to activate Rho-activated kinase
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?
additional information
?
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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-
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ir
GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
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the enzyme is involved in nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Nuclear import of Ran relies on a small RanGTP-binding protein, nuclear transport factor 2
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?
GTP + H2O
GDP + phosphate
-
Arabidopsis thaliana circadian clock is regulated by the small GTPase LIP1. LIP1 plays a unique negative role in controlling circadian light input and is required for precise entrainment of the plant
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?
GTP + H2O
GDP + phosphate
transport of precursor proteins across chloroplast membranes involves the GTPases Toc33/34 and Toc159 at the outer chloroplast envelope
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?
GTP + H2O
GDP + phosphate
-
assay at pH 7.8, 30°C, 30 min
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?
GTP + H2O
GDP + phosphate
-
-
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ir
GTP + H2O
GDP + phosphate
-
-
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ir
GTP + H2O
GDP + phosphate
-
-
-
ir
GTP + H2O
GDP + phosphate
-
increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP
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ir
GTP + H2O
GDP + phosphate
-
increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP
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ir
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
RHO-1 plays a role in hypodermal P cell migration to a ventral position during larval development
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?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
GTP binds to Der in a cooperative manner and the interruption of cooperative nucleotide association disrupts the interaction of Der with the 50S subunit
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-
?
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
Rab11 plays a central role in the transport and secretion of pathogenic factors
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?
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off
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ir
GTP + H2O
GDP + phosphate
GTP binds to Der in a cooperative manner and the interruption of cooperative nucleotide association disrupts the interaction of Der with the 50S subunit
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-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off
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ir
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
-
Rac-1 coordinates changes in chondrocyte phenotype and function and stimulates the maturation process essential for skeletal development
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?
GTP + H2O
GDP + phosphate
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-
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?
GTP + H2O
GDP + phosphate
-
GhRac1 GTPase may be a potential regulator of fiber elongation by controlling cytoskeletal assembly
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?
GTP + H2O
GDP + phosphate
-
-
657726, 659553, 696043, 696313, 696514, 696950, 697093, 697499, 700071, 720356, 733639, 755731 -
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?
GTP + H2O
GDP + phosphate
-
-
-
ir
GTP + H2O
GDP + phosphate
-
-
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ir
GTP + H2O
GDP + phosphate
-
-
-
ir
GTP + H2O
GDP + phosphate
-
-
-
ir
GTP + H2O
GDP + phosphate
-
-
-
ir
GTP + H2O
GDP + phosphate
-
-
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ir
GTP + H2O
GDP + phosphate
-
-
-
ir
GTP + H2O
GDP + phosphate
-
-
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ir
GTP + H2O
GDP + phosphate
-
-
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ir
GTP + H2O
GDP + phosphate
-
-
-
ir
GTP + H2O
GDP + phosphate
-
-
-
ir
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
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-
?
GTP + H2O
GDP + phosphate
-
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?
GTP + H2O
GDP + phosphate
-
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?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
-
high affinity for GTP, significant GTPase activity
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ir
GTP + H2O
GDP + phosphate
-
increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP
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ir
GTP + H2O
GDP + phosphate
-
cycling between the active GTP bound and the inactive GDP bound state, slow GTPase activity
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ir
GTP + H2O
GDP + phosphate
-
unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off
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ir
GTP + H2O
GDP + phosphate
-
increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP
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ir
GTP + H2O
GDP + phosphate
-
Cdc42 causes formation of filopodia, which might be involved in the recognition of the extracellular environment
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?
GTP + H2O
GDP + phosphate
Rab21 has a role in the dynamics of the early endocytic pathway
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?
GTP + H2O
GDP + phosphate
-
Rab27a has a determinant role in melanocytes and lymphocytes, role in melanosome peripheral transfer, required for cytotoxic granule exocytosis
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?
GTP + H2O
GDP + phosphate
-
Rac1 promotes actin polymerization and the formation of lamellipodia of migrating cells
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?
GTP + H2O
GDP + phosphate
Rac1 regulates gene expression, cell cycle progression and rearrangement of the actin cytoskeleton, Rac1 is ubiquitously expressed and regulates a wide variety of cellular processes
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?
