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BRENDA support

Literature summary for 3.6.5.2 extracted from

  • Fu, D.; van Dam, E.M.; Brymora, A.; Duggin, I.G.; Robinson, P.J.; Roufogalis, B.D.
    The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein (2007), Biochim. Biophys. Acta, 1773, 1062-1072.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein. Altering the intracellular trafficking of P-glycoprotein by modulation of its small GTPase regulators can be potential strategy to overcome multidrug resistance, a major obstacle in cancer chemotherapy GDP + phosphate
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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MCF-7 cell
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Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein. Altering the intracellular trafficking of P-glycoprotein by modulation of its small GTPase regulators can be potential strategy to overcome multidrug resistance, a major obstacle in cancer chemotherapy Homo sapiens GDP + phosphate
-
?

Synonyms

Synonyms Comment Organism
small GTPases Rab5
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Homo sapiens
small GTPases Ral5
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Homo sapiens