Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | regulation of Cdc42 activity | Homo sapiens | |
additional information | regulation of Rac1 activity | Homo sapiens | |
additional information | regulation of RhoA activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | regulation of Cdc42 activity; regulation of Rac1 activity; regulation of RhoA activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Homo sapiens | Cdc42 causes formation of filopodia, which might be involved in the recognition of the extracellular environment | GDP + phosphate | - |
? | |
GTP + H2O | Homo sapiens | Rac1 promotes actin polymerization and the formation of lamellipodia of migrating cells | GDP + phosphate | - |
? | |
GTP + H2O | Homo sapiens | RhoA promotes actin-myosin contractility and, thereby, the formation of stress fibers and focal adhesions, regulating cell shape, attachment and motility | GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | contains a geranylgeranyl prenylation motif | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | ubiquitous expression pattern | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | Cdc42 causes formation of filopodia, which might be involved in the recognition of the extracellular environment | Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | Rac1 promotes actin polymerization and the formation of lamellipodia of migrating cells | Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | RhoA promotes actin-myosin contractility and, thereby, the formation of stress fibers and focal adhesions, regulating cell shape, attachment and motility | Homo sapiens | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdc42 | member of the Rho-family | Homo sapiens |
Rac1 | member of the Rho-family | Homo sapiens |
RhoA | member of the Rho-family | Homo sapiens |