GTP + H2O
GDP + phosphate
Rac2 may be responsible for the regulation of the oxidative burst in hematopoietic cells
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?
GTP + H2O
GDP + phosphate
Rac3 is ubiquitously expressed and regulates a wide variety of cellular processes
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?
GTP + H2O
GDP + phosphate
-
RhoA promotes actin-myosin contractility and, thereby, the formation of stress fibers and focal adhesions, regulating cell shape, attachment and motility
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?
GTP + H2O
GDP + phosphate
-
intrinsic GTPase reaction mechanism, biphasic reaction
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?
GTP + H2O
GDP + phosphate
nucleotide binding and hydrolysis properties, comparison with the properties of the Rac isoforms Rac1 and Rac2
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?
GTP + H2O
GDP + phosphate
nucleotide binding and hydrolysis properties, comparison with the properties of the Rac isoforms Rac1 and Rac3, Rac2 structure, altered dynamics of Rac2 at the switch I region may be responsible for the differing biochemical properties compared with Rac1 and 3
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?
GTP + H2O
GDP + phosphate
nucleotide binding and hydrolysis properties, comparison with the properties of the Rac isoforms Rac2 and Rac3, enzyme structure
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?
GTP + H2O
GDP + phosphate
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Trp-73 is a key position for interaction with the specific effectors of Rab27a, both in melanocytes and cytotoxic cells, Trp-73 is essential for the intrinsic GTPase activity, Gln-78 may stabilize the catalytic transition state between switch I and II
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?
GTP + H2O
GDP + phosphate
RHEBL1 may play an important role in the NF-kappa B-mediated gene transcription
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?
GTP + H2O
GDP + phosphate
-
tuberous sclerosis complex TSC2 displays activity of a GTPase-activating protein specifically towards the small G protein Rheb and inhibits its ability to stimulate the mTOR signalling pathway
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?
GTP + H2O
GDP + phosphate
-
small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells
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?
GTP + H2O
GDP + phosphate
-
small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein. Altering the intracellular trafficking of P-glycoprotein by modulation of its small GTPase regulators can be potential strategy to overcome multidrug resistance, a major obstacle in cancer chemotherapy
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?
GTP + H2O
GDP + phosphate
-
small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran has important roles during mitosis, when the nucleus is reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions
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?
GTP + H2O
GDP + phosphate
-
the small GTPase Rac plays a crucial role in activation of Nox2- and Nox1-based oxidases i all the possible combinations of the organizer p47phox or Noxo1 with the activator p67phox or Noxa1
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?
GTP + H2O
GDP + phosphate
-
two conformational states of Ras GTPase exhibit differential GTP-binding kinetics
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?
GTP + H2O
GDP + phosphate
enzyme Rheb contains a high basal GTP level
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?
GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
-
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?
GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran has important roles during mitosis, when the nucleus is reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions
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?
GTP + H2O
GDP + phosphate
-
two conformational states of Ras GTPase exhibit differential GTP-binding kinetics
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?
GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
-
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?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off
-
ir
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
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?
GTP + H2O
GDP + phosphate
-
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?
GTP + H2O
GDP + phosphate
-
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?
GTP + H2O
GDP + phosphate
-
acts on the intracellular membrane through the trafficking pathway
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?
GTP + H2O
GDP + phosphate
transport of precursor proteins across chloroplast membranes involves the GTPases Toc33/34 and Toc159 at the outer chloroplast envelope
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?
GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
-
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?
GTP + H2O
GDP + phosphate
-
-
-
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?
GTP + H2O
GDP + phosphate
-
small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression
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?
GTP + H2O
GDP + phosphate
-
Rnd1 is involved in signaling pathways of neuronal activity-dependent dendritic development
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?
GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
-
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ir
GTP + H2O
GDP + phosphate
-
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ir
GTP + H2O
GDP + phosphate
-
Rho A-linked pathway important in the endothelin-1 signaling to c-fos SRC
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ir
GTP + H2O
GDP + phosphate
-
increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP
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ir
GTP + H2O
GDP + phosphate
-
slow time-dependent GTPase activity
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ir
GTP + H2O
GDP + phosphate
-
increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP
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ir
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
-
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ir
GTP + H2O
GDP + phosphate
-
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ir
GTP + H2O
GDP + phosphate
-
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ir
GTP + H2O
GDP + phosphate
-
-
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ir
GTP + H2O
GDP + phosphate
-
-
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ir
GTP + H2O
GDP + phosphate
-
-
-
ir
GTP + H2O
GDP + phosphate
-
unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off
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ir
GTP + H2O
GDP + phosphate
-
Rho3p and Rho4p are involved in regulating cell polarity by controlling polarized exocytosis. It is proposed that Wsc1p participates in the regulation of a Rho3/4-dependent cellular mechanism
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?
GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
-
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?
GTP + H2O
GDP + phosphate
-
-
-
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?
GTP + H2O
GDP + phosphate
-
GTP binds to Der in a cooperative manner and the interruption of cooperative nucleotide association disrupts the interaction of Der with the 50S subunit
-
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?
GTP + H2O
GDP + phosphate
-
-
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?
GTP + H2O
GDP + phosphate
GTP binds to Der in a cooperative manner and the interruption of cooperative nucleotide association disrupts the interaction of Der with the 50S subunit
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?
GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
nucleotide binding pocket and binding structures, overview
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GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
-
GTPase TcRho1 is required for differentiation of epimastigote to trypomastigote forms during the parasite cell cycle. TcRho1 plays a conserved regulatory role in cell-substrate adhesion in both NIH-3T3 fibroblasts and Trypanosoma cruzi epimastigotes. TcRho1 may regulate the substrate-adhesion in Trypanosoma cruzi,a critical step for successful progression of the parasite life cycle
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?
GTP + H2O
GDP + phosphate
-
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ir
guanosine 5'-O-(3-thiotriphosphate) + H2O
guanosine 5'-O-diphosphate + thiophosphate
-
poorly hydrolyzable, GTP[S]-activated Rac1 and Cdc42, but not RhoA, stimulate activity of phospholipase C-beta2 protein in complex with Rho GDP dissociation inhibitor protein LyGDL
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?
guanosine 5'-O-(3-thiotriphosphate) + H2O
guanosine 5'-O-diphosphate + thiophosphate
-
no detectable hydrolysis of GTP at the ARF domain p3, 35-40% of the GTP bound to ARD1 domain p8 hydrolyzed in 1 h at room temperature
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?
guanosine 5'-O-(3-thiotriphosphate) + H2O
guanosine 5'-O-diphosphate + thiophosphate
-
poorly hydrolyzable, GTP[S]-activated Rac1 and Cdc42, but not RhoA, stimulate activity of phospholipase C-beta2 protein in complex with Rho GDP dissociation inhibitor protein LyGDL
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?
guanosine 5'-O-(3-thiotriphosphate) + H2O
guanosine 5'-O-diphosphate + thiophosphate
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?
additional information
?
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role of small GTPases in endothelial cytoskeletal dynamics and the shear stress response
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?
additional information
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GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48
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?
additional information
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small GTPase Rab2 functions in the removal of apoptotic cells
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?
additional information
?
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Campylobacter jejuni invade host target cells by a unique mechanism and the activation of the Rho GTPase members Rac1 and Cdc42 play a crucial role in this entry process
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?
additional information
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Rhb1 is involved in the cell wall integrity pathway via activation of mitogen-activated protein kinase Mkc1
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?
additional information
?
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Rhb1 is involved in the cell wall integrity pathway via activation of mitogen-activated protein kinase Mkc1
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?
additional information
?
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p21-activated kinase Cla4 is a major downstream partner of Rac. Rac has strong effect on hyphal morphology
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?
additional information
?
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p21-activated kinase Cla4 is a major downstream partner of Rac. Rac has strong effect on hyphal morphology
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?
additional information
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small GTPases are involved in chemotaxis
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?
additional information
?
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Rho1 activity is required for proper development of the circular visceral mesoderm upon which the gland migrates, Rho1 GTPase regulates salivary gland invagination by maintaining apical localization of Crumbs, Drosophila atypical protein kinase C and Stardust and that this occurs partially through regulation of Crumbs RNA level and apical localization of the transcript and by inducing apical constriction and cell shape change through Rho-kinase
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?
additional information
?
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Drosophila sp. (in: flies)
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crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger
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?
additional information
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
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A0A098E0E9
FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
-
A0A098E0E9
FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
-
FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
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FgRac1 interacts with the PBD domain of FgCla4
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?
additional information
?
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RASL11A is down-regulated in prostate tumors and may have a tumor suppressor role in prostate cancer
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?
additional information
?
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RASL11A is down-regulated in prostate tumors and may have a tumor suppressor role in prostate cancer
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?
additional information
?
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RASL11A is down-regulated in prostate tumors and may have a tumor suppressor role in prostate cancer
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?
additional information
?
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Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac
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?
additional information
?
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small GTPase Rac is directly involved in activation of the superoxide-producing NADPH oxidase Nox1
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?
additional information
?
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the Ral-exocyst pathway participates in the regulation of platelet dense granule secretion by enhancing the Ca2+ sensitivity of the secretion
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?
additional information
?
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Rap1 plays a critical role in the regulation of beta1-integrin affinity, adhesion, and migration in endothelial cells and in postnatal neovascularization
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?
additional information
?
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Rho and Rac play a role in the regulation cytoskeletal remodeling and EC barrier regulation
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?
additional information
?
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RhoA activity is required for modulating cell migration and proliferation through cytoskeleton reorganization and focal adhesion formation in response to wounding
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?
additional information
?
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RhoA may serve as intermediary for functional receptor for thromboxane A2-signaling axis to regulate tumor cell motility
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?
additional information
?
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RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity
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?
additional information
?
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RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity
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?
additional information
?
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the small GTPase RhoH is an atypical regulator of haematopoietic cells
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?
additional information
?
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the small GTPase RhoH is an atypical regulator of haematopoietic cells
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?
additional information
?
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at least 3 mitogen-activated protein kinases (MAPKs) are direct targets of Rac1: MLK2, MLK3, and MEKK4
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?
additional information
?
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at least 3 mitogen-activated protein kinases (MAPKs) are direct targets of Rac1: MLK2, MLK3, and MEKK4
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?
additional information
?
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at least 3 mitogen-activated protein kinases (MAPKs) are direct targets of Rac1: MLK2, MLK3, and MEKK4
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?
additional information
?
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enzyme Rheb does not co-localize with microtubules but interacts with unpolymerized free alphabeta-tubulin, alphabeta-tubulin is a Rheb-binding protein. Rheb binds to deacetylated soluble alphabeta-tubulin
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?
additional information
?
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kinetic analysis of the GTPase nucleotide exchange reaction via homogeneous quenching resonance energy transfer assay, method development overview
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?
additional information
?
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kinetic analysis of the GTPase nucleotide exchange reaction via homogeneous quenching resonance energy transfer assay, method development overview
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?
additional information
?
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kinetic analysis of the GTPase nucleotide exchange reaction via homogeneous quenching resonance energy transfer assay, method development overview
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?
additional information
?
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binding of GppNHp by Rab8 leads to the active form of Rab8, like with GTP, but GppNHp is unhydrolyzable, binding studies
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-
additional information
?
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binding of GppNHp by Rab8 leads to the active form of Rab8, like with GTP, but GppNHp is unhydrolyzable, binding studies
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-
additional information
?
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Ras binds guanine nucleotides in its guanine nucleotide-binding cleft composed of G-box elements that are conserved among all GTPase proteins
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additional information
?
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Knock down of Rab21 impairs integrin-mediated cell adhesion and motility, its overexpression stimulates cell migration and cancer cell adhesion to collagen and human bone
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?
additional information
?
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in 3T3-L1 adipocytes, stimulation of lipolysis increases the association of Rab18 with lipid droplets, suggesting that recruitment of Rab18 is regulated by the metabolic state of individual lipid droplets
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?
additional information
?
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Rab and Ral GTPases function in exocyst assembly and vesicle-tethering processes, whereas the Rho family of GTPases functions in the local activation of the exocyst complex to facilitate downstream vesicle-fusion events
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additional information
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Rac GTPases play an important role in enucleation of mammalian erythroblasts
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Rac1 and Cdc42 are not required for differentiation and migration of neural crest cells, but are essential for mitotic activity and cell-cycle control in neural crest cell target structures
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Rac1 is a central regulator of rapid encoding of novel spatial information in vivo, Rac1 mutants display deficits in working/episodic-like memory in the delayed matching-to-place
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Rac2 selectively controls phagosomal alkalinization and antigen crosspresentation in CD8+ dendritic cells, Rac2 determines the subcellular assembly of the NADPH oxidase complex to phagosomes in CD8+ cells whereas in CD8- cells Rac1 mediates the assembly of NOX2 at the plasma membrane
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RalA is a critical component in biphasic insulin release from pancreatic beta cells
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Rap1 plays a critical role in the regulation of beta1-integrin affinity, adhesion, and migration in endothelial cells and in postnatal neovascularization
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RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity
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RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity
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the small GTPase RhoA is crucial for MC3T3-E1 osteoblastic cell survival
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the small GTPase RhoH is an atypical regulator of haematopoietic cells
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the small GTPase RhoH is an atypical regulator of haematopoietic cells
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Ras-related, small GTPases act as molecular switches that control a variety of cellular processes by cycling between alternative conformational states: in the active state, they are bound with GTP, and in the inactive state, they are bound with GDP. In their active state, GTPases recognize their target effector proteins and evoke responses until GTP hydrolysis returns the switch to the off position
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additional information
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Ras-related, small GTPases act as molecular switches that control a variety of cellular processes by cycling between alternative conformational states: in the active state, they are bound with GTP, and in the inactive state, they are bound with GDP. In their active state, GTPases recognize their target effector proteins and evoke responses until GTP hydrolysis returns the switch to the off position
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recombinant RhoA activity reduces Ba2+ currents through CaV2.1, CaV2.2 and CaV2.3 Ca2+ channels independently of CaVbeta subunit. This inhibition occurs independently of RGKs activity and without modification of biophysical properties and global level of expression of the channel subunit
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additional information
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Ras-related, small GTPases act as molecular switches that control a variety of cellular processes by cycling between alternative conformational states: in the active state, they are bound with GTP, and in the inactive state, they are bound with GDP. In their active state, GTPases recognize their target effector proteins and evoke responses until GTP hydrolysis returns the switch to the off position
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additional information
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Ras-related, small GTPases act as molecular switches that control a variety of cellular processes by cycling between alternative conformational states: in the active state, they are bound with GTP, and in the inactive state, they are bound with GDP. In their active state, GTPases recognize their target effector proteins and evoke responses until GTP hydrolysis returns the switch to the off position
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interaction site of HsRac1 with p67phox, an essential component of the NADPH oxidase complex
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interaction site of HsRac1 with p67phox, an essential component of the NADPH oxidase complex
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no activity with unhydrolyzable GTPgammaS, which is used for association/dissociation and binding analysis
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no activity with unhydrolyzable GTPgammaS, which is used for association/dissociation and binding analysis
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Rac1 can interact with the PBD domain of p21-activated kinase 1 (PAK1)
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RalA is a critical component in biphasic insulin release from pancreatic beta cells
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Rho1p and its downstream regulatory pathways are involved in controlling cell size in Saccharomyces cerevisiae
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vacuole fusion assays
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vacuole fusion assays
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Alp41 GTPase interacts with cofactor C, but with cofactor D, Alp1D, only when bound to GDP
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Alp41 GTPase interacts with cofactor C, but with cofactor D, Alp1D, only when bound to GDP
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additional information
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Alp41 GTPase interacts with cofactor C, but with cofactor D, Alp1D, only when bound to GDP
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RhoA activity is required for modulating cell migration and proliferation through cytoskeleton reorganization and focal adhesion formation in response to wounding
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the enzyme interacts with tubulin and co-localises to the flagellar pocket with BBS1 when this protein is overexpressed
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additional information
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the enzyme interacts with tubulin and co-localises to the flagellar pocket with BBS1 when this protein is overexpressed
